A partir d'une revue systématique de la littérature (49 études), cette étude fait le point sur divers agents naturels pour la prévention et le traitement d'une mucite buccale chez les patients atteints de cancer et définit des recommandations de pratique clinique pour deux d'entre eux

Systematic review of natural agents for the management of oral mucositis in cancer patients

Yarom, Noam ; Ariyawardana, Anura ; Hovan, Allan ; Barasch, Andrei ; Jarvis, Virginia ; Jensen, SiriBeier ; Zadik, Yehuda ; Elad, Sharon ; Bowen, Joanne ; Lalla, RajeshV

Purpose : The aim of this study was to review the available literature and define clinical practice guidelines for the use of natural agents for the prevention and treatment of oral mucositis. Methods : A systematic review was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology. The body of evidence for each intervention, in each cancer treatment setting, was assigned an evidence level. Based on the [...]

A partir d'une revue de la littérature publiée de 2000 à 2010, cette étude américaine analyse les besoins psychosociaux des survivantes d'un cancer de l'ovaire

A literature review of the social and psychological needs of ovarian cancer survivors

Roland, Katherine B. ; Rodriguez, Juan L. ; Patterson, Jennifer Rees ; Trivers, Katrina F.

Objective To identify and comprehensively present the psychosocial needs of ovarian cancer (OvCa) survivors, including young survivors <45 years of age. Methods A literature review was conducted using keywords specific to psychosocial health and OvCa survivorship to identify peer-reviewed, original research articles published in English between January 2000 and December 2010; 28 articles were identified as relevant. Articles were abstracted and results categorized according to six psychosocial [...]

Menée à Taïwan, cette étude de cohorte rétrospective incluant 9 918 cas et 99 180 témoins analyse la survie des patients infectés par le VIH, recevant une thérapie antirétrovirale et atteints de cancer

Cancer survival in patients with HIV/AIDS in the era of highly active antiretroviral therapy in Taiwan: A population-based cohort study

Lin, Chih-Shin ; Lin, Charlene ; Weng, Shih-Feng ; Lin, Shih-Wei ; Lin, Yung-Song

Objectives: HIV-related immunosuppression has been associated with the development of AIDS-defining malignancies. We examined the overall survival of HIV-infected patients who developed cancer. Design: A retrospective cohort study. Methods: Using the Taiwan Longitudinal Health Insurance Database, we compared patients diagnosed with HIV (n = 9918) between January 1, 2002, and December 31, 2007 with age-matched controls (n = 99,180). Each patient was followed until the end of 2009 (least 2 years [...]

A partir de données des registres suisses des cancers, cette étude analyse l'évolution du nombre de survivants d'un cancer sur la période 1970-2010

Cancer survivors in Switzerland: a rapidly growing population to care for

Herrmann, Christian ; Cerny, Thomas ; Savidan, Anita ; Vounatsou, Penelope ; Konzelmann, Isabelle ; Bouchardy, Christine ; Frick, Harald ; Ess, Silvia

Background : Cancer survivors are a heterogeneous group with complex health problems. Data concerning its total number and growing dynamics for Switzerland are scarce and outdated. Methods : Population and mortality data were retrieved from the Swiss Federal Statistical Office (FSO). Incidence and relative survival for invasive cancers were computed using data from the cancer registries Geneva (1970–2009), St. Gallen - Appenzell (1980–2010), Grisons & Glarus (1989–2010), and Valais (1989–2010). [...]

A partir des données écossaises du registre des cancers et du registre des décès, cette étude de cohorte rétrospective incluant 5 229 participants atteints de cancer avant l'âge de 25 ans analyse l'évolution, sur la période 1981-2003, de la mortalité des patients ayant eu un cancer durant l'enfance, l'adolescence ou le début de l'âge adulte

Subsequent mortality experience in five-year survivors of childhood, adolescent and young adult cancer in Scotland: A population based, retrospective cohort study

Brewster, David H. ; Clark, David ; Hopkins, Leanne ; Bauer, Jacqui ; Wild, Sarah H. ; Edgar, Angela B. ; Hamish Wallace, W.

To assess the risk of death in patients who survive at least 5years after diagnosis of childhood, adolescent or young adult cancer. This was a population-based retrospective cohort study using linked national cancer registry and mortality records in Scotland. The study population consisted of 5229 individuals who were diagnosed with cancer before the age of 25years between 1981 and 2003, and who survived at least 5years after the date of diagnosis of their primary cancer. Indirect [...]

A partir de données du registre national irlandais des cancers portant sur une cohorte de 315 patients diabétiques atteints d'un cancer colorectal de stade I-III diagnostiqué entre 2001 et 2006, cette étude évalue l'association entre l'utilisation de metformine, un antidiabétique oral, et la survie spécifique

A cohort study of metformin exposure and survival in patients with stage I-III colorectal cancer

Spillane, Susan C. ; Bennett, Kathleen ; Sharp, Linda ; Barron, Thomas I.

Background : Preclinical evidence suggests a beneficial effect of metformin in colorectal cancer. This study aimed to investigate associations between metformin exposure and colorectal cancer-specific survival using population-level data.  Methods : Adult stage I-III colorectal cancer patients diagnosed 2001-2006 were identified from the National Cancer Registry Ireland. Use of metformin and other anti-diabetic medications was determined from a linked national prescription claims database. [...]

A partir des données de la cohorte "Women's Health Initiative" incluant 2 066 femmes ménopausées, cette étude américaine évalue l'association entre un diabète, l'utilisation de la metformine et la survie des patientes atteintes d'un cancer colorectal

Diabetes, metformin use, and colorectal cancer survival in postmenopausal women

Cossor, Furha Iram ; Adams-Campbell, Lucile L. ; Chlebowski, Rowan T. ; Gunter, Marc J. ; Johnson, Karen ; Martell, Robert E. ; McTiernan, Anne ; Simon, Michael S. ; Rohan, Thomas ; Wallace, Robert B. ; Paulus, Jessica K.

Background: Observational studies have associated metformin use with lower colorectal cancer (CRC) incidence but few studies have examined metformin's influence on CRC survival. We examined the relationships among metformin use, diabetes, and survival in postmenopausal women with CRC in the Women's Health Initiative (WHI) clinical trials and observational study. Methods: 2066 postmenopausal women with CRC were followed for a median of 4.1 years, with 589 deaths after CRC diagnosis from all [...]

Menée aux Etats-Unis à partir des données des certificats de décès en examinant la cause initiale comme les causes multiples, cette étude analyse l'évolution, sur la période 1999-2009, de la mortalité par syndrome myélodysplasique

Trend (1999–2009) in U.S. death rates from myelodysplastic syndromes: Utility of multiple causes of death in surveillance

Polednak, Anthony P.

Background : For myelodysplastic syndromes (MDS) (formerly known as preleukemia), a diverse group of myeloid neoplasms usually involving anemia in elderly persons, trends in U.S. death rates apparently have not been reported. Methods : Trends in annual age-standardized rates per 100,000 from 1999 to 2009 were examined for MDS using multiple causes vs. underlying cause alone, coded on death certificates for U.S. residents. Results : The death rate (all ages combined) for MDS increased from 1999 [...]

A partir des données de 37 registres de sept pays européens (Belgique, Bulgarie, France, Italie, Portugal, Espagne, Suisse), cette étude analyse l'évolution, sur la période 1990-2008, de l'incidence du cancer du sein chez les femmes d'âge inférieur à 40 ans

Trends in incidence of breast cancer among women under 40 in seven European countries: A GRELL cooperative study

Leclère, Brice ; Molinié, Florence ; Tretarre, Brigitte ; Stracci, Fabrizio ; Daubisse-Marliac, Laetitia ; Colonna, Marc

Young women are not usually screened for breast cancer (BC). The trends in incidence in this population may better reflect changes in risk factors. However, studies on this subject are scarce and heterogeneous. The aim of this study was to describe the trends in incidence of BC in women under 40 from 1990 to 2008, using pooled European data. Thirty-seven European population-based cancer registries from Belgium, Bulgaria, France, Italy, Portugal, Spain and Switzerland participated in this study. [...]

Menée au Danemark, cette étude analyse, sur la période 1993-2010, l'évolution de l'incidence du cancer du sein selon le statut du récepteur aux œstrogènes

Divergent estrogen receptor-positive and -negative breast cancer trends and etiologic heterogeneity in Denmark

Anderson, William F. ; Rosenberg, Philip S. ; Petito, Lucia ; Katki, Hormuzd A. ; Ejlertsen, Bent ; Ewertz, Marianne ; Rasmussen, Birgitte B. ; Jensen, Maj-Britt ; Kroman, Niels

Long-term breast cancer trends in incidence in the United States (US) show rising estrogen receptor (ER)-positive rates and falling ER-negative rates. We hypothesized that these divergent trends reflect etiologic heterogeneity and that comparable trends should be observed in other countries with similar risk factor profiles. Therefore, we analyzed invasive female breast cancers in Denmark, a country with similar risk factors as the US. We summarized the overall trend in age-standardized rates [...]

Menée à Taïwan auprès de 447 soignants de patients atteints de cancer et en fin de vie, cette étude analyse l'évolution de leurs symptômes dépressifs face à la mort imminente de leurs patients

Trajectories of caregiver depressive symptoms while providing end-of-life care

Tang, Siew Tzuh ; Huang, Guan-Hua ; Wei, Yu-Chung ; Chang, Wen-Cheng ; Chen, Jen-Shi ; Chou, Wen-Chi

Objective : The course of caregivers' depressive symptoms may not be homogenous. This study identified trajectories of depressive symptoms among caregivers providing end-of-life care to cancer patients and profiled the unique characteristics of caregivers within each trajectory. Methods : Trajectories of depressive symptoms were explored in 447 caregivers who completed the Center for Epidemiological Studies Depression Scale over four periods close to the patient's death (1–30, 31–90, 91–180, [...]

A partir des données de deux registres américains des cancers incluant 1 154 survivants, cette étude longitudinale analyse la prévalence et l'évolution des symptômes d'anxiété et de dépression dans l'année suivant le diagnostic

Prevalence and Predictors of the Short-Term Trajectory of Anxiety and Depression in the First Year After a Cancer Diagnosis: A Population-Based Longitudinal Study

Boyes, Allison W. ; Girgis, Afaf ; D’Este, Catherine A. ; Zucca, Alison C. ; Lecathelinais, Christophe

Purpose : Few studies have examined psychological adjustment for cancer survivors in late treatment and early survivorship stages. Our study investigated the prevalence and short-term trajectories of anxiety, depression, and comorbid anxiety-depression among adult cancer survivors, and identified the individual, disease, health behavior, psychological, and social predictors of chronic and late psychological morbidity. Methods : A heterogeneous sample of adult cancer survivors was recruited from [...]

Cette étude présente et définit le concept d'équipe virtuelle pour améliorer l'efficacité des réunions de concertation pluridisciplinaire en cancérologie

What is a virtual multidisciplinary team (vMDT) ?

Munro, A. J. ; Swartzman, S.

Background: Multidisciplinary team meetings (MDTs), also known as tumour boards or multidisciplinary case conferences, are an integral component of contemporary cancer care. There are logistical problems with setting up and maintaining participation in these meetings. An ill-defined concept, the virtual MDT (vMDT), has arisen in response to these difficulties. We have, in order to provide clarity and to generate discussion, attempted to define the concept of the vMDT, outline its advantages and [...]

A partir des données issues d'une cohorte de patients traités pour un cancer du poumon et relevant du système américain d'assurance maladie "Veterans Health Administration", cette étude analyse la mise en oeuvre des six indicateurs de qualité relatifs aux traitements et évalue la proportion de patients acceptant ou refusant les thérapies recommandées ou pour lesquels des contre-indications ont été identifiées

Patient Preference and Contraindications in Measuring Quality of Care: What Do Administrative Data Miss?

Ryoo, Joan J. ; Ordin, Diana L. ; Antonio, Anna Liza M. ; Oishi, Sabine M. ; Gould, Michael K. ; Asch, Steven M. ; Malin, Jennifer L.

Purpose : Prior studies report that half of patients with lung cancer do not receive guideline-concordant care. With data from a national Veterans Health Administration (VHA) study on quality of care, we sought to determine what proportion of patients refused or had a contraindication to recommended lung cancer therapy. Patients and Methods : Through medical record abstraction, we evaluated adherence to six quality indicators addressing lung cancer–directed therapy for patients diagnosed within [...]

Menée aux Pays-Bas, cette étude analyse l'utilisation, par des équipes multidisciplinaires en cancérologie dédiées au cancer du sein, d'indicateurs permettant d'améliorer la qualité des soins

How teams use indicators for quality improvement - a multiple-case study on the use of multiple indicators in multidisciplinary breast cancer teams

Gort, Marjan ; Broekhuis, Manda ; Regts, Gerdien

A crucial issue in healthcare is how multidisciplinary teams can use indicators for quality improvement. Such teams have increasingly become the core component in both care delivery and in many quality improvement methods. This study aims to investigate the relationships between (1) team factors and the way multidisciplinary teams use indicators for quality improvement, and (2) both team and process factors and the intended results. An in-depth, multiple-case study was conducted in the [...]

Menée auprès de 62 parents d'enfants atteints de cancer, cette étude transversale américaine analyse leurs préférences et besoins en termes d'informations lors de l'annonce du diagnostic

Day One Talk: parent preferences when learning that their child has cancer

Kessel, RachelM ; Roth, Michael ; Moody, Karen ; Levy, Adam

Purpose : The discussion that occurs between a pediatric oncologist and a family when they first learn about their child’s new diagnosis of cancer is known as the “Day One Talk.” Few studies have addressed parent preferences when learning that their child has been diagnosed with cancer. The objective of this study is to assess what information parents of children with newly diagnosed cancer believe is important to learn during the Day One Talk. Methods : In this cross-sectional study, a survey [...]

Menée aux Etats-Unis par enquête auprès de 384 patients atteints d'un cancer incurable du poumon, cette étude de cohorte analyse leurs attentes et espérances relatives à une radiothérapie à vocation autre que curative

Expectations About the Effectiveness of Radiation Therapy Among Patients With Incurable Lung Cancer

Chen, Aileen B. ; Cronin, Angel ; Weeks, Jane C. ; Chrischilles, Elizabeth A. ; Malin, Jennifer ; Hayman, James A. ; Schrag, Deborah

Purpose : Although radiation therapy (RT) can palliate symptoms and may prolong life, it is not curative for patients with metastatic lung cancer. We investigated patient expectations about the goals of RT for incurable lung cancers. Patients and Methods : The Cancer Care Outcomes Research and Surveillance Consortium enrolled a population- and health system–based cohort of patients diagnosed with lung cancer from 2003 to 2005. We identified patients with stage wet IIIB or IV lung cancer who [...]