A partir des données des registres nationaux de cinq pays nordiques portant sur 16 422 pompiers masculins, cette étude de cohorte analyse l'évolution de l'incidence des cancers sur la période 1961-2005

Cancer incidence among firefighters: 45 years of follow-up in five Nordic countries

Pukkala, Eero ; Martinsen, Jan Ivar ; Weiderpass, Elisabete ; Kjaerheim, Kristina ; Lynge, Elsebeth ; Tryggvadottir, Laufey ; Sparén, Pär ; Demers, Paul A

Objectives : Firefighters are potentially exposed to a wide range of known and suspected carcinogens through their work. The objectives of this study were to examine the patterns of cancer among Nordic firefighters, and to compare them with the results from previous studies. Methods : Data for this study were drawn from a linkage between the census data for 15 million people from the five Nordic countries and their cancer registries for the period 1961–2005. SIR analyses were conducted with the [...]

Menée en Suède à partir de données portant sur 4 219 691 personnes, cette étude évalue l'association entre un stress émotionnel sévère durant l'enfance, comme la perte d'un parent, et le risque de développer un cancer à un âge précoce

Loss of a parent and the risk of cancer in early life: a nationwide cohort study

Kennedy, Beatrice ; Valdimarsdóttir, Unnur ; Sundström, Karin ; Sparén, Pär ; Lambe, Mats ; Fall, Katja ; Fang, Fang

Background : While early-life exposure to stress has been associated with subsequent psychiatric and cardiovascular morbidity, little is known regarding its potential role in cancer development. We hypothesized that severe emotional stress, such as the loss of a parent through death during childhood, may increase the risk of cancer in early life. Method : Based on the Swedish Multi-Generation Register, we identified a cohort of 4,219,691 individuals who had both parents identifiable in the same [...]

A partir d'une revue systématique de la littérature, cette méta-analyse évalue l'association entre une greffe de rein et le risque de cancer de la vessie

Risk of bladder cancer in renal transplant recipients: a meta-analysis

Yan, L. ; Chen, P. ; Chen, E. Z. ; Gu, A. ; Jiang, Z. Y.

Background: Renal transplantation has been associated with a significantly increased risk of developing cancers during long-term follow-up, but for bladder cancer, this risk is less clear. We therefore performed a meta-analysis to determine whether bladder cancer risk in renal transplant recipients was increased. Methods: Eligible studies were identified through searches of PubMed and other public resources. Random-effects meta-analyses were used to pool overall estimates for standardised [...]

A partir des données de six études de cohortes prospectives incluant 42 843 participants et 2 156 patients atteints d'un cancer (durée moyenne de suivi : 5,4 ans), cette méta-analyse fait le point sur l'association entre des traits de personnalité, le risque de cancer et la mortalité par cancer

Is personality associated with cancer incidence and mortality ? An individual-participant meta-analysis of 2156 incident cancer cases among 42 843 men and women

Jokela, M. ; Batty, G. D. ; Hintsa, T. ; Elovainio, M. ; Hakulinen, C. ; Kivimaki, M.

Background: The putative role of personality in cancer risk has been controversial, and the evidence remains inconclusive. Methods: We pooled data from six prospective cohort studies (British Household Panel Survey; Health and Retirement Study; Household, Income, and Labour Dynamics in Australia; Midlife in the United Survey; Wisconsin Longitudinal Study Graduate; and Sibling samples) for an individual-participant meta-analysis to examine whether personality traits of the Five Factor Model [...]

Menée en population chinoise, cette étude identifie une association entre des variations du nombre de copies du gène ABCC4 et le risque de carcinome épidermoïde de l'œsophage

ABCC4 Copy Number Variation is Associated with Susceptibility to Esophageal Squamous Cell Carcinoma

Sun, YuLin ; Shi, Ni ; Lu, Haizhen ; Zhang, JinQiang ; Ma, YuLong ; Qiao, Yuanyuan ; Mao, YongHong ; Jia, Kun ; Han, LiFen ; Liu, Fang ; Li, HongXia ; Lin, Zhengwei ; Li, Xinmin ; Zhao, XiaoHang

Esophageal squamous cell carcinoma (ESCC) is the eighth most common cause of cancer-related death worldwide. However, previous genome-wide single nucleotide polymorphism (SNP) association analyses have not explained the high heritability associated with ESCC. In this study, we performed genome-wide copy number variation (CNV) analysis on 128 discordant sibling pairs to identify novel genes that contribute to ESCC susceptibility. A total of 57,774 individual CNVs were identified, and an [...]

Menée en population afro-américaine et hispanique aux Etats-Unis à partir d'échantillons sanguins prélevés sur 78 patients atteints d'un cancer colorectal et sur 300 témoins (230 sans polypes, 70 avec polypes), cette étude évalue l'association entre des polymorphismes du gène VDR et le risque de développer la maladie

Vitamin D receptor FokI gene polymorphisms may be associated with colorectal cancer among African American and Hispanic participants

Sarkissyan, Marianna ; Wu, Yanyuan ; Chen, Zujian ; Mishra, Dhruva K. ; Sarkissyan, Suren ; Giannikopoulos, Ioannis ; Vadgama, Jaydutt V.

BACKGROUND : Vitamin D plays a role in cancer tumorogenesis and acts through the vitamin D receptor (VDR). Although African Americans have the lowest serum vitamin D levels, supplementation has not yielded a significant improvement in cancer. Gene polymorphisms in VDR may play a role. There is a dearth of information on VDR gene polymorphisms and colorectal cancer (CRC) among under-represented ethnic groups. In this study, the authors examined whether VDR gene single nucleotide polymorphisms [...]

Couplée aux données de la cohorte observationnelle "Women's Health Initiative" et portant sur 258 cas et 515 témoins, cette étude évalue l'association entre le niveau de mélatonine contenu dans les urines et le risque de cancer du sein après la ménopause

Urinary Levels of Melatonin and Risk of Postmenopausal Breast Cancer: Women's Health Initiative Observational Cohort

Sturgeon, Susan R ; Doherty, Ashley ; Reeves, Katherine W ; Bigelow, Carol ; Stanczyk, Frank Z. ; Ockene, Judith K. ; Liu, Simin ; Manson, JoAnn E. ; Neuhouser, Marian L.

Background: Results from prospective studies on the association between urinary levels of melatonin and risk of postmenopausal breast cancer have been mixed. Several although not all studies have found lower urinary levels of melatonin in women who developed breast cancer compared to cancer-free women. Methods: We examined the association between urinary levels of melatonin and breast cancer risk in postmenopausal women in a case-control study nested in the Women's Health Initiative [...]

Menée aux Etats-Unis auprès de 961 femmes atteintes d'un cancer du sein et auprès de 939 témoins (âge compris entre 20 et 44 ans), cette étude en population évalue l'association entre des facteurs anthropométriques tels que la taille, l'indice de masse corporelle, des variations de poids et le risque de cancer du sein, par sous-type histologique

Height, body mass index (BMI), BMI change, and the risk of estrogen receptor-positive, HER2-positive, and triple-negative breast cancer among women ages 20 to 44 years

Kawai, Masaaki ; Malone, Kathleen E. ; Tang, Mei-Tzu C. ; Li, Christopher I.

BACKGROUND The evidence regarding correlations between various anthropometric characteristics and breast cancer risk among young women is mixed, and few studies have assessed these associations by subtype. METHODS This was a population-based, case-control study of 779 women with estrogen receptor (ER)-positive breast cancer; 182 women with ER-negative/human epidermal growth factor-2 (HER2)-negative/progesterone receptor-negative (triple-negative [TN]) breast cancer; and 60 women with [...]

Couplée aux données de la cohorte "E3N" et portant sur 549 cas et 1 040 témoins, cette étude évalue l'association entre le niveau sérique de la protéine C-réactive et le risque de cancer du sein chez des femmes ménopausées

C-reactive protein and postmenopausal breast cancer risk: results from the E3N cohort study

Dossus, Laure ; Jimenez-Corona, Aida ; Romieu, Isabelle ; Boutron-Ruault, Marie-Christine ; Boutten, Anne ; Dupré, Thierry ; Fagherazzi, Guy ; Clavel-Chapelon, Françoise ; Mesrine, Sylvie

Background: C-reactive protein (CRP), a marker of low-grade inflammation, has been associated with breast cancer risk, but results are scarce and inconsistent. Methods : A case–control study nested within the E3N prospective cohort included 549 postmenopausal breast cancer cases and 1,040 matched controls, all free of breast cancer at baseline. Serum levels of CRP were measured in samples collected between 1995 and 1999. Unconditional logistic regression models were used to evaluate the [...]