A partir des données de l'essai "NSABP P-1" incluant 13 388 femmes à haut risque de cancer du sein (durée médiane de suivi : 7 ans), cet essai évalue l'association entre le tabagisme, une activité physique, une consommation d'alcool, et le risque de cancer

Cigarette smoking, physical activity, and alcohol consumption as predictors of cancer incidence among women at high risk of breast cancer in the NSABP P-1 Trial

Land, Stephanie R. ; Liu, Qing ; Wickerham, D. Lawrence ; Costantino, Joseph P. ; Ganz, Patricia A.

Background: NSABP P-1 provides an opportunity to examine the association of behavioral factors with prospectively monitored cancer incidence and interactions with tamoxifen. Methods: From 1992-1997, 13,388 women with estimated 5-year breast cancer (BC) risk greater than 1.66% or a history of lobular carcinoma in situ (87% under age 65; 67% post-menopausal) were randomly assigned to tamoxifen versus placebo. Invasive BC, lung (LC), colon (CC), and endometrial cancers (EC) were analyzed with Cox [...]

A partir des données de la base de l'assurance maladie à Taïwan, cette étude évalue l'association entre une pneumoconiose et le risque de cancer chez les ouvriers des mines de charbon

Cancer risk among patients with coal workers' pneumoconiosis in Taiwan: A nationwide population-based study

Hung, Yi-Ping ; Teng, Chung-Jen ; Liu, Chia-Jen ; Hu, Yu-Wen ; Hung, Man-Hsin ; Tzeng, Cheng-Hwai ; Liu, Chun-Yu ; Yeh, Chiu-Mei ; Chen, Tzeng-Ji ; Chiou, Tzeon-Jye

This study is aimed to evaluate the cancer risk among patients with coal workers' pneumoconiosis (CWP) using a nationwide population-based dataset. Patients without previous cancer who had been diagnosed with CWP and followed-up for more than 1 year between 1997 and 2006 were recruited from the Taiwan National Health Insurance database. Standardized incidence ratios (SIRs) of cancers in CWP patients were calculated and compared to the cancer incidence in the general population. Risk factors for [...]

A partir des données de la cohorte "The Cancer Prevention Study II Nutrition Cohort" incluant 61 326 hommes et femmes n'ayant jamais fumé, cette étude américaine évalue l'association entre une exposition au tabagisme passif et le risque de lymphome non-hodgkinien

Exposure to Environmental Tobacco Smoke and Risk of Non-Hodgkin Lymphoma in Nonsmoking Men and Women

Diver, W. Ryan ; Teras, Lauren R. ; Gaudet, Mia M. ; Gapstur, Susan M.

Little is known about the risk of non-Hodgkin lymphoma (NHL) in nonsmokers who are exposed to environmental tobacco smoke (ETS). Previous research on NHL and ETS has not included men or examined doses of ETS exposure during childhood. The Cancer Prevention Study II Nutrition Cohort collected information on smoking habits and exposure to ETS during childhood and adulthood. Among 61,326 never-smoking men and women, 884 incident cases of NHL were identified between 1992 and 2009. [...]

A partir d'une modélisation bayésienne, cette étude américaine évalue l'association entre une exposition à des fibres d'amiante de différentes tailles et le risque de cancer du poumon

Examining the association of lung cancer and highly correlated fibre size-specific asbestos exposures with a hierarchical Bayesian model

Hamra, Ghassan B ; Loomis, Dana ; Dement, John

Background : Asbestos is a known carcinogen. However, little is known about the differential effects of size-specific asbestos fibres. Previous research has examined the relationship with lung cancer of each fibre group in the absence of others. Attempts to model all fibre groups within a single regression model have failed due to high correlations across fibre size groups. Methods : We compare results from frequentist models for individual fibre size groups, and a hierarchical Bayesian model [...]

Menée à Taïwan sur une cohorte incluant 24 418 participants de moins de 18 ans, cette étude évalue l'association entre un examen de la tête par tomodensitométrie chez l'enfant et le risque ultérieur de tumeurs bénignes ou malignes du cerveau

Paediatric head CT scan and subsequent risk of malignancy and benign brain tumour: a nation-wide population-based cohort study

Huang, W. Y. ; Muo, C. H. ; Lin, C. Y. ; Jen, Y. M. ; Yang, M. H. ; Lin, J. C. ; Sung, F. C. ; Kao, C. H.

Background: To evaluate the possible association between paediatric head computed tomography (CT) examination and increased subsequent risk of malignancy and benign brain tumour. Methods: In the exposed cohort, 24 418 participants under 18 years of age, who underwent head CT examination between 1998 and 2006, were identified from the Taiwan National Health Insurance Research Database (NHIRD). Patients were followed up until a diagnosis of malignant disease or benign brain tumour, withdrawal [...]

Couplée aux données de la cohorte "Cancer Prevention Study II Nutrition Cohort" et portant sur 272 cas et 272 témoins, cette étude évalue l'association entre les niveaux plasmatiques d'adiponectine et de peptide-C et le risque de cancer aggressif de la prostate

No association of plasma levels of adiponectin and c-peptide with risk of aggressive prostate cancer in the Cancer Prevention Study II Nutrition Cohort

Stevens, Victoria L. ; Jacobs, Eric J. ; Sun, Juzhong ; Gapstur, Susan M.

Background: Obesity is associated with higher risk of aggressive prostate cancer and alters circulating levels of insulin and adiponectin, two hormones which influence biological processes implicated in carcinogenesis. Results of some studies showed associations of circulating levels of adiponectin, insulin, and c-peptide (a marker of insulin secretion) with aggressive prostate cancer, but the size of these studies was limited. Methods: A nested case-control study of 272 aggressive prostate [...]

A partir des données de l'étude "Collaborative Breast Cancer Study" portant sur 6 131 cas et 7 274 témoins, cette étude évalue l'association entre des critères reproductifs (délai entre les premières règles et la première naissance, délai entre les premières règles et la ménopause), 13 variants génétiques déjà identifiés dans des études d'association sur le génome entier et le risque de cancer du sein

Reproductive windows, genetic loci and breast cancer risk

Shaneda Warren Andersen ; Amy Trentham-Dietz ; Ronald E. Gangnon

Purpose : The reproductive windows between age at menarche and first childbirth (standardized AFB) and from menarche to menopause (reproductive lifespan) may interact with genetic variants in association with breast cancer risk. Methods : We assessed this hypothesis in 6131 breast cancer cases and 7274 controls who participated in the population-based Collaborative Breast Cancer Study. Risk factor information was collected through telephone interviews and DNA samples were collected on a [...]