Menée en France à partir de questionnaires auprès de 5 165 adultes fumeurs légers ayant consulté entre 2007 et 2010 un service d'aide à l'arrêt du tabagisme, cette étude identifie les risques perçus vis-à-vis du sevrage tabagique, puis analyse le lien entre ces perceptions et les résultats obtenus un mois après l'arrêt du tabagisme

Perceived risks to smoking cessation among treatment-seeking French light smokers

Baha, Monique ; Le Faou, Anne-Laurence

Objective : This study investigated perceived risks to cessation expressed by light smokers and the association with cessation outcomes at one month post-quit date. Method : Data from adult light smokers attending French smoking cessation services nationwide between October 2007 and December 2010 were analyzed, retrospectively. In order to identify perceived risks, we performed a thematic analysis of answers to an open-ended question. Bivariate analysis and multivariate logistic modelling were [...]

A partir d'une revue systématique de la littérature publiée jusqu'en décembre 2012 (21 études prospectives de cohorte, 883 585 participants, 20 905 cas), cette méta-analyse évalue l'association entre la consommation de poisson ou d'acides gras poly-insaturés oméga-3 d'origine marine et le risque de cancer du sein

Intake of fish and marine n-3 polyunsaturated fatty acids and risk of breast cancer: meta-analysis of data from 21 independent prospective cohort studies

Ju-Sheng Zheng ; Xiao-Jie Hu ; Yi-Min Zhao ; Jing Yang ; Duo Li

Objectives : To investigate the association between intake of fish and n-3 polyunsaturated fatty acids (n-3 PUFA) and the risk of breast cancer and to evaluate the potential dose-response relation. Design : Meta-analysis and systematic review of prospective cohort studies. Data sources PubMed and Embase up to December 2012 and references of retrieved relevant articles. Eligibility criteria for selecting studies Prospective cohort studies with relative risk and 95% confidence intervals for [...]

Cet article passe en revue les études concernant les mécanismes intracellulaires associés aux effets préventifs et thérapeutiques des tocotriénols dans le cancer du sein

Potential role of tocotrienols in the treatment and prevention of breast cancer

Sylvester, P. W. ; Akl, M. R. ; Malaviya, A. ; Parajuli, P. ; Ananthula, S. ; Tiwari, R. V. ; Ayoub, N. M.

Vitamin E is a generic term that refers to a family of compounds that is further divided into two subgroups called tocopherols and tocotrienols. Although all natural forms of vitamin E display potent antioxidant activity, tocotrienols are significantly more potent than tocopherols in inhibiting tumor cell growth and viability, and anticancer activity of tocotrienols is mediated independently of their antioxidant activity. In addition, the anticancer effects of tocotrienols are observed using [...]

Menée sur des lignées cellulaires de carcinome de la tête et du cou et à l'aide d'une xénogreffe sur un modèle murin, cette étude montre que le garcinol, une substance végétale (Garcinia indica), peut supprimer la croissance et la survie des cellules tumorales en régulant de multiples cascades de signalisation pro-inflammatoire

Garcinol, a polyisoprenylated benzophenone modulates multiple pro-inflammatory signaling cascades leading to suppression of growth and survival of head and neck carcinoma

Li, Feng ; Shanmugam, Muthu K. ; Chen, Luxi ; Chatterjee, Snehajyoti ; Basha, Jeelan ; Kumar, Alan Prem ; Kundu, Tapas Kumar ; Sethi, Gautam

Constitutive activation of pro-inflammatory transcription factors such as signal transducers and activators of transcription 3 (STAT3) and nuclear factor kappa B (NF-κB) plays a pivotal role in the proliferation and survival of head and neck squamous cell carcinoma (HNSCC). Thus, agents which can modulate deregulated STAT3 and NF-κB activation have a great potential both for the prevention and treatment of HNSCC. In the present report, we investigated the potential effects of garcinol, an [...]

Cette étude analyse, pour 69 plans d'intervention élaborés par les partenaires du réseau "Comprehensive Cancer Control", l'application des recommandations de l'organisme américain "Centers for Disease Control and Prevention" en matière de lutte contre le tabagisme et de financement des programmes

An Update on Tobacco Control Initiatives in Comprehensive Cancer Control Plans

Dunne, Katherine ; Henderson, Susan ; Stewart, Sherri L. ; Moore, Angela ; Hayes, Nikki S. ; Jordan, Jerelyn

INTRODUCTION : Comprehensive cancer control (CCC) coalitions address tobacco use, the leading cause of preventable death in the United States, through formal plans to guide tobacco control activities and other cancer prevention strategies. Best Practices for Comprehensive Tobacco Control Programs (Best Practices) and The Guide to Community Preventive Services (The Community Guide) are used to assist with this effort. We examined CCC plans to determine the extent to which they followed the [...]

Menée in vitro, cette étude montre que la NAD(P)H quinone oxydoréductase prévient l'aneuploïdie induite par les rayonnements ionisants en agissant sur la kinase Aurora-A

NQO1 prevents radiation-induced aneuploidy by interacting with Aurora-A

Park, Moon-Taek ; Oh, Eun-Taex ; Song, Min-Jeong ; Lee, Hyemi ; Choi, Eun Kyung ; Park, Heon Joo

Aneuploidy is the most common characteristic of human cancer cells. It also causes genomic instability which is involved in the initiation of cancer development. Various lines of evidence indicate that NAD(P)H quinone oxidoreductase 1 (NQO1) plays an important role in cancer prevention, but the molecular mechanisms underlying this effect have not yet been fully elucidated. Here, we report that ionizing radiation (IR) induces substantial aneuploidy and centrosome amplification in NQO1-deficient [...]