A partir de questionnaires auprès de 481 419 participants et 137 patients atteints d'un cancer de l'œsophage (durée moyenne de suivi : 11 ans), cette étude, couplée à la cohorte EPIC, évalue l'association entre la consommation de viande rouge (transformée ou non), de viande blanche ou de fer héminique et le risque de développer la maladie

Meat and heme iron intake and esophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study

Jakszyn, Paula ; Luján-Barroso, Leila ; Agudo, Antonio ; Bueno-de-Mesquita, H. Bas ; Molina, Esther ; Sánchez, Mª José ; Fonseca-Nunes, Ana ; Siersema, Peter D. ; Matiello, Amalia ; Tumino, Rosario ; Saieva, Calogero ; Pala, Valeria ; Vineis, Paolo ; Boutron-Ruault, Marie-Christine ; Racine, Antoine ; Bastide, Nadie ; Travis, Ruth C. ; Khaw, Kay-Tee ; Riboli, Elio ; Murphy, Neil ; Vergnaud, Anne-Claire ; Trichopoulou, Antonia ; Valanou, Elissavet ; Oikonomidou, EDespina ; Weiderpass, Elisabete ; Skeie, Guri ; Johansen, Dorthe ; Lindkvist, Björn ; Johansson, Mattias ; Duarte-Salles, Talita ; Freisling, Heinz ; Barricarte, Aurelio ; Mª Huerta, Jose ; Amiano, Pilar ; Tjonneland, Anne ; Overvad, Kim ; Kuehn, Tilman ; Grote, Verena ; Boeing, Heiner ; Peeters, Petra H. M. ; A González, Carlos

Although recent studies suggest that high intakes of meat and heme iron are risk factors for several types of cancer, studies in relation to esophageal adenocarcinoma (EAC) are scarce. Previous results in the European Prospective Investigation into Cancer and Nutrition (EPIC) based on a relatively small number of cases suggested a positive association between processed meat and EAC. In this study, we investigate the association between intake of different types of meats and heme iron intake and [...]

Menée à Shanghai à partir de données portant sur 444 ouvriers de l'industrie du coton et auprès de 467 témoins (durée de suivi : 26 777 personnes-années), cette étude évalue l'association entre une exposition professionnelle à la poussière de coton et à des endotoxines et le risque de décès par type de cancer

Cotton dust, endotoxin and cancer mortality among the Shanghai textile workers cohort: a 30-year analysis

Fang, S C ; Mehta, A J ; Hang, J Q ; Eisen, E A ; Dai, H L ; Zhang, H X ; Su, L ; Christiani, D C

Background : Although occupational exposure to cotton dust and endotoxin is associated with adverse respiratory health, associations with cancer are unclear. We investigated cancer mortality in relation to cotton dust and endotoxin exposure in the Shanghai textile workers cohort. Methods : We followed 444 cotton textile and a reference group of 467 unexposed silk workers for 30 years (26 777 person-years). HRs for all cancers combined (with and without lung cancer) and gastrointestinal cancer [...]

Menée à partir des données de mortalité sur la période1950-2008 d'une étude de cohorte incluant tous les sites de production européens ou nord-américains du polytétrafluoroéthylène et à l'aide d'une matrice emploi-exposition, cette étude évalue l'association entre une exposition professionnelle au tétrafluoroéthylène et le risque de cancer chez 4 773 travailleurs

Cancer Risk Among Tetrafluoroethylene Synthesis and Polymerization Workers

Consonni, Dario ; Straif, Kurt ; Symons, J. Morel ; Tomenson, John A. ; van Amelsvoort, Ludovic G. P. M. ; Sleeuwenhoek, Anne ; Cherrie, John W. ; Bonetti, Paolo ; Colombo, Ilaria ; Farrar, David G. ; Bertazzi, Pier Alberto

Tetrafluoroethylene (TFE), a compound used for the production of fluorinated polymers including polytetrafluoroethylene, increases the incidence of liver and kidney cancers and leukemia in rats and mice. This is the first time the cancer risk in humans has been explored comprehensively in a cohort mortality study (1950–2008) that included all polytetrafluoroethylene production sites in Europe and North America at the time it was initiated. A job-exposure matrix (1950–2002) was developed for TFE [...]

A partir de données portant sur 618 patients atteints d'un cancer de la peau hors mélanome et 527 témoins (âge 30 à 79 ans), cette étude européenne évalue l'association entre une exposition professionnelle à l'arsenic en suspension dans l'air (poussière, fumée) et le risque de développer la maladie

Occupational exposure to arsenic and risk of nonmelanoma skin cancer in a multinational European study

Surdu, Simona ; Fitzgerald, Edward F. ; Bloom, Michael S. ; Boscoe, Francis P. ; Carpenter, David O. ; Haase, Richard F. ; Gurzau, Eugen ; Rudnai, Peter ; Koppova, Kvetoslava ; Févotte, Joëlle ; Vahter, Marie ; Leonardi, Giovanni ; Goessler, Walter ; Kumar, Rajiv ; Fletcher, Tony

Occupational studies show a high risk of lung cancer related to arsenic exposure by inhalation; however, only a few studies, and with conflicting results, previously examined a potential link between arsenic exposure at work and skin cancer. The aim of this study is to assess airborne arsenic exposures at the workplace and to quantify associations with nonmelanoma skin cancer (NMSC). The study sample consists of 618 incident cases of NMSC and 527 hospital-based controls aged 30–79 years from [...]

Menée sur deux cohortes américaines de professionnels de santé comportant au total 140 171 participants, cette étude évalue, en fonction du sexe, l'incidence du carcinome basocellulaire et identifie les facteurs de risque associés

Basal-Cell Carcinoma Incidence and Associated Risk Factors in US Women and Men

Wu, Shaowei ; Han, Jiali ; Li, Wen-Qing ; Li, Tricia ; Qureshi, Abrar A.

There is a paucity of data on basal-cell carcinoma (BCC) in the United States, since most national registries do not collect information on BCC. We evaluated BCC incidence trends and associated risk factors for BCC in 140,171 participants from a US female cohort, the Nurses' Health Study (1986–2006), and a US male cohort, the Health Professionals' Follow-up Study (1988–2006). Age-adjusted BCC incidence rates increased from 519 cases per 100,000 person-years to 1,019 cases per 100,000 person [...]

A partir d'une revue systématique de la littérature publiée jusqu'en janvier 2013 (7 études), cette méta-analyse évalue l'association entre des dommages cutanés liés à une exposition chronique au soleil (kératoses actiniques, élastose solaire, lentigos solaires ou télangiectasie) et le risque de carcinome basocellulaire

Cutaneous markers of photo-damage and risk of basal cell carcinoma of the skin: A meta-analysis

Khalesi, Mohammad ; Whiteman, David C. ; Doi, Suhail A.R. ; Clark, Justin ; Kimlin, Michael G. ; Neale, Rachel E.

BACKGROUND : Epidemiologic research has demonstrated that cutaneous markers of photo-damage are associated with risk of basal cell carcinoma (BCC). However there has been no previous attempt to calculate pooled risk estimates. METHODS: We conducted a systematic review and meta-analysis after extracting relevant studies published up to January 2013 from five electronic databases. Eligible studies were those that permitted quantitative assessment of the association between [...]

Menée à partir de données médicales portant sur 4 216 patientes atteintes d'un cancer du sein de stade I/II diagnostiqué entre 1990 et 2008 (âge : 18 ans et plus ; durée médiane de suivi : 6,7 ans), cette étude évalue l'association entre l'utilisation régulière d'antibiotiques et le risque de développer un second cancer du sein

Frequent Antibiotic Use and Second Breast Cancer Events

Wirtz, Heidi S. ; Buist, Diana S.M. ; Gralow, Julie R. ; Barlow, William E. ; Gray, Shelly ; Chubak, Jessica ; Yu, Onchee ; Bowles, Erin J.A. ; Fujii, Monica ; Boudreau, Denise M.

Background : Antibiotic use may be associated with higher breast cancer risk and breast cancer mortality, but no study has evaluated the relation between antibiotic use and second breast cancer events (SBCE). Methods : We conducted a retrospective cohort study among women ≥18 years, diagnosed with incident stage I/II breast cancer during 1990-2008. Antibiotic use and covariates were obtained from health plan administrative databases and medical record review. Frequent antibiotic use was defined [...]

Menée à partir de questionnaires auprès de 1 984 patientes atteintes d'un carcinome canalaire invasif ou d'un carcinome lobulaire invasif du sein diagnostiqué entre 2000 et 2008 et menée auprès de 902 témoins (âge : 55 à 74 ans), cette étude évalue l'association entre l'utilisation à long terme de statines et le risque de développer ces maladies

Long-term statin use and risk of ductal and lobular breast cancer among women 55-74 years of age

McDougall, Jean A. ; Malone, Kathleen E. ; Daling, Janet R ; Cushing-Haugen, Kara L. ; Porter, Peggy L ; Li, Christopher I.

Background : Mechanistic studies largely support the chemopreventive potential of statins. However, results of epidemiologic studies investigating statin use and breast cancer risk have been inconsistent and lacked the ability to evaluate long-term statin use. Methods : We utilized data from a population-based case-control study of breast cancer conducted in the Seattle-Puget Sound region to investigate the relationship between long-term statin use and breast cancer risk. 916 invasive ductal [...]

Menée en Espagne sur 837 patients atteints d'un mélanome cutané et sur 1 154 témoins, cette étude évalue l'association entre des variants génétiques de la région chromosomique 9p21 et le risque de développer la maladie

Variants at the 9p21 locus and melanoma risk

Maccioni, Livia ; Rachakonda, Panduranga ; Bermejo, Justo ; Planelles, Dolores ; Requena, Celia ; Hemminki, Kari ; Nagore, Eduardo ; Kumar, Rajiv

Background : The influence of variants at the 9p21 locus on melanoma risk has been reported through investigation of CDKN2A variants through candidate gene approach as well as by genome wide association studies (GWAS). Methods : In the present study we genotyped, 25 SNPs that tag 273 variants on chromosome 9p21 in 837 melanoma cases and 1154 controls from Spain. Ten SNPs were selected based on previous associations, reported in GWAS, with either melanocytic nevi or melanoma risk or both. The [...]

Menée à partir de données portant sur 2 cohortes incluant au total 125 437 femmes, cette étude évalue l'association entre des facteurs hormonaux et le risque de cancer épithélial invasif de l'ovaire (623 cas) chez les femmes n'ayant pas eu d'enfant et chez les femmes ayant eu un enfant

Hormonal risk factors and invasive epithelial ovarian cancer risk by parity

Bodelon, C. ; Wentzensen, N. ; Schonfeld, S. J. ; Visvanathan, K. ; Hartge, P. ; Park, Y. ; Pfeiffer, R. M.

Background : Recent studies have suggested that several ovarian cancer risk factors differ by parity status, but these findings have not been confirmed. We evaluated whether known risk factors of ovarian cancer differ between nulliparous and parous women using data from two large prospective cohorts. Methods : Data from the National Institutes of Health-AARP Diet and Health Study and the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial were combined for this analysis. Cox [...]

Menée sur 307 patients atteints d'un carcinome épidermoïde de l'œsophage et sur 311 témoins, cette étude évalue, en fonction de la séropositivité au papillomavirus humain de type 16, de la consommation d'alcool et du comportement tabagique, l'association entre des polymorphismes à simple nucléotide des gènes p53 et MDM2 et le risque de développer la maladie

Association of p53 and MDM2 polymorphisms with risk of human papillomavirus (HPV)-related esophageal squamous cell carcinoma (ESCC)

Yang, Ju ; Liu, Bo ; Li, Wen ; Xiong, Huihua ; Qiu, Hong ; Fu, Qiang ; Chen, Bei ; Hu, Guangyuan ; Yuan, Xianglin

Purpose : Though polymorphisms of the tumor suppressor gene p53 have been extensively investigated in numerous tumors, particularly tumors associated with human papillomavirus (HPV) infection. However, the results remain controversial. Our previous study showed that HPV serostatus is not an independent risk factor for esophageal squamous cell carcinoma (ESCC) in nonsmokers and nondrinkers. Given the roles of p53 and HPV E6 as well as MDM2 oncoproteins in p53 degradation, we validated the [...]

Menée sur 776 patients atteints d'un cancer de la prostate et sur 1 444 témoins, cette étude évalue l'association entre 41 pesticides, 152 polymorphismes à simple nucléotide de 9 gènes impliqués dans la voie de la vitamine D et le risque de développer la maladie

Pesticide exposure and inherited variants in vitamin D pathway genes in relation to prostate cancer

Karami, Sara ; Andreotti, Gabriella ; Koutros, Stella ; Barry, Kathryn Hughes ; Moore, Lee E. ; Han, Summer S ; Hoppin, Jane A ; Sandler, Dale P. ; Lubin, Jay H ; Burdette, Laurie ; Yuenger, Jeffrey ; Yeager, Meredith ; Beane Freeman, Laura ; Blair, Aaron ; Alavanja, Michael C.R.

Background : Vitamin D and its metabolites are believed to impede carcinogenesis by stimulating cell differentiation, inhibiting cell proliferation, and inducing apoptosis. Certain pesticides have been shown to deregulate vitamin D's anti-carcinogenic properties. We hypothesize that certain pesticides may be linked to prostate cancer via an interaction with vitamin D genetic variants. Methods : We evaluated interactions between 41 pesticides and 152 single nucleotide polymorphisms (SNPs) in [...]

Nichée dans une étude de cohorte norvégienne incluant 49 402 infirmières âgées de 35 à 74 ans, cette étude (563 cas et 619 témoins) évalue l'association entre 60 polymorphismes à simple nucléotide de 17 gènes impliqués dans la régulation du cycle circadien et une susceptibilité au cancer du sein lié au travail posté

Analysis of polymorphisms in the circadian-related genes and breast cancer risk in the Norwegian nurses working night shifts

Zienolddiny, Shanbeh ; Haugen, Aage ; Lie, Jenny-Anne ; Kjuus, Helge ; Haugen Anmarkrud, Kristine ; Kjaerheim, Kristina

Introduction : Some studies suggest that night work may be associated with an increased risk of breast cancer in nurses. We aimed to explore the role of circadian gene polymorphisms in the susceptibility to night work-related breast cancer risk. Methods : A nested case-control study of Norwegian nurses comprising of 563 breast cancer cases and 619 controls was carried out within a cohort of 49402 Norwegian nurses, aged 35-74 years. We studied 60 SNPs in 17 genes involved in regulation of the [...]