Menée auprès de 277 survivants d'un cancer pédiatrique et de 130 témoins, cette étude analyse la prévalence des dommages vasculaires liés aux traitements du cancer

Endothelial Damage in Long-Term Survivors of Childhood Cancer

Brouwer, Cornelia A.J. ; Postma, Aleida ; Hooimeijer, H. Louise H. ; Smit, Andries J. ; Vonk, Judith M. ; van Roon, Arie M. ; van den Berg, Maarten P. ; Dolsma, Wil V. ; Lefrandt, Joop D. ; Bink-Boelkens, Margreet T.E. ; Zwart, Nynke ; de Vries, Elisabeth G.E. ; Tissing, Wim J.E. ; Gietema, Jourik A.

Purpose : To evaluate the presence of vascular damage in long-term childhood cancer survivors (CCS) and sibling controls, and to evaluate the association between vascular damage parameters and cancer treatment and influence of cardiovascular risk factors. Patients and Methods : Vascular assessment was performed in 277 adult CCSs (median age at diagnosis, 9 years; range, 0 to 20 years; median current age, 28 years; range, 18 to 48 years) treated with potentially cardiovascular toxic anticancer [...]

Menée auprès de 1 122 survivants d'un cancer pédiatrique âgés de plus de 18 ans, cette étude longitudinale analyse l'évolution de la fonction glomérulaire (durée médiane de suivi : 21 ans)

Glomerular Function Time Trends in Long-Term Survivors of Childhood Cancer: A Longitudinal Study

Mulder, Renée L. ; Knijnenburg, Sebastiaan L. ; Geskus, Ronald B. ; van Dalen, Elvira C. ; van der Pal, Helena J.H. ; Koning, Caro C.E. ; Bouts, Antonia H. ; Caron, Huib N. ; Kremer, Leontien C.M.

Background: Impaired glomerular function is one of the health problems affecting childhood cancer survivors (CCS). It is unclear whether glomerular function deteriorates or recovers. We investigated time trends and predictors of glomerular function in CCS. Methods: We evaluated repeated observations of estimated glomerular filtration rate (GFR) and glomerular dysfunction (GFR <90 mL/min/1.73 m2) among adult five-year CCS treated in the EKZ/AMC between 1966 and 2003. Ifosfamide, cisplatin, [...]

Menée par enquête auprès de 1 001 patients atteints d'un cancer de la prostate et vivant dans sept pays européens, cette étude analyse l'association entre la qualité des soins infirmiers post-traitement et leurs besoins ultérieurs en soins de support

The impact of supportive nursing care on the needs of men with prostate cancer: a study across seven European countries

Cockle-Hearne, J. ; Charnay-Sonnek, F. ; Denis, L. ; Fairbanks, H. E. ; Kelly, D. ; Kav, S. ; Leonard, K. ; van Muilekom, E. ; Fernández-Ortega, P. ; Jensen, B. T. ; Faithfull, S.

Background: Prostate cancer is for many men a chronic disease with a long life expectancy after treatment. The impact of prostate cancer therapy on men has been well defined, however, explanation of the consequences of cancer treatment has not been modelled against the wider variables of long-term health-care provision. The aim of this study was to explore the parameters of unmet supportive care needs in men with prostate cancer in relation to the experience of nursing care. Methods: A survey [...]

Menée auprès de 135 patients agés de plus de 40 ans et atteints de tumeurs des cellules germinales ainsi qu'auprès d'un groupe témoin de 135 patients âgés de 18 à 35 ans, cette étude analyse l'association entre l'intensité de la chimiothérapie, la toxicité associée aux traitements et la survie des patients

Survival and toxicity in patients with disseminated germ cell cancer aged 40 years and older

Thomsen, Frederik B. ; Bandak, Mikkel ; Thomsen, Maria F. ; Lauritsen, Jakob ; Christensen, Ib J. ; Daugaard, Gedske

BACKGROUND : Germ-cell cancer (GCC) patients aged ≥40 years have a two-fold higher GCC-specific mortality. It has been hypothesized that reduced treatment intensity combined with increased treatment related toxicity could be the explanation. The objective was to analyze chemotherapy intensity, treatment related toxicity and survival in patients aged ≥40 years treated with standard chemotherapy for GCC compared with a younger control group that received similar treatment during the same period. [...]

Menée en France auprès de 364 patients âgés de plus de 70 ans et atteints de cancer, cette étude multicentrique analyse l'association entre une chimiothérapie de première ligne et le déclin de leurs capacités fonctionnelles

Functional Decline in Older Patients With Cancer Receiving First-Line Chemotherapy

Hoppe, Stéphanie ; Rainfray, Muriel ; Fonck, Marianne ; Hoppenreys, Laurent ; Blanc, Jean-Frederic ; Ceccaldi, Joël ; Mertens, Cécile ; Blanc-Bisson, Christèle ; Imbert, Yves ; Cany, Laurent ; Vogt, Luc ; Dauba, Jerome ; Houédé, Nadine ; Bellera, Carine A. ; Floquet, Anne ; Fabry, Marie-Noëlle ; Ravaud, Alain ; Chakiba, Camille ; Mathoulin-Pelissier, Simone ; Soubeyran, Pierre

Purpose : To determine factors associated with early functional decline during first-line chemotherapy in older patients. Patients and Methods : Patients age ≥ 70 years receiving first-line chemotherapy for cancer were prospectively considered for inclusion across 12 centers in France. Functional decline was defined as a decrease of ≥ 0.5 points on the Activities of Daily Living (ADL) scale between the beginning of chemotherapy and the second cycle. Factors associated with functional decline [...]

Menée en population canadienne, cette étude de cohorte rétrospective évalue l'association entre l'utilisation de médicaments contre l'hypertension et la survie des patients atteints de cancer, sur la période 2004-2008

Antihypertensive medications and survival in patients with cancer: A population-based retrospective cohort study

Holmes, Signy ; Griffith, E. Jane ; Musto, Grace ; Minuk, Gerald Y.

Background: The association between antihypertensive medications and survival in cancer patients remains unclear. Objectives: To explore the association between classes of antihypertensive drugs and survival in cancer patients. Methods: Provincial Cancer Registry data was linked with a Provincial Drug Program Information Network (DPIN) for patients with lung (n = 4241), colorectal (n = 3967), breast (n = 4019) or prostate (n = 3355) cancer between the years of 2004 and 2008. Cox regression [...]

Menée en Angleterre auprès de 21 044 cas, cette étude analyse l'évolution de l'incidence du cancer de la prostate sur la période 2000-2010 ainsi que l'évolution des caractéristiques de la maladie et des patients

Changing presentation of prostate cancer in a UK population - 10 year trends in prostate cancer risk profiles in the East of England

Greenberg, D. C. ; Wright, K. A. ; Lophathanon, A. ; Muir, K. R. ; Gnanapragasam, V. J.

Background: Prostate cancer incidence is rising in the United Kingdom but there is little data on whether the disease profile is changing. To address this, we interrogated a regional cancer registry for temporal changes in presenting disease characteristics. Methods: Prostate cancers diagnosed from 2000 to 2010 in the Anglian Cancer Network (n=21 044) were analysed. Risk groups (localised disease) were assigned based on NICE criteria. Age standardised incidence rates (IRs) were compared between [...]

A partir des données de deux cohortes "ESTHER II" et "VERDI" portant sur 1 397 patients atteints de cancer colorectal, cette étude analyse l'association entre des polymorphismes du récepteur de la vitamine D et la mortalité, par cancer et toutes causes confondues

Vitamin D receptor polymorphism and colorectal cancer-specific and all-cause mortality

Perna, Laura ; Hoffmeister, Michael ; Schottker, Ben ; Arndt, Volker ; Haug, Ulrike ; Holleczek, Bernd ; Burwinkel, Barbara ; Ordóñez-Mena, José M. ; Brenner, Hermann

Background : The vitamin D receptor (VDR) gene is present in colorectal cancer (CRC) cells and its genetic variants have been associated with an increased risk of CRC. The association with colorectal cancer prognosis remains widely unexplored. Methods : 1 397 colorectal cancer patients participating in two cancer cohorts (ESTHER II and VERDI) and in a population-based case–control study (DACHS) were followed for 5 years. Unadjusted and adjusted hazard ratios for all-cause mortality (469 events) [...]

A partir des données de la base Medicare portant sur 406 602 bénéficiaires, cette étude américaine analyse et compare, chez les femmes blanches et chez les femmes noires, l'utilisation de mammographies de dépistage pour tenter d'expliquer les disparités ethniques dans la mortalité par cancer du sein

Mammography utilization among Black and White Medicare beneficiaries in high breast cancer mortality US counties

Virk-Baker, MandeepK ; Martin, MichelleY ; Levine, RobertS ; Wang, Xin ; Nagy, TimR ; Pisu, Maria

Background : Disparities in US breast cancer mortality between older Black and White women have increased in the last 20 years. Regular mammography use is important for early detection and treatment: its utilization among older Blacks especially in counties with high Black mortality is of interest, but its extent and determinants are unknown. Methods : We used Medicare claims for Black and White women 65–74 years old in 203 counties with the highest Black breast cancer mortality. Outcomes over [...]

A partir des données du registre néerlandais des cancers portant sur 11 227 patientes atteintes d'un cancer du sein et âgées de 50 à 74 ans sur la période 1996-2007, cette étude en population analyse les facteurs associés à leur adhésion au programme de dépistage du cancer du sein durant la période de suivi après un premier traitement

Attending the breast screening programme after breast cancer treatment: A population-based study

de Munck, Linda ; Kwast, Annemiek ; Reiding, Dick ; de Bock, Geertruida H. ; Otter, Renee ; Willemse, Pax H. B. ; Siesling, Sabine

Abstract : In the Netherlands, breast cancer patients are treated and followed at least 5 years after diagnosis. Furthermore, all women aged 50–74 are invited biennially for mammography by the nationwide screening programme. The relation between the outpatient follow-up (follow-up visits in the outpatient clinic for 5 years after treatment) and the screening programme is not well established and attending the screening programme as well as outpatient follow-up is considered undesirable. This [...]

Menée auprès de 190 patientes atteintes d'un cancer du sein non métastatique (âge moyen : 75 ans) diagnostiqué entre 2008 et 2012, cette étude transversale analyse les disparités ethniques dans leurs déficiences et leurs incapacités fonctionnelles

Racial disparities in functional disability among older women with newly diagnosed nonmetastatic breast cancer

Owusu, Cynthia ; Schluchter, Mark ; Koroukian, Siran M. ; Mazhuvanchery, Suzanne ; Berger, Nathan A.

BACKGROUND : This study sought to assess racial differences in functional disability among older women with nonmetastatic breast cancer. METHODS : In this cross-sectional study, between April 2008 and December 2012, women aged≥65 years with newly diagnosed stage I through III breast cancer were recruited from ambulatory oncology clinics at an academic center. Prior to receiving any adjuvant treatment, participants completed a comprehensive geriatric assessment. The primary outcome was [...]

Menée auprès de 1 281 survivants d'un cancer, cette étude allemande analyse leur participation à des groupes de soutien et d'échanges à la fin de leur programme de réadaptation, en lien avec des facteurs démographiques, médicaux et psychosociaux

Participation in patient support groups among cancer survivors: do psychosocial and medical factors have an impact?

Sautier, L. ; Mehnert, A. ; Höcker, A. ; Schilling, G.

A better understanding of the role of psychosocial resources and factors associated with participating in patient support groups appears to be important for the development and implementation of cancer survivorship care plans. We therefore investigated the frequency of participation in and satisfaction with patient support groups after completion of a rehabilitation programme and aimed to examine differences in demographic, medical and psychosocial characteristics between group participants and [...]

Menée auprès de 496 patients atteints d'un cancer colorectal, cette étude britannique analyse les facteurs associés aux risques de symptômes d'anxiété et de dépression

Predictors of anxiety and depression in people with colorectal cancer

Gray, NicolaM ; Hall, SusanJ ; Browne, Susan ; Johnston, Marie ; Lee, AmandaJ ; Macleod, Una ; Mitchell, ElizabethD ; Samuel, Leslie ; Campbell, NeilC

Background : People living with colorectal cancer are at risk of anxiety and depression. We investigated what factors were most highly associated with these. Methods : Four hundred and ninety-six people with colorectal cancer completed the Hospital Anxiety and Depression Scale (HADS). Data on functioning, symptoms, illness perceptions and social difficulties were collected by questionnaire. Case-note-identified disease, treatment and co-morbidity data were recorded. Multiple logistic regression [...]

A partir de données publiées par l'Organisation Mondiale de la Santé, cette étude analyse les disparités d'incidence de cancer et de mortalité, en lien avec les politiques et les dépenses de santé, parmi les 27 pays membres de l'Union européenne

Discrepancies in cancer incidence and mortality and its relationship to health expenditure in the 27 European Union member states

Ades, F. ; Senterre, C. ; de Azambuja, E. ; Sullivan, R. ; Popescu, R. ; Parent, F. ; Piccart, M.

Background : The European Union (EU) is a confederation of 27 member states, the institutions of which work according to negotiated decisions. The EU has implemented similar legislation and a common market, and has adopted the same currency in most of its member states. Although financing health systems is a responsibility of the national governments, the EU has enacted the Charter of Fundamental Rights to standardize public health policies. However, for historical reasons, health policy and [...]

A partir des données de 53 essais cliniques menés dans des institutions au Royaume-Uni sur la période 2009-2010 et portant sur 357 patients adultes atteints de cancer, cette étude rétrospective analyse les coûts associés aux traitements reçus dans le cadre de ces essais

Treatment costs associated with interventional cancer clinical trials conducted at a single UK institution over 2 years (2009-2010)

Liniker, E. ; Harrison, M. ; Weaver, J. M. J. ; Agrawal, N. ; Chhabra, A. ; Kingshott, V. ; Bailey, S. ; Eisen, T. G. G. ; Corrie, P. G.

Background: The conduct of clinical trials should be an integral part of routine patient care. Treating patients in trials incurs additional costs over and above standard of care (SOC), but the extent of the cost burden is not known. We undertook a retrospective cost attribution analysis to quantitate the treatment costs associated with cancer clinical trial protocols conducted over a 2 year period. Methods: All patients entered into oncology (non-haematology) clinical trials involving [...]

A partir des données des dossiers médicaux électroniques issus de deux systèmes de santé ainsi que celles du registre californien des cancers (13 980 patientes), cette étude américaine analyse les différences de traitements reçus, sur la période 2000-2010, chez des patientes atteintes d'un cancer du sein

Breast cancer treatment across health care systems

Kurian, Allison W. ; Mitani, Aya ; Desai, Manisha ; Yu, Peter P. ; Seto, Tina ; Weber, Susan C. ; Olson, Cliff ; Kenkare, Pragati ; Gomez, Scarlett L. ; de Bruin, Monique A. ; Horst, Kathleen ; Belkora, Jeffrey ; May, Suepattra G. ; Frosch, Dominick L. ; Blayney, Douglas W. ; Luft, Harold S. ; Das, Amar K.

BACKGROUND : Understanding of cancer outcomes is limited by data fragmentation. In the current study, the authors analyzed the information yielded by integrating breast cancer data from 3 sources: electronic medical records (EMRs) from 2 health care systems and the state registry. METHODS : Diagnostic test and treatment data were extracted from the EMRs of all patients with breast cancer treated between 2000 and 2010 in 2 independent California institutions: a community-based practice (Palo [...]

Menée dans l'Etat du Michigan à partir de données portant sur 17 828 patients atteints d'un cancer de la tête et du cou, cette étude de cohorte rétrospective analyse les disparités dans l'utilisation de la bronchoscopie et de l'endoscopie de l'œsophage pour le diagnostic

Association between hospital case volume and the use of bronchoscopy and esophagoscopy during head and neck cancer diagnostic evaluation

Sun, Gordon H. ; Aliu, Oluseyi ; Moloci, Nicholas M. ; Mondschein, Joshua K. ; Burke, James F. ; Hayward, Rodney A.

BACKGROUND There are no clinical guidelines on best practices for the use of bronchoscopy and esophagoscopy in diagnosing head and neck cancer. This retrospective cohort study examined variation in the use of bronchoscopy and esophagoscopy across hospitals in Michigan. METHODS A total of 17,828 patients were identified with head and neck cancer in the 2006 to 2010 Michigan State Ambulatory Surgery Databases. A hierarchical, mixed-effect logistic regression was used to examine whether a [...]

Menée auprès de 374 survivants d'un lymphome non hodgkinien, cette étude analyse la communication entre le patient et son médecin relative à la santé et à la qualité de vie

Patient-Physician Communication About Health-Related Quality-of-Life Problems: Are Non-Hodgkin Lymphoma Survivors Willing to Talk?

Arora, Neeraj K. ; Jensen, Roxanne E. ; Sulayman, Nadiyah ; Hamilton, Ann S. ; Potosky, Arnold L.

Purpose : To investigate non-Hodgkin lymphoma (NHL) survivors’ willingness to discuss health-related quality-of-life (HRQOL) problems with their follow-up care physician. Patients and Methods : Willingness to discuss HRQOL problems (physical, daily, emotional, social, and sexual functioning) was examined among 374 NHL survivors, 2 to 5 years postdiagnosis. Survivors were asked if they would bring up HRQOL problems with their physician and indicate reasons why not. Logistic regression models [...]

Menée dans la ville de New York auprès d'une cohorte d'immigrants chinois, cette étude américaine analyse le recours à la médecine traditionnelle chinoise chez des patients atteints de cancer

Traditional Chinese Medicine Use among Chinese Immigrant Cancer Patients

Leng, JenniferC F. ; Gany, Francesca

Traditional Chinese Medicine (TCM) includes both herbal remedies and non-herbal practices. Chinese cancer patients are particularly at high risk for herb–drug interactions. Providers, both primary care physicians and oncologists, frequently do not ask patients about TCM use, which has potentially dangerous consequences. This study describes an assessment of TCM use while undergoing conventional cancer treatment, among a cohort of Chinese immigrant cancer patients in New York City. The Immigrant [...]