Menée en population norvégienne auprès de 3 915 cas et 144 653 témoins, cette étude met notamment en évidence une incidence accrue des accouchements prématurés et d'un faible poids à la naissance chez les femmes ayant survécu à un cancer

Birth outcomes among offspring of adult cancer survivors: A population-based study

Stensheim, Hanne ; Klungsøyr, Kari ; Skjærven, Rolv ; Grotmol, Tom ; Fosså, Sophie D.

Do cancer and cancer treatment influence patients' subsequent pregnancies and outcomes for the offspring? In this study, we compared birth outcomes in 3,915 female and male survivors and 144,653 controls from the general population with similar parity, by merging data from the Cancer Registry and the Medical Birth Registry of Norway. The cancer survivors were diagnosed at age 16–45 in the period 1967–2004. Subgroups of nulliparous survivors (childless before cancer) and primiparous (one [...]

Menée par entretiens auprès de 24 participants, cette étude qualitative analyse les bénéfices perçus ainsi que les freins à la pratique d'une activité physique par les patients ayant été traités pour un myélome multiple au cours des 12 derniers mois

Perceived benefits and barriers to exercise for recently treated patients with multiple myeloma: a qualitative study

Craike, Melinda ; Hose, Kaye ; Courneya, Kerry ; Harrison, Simon ; Livingston, Patricia

BACKGROUND:Understanding the physical activity experiences of patients with multiple myeloma (MM) is essential to inform the development of evidence-based interventions and to quantify the benefits of physical activity. The aim of this study was to gain an in-depth understanding of the physical activity experiences and perceived benefits and barriers to physical activity for patients with MM. METHODS:This was a qualitative study that used a grounded theory approach. Semi-structured interviews [...]

Menée aux Etats-Unis, cette étude prospective longitudinale analyse les troubles du sommeil, la détresse émotionnelle et la qualité de vie de patientes atteintes d'un cancer de l'ovaire, la première année suivant le diagnostic

Sleep disturbance, distress, and quality of life in ovarian cancer patients during the first year after diagnosis

Clevenger, Lauren ; Schrepf, Andrew ; DeGeest, Koenraad ; Bender, David ; Goodheart, Michael ; Ahmed, Amina ; Dahmoush, Laila ; Penedo, Frank ; Lucci, Joseph ; Thaker, Premal H. ; Mendez, Luis ; Sood, Anil K. ; Slavich, George M. ; Lutgendorf, Susan K.

BACKGROUND Sleep disturbance is a common clinical complaint of oncology patients and contributes to substantial morbidity. However, because most sleep studies have been cross-sectional, associations between sleep quality and distress in patients with ovarian cancer over time remain unclear. This prospective longitudinal study examined rates of sleep disturbance; contributions of depression, anxiety, and medication use in sleep disturbance; and associations between sleep quality and quality of [...]

Mené auprès de 345 patients atteints d'un adénocarcinome pulmonaire de stade avancé avec mutation du gène EGFR, cet essai de phase III évalue les symptômes auto-déclarés et la qualité de vie des patients ayant reçu un traitement par afatinib ou une combinaison cisplatine-pemetrexed

Symptom Control and Quality of Life in LUX-Lung 3: A Phase III Study of Afatinib or Cisplatin/Pemetrexed in Patients With Advanced Lung Adenocarcinoma With EGFR Mutations

Yang, James Chih-Hsin ; Hirsh, Vera ; Schuler, Martin ; Yamamoto, Nobuyuki ; O’Byrne, Kenneth J. ; Mok, Tony S.K. ; Zazulina, Victoria ; Shahidi, Mehdi ; Lungershausen, Juliane ; Massey, Dan ; Palmer, Michael ; Sequist, Lecia V.

Purpose : Patient-reported symptoms and health-related quality of life (QoL) benefits were investigated in a randomized, phase III trial of afatinib or cisplatin/pemetrexed. Patients and Methods : Three hundred forty-five patients with advanced epidermal growth factor receptor (EGFR) mutation–positive lung adenocarcinoma were randomly assigned 2:1 to afatinib 40 mg per day or up to six cycles of cisplatin/pemetrexed. Lung cancer symptoms and health-related QoL were assessed every 21 days until [...]

Cette étude analyse les disparités géographiques de la prévalence de 20 types de cancers dans des pays d'Europe du nord, en Italie, en France, en Australie et aux Etats-Unis, au milieu des années 2000

Cancer prevalence in United States, Nordic Countries, Italy, Australia, and France: an analysis of geographic variability

Crocetti, E. ; De Angelis, R. ; Buzzoni, C. ; Mariotto, A. ; Storm, H. ; Colonna, M. ; Zanetti, R. ; Serraino, D. ; Michiara, M. ; Cirilli, C. ; Iannelli, A. ; Mazzoleni, G. ; Sechi, O. ; Sanoja Gonzalez, M. E. ; Guzzinati, S. ; Capocaccia, R. ; Dal Maso, L.

Background: The objectives of this study were to quantitatively assess the geographic heterogeneity of cancer prevalence in selected Western Countries and to explore the associations between its determinants. Methods: For 20 cancer sites, 5-year cancer prevalence, incidence, and survival were observed and age standardised for the mid 2000s in the United States, Nordic European Countries, Italy, Australia, and France. Results: In Italy, 5-year crude prevalence for all cancers was 1.9% in men and [...]

Menée en Angleterre à partir de données d'enquêtes portant sur 920 patients atteints d'un cancer de la vessie et sur 398 patients atteints d'un cancer rénal, cette étude prospective analyse, en fonction du sexe, les disparités dans le délai séparant le diagnostic et la première visite chez le médecin généraliste

Gender inequalities in the promptness of diagnosis of bladder and renal cancer after symptomatic presentation: evidence from secondary analysis of an English primary care audit survey

Lyratzopoulos, Georgios ; Abel, Gary A ; McPhail, Sean ; Neal, Richard D ; Rubin, Gregory P

Objectives : To explore whether women experience greater delays in the diagnosis of bladder and renal cancer when first presenting to a general practitioner with symptoms caused by those cancers and potential reasons for such gender inequalities. Design : Prospective national audit survey of cancer diagnosis. Setting : English primary care (2009–2010). Participants : 920 patients with bladder and 398 patients with renal cancer (252 (27%) and 165 (42%), respectively, were women).Primary and [...]

A partir des données des registres suédois des décès et des cancers, cette étude analyse l'association entre le niveau d'éducation et la survie des patients diagnostiqués avec un cancer sur la période 1970-2007

Widening educational differences in cancer survival in Norway

Kravdal, Håkon

Background: All-cause and cause-specific mortality have long been known to be associated with various indicators of socio-economic status, and social gradients have been shown also for cancer survival. In recent decades, several studies have reported increasing social differentials in mortality rates. This study aims to investigate the development with respect to cancer survival, which has not been done before. Methods: Discrete-time hazard regression models for cancer deaths among women and [...]

Menée en Suisse, cette étude présente, au niveau de chaque canton, les projections de mortalité par cancer lié au tabac sur les périodes 2009-2013 et 2014-2018

Tobacco-related cancer mortality: projections for different geographical regions in Switzerland

Verena Jürgensa ; Silvia Ess ; Harish C. Phuleriaa ; Martin Frühd ; Matthias Schwenkglenkse ; Harald Frickf ; Thomas Cerny ; Penelope Vounatsou

PRINCIPLES: Switzerland is divided into 26 cantons of variable population size and cultural characteristics. Although a federal law to protect against passive smoking and a national tobacco control programme exist, details of tobacco-related policies are canton-specific. This study aimed to project gender-specific tobacco-related cancer mortality in Switzerland at different geographical levels for the periods 2009–2013 and 2014–2018. METHODS: In this analysis, data on Swiss tobacco-related [...]

A partir des données de onze registres allemands et américains des cancers, cette étude analyse et compare, pour ces deux pays, la survie des patients adolescents ou jeunes adultes atteints de cancer, sur la période 2002-2006

Survival among adolescents and young adults with cancer in Germany and the United States: An international comparison

Gondos, Adam ; Hiripi, Eva ; Holleczek, Bernd ; Luttmann, Sabine ; Eberle, Andrea ; Brenner, Hermann ; the, Gekid Cancer Survival Working Group

Serious concern arose in the scientific literature about the state of and progress in cancer survival among adolescent and young adult (AYA) patients in the recent years. We provide an up-to-date international comparison of survival among AYA patients. Using population-based cancer data from 11 German cancer registries and the SEER Program of the United States (covering populations of 39 and 33 million people, respectively), standardized tumor group classifications, period analysis and [...]

A partir des données de trois études prospectives japonaises incluant 2 276 patients traités par chimiothérapie intensive pour une leucémie myéloïde aiguë, cette étude analyse, par catégorie d'âge (40-49 ans, 50-65 ans), la survie des patients

The demarcation between younger and older acute myeloid leukemia patients: A pooled analysis of 3 prospective studies

Yanada, Masamitsu ; Ohtake, Shigeki ; Miyawaki, Shuichi ; Sakamaki, Hisashi ; Sakura, Toru ; Maeda, Tomoya ; Miyamura, Koichi ; Asou, Norio ; Oh, Iekuni ; Miyatake, Junichi ; Kanbayashi, Hiroyuki ; Takeuchi, Jin ; Takahashi, Masatomo ; Dobashi, Nobuaki ; Kiyoi, Hitoshi ; Miyazaki, Yasushi ; Emi, Nobuhiko ; Kobayashi, Yukio ; Ohno, Ryuzo ; Naoe, Tomoki ; for the Japan Adult Leukemia Study, Group

BACKGROUND : Contemporary treatment protocols for adult acute myeloid leukemia (AML) are age-specific, and older patients are generally treated less intensively than younger patients. However, it remains uncertain whether older but fit patients with AML really need to have their treatment attenuated. METHODS : To evaluate the contribution of age to outcome for patients with AML receiving intensive chemotherapy, data were analyzed for 2276 patients aged less than 65 years who were treated [...]

A partir des données des registres américains des cancers portant sur 26 826 cas diagnostiqués entre 1992 et 2009, cette étude analyse le risque de second lymphome non hodgkinien chez des survivants d'un lymphome hodgkinien classique

Risk and outcome of non-Hodgkin lymphoma among classical Hodgkin lymphoma survivors

Xavier, Ana C. ; Armeson, Kent E. ; Hill, Elizabeth G. ; Costa, Luciano J.

BACKGROUND : Survivors of classical Hodgkin lymphoma (cHL) are at an increased risk of developing secondary non-Hodgkin lymphomas (sNHLs). To the authors' knowledge, the outcome of patients with sNHL compared with their de novo counterparts (dnNHL) is unknown. METHODS : Data from 26,826 cases of HL from the Surveillance, Epidemiology, and End Results (SEER) program that were diagnosed between 1992 and 2009 were used to obtain the risk of further development of different subtypes of sNHL. The [...]

Menée auprès de 2 315 participants, cette étude de cohorte américaine évalue l'association entre la consommation de viande rouge ou de viande transformée et la mortalité chez des patients atteints d'un cancer colorectal

Association Between Red and Processed Meat Intake and Mortality Among Colorectal Cancer Survivors

McCullough, Marjorie L. ; Gapstur, Susan M. ; Shah, Roma ; Jacobs, Eric J. ; Campbell, Peter T.

Purpose : Red and processed meat intake is convincingly associated with colorectal cancer (CRC) incidence, but its impact on prognosis after CRC diagnosis is unknown. We examined associations of red and processed meat consumption, self-reported before and after cancer diagnosis, with all-cause and cause-specific mortality among men and women with invasive, nonmetastatic CRC. Patients and Methods : Participants in the Cancer Prevention Study II Nutrition Cohort reported information on diet and [...]

Menée en Chine auprès de 1 773 patients atteints d'un cancer du rhinopharynx, cette étude rétrospective évalue l'impact d'une histoire familiale de cancer sur la survie des patients

Prognostic impact of family history in southern Chinese patients with undifferentiated nasopharyngeal carcinoma

OuYang, P. Y. ; Su, Z. ; Mao, Y. P. ; Liang, X. X. ; Liu, Q. ; Xie, F. Y.

Background: Family history of cancer is associated with developing nasopharyngeal carcinoma (NPC); however, the impact of it on survival among established NPC patients remains unknown. Methods: We retrospectively analysed 1773 southern Chinese patients. Associations between a first-degree family history of NPC and overall survival (OS), locoregional relapse-free survival (LRFS) and distant metastasis-free survival (DMFS) were estimated by Cox regression. Results: Among 1773 patients, 207 [...]

A partir des données des registres de décès et des registres des cancers de Lituanie, cette étude identifie les facteurs socio-démographiques associés au taux de suicide des patients atteints de cancer

Suicides among cancer patients in Lithuania: A population-based census-linked study

Smailyte, Giedre ; Jasilionis, Domantas ; Kaceniene, Auguste ; Krilaviciute, Agne ; Ambrozaitiene, Dalia ; Stankuniene, Vladislava

Background: This study aims to estimate suicide risk and its socio-demographic determinants among cancer patients in the country showing the highest suicide rates among developed countries. Methods: The study is based on a unique census-linked dataset based on the linkages between the records from death and cancer registers and the 2001 population census records. Standardized mortality ratios for suicide (SMRs) were calculated for patients diagnosed with cancer in Lithuania between April 6, [...]

A partir d'une revue de la littérature publiée sur la période 2002-2011, cette étude fait le point sur les sujets de recherche analysant les troubles psychiques chez les patients atteints de cancer

Cancer and mental health—a clinical and research unmet need

Purushotham, A. ; Bains, S. ; Lewison, G. ; Szmukler, G. ; Sullivan, R.

Background : Poor mental health is the largest single source of disability in the UK, and co-morbid health problems, particularly with cancer, raise total health care costs significantly. Methods : This study examined what research is being conducted into the intersection between cancer and mental health. Research papers captured by the intersection of sub-field filters—‘mental disorder’ and ‘cancer’—were studied from the Web of Science over a 10-year period (2002–2011). Results : There were [...]

Menée au Royaume-Uni par entretiens auprès de 48 participantes, cette étude qualitative analyse les expériences de femmes participant à un dépistage du cancer familial de l'ovaire

A qualitative study of women's experiences of familial ovarian cancer screening

Lifford, Kate J. ; Clements, Alison ; Fraser, Lindsay ; Lancastle, Deborah ; Brain, Kate ; on behalf of the Psy, Focs Management Group

Objective : One risk management strategy that women at increased familial risk of ovarian cancer may use is screening. Until recently, this has been available as part of the UK Familial Ovarian Cancer Screening Study (UKFOCSS), using ultrasound scans of the ovaries and tumour marker blood tests. The present study aimed to gain an in-depth understanding of women's experiences of participating in ovarian cancer screening. Methods : Semi-structured interviews were conducted with 48 UKFOCSS [...]

A partir de données d'une enquête menée en Angleterre en 2010 auprès de 41 441 patients atteints de cancer, cette étude analyse leurs expériences relatives à leur participation aux prises de décisions thérapeutiques

Variation in reported experience of involvement in cancer treatment decision making: evidence from the National Cancer Patient Experience Survey

El Turabi, A. ; Abel, G. A. ; Roland, M. ; Lyratzopoulos, G.

Background: Exploring variation in patients’ experiences of involvement in treatment decision making can identify groups needing extra support, such as additional consultation time, when considering treatment options. Methods: We analysed data from the 2010 English National Cancer Patient Experience Survey, a national survey of all patients attending hospitals in England for cancer treatment over a 3-month period, to examine how experience of involvement in decisions about treatment varied [...]

Cette étude compare le rapport coût-efficacité d'un nouveau test basé sur l'ADN méthylé du gène de la septine 9 et celui d'autres procédures déjà utilisées pour le dépistage du cancer colorectal (test de recherche de sang occulte dans les selles, test immunochimique,sigmoïdoscopie et coloscopie)

Colorectal Cancer Screening with Blood-Based Biomarkers: Cost-Effectiveness of Methylated Septin 9 DNA vs. Current Strategies

Ladabaum, Uri ; Allen, John ; Wandell, Michael ; Ramsey, Scott D

Background: Screening reduces colorectal cancer (CRC) mortality, but many persons remain unscreened. Screening with a blood test could improve screening rates. We estimated the comparative effectiveness and cost-effectiveness of CRC screening with emerging biomarkers, illustrated by a methylated Septin 9 DNA plasma assay (mSEPT9), vs. established strategies. Methods: We conducted a cost-utility analysis using a validated decision analytic model comparing mSEPT9, fecal occult blood testing [...]

Menée en Angleterre à partir des données portant sur 53 689 femmes diagnostiquées avec un cancer du sein localisé entre 1996 et 2009, cette étude analyse l'impact, sur la survie des patientes, du délai entre le moment du diagnostic et l'intervention chirurgicale

The association of waiting times from diagnosis to surgery with survival in women with localised breast cancer in England

Redaniel, M. T. ; Martin, R. M. ; Cawthorn, S. ; Wade, J. ; Jeffreys, M.

Background: Survival from breast cancer in the United Kingdom is lower than in other developed countries. It is unclear to what extent waiting times for curative surgery affect survival. Methods: Using national databases for England (cancer registries, Hospital Episode Statistics and Office of National Statistics), we identified 53 689 women with localised breast cancer, aged 15 years, diagnosed between 1996 and 2009, who had surgical resection with curative intent within 62 days of diagnosis. [...]

Menée en Espagne par entretiens auprès de 7 938 participants, cette étude transversale analyse le niveau de connaissances relatives aux tests de dépistage des cancers du côlon-rectum, du col de l'utérus et de la prostate en association avec des caractéristiques socio-démographiques

Awareness and uptake of colorectal, breast, cervical and prostate cancer screening tests in Spain

Carrasco-Garrido, Pilar ; Hernandez-Barrera, Valentın ; Lopez de Andres, Ana ; Jimenez-Trujillo, Isabel ; Gallardo Pino, Carmen ; Jimenez-Garcıa, Rodrigo

Background: We aim to describe levels of awareness and uptake of colorectal, breast, cervical and prostate cancer screening tests and to analyze the association to socio-demographic and health-related variables. Methods: Population-based cross-sectional study conducted using a home-based personal interview survey on a nationwide representative sample (n = 7938) of population aged ≥18 years (Oncobarometro Survey). Awareness was assessed by asking participants: Now I am going to mention several [...]

A partir des données d'un registre américain des cancers portant sur 2 191 patientes atteintes d'un cancer du sein et âgées de 18 à 64 ans, cette étude analyse les connaissances des femmes relatives au satut hormonal de leur cancer

Agreement of self-reported hormone receptor status with cancer registry data in young breast cancer patients

McCarthy, Anne Marie ; McGuire, Erin ; Bristol, Mirar ; Fredricks, Tracey ; Domchek, Susan M. ; Armstrong, Katrina

Abstract : Background Though breast cancer subtype is a key determinant of treatment choice and prognosis, few studies have assessed breast cancer patients’ knowledge of estrogen and progesterone receptor (ER/PR) status. Methods : Women diagnosed with invasive breast cancer at age 18–64 years in 2007 were recruited from the Pennsylvania Cancer Registry, and mailed a questionnaire that asked respondents to identify their ER/PR status. There were 2191 respondents included in the analysis. [...]

Dans le but d'élaborer le prochain Plan Cancer en Autriche, cette étude analyse la littérature relative à la mise en place d'indicateurs de la qualité des soins aux Etats-Unis, au Canada et dans divers pays européens

Measuring quality in cancer care: overview of initiatives in selected countries

Wild, C. ; Patera, N.

To inform the Austrian National Cancer Plan on possible generic quality indicators that might be derived from routine data a systematic literature search in three databases, followed by extensive hand-searching to locate initiatives and their publications was carried out in spring 2011. Twenty-one initiatives that developed indicators for measuring quality of cancer care were identified: longer standing and decentralised initiatives are characteristics of the USA. The Canadian province of [...]