Menée en France à partir de 2 926 cas et de 3 555 témoins, cette étude analyse et compare, chez les hommes et chez les femmes, l'association entre le tabagisme et le risque de cancer du poumon

Heavy smoking and lung cancer: Are women at higher risk? Result of the ICARE study

Papadopoulos, A. ; Guida, F. ; Leffondre, K. ; Cenee, S. ; Cyr, D. ; Schmaus, A. ; Radoi, L. ; Paget-Bailly, S. ; Carton, M. ; Menvielle, G. ; Woronoff, A. S. ; Tretarre, B. ; Luce, D. ; Stucker, I.

Background: Whether women are more or equally susceptible to the carcinogenic effects of cigarette smoke on the lungs compared with men is a matter of controversy. Using a large French population-based case–control study, we compared the lung cancer risk associated with cigarette smoking by gender. Methods: The study included 2276 male and 650 female cases and 2780 male and 775 female controls. Lifetime smoking exposure was represented by the comprehensive smoking index (CSI), which combines [...]

A partir des données de la cohorte européenne EPIC incluant 322 988 participantes, cette étude évalue l'association entre le tabagisme, actif et passif, et le risque de cancer du sein

Active and passive cigarette smoking and breast cancer risk: Results from the EPIC cohort

Dossus, Laure ; Boutron-Ruault, Marie-Christine ; Kaaks, Rudolf ; Gram, Inger T. ; Vilier, Alice ; Fervers, Beatrice ; Manjer, Jonas ; Tjonneland, Anne ; Olsen, Anja ; Overvad, Kim ; Chang-Claude, Jenny ; Boeing, Heiner ; Steffen, Annika ; Trichopoulou, Antonia ; Lagiou, Pagona ; Sarantopoulou, Maria ; Palli, Domenico ; Berrino, Franco ; Tumino, Rosario ; Vineis, Paolo ; Mattiello, Amalia ; Bueno-de-Mesquita, H. Bas ; van Duijnhoven, Fränzel J. B. ; Bakker, Marieke F. ; Peeters, Petra H. M. ; Weiderpass, Elisabete ; Bjerkaas, Eivind ; Braaten, Tonje ; Menéndez, Virginia ; Agudo, Antonio ; Sánchez, María-José ; Amiano, Pilar ; Tormo, Maria-José ; Barricarte, Aurelio ; Butt, Salma ; Khaw, Kay-Tee ; Wareham, Nicholas ; Key, Tim J. ; Travis, Ruth C. ; Rinaldi, Sabina ; McCormack, Valerie ; Romieu, Isabelle ; Cox, David G. ; Norat, Teresa ; Riboli, Elio ; Clavel-Chapelon, Françoise

Recent cohort studies suggest that increased breast cancer risks were associated with longer smoking duration, higher pack-years and a dose-response relationship with increasing pack-years of smoking between menarche and first full-term pregnancy (FFTP). Studies with comprehensive quantitative life-time measures of passive smoking suggest an association between passive smoking dose and breast cancer risk. We conducted a study within the European Prospective Investigation into Cancer and [...]

Menée en Chine auprès de 1 539 travailleurs dans une mine d'amiante (durée de suivi : 26 ans), cette étude de cohorte évalue l'association entre une exposition professionnelle aux poussières d'amiante chrysotile et la mortalité par cancer des voies digestives

Exposure to chrysotile mining dust and digestive cancer mortality in a Chinese miner/miller cohort

Lin, Sihao ; Wang, Xiaorong ; Yano, Eiji ; Yu, Ignatius ; Lan, Yajia ; Courtice, Midori N ; Christiani, David C

Objectives : To examine mortality from digestive cancers in a Chinese miner cohort and to explore the exposure–response relationship between chrysotile mining dust and site-specific digestive cancers. Methods : A cohort of 1539 asbestos miners was followed for 26 years. Information on vital status and death causes was collected from personnel records and hospitals. Underlying causes of death from cancers were determined by combination of clinical manifestations and pathological confirmation. [...]

A partir des données des registres britanniques des cancers portant sur 2 566 patients atteints d'ostéosarcome et 1 650 patients atteints d'un sarcome d'Ewing (âge au diagnostic : avant 49 ans), cette étude évalue l'association entre une exposition à une eau potable à haute concentration de fluorure et le risque de tumeurs osseuses, sur la période 1980-2005

Is fluoride a risk factor for bone cancer? Small area analysis of osteosarcoma and Ewing sarcoma diagnosed among 0–49-year-olds in Great Britain, 1980–2005

Blakey, Karen ; Feltbower, Richard G ; Parslow, Roger C ; James, Peter W ; Gómez Pozo, Basilio ; Stiller, Charles ; Vincent, Tim J ; Norman, Paul ; McKinney, Patricia A ; Murphy, Michael F ; Craft, Alan W ; McNally, Richard JQ

Background: Artificial fluoridation of drinking water to improve dental health has long been a topic of controversy. Opponents of this public health measure have cited the possibility of bone cancer induction. The study objective was to examine whether increased risk of primary bone cancer was associated with living in areas with higher concentrations of fluoride in drinking water. Methods: Case data on osteosarcoma and Ewing sarcoma, diagnosed at ages 0–49 years in Great Britain (GB) (defined [...]

Menée en Suède auprès de 451 cas âgés de 20 à 69 ans et de 710 témoins, cette étude en population analyse l'association entre l'utilisation à long terme de téléphones mobiles et le risque de neurinome de l'acoustique (tumeur bénigne développée aux dépens de la gaine du nerf vestibulaire situé dans le conduit auditif interne)

Long-term Mobile Phone Use and Acoustic Neuroma Risk

Pettersson, David ; Mathiesen, Tiit ; Prochazka, Michaela ; Bergenheim, Tommy ; Florentzson, Rut ; Harder, Henrik ; Nyberg, Gunnar ; Siesjö, Peter ; Feychting, Maria

Background: There is concern about potential effects of radiofrequency fields generated by mobile phones on cancer risk. Most previous studies have found no association between mobile phone use and acoustic neuroma, although information about long-term use is limited. Methods: We conducted a population-based, nation-wide, case-control study of acoustic neuroma in Sweden. Eligible cases were persons aged 20 to 69 years, who were diagnosed between 2002 and 2007. Controls were randomly selected [...]

A partir des données de deux études cas-témoins, cette étude évalue l'association entre un indicateur de l'équilibre oxydant-antioxydant, des marqueurs du stress oxydant et de l'inflammation, et le risque d'adénome colorectal

Oxidative Balance Score, Colorectal Adenoma, and Markers of Oxidative Stress and Inflammation

KONG, SOYEON J ; Bostick, Roberd ; Flanders, W. Dana ; McClellan, William M. ; Thyagarajan, Bharat ; Gross, Myron D ; Judd, Suzanne ; Goodman, Michael

Background: An oxidative balance score (OBS) that combines pro- and anti-oxidant exposures was previously reported to be associated with incident sporadic colorectal adenoma. We extend the previous analyses by assessing associations of the OBS and colorectal adenoma with circulating biomarkers of oxidative stress (F2-isoprostanes [FIP] and fluorescent oxidation products [FOP]), and inflammation (C-reactive protein [CRP]). Methods: Using pooled data from two previously conducted [...]

Menée au Canada auprès de 299 femmes âgées de 40 à 49 ans, cette étude évalue l'association entre la résistance à l'insuline, les niveaux sériques d'hormones endogènes et la densité mammaire, un facteur lié à une augmentation de risque de cancer du sein

Fasting insulin and endogenous hormones in relation to premenopausal breast density (Canada)

Borugian, MarilynJ ; Spinelli, JohnJ ; Gordon, PaulaB ; Abanto, Zenaida ; Brooks-Wilson, Angela ; Pollak, MichaelN ; Warren, LindaJ ; Hislop, T. Gregory ; Gallagher, RichardP

Purpose : Mammographic breast density (BD) is associated with increased risk of breast cancer. This study asks which circulating metabolic and reproductive biomarkers are associated with BD, particularly dense breast area, in premenopausal women not taking exogenous hormones. Methods : In a cross-sectional study, 299 premenopausal women aged 40–49 completed questionnaires, provided a fasting blood sample, had height, weight, percentage body fat, waist and hip measurements taken, and attended a [...]

Couplée aux données de la cohorte "Nurses' Health Study II" et portant sur 1 560 cas et sur 2 163 témoins, cette étude évalue l'association entre le niveau plasmatique de ferritine, 15 polymorphismes à simple nucléotide du gène de l'hémochromatose et le risque de cancer du sein avant la ménopause

Premenopausal Plasma Ferritin Levels, HFE Polymorphisms, and Risk of Breast Cancer in the Nurses' Health Study II

Graff, Rebecca E. ; Cho, Eunyoung ; Lindström, Sara ; Kraft, Peter ; Willett, Walter C. ; Eliassen, A. Heather

Background: Evidence from the Nurses' Health Study II (NHSII) suggests that red meat consumption is associated with increased breast cancer risk in premenopausal women. Iron may be responsible by contributing to oxidative stress or effects on immune function. Methods: We conducted a case-control study nested within the NHSII examining prediagnostic plasma ferritin (n=795 cases, 795 controls), 15 hemochromatosis gene (HFE) SNPs (n=765 cases, 1,368 controls), and breast cancer risk. Cases were [...]

Menée aux Etats-Unis et en Chine auprès de 988 cas et 1 004 témoins, cette étude évalue l'association entre le tabagisme, des polymorphismes à simple nucléotide de 28 gènes associés aux voies de réparation de l'ADN et le risque de cancer de la vessie

Comprehensive analyses of DNA repair pathways, smoking and bladder cancer risk in Los Angeles and Shanghai

Corral, Roman ; Lewinger, Juan Pablo ; Van Den Berg, David ; Joshi, Amit D. ; Yuan, Jian-Min ; Gago-Dominguez, Manuela ; Cortessis, Victoria K. ; Pike, Malcolm C. ; Conti, David V. ; Thomas, Duncan C. ; Edlund, Christopher K. ; Gao, Yu-Tang ; Xiang, Yong-Bing ; Zhang, Wei ; Su, Yu-Chen ; Stern, Mariana C.

Tobacco smoking is a bladder cancer risk factor and a source of carcinogens that induce DNA damage to urothelial cells. Using data and samples from 988 cases and 1,004 controls enrolled in the Los Angeles County Bladder Cancer Study and the Shanghai Bladder Cancer Study, we investigated associations between bladder cancer risk and 632 tagSNPs that comprehensively capture genetic variation in 28 DNA repair genes from four DNA repair pathways: base excision repair (BER), nucleotide excision [...]