A partir d'une revue systématique de la littérature publiée jusqu'en septembre 2012 (46 articles), cette étude évalue l'association entre des facteurs alimentaires et le risque de cancer avancé de la prostate

Dietary factors and risk for advanced prostate cancer

Gathirua-Mwangi, Wambui G. ; Zhang, Jianjun

Prostate cancer is the second most common cancer among men worldwide. Although some nutrients have been linked to the development of total prostate cancer, it remains unclear whether these nutrients modulate the risk of its clinically significant form - advanced tumor. Therefore, this study sought to perform a systematic review of the literature on this topic. The papers reviewed were identified from PubMed using keywords diet and advanced, metastatic, or lethal prostate cancer. A total of 46 [...]

Menée à partir de données portant sur 3 788 patients atteints d'un lymphome non hodgkinien et sur 4 279 témoins, cette étude évalue l'association entre une exposition professionnelle au trichloroéthylène et le risque de développer la maladie et ses principaux sous-types (lymphome folliculaire, leucémie lymphoïde chronique, lymphome diffus à grandes cellules B)

Occupational exposure to trichloroethylene and risk of non-Hodgkin lymphoma and its major subtypes: a pooled IinterLlymph analysis

Cocco, P ; Vermeulen, R ; Flore, V ; Nonne, T ; Campagna, M ; Purdue, M ; Blair, A ; Monnereau, A ; Orsi, L ; Clavel, J ; Becker, N ; de Sanjosé, S ; Foretova, L ; Staines, A ; Maynadié, M ; Nieters, A ; Miligi, L ; ‘t Mannetje, A ; Kricker, A ; Brennan, P ; Boffetta, P ; Lan, Q ; Rothman, N

Objectives : We evaluated the association between occupational exposure to trichloroethylene (TCE) and risk of non-Hodgkin lymphoma (NHL) in a pooled analysis of four international case-control studies. Methods : Overall, the pooled study population included 3788 NHL cases and 4279 controls. Risk of NHL and its major subtypes associated with TCE exposure was calculated with unconditional logistic regression and polytomous regression analysis, adjusting by age, gender and study. Results : Risk [...]

Menée à partir des données de deux registres britanniques de médecine générale portant au total sur 180 401 patients atteints d'un cancer primitif non gastro-intestinal diagnostiqué entre 1997 et 2011 (sein, prostate, poumon, vessie, mélanome, ovaire, pancréas, utérus et col de l'utérus) et sur 843 257 témoins (âge : 50 ans et plus), cette étude évalue l'association entre l'utilisation de bisphosphonates et le risque de développer la maladie

Exposure to bisphosphonates and risk of common non-gastrointestinal cancers : series of nested case-control studies using two primary-care databases

Vinogradova, Y. ; Coupland, C. ; Hippisley-Cox, J.

Background : Bisphosphonates are the most commonly prescribed osteoporosis drugs but long-term effects are unclear, although antitumour properties are known from preclinical studies. Methods : Nested case–control studies were conducted to investigate bisphosphonate use and risks of common non-gastrointestinal cancers (breast, prostate, lung, bladder, melanoma, ovarian, pancreas, uterus and cervical). Patients 50 years and older, diagnosed with primary cancers between 1997 and 2011, were matched [...]

Menée en population chinoise sur 1 493 patients atteints d'un carcinome épidermoïde de l'œsophage et 1 553 témoins, cette étude montre une association entre un polymorphisme à simple nucléotide du gène d'un long ARN intergénique non codant (lincRNA-uc003opf.1) et une susceptibilité à cette maladie

A genetic polymorphism in lincRNA-uc003opf.1 is associated with susceptibility to esophageal squamous cell carcinoma in Chinese populations

Wu, Hongchun ; Zheng, Jian ; Deng, Jieqiong ; Hu, Min ; You, Yonghe ; Li, Na ; Li, Wei ; Lu, Jiachun ; Zhou, Yifeng

The development of esophageal squamous cell carcinoma (ESCC) is a multifactorial process, and associations between genetic variants (GVs) and ESCC have been identified in genome-wide association studies (GWAS). The aim of this study was to evaluate the effects of single nucleotide polymorphisms (SNPs) of long intergenic non-coding RNAs (lincRNAs) on ESCC susceptibility in Chinese populations. We scoured exons of lincRNAs located in ESCC susceptibility loci for all probable functional SNPs. [...]

Menée sur une cohorte norvégienne incluant 28 153 femmes (durée de suivi : jusqu'à 30 ans), cette étude évalue l'association entre le changement de poids à l'âge adulte et le risque de cancer du sein après la ménopause

Weight change in adulthood and risk of postmenopausal breast cancer: the HUNT study of Norway

Alsaker, M. D. K. ; Janszky, I. ; Opdahl, S. ; Vatten, L. J. ; Romundstad, P. R.

Background : Adult weight gain is associated with increased risk of postmenopausal breast cancer. Most previous studies are limited by using recalled or self-reported data, and it is not known if age-specific weight changes are important for breast cancer risk. Methods : In a Norwegian cohort of 28 153 women (and 900 incident breast cancers) with longitudinal anthropometric measurements over up to 30 years, we studied both overall and age-related weight changes in adulthood and risk of [...]

Menée à partir des données de 7 études prospectives incluant 767 patientes atteintes d'un cancer du sein et 1 699 témoins, cette étude évalue l'association entre les niveaux de plusieurs hormones sexuelles circulantes (œstradiol, œstrone, androstènedione, testostérone, progestérone) et le risque de cancer du sein chez les femmes avant la ménopause

Sex hormones and risk of breast cancer in premenopausal women : a collaborative reanalysis of individual participant data from seven prospective studies

Background : Associations between circulating concentrations of oestrogens, progesterone, and androgens with breast cancer and related risk factors in premenopausal women are not well understood. We aimed to characterise these associations with a pooled analysis of data from seven studies. Methods : Individual participant data for prediagnostic sex hormone and sex hormone-binding globulin (SHBG) concentrations were contributed from seven prospective studies. We restricted analyses to women who [...]

Menée sur 176 patients atteints d'un carcinome épidermoïde de l'oropharynx, sur 325 patients atteints d'un carcinome épidermoïde de la cavité buccale et sur 335 témoins, cette étude évalue l'association entre 4 polymorphismes à simple nucléotide du promoteur du gène du TNF-alpha et le risque de carcinome épidermoïde de la cavité buccale lié au papillomavirus humain de type 16

Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma

Jin, Lei ; Sturgis, Erich ; Zhang, Yang ; Huang, Zhigang ; Song, Xicheng ; Li, Chao ; Wei, Qingyi ; Li, GuoJun

Background : Tumor necrosis factor alpha (TNF-alpha) plays an important role in inflammation, immunity, and defense against infection and clearance of human papillomavirus (HPV). Thus, genetic variants may modulate individual susceptibility to HPV-associated oral squamous cell carcinoma (OSCC). Methods : In this study we genotyped four common single nucleotide polymorphisms (SNPs) in the TNF-alpha promoter [ -308G > A(rs1800629), -857C > T (rs1799724), -863C > A (rs1800630), and -1031T > C [...]