Menée sur 3 862 cas et 1 646 témoins, cette étude américaine analyse l'association entre le tabagisme et le risque de cancer du poumon non à petites cellules coexistant avec une maladie pulmonaire obstructive chronique

Smoking and smoking cessation in relation to the development of co-existing non-small cell lung cancer with chronic obstructive pulmonary disease

Zhai, Rihong ; Yu, Xiaojin ; Wei, Yongyue ; Su, Li ; Christiani, David C.

Previous studies have identified a mixed-phenotype of non-small cell lung cancer (NSCLC) with co-existing chronic obstructive pulmonary disease (COPD). Although NSCLC and COPD share a common risk factor in smoking, whether and how smoking may contribute to the coexistence of NSCLC with COPD (NSCLC-COPD) is unclear. Our study suggests that cigarette smoking is the major risk factor for the development of NSCLC-COPD, especially in females and among patients with squamous cell carcinoma subtype.

Menée au Japon auprès de 32 989 hommes et de 63 894 femmes âgés de 40 à 79 ans, cette étude de cohorte évalue l'association entre la durée du tabagisme et le risque de mortalité par cancer de l'oropharynx

Duration of cigarette smoking is a risk factor for oropharyngeal cancer mortality among Japanese men and women: the Ibaraki Prefectural Health Study (IPHS)

Saito, Nobue ; Sairenchi, Toshimi ; Irie, Fujiko ; Iso, Hiroyasu ; Iimura, Kyoko ; Watanabe, Hiroshi ; Muto, Takashi ; Ota, Hitoshi

Purpose : The relationship between duration of cigarette smoking and the risk of oropharyngeal cancer has not been studied in the general Japanese population. Thus, the aim of the present study was to examine the relationship between the duration of cigarette smoking and the risk of oropharyngeal cancer mortality in the Japanese population. Methods : In this large cohort study, 32,989 men and 63,894 women, ages 40–79 years, who completed health check-ups in Ibaraki Prefecture, Japan, in 1993 [...]

A partir des données de 11 études portant sur 2 648 participants, cette étude analyse l'association entre le tabagisme, une consommation d'alcool et le risque de cancer de l'estomac associé au virus d'Epstein-Barr

Case–case comparison of smoking and alcohol risk associations with Epstein–Barr virus-positive gastric cancer

Camargo, M. Constanza ; Koriyama, Chihaya ; Matsuo, Keitaro ; Kim, Woo-Ho ; Herrera-Goepfert, Roberto ; Liao, Linda M. ; the Eurgast, Epic Group ; Yu, Jun ; Carrasquilla, Gabriel ; Sung, Joseph J. Y. ; Alvarado-Cabrero, Isabel ; Lissowska, Jolanta ; Meneses-González, Fernando ; Yatabe, Yashushi ; Ding, Ti ; Hu, Nan ; Taylor, Philip R. ; Morgan, Douglas R. ; Gulley, Margaret L. ; Torres, Javier ; Akiba, Suminori ; Rabkin, Charles S.

Helicobacter pylori is the primary cause of gastric cancer. However, monoclonal Epstein–Barr virus (EBV) nucleic acid is also present in up to 10% of these tumors worldwide. EBV prevalence is increased with male sex, nonantral localization and surgically disrupted anatomy. To further examine associations between EBV and gastric cancer, we organized an international consortium of 11 studies with tumor EBV status assessed by in situ hybridization. We pooled individual-level data on 2,648 gastric [...]

Menée au Canada et incluant 514 cas et 962 témoins, cette étude évalue l'association entre la consommation d'alcool et le risque de cancer de l'endomètre

Case–control study of lifetime alcohol consumption and endometrial cancer risk

Friedenreich, ChristineM ; Speidel, ThomasP ; Neilson, HeatherK ; Langley, AnnieR ; Courneya, KerryS ; Magliocco, AnthonyM ; Cook, LindaS

Purpose : Alcohol consumption is hypothesized to increase the risk of endometrial cancer by increasing circulating estrogen levels. This study sought to investigate the association between lifetime alcohol consumption and endometrial cancer risk. Methods : We recruited 514 incident endometrial cancer cases and 962 frequency age-matched controls in this population-based case–control study in Alberta, Canada, from 2002 to 2006. Participants completed in-person interviews querying lifetime alcohol [...]

Menée en Grande Bretagne à partir des données de travailleurs du secteur de l'amiante morts d'un mésothéliome sur la période 1978-2005, cette étude de cohorte prospective analyse l'association entre l'intensité de l'exposition à l'amiante, l'emploi occupé, le sexe de l'individu et le temps de latence avant le décès par mésothéliome

The latency period of mesothelioma among a cohort of British asbestos workers (1978-2005)

Frost, G.

Background: The Great Britain (GB) Asbestos Survey is a prospective cohort of asbestos workers in GB. The objective of this study was to investigate determinants of mesothelioma latency, paying particular attention to indicators of intensity of asbestos exposure such as occupation, sex, and presence of asbestosis. Methods: The analysis included members of the cohort who died with mesothelioma between 1978 and 2005. The primary outcome was the latency period defined as the time from first [...]

A partir d'une revue systématique de la littérature (10 études publiées de 1971 à 2013), cette méta-analyse évalue la relation exposition-réponse entre le travail posté et le risque de cancer du sein

A meta-analysis on dose–response relationship between night shift work and the risk of breast cancer

Wang, F. ; Yeung, K. L. ; Chan, W. C. ; Kwok, C. C. H. ; Leung, S. L. ; Wu, C. ; Chan, E. Y. Y. ; Yu, I. T. S. ; Yang, X. R. ; Tse, L. A.

This study aimed to conduct a systematic review to sum up evidence of the associations between different aspects of night shift work and female breast cancer using a dose–response meta-analysis approach.We systematicly searched all cohort and case–control studies published in English on MEDLINE, Embase, PSYCInfo, APC Journal Club and Global Health, from January 1971 to May 2013. We extracted effect measures (relative risk, RR; odd ratio, OR; or hazard ratio, HR) from individual studies to [...]

A partir des données de la cohorte américaine "Air Pollution and Childhood Cancers Study", cette étude évalue l'association entre une exposition prénatale à la pollution atmosphérique liée au trafic routier et le risque de cancer chez l'enfant

Prenatal Exposure to Traffic-related Air Pollution and Risk of Early Childhood Cancers

Ghosh, Jo Kay C. ; Heck, Julia E. ; Cockburn, Myles ; Su, Jason ; Jerrett, Michael ; Ritz, Beate

Exposure to air pollution during pregnancy has been linked to the risk of childhood cancer, but the evidence remains inconclusive. In the present study, we used land use regression modeling to estimate prenatal exposures to traffic exhaust and evaluate the associations with cancer risk in very young children. Participants in the Air Pollution and Childhood Cancers Study who were 5 years of age or younger and diagnosed with cancer between 1988 and 2008 were had their records linked to California [...]

Menée au Bangladesh auprès de 1 489 participants vivant dans des zones rurales, cette étude évalue l'association entre une exposition à de l'eau potable contaminée par de l'arsenic et le risque de cancer du rein

Arsenic in drinking water and renal cancers in rural Bangladesh

Mostafa, MG ; Cherry, Nicola

Objectives : Data on the role of arsenic in renal cancer are suggestive but inconclusive. The present analysis aimed to determine whether renal cancers were more likely in Bangladeshi villagers exposed to high arsenic concentration in well water and, if so, whether this excess was limited to transitional cell cancers (TCC) or occurred also for renal cell cancers (RCC). Methods : Histology/cytology results from renal biopsies carried out at a single clinic in Dhaka, Bangladesh, from January 2008 [...]

A partir de données de deux études de cohorte portant sur des échantillons de 856 000 donneurs sains et couplée aux données des registres suédois et norvégiens des cancers, cette étude prospective évalue l'association entre une infection par le polyomavirus des cellules de Merkel et le risque de carcinome à cellules de Merkel

Prospective study of Merkel cell polyomavirus and risk of Merkel cell carcinoma

Faust, Helena ; Andersson, Kristin ; Ekström, Johanna ; Hortlund, Maria ; Robsahm, Trude Eid ; Dillner, Joakim

Merkel cell carcinoma (MCC) is a rare type of skin cancer that has a characteristically increased incidence among immunosuppressed subjects. The DNA of Merkel cell polyomavirus (MCV) is regularly found in most MCC tumors. We investigated whether Merkel cell polyomavirus (MCV) infection increases the risk for future MCC. Two large biobank cohorts (Southern Sweden Microbiology Biobank and the Janus Biobank), containing samples from 856,000 healthy donors, were linked to the Cancer Registries in [...]

Cette étude passe en revue le rôle des virus (herpès, polyomavirus, papillomavirus humain) impliqués dans le developpement du cancer du sein

Role of viruses in the development of breast cancer

Alibek, Kenneth ; Kakpenova, Ainur ; Mussabekova, Assel ; Sypabekova, Marzhan ; Karatayeva, Nargis

The most common cancer worldwide among women is breast cancer. The initiation, promotion, and progression of this cancer result from both internal and external factors. The International Agency for Research on Cancer stated that 18-20% of cancers are linked to infection, and the list of definite, probable, and possible carcinogenic agents is growing each year. Among them, biological carcinogens play a significant role. In this review, data covering infection-associated breast and lung cancers [...]

Menée au Danemark auprès de participants âgés de plus de 16 ans sur la période 1996-2010, cette étude de cohorte évalue l'association entre l'épilepsie, la prise de médicaments anti-épileptiques et le risque de cancer

Epilepsy, anti-epileptic medication use and risk of cancer

Kaae, Jeanette ; Carstensen, Lisbeth ; Wohlfahrt, Jan ; Melbye, Mads ; Allison Boyd, Heather

Whether the powerful medications used to treat epilepsy increase the risk of cancer has been debated for decades, but until now no study could disentangle the contributions of anti-epileptic medications and epilepsy itself to cancer risk. Using a cohort comprising all Danish residents ≥16 years old at some point during the period 1996–2010 (>56 million person-years of follow-up) and information from national health registers, we examined associations between anti-epileptic medication use and [...]

A partir des données de 10 études incluant 4 717 cas et 9 374 témoins, cette étude évalue l'association entre un ulcère peptique, une gastrectomie ou des traitements médicamenteux et le risque de cancer du pancréas

Ulcer, gastric surgery and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case–Control Consortium (PanC4)

Bosetti, C. ; Lucenteforte, E. ; Bracci, P. M. ; Negri, E. ; Neale, R. E. ; Risch, H. A. ; Olson, S. H. ; Gallinger, S. ; Miller, A. B. ; Bueno-de-Mesquita, H. B. ; Talamini, R. ; Polesel, J. ; Ghadirian, P. ; Baghurst, P. A. ; Zatonski, W. ; Fontham, E. ; Holly, E. A. ; Gao, Y. T. ; Yu, H. ; Kurtz, R. C. ; Cotterchio, M. ; Maisonneuve, P. ; Zeegers, M. P. ; Duell, E. J. ; Boffetta, P. ; La Vecchia, C.

Background : Peptic ulcer and its treatments have been associated to pancreatic cancer risk, although the evidence is inconsistent. Methods : We pooled 10 case–control studies within the Pancreatic Cancer Case–control Consortium (PanC4), including 4717 pancreatic cancer cases and 9374 controls, and estimated summary odds ratios (OR) using multivariable logistic regression models. Results : The OR for pancreatic cancer was 1.10 [95% confidence interval (CI) 0.98–1.23] for history of ulcer (OR = [...]

Menée au Royaume-Uni auprès de 33 625 participants, cette étude de cohorte rétrospective évalue l'association entre le début d'un traitement par orlistat (médicament anti-obésité)et le risque de cancer colorectal

Risk of colorectal cancer after initiation of orlistat: matched cohort study

Jin-Liern Hong ; Christoph R Meier ; Robert S Sandler ; Susan S Jick ; Til Stürmer

Objective To examine the risk of colorectal cancer after orlistat initiation in the UK population. Design Retrospective matched cohort study. Setting Data from the UK Clinical Practice Research Datalink from September 1998 to December 2008. Participants 33 625 adults aged 18 years or over who started treatment with orlistat; each orlistat initiator was matched to up to five non-initiators (n=160 347) on age, sex, body mass index, and calendar time. Main outcome measures Associations between [...]

A partir des données de l'essai "PLCO Cancer Screening Trial" portant sur 1 272 femmes ménopausées âgées de 55 à 74 ans, cette étude évalue l'association entre l'épaisseur de l'endomètre et le risque de carcinome du corps de l'utérus ou du sein

Endometrial thickness and risk of breast and endometrial carcinomas in the prostate, lung, colorectal and ovarian cancer screening trial

Felix, Ashley S. ; Weissfeld, Joel L. ; Pfeiffer, Ruth M. ; Modugno, Francesmary ; Black, Amanda ; Hill, Lyndon M. ; Martin, Jerry ; Sit, Anita S. ; Sherman, Mark E. ; Brinton, Louise A.

Postmenopausal women with higher circulating estrogen levels are at increased risk of developing breast and endometrial carcinomas. In the endometrium, excess estrogen relative to progesterone produces a net proliferative stimulus, which may result in endometrial thickening. Therefore, the hypothesis that endometrial thickness is a biological marker of excess estrogen stimulation that is associated with risk of breast and endometrial carcinomas was tested. Endometrial thickness was measured in [...]

Menée sur 3 107 cas et 6 211 témoins, cette étude d'association sur le génome entier identifie des variants situés sur les régions chromosomiques 10p12.2 et 10p14 en association avec un risque accru de leucémie lymphoblastique aiguë à précurseurs B chez les enfants

Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype

Migliorini, Gabriele ; Fiege, Bettina ; Hosking, Fay J. ; Ma, Yussanne ; Kumar, Rajiv ; Sherborne, Amy L. ; da Silva Filho, Miguel Inacio ; Vijayakrishnan, Jayaram ; Koehler, Rolf ; Thomsen, Hauke ; Irving, Julie A. ; Allan, James M. ; Lightfoot, Tracy ; Roman, Eve ; Kinsey, Sally E. ; Sheridan, Eamonn ; Thompson, Pamela ; Hoffmann, Per ; Nothen, Markus M. ; Muhleisen, Thomas W. ; Eisele, Lewin ; Zimmermann, Martin ; Bartram, Claus R. ; Schrappe, Martin ; Greaves, Mel ; Stanulla, Martin ; Hemminki, Kari ; Houlston, Richard S.

Acute lymphoblastic leukemia (ALL) is the major pediatric cancer diagnosed in economically developed countries with B-cell precursor (BCP) ALL accounting for approximately 70% of ALL. Recent genome-wide association studies (GWASs) have provided the first unambiguous evidence for common inherited susceptibility to BCP-ALL identifying susceptibility loci at 7p12.2, 9p21.3, 10q21.2 and 14q11.2. To identify additional BCP-ALL susceptibility loci, we conducted a GWAS and performed a meta-analysis [...]

Menée auprès de 1 715 participantes, cette étude de cohorte nigériane analyse les facteurs de risque d'un cancer du sein diagnostiqué durant la grossesse ou la période suivant l'accouchement

Risk factors for pregnancy-associated breast cancer: a report from the Nigerian Breast Cancer Study

Hou, Ningqi ; Ogundiran, Temidayo ; Ojengbede, Oladosu ; Morhason-Bello, Imran ; Zheng, Yonglan ; Fackenthal, James ; Adebamowo, Clement ; Anetor, Imaria ; Akinleye, Stella ; Olopade, Olufunmilayo I. ; Huo, Dezheng

Purpose : Little is known about risk factors for pregnancy-associated breast cancer (PABC), diagnosed during pregnancy or postpartum. Methods : We enrolled 1715 premenopausal women from the Nigerian Breast Cancer Study from 1998 to 2011. Based on recency of last pregnancy from diagnosis, breast cancer cases were categorized as (1) PABC diagnosed 2 years or longer postpartum, (2) PABC diagnosed 3 to 5 years postpartum, or (3) non-PABC diagnosed more than 5 years postpartum. Controls were matched [...]

Menée auprès de 477 cas et de 477 témoins, cette étude coréenne évalue l'association entre une ingestion d'aflatoxine B1 d'origine alimentaire, des polymorphisme des gènes CYP1A2, CYP2E1, EPHX1, GSTM1, GSTT1 et le risque de cancer de l'estomac

Dietary aflatoxin B1 intake, genetic polymorphisms of CYP1A2, CYP2E1, EPHX1, GSTM1, and GSTT1, and gastric cancer risk in Korean

Eom, Sang-Yong ; Yim, Dong-Hyuk ; Zhang, Yanwei ; Yun, Jung-Kuk ; Moon, SunIn ; Yun, Hyo-Yung ; Song, Young-Jin ; Youn, Sei-Jin ; Hyun, Taisun ; Park, Joo-Seung ; Kim, ByungSik ; Lee, Jong-Young ; Kim, Yong-Dae ; Kim, Heon

Purpose : We investigated the effects of aflatoxin B1 (AFB1) intake, genetic polymorphisms of AFB1 metabolic enzymes, and interactions between the polymorphisms and intake of AFB1 with regard to the risk of gastric cancer in Korean. Methods : The participants in the study included 477 gastric cancer patients and 477 age- and sex-matched control subjects. Direct interviews and a structured questionnaire were used to determine the level of exposure to AFB1, and the GoldenGate assay and multiplex [...]

A partir des données de 13 études portant sur 10 061 cas et 12 768 témoins, cette étude analyse les relations entre six polymorphismes de gènes associés aux niveaux de vitamine D circulante et le risque de cancer colorectal

Genetic Predictors of Circulating 25-Hydroxyvitamin D and Risk of Colorectal Cancer

Hiraki, Linda T. ; Qu, Conghui ; Hutter, Carolyn M. ; Baron, John ; Berndt, Sonja I. ; Bézieau, Stéphane ; Brenner, Hermann ; Caan, Bette J. ; Casey, Graham ; Chang-Claude, Jenny ; Chanock, Stephen J. ; Conti, David V ; Duggan, David ; Fuchs, Charles S. ; Gallinger, steven ; Giovannucci, Edward L. ; Harrison, Tabitha A. ; Hayes, Richard B. ; Hazra, Aditi ; Henderson, Brian ; Hoffmeister, Michael ; Hopper, John L. ; Hudson, Thomas J ; Jenkins, Mark A. ; Küry, Sébastien ; Le Marchand, Loic ; Lemire, Mathieu ; Ma, Jing ; Manson, JoAnn E. ; Nan, Hongmei ; Newcomb, Polly A. ; Ng, Kimmie ; Potter, John D. ; Schoen, Robert E. ; Schumacher, Frederick ; Seminara, Daniela ; Slattery, Martha L. ; Wactawski-Wende, Jean ; White, Emily ; Wu, Kana ; Zanke, Brent W ; Kraft, Peter ; Peters, Ulrike ; Chan, Andrew T.

Background: Experimental evidence has demonstrated an anti-neoplastic role for vitamin D in the colon and higher circulating 25-hydroxyvitamin D (25[OH]D) levels are consistently associated with a lower risk of colorectal cancer (CRC). Genome-wide association studies have identified loci associated with levels of circulating 25(OH)D. The identified SNPs from four gene regions, collectively explain approximately 5% of the variance in circulating 25(OH)D. Methods: We investigated whether six [...]

A partir des données de la cohorte "Long Island Breast Cancer Study Project", cette étude américaine évalue l'association entre des polymorphismes des gènes liés à la réparation de l'ADN, la pratique d'une activité physique de loisir et le risque de cancer du sein

Polymorphisms in DNA repair genes, recreational physical activity and breast cancer risk

McCullough, Lauren E. ; Santella, Regina M. ; Cleveland, Rebecca J. ; Millikan, Robert C. ; Olshan, Andrew F. ; North, Kari E. ; Bradshaw, Patrick T. ; Eng, Sybil M. ; Terry, Mary Beth ; Shen, Jing ; Crew, Katherine D. ; Rossner, Pavel ; Teitelbaum, Susan L. ; Neugut, Alfred I. ; Gammon, Marilie D.

The mechanisms driving the inverse association between recreational physical activity (RPA) and breast cancer risk are complex. While exercise is associated with increased reactive oxygen species production it may also improve damage repair systems, particularly those that operate on single-strand breaks including base excision repair (BER), nucleotide excision repair (NER) and mismatch repair (MMR). Of these repair pathways, the role of MMR in breast carcinogenesis is least investigated. [...]