Menée auprès de 405 patients atteints d'un cancer de stade avancé, cette étude analyse l'association entre divers critères de diagnostic d'une cachéxie, la qualité de vie et la survie des patients traités dans des unités de soins palliatifs

Diagnostic criteria of cancer cachexia: relation to quality of life, exercise capacity and survival in unselected palliative care patients

Wallengren, Ola ; Lundholm, Kent ; Bosaeus, Ingvar

Purpose : Cachexia is associated with adverse outcomes. There is limited information on the impact of different diagnostic criteria of cachexia on patient centered outcomes. Methods : We compared the prevalence of reduced quality of life (QoL), physical function and survival in palliative care cancer patients classified by different cachexia criteria. Four hundred and five patients with advanced cancer were included. Cachexia criteria were BMI, weight loss, fatigue, Karnofsky performance score, [...]

A partir des données d'une cohorte américaine constituée de 523 participants, cette étude analyse la qualité de vie de patients adolescents et jeunes adultes (âgés de de 15 à 39 ans) atteints d'un cancer diagnostiqué de 2007 à 2009

Health-Related Quality of Life of Adolescent and Young Adult Patients With Cancer in the United States: The Adolescent and Young Adult Health Outcomes and Patient Experience Study

Smith, Ashley Wilder ; Bellizzi, Keith M. ; Keegan, Theresa H.M. ; Zebrack, Brad ; Chen, Vivien W. ; Neale, Anne Victoria ; Hamilton, Ann S. ; Shnorhavorian, Margarett ; Lynch, Charles F.

Purpose : Adolescents and young adults (AYAs) diagnosed with cancer face numerous physical, psychosocial, and practical challenges. This article describes the health-related quality of life (HRQOL) and associated demographic and health-related characteristics of this developmentally diverse population. Patients and Methods : Data are from the Adolescent and Young Adult Health Outcomes and Patient Experience (AYA HOPE) study, a population-based cohort of 523 AYA patients with cancer, ages 15 to [...]

A partir d'une revue systématique de la littérature publiée de 2001 à 2011 (21 études), cette étude analyse la prévalence et le degré de sévérité des symptômes associés à différents traitements du cancer

A literature synthesis of symptom prevalence and severity in persons receiving active cancer treatment

Reilly, CarolynMiller ; Bruner, DeborahWatkins ; Mitchell, SandraA ; Minasian, LoriM ; Basch, Ethan ; Dueck, AmylouC ; Cella, David ; Reeve, BryceB

Purpose : Patients with cancer experience acute and chronic symptoms caused by their underlying disease or by the treatment. While numerous studies have examined the impact of various treatments on symptoms experienced by cancer patients, there are inconsistencies regarding the symptoms measured and reported in treatment trials. This article presents a systematic review of the research literature of the prevalence and severity of symptoms in patients undergoing cancer treatment. Methods : A [...]

Menée auprès de 243 survivants d'une leucémie lymphoblastique aiguë pédiatrique, cette étude analyse l'association entre des polymorphismes de divers gènes et le risque aggravé de dysfonctionnements neurocognitifs

Genetic Mediators of Neurocognitive Outcomes in Survivors of Childhood Acute Lymphoblastic Leukemia

Krull, Kevin R. ; Bhojwani, Deepa ; Conklin, Heather M. ; Pei, Deqing ; Cheng, Cheng ; Reddick, Wilburn E. ; Sandlund, John T. ; Pui, Ching-Hon

Purpose : Survivors of childhood acute lymphoblastic leukemia (ALL) are at increased risk for neurocognitive problems, with significant interindividual variability in outcome. This study examined genetic polymorphisms associated with variability in neurocognitive outcome. Patients and Methods: Neurocognitive outcomes were evaluated at the end of therapy in 243 survivors treated on an institutional protocol featuring risk-adapted chemotherapy without prophylactic cranial irradiation. [...]

A partir des données de registres européens des cancers (Bulgarie, Grèce, Russie, Turquie), cette étude analyse l'évolution de l'incidence des leucémies pédiatriques et des lymphomes ainsi que la survie sur la période 1996-2010

Childhood leukemia and lymphoma: time trends and factors affecting survival in five Southern and Eastern European Cancer Registries

Petridou, EleniTh ; Dimitrova, Nadya ; Eser, Sultan ; Kachanov, Denis ; Karakilinc, Hulya ; Varfolomeeva, Svetlana ; Belechri, Maria ; Baka, Margarita ; Moschovi, Maria ; Polychronopoulou, Sofia ; Athanasiadou-Piperopoulou, Fani ; Fragandrea, Ioanna ; Stiakaki, Eftichia ; Pourtsidis, Apostolos ; Stefanadis, Christodoulos ; Coebergh, Jan-Willem ; Sergentanis, TheodorosN

Purpose : Within Europe, incidence and mortality rates of childhood leukemia and lymphoma are rather heterogeneous. The present study comprising data from five Southern and Eastern European Cancer Registries aims to compare time trends and examine whether sociodemographic variables, clinical parameters, and proxies of efficient care affect survival. Methods : Data spanning 1996–2010 were obtained for a total of 3,041 newly diagnosed childhood leukemia and 1,183 lymphoma cases reported by the [...]

Menée en Angleterre auprès de 1 007 enfants d'âge inférieur à 14 ans et atteints de leucémie, cette étude analyse l'association entre le statut socioéconomique du père et la survie sur la période 1968-2010

Socioeconomic variation in survival from childhood leukaemia in northern England, 1968-2010

Njoku, K. ; Basta, N. ; Mann, K. D. ; McNally, R. J. Q. ; Pearce, M. S.

Background: Despite marked improvements in childhood leukaemia survival, 20% still die within 5 years of diagnosis. The aim of this study was to evaluate the relationship between socioeconomic status, as assessed by paternal occupation at birth, and survival from childhood leukaemia in children, using data from the Northern Region Young Persons Malignant Disease Registry. Methods: All 1007 cases of leukaemia in children aged 0–14 years, diagnosed between 1968 and 2010 and registered with the [...]

A partir des données des registres américains des cancers, cette étude analyse l'évolution de l'incidence du cancer de l'ovaire sur la période 1995-2008, et notamment après la baisse de l'usage des traitements hormonaux substitutifs observée en 2002

Ovarian Cancer Incidence Trends in Relation to Changing Patterns of Menopausal Hormone Therapy Use in the United States

Yang, Hannah P. ; Anderson, William F. ; Rosenberg, Philip S. ; Trabert, Britton ; Gierach, Gretchen L. ; Wentzensen, Nicolas ; Cronin, Kathleen A. ; Sherman, Mark E.

Purpose : After a report from the Women’s Health Initiative (WHI) in 2002, a precipitous decline in menopausal hormonal therapy (MHT) use in the United States was linked to a decline in breast cancer incidence rates. Given that MHT use is also associated with increased ovarian cancer risk, we tested whether ovarian cancer incidence rates changed after 2002. Methods : Using the North American Association of Central Cancer Registries database (1995 to 2008; N = 171,142 incident ovarian cancers), [...]

A partir des données d'un registre français des cancers portant sur 3 804 patients atteints d'un cancer colorectal métastatique non résécable diagnostiqué entre 1976 et 2009, cette étude analyse l'évolution de la survie en lien avec les progrès de la recherche clinique

Improvement in survival of metastatic colorectal cancer: Are the benefits of clinical trials reproduced in population-based studies?

Mitry, E. ; Rollot, F. ; Jooste, V. ; Guiu, B. ; Lepage, C. ; Ghiringhelli, F. ; Faivre, J. ; Bouvier, A. M.

To describe trends in survival of non-resectable metastatic colorectal cancer (MCRC) over a 34-year period in a French population-based registry taking into account major advances in medical therapy. 3804 patients with non-resectable metastatic colorectal cancer diagnosed between 1976 and 2009 were included. Three periods (1976–96, 1997–2004 and 2005–09) were considered. The proportion of patients receiving chemotherapy dramatically increased from 19% to 57% between the first two periods, then [...]

Menée au Danemak auprès de 18 733 femmes, cette étude de cohorte prospective évalue l'association entre l'utilisation de béta-bloquants, d'inhibiteurs de l'enzyme de conversion de l'angiotensine, d'antagonistes des récepteurs de l'angiotensine II, et le risque de récidive de cancer du sein

Use of β-Blockers, Angiotensin-Converting Enzyme Inhibitors, Angiotensin II Receptor Blockers, and Risk of Breast Cancer Recurrence: A Danish Nationwide Prospective Cohort Study

Sørensen, Gitte Vrelits ; Ganz, Patricia A. ; Cole, Steven W. ; Pedersen, Lars A. ; Sørensen, Henrik Toft ; Cronin-Fenton, Deirdre P. ; Garne, Jens Peter ; Christiansen, Peer M. ; Lash, Timothy L. ; Ahern, Thomas P.

Purpose : To estimate associations between use of β-blockers, angiotensin-converting enzyme (ACE) inhibitors, or angiotensin receptor blockers (ARBs) and breast cancer recurrence in a large Danish cohort. Patients and Methods : We enrolled 18,733 women diagnosed with nonmetastatic breast cancer between 1996 and 2003. Patient, treatment, and 10-year recurrence data were ascertained from the Danish Breast Cancer Cooperative Group registry. Prescription and medical histories were ascertained by [...]

A partir des données de 13 registres américains des cancers, cette étude analyse l'incidence des épendymomes ainsi que la survie, sur la période 2004-2009

Descriptive epidemiology of ependymal tumours in the United States

Villano, J. L. ; Parker, C. K. ; Dolecek, T. A.

Background: Ependymomas are rare primary gliomas that commonly affect both children and adults, but unique as survival is worse in children. Methods: Data on brain and central nervous system primary malignant and non-malignant ependymal tumours from the Central Brain Tumor Registry of the United States analytic data set and primary malignant ependymal tumours from the SEER 13 registries research data file were used to evaluate incidence and survival, respectively. Results: The 2004–2009 average [...]

Menée aux Etats-Unis sur 832 femmes âgées de 18 à 39 ans présentant des lésions cervicales de haut grade, cette étude évalue les disparités individuelles et géographiques dans la prévalence d'une infection par le papillomavirus humain de type 16 ou 18

Individual and geographic disparities in human papillomavirus types 16/18 in high-grade cervical lesions

Niccolai, Linda M. ; Russ, Chelsea ; Julian, Pamela J. ; Hariri, Susan ; Sinard, John ; Meek, James I. ; McBride, Vanessa ; Markowitz, Lauri E. ; Unger, Elizabeth R. ; Hadler, James L. ; Sosa, Lynn E.

BACKGROUND Current vaccines protect against 2 human papillomavirus (HPV) types, HPV 16 and 18, which are associated with 70% of cervical cancers and 50% of high-grade cervical lesions. HPV type distribution was examined among women with high-grade lesions by individual and area-based measures of race, ethnicity, and poverty. METHODS This analysis included 832 women aged 18 to 39 years reported to a surveillance registry in Connecticut during 2008 to 2010. Diagnostic specimens were obtained for [...]

Menée auprès de 215 patients atteints de cancer âgés de 14 à 39 ans, cette étude prospective longitudinale américaine analyse l'évolution de leur détresse psychologique, du diagnostic sur une période de 12 mois

Trajectories of Psychological Distress in Adolescent and Young Adult Patients With Cancer: A 1-Year Longitudinal Study

Kwak, Minyoung ; Zebrack, Brad J. ; Meeske, Kathleen A. ; Embry, Leanne ; Aguilar, Christine ; Block, Rebecca ; Hayes-Lattin, Brandon ; Li, Yun ; Butler, Melissa ; Cole, Steven

Purpose : To examine prevalence and changes in symptoms of psychological distress over 1 year after initial cancer diagnosis in adolescent and young adult (AYA) patients with cancer. Sociodemographic and clinical predictors of changes in distress were examined. Patients and Methods : In this multisite, longitudinal, prospective study of an ethnically diverse sample, 215 patients age 14 to 39 years were assessed for psychological distress within the first 4 months of diagnosis and again 6 and 12 [...]

Menée auprès de 186 patients atteints de tumeurs primitives du cerveau, cette étude analyse leurs symptômes de détresse et leurs troubles de l'humeur

Uncertainty, mood states, and symptom distress in patients with primary brain tumors

Lin, Lin ; Chiang, Hui-Hsun ; Acquaye, Alvina A. ; Vera-Bolanos, Elizabeth ; Gilbert, Mark R. ; Armstrong, Terri S.

BACKGROUND : Patients with primary brain tumors (PBTs) face uncertainty related to prognosis, symptoms, treatment response, and toxicity. The authors of this report examined the direct/indirect relations among patients' uncertainty, mood states, and symptoms. METHODS : In total, 186 patients with PBTs were accrued at various points in the illness trajectory. Data-collection tools included an investigator-completed clinician checklist, a patient-completed demographic data sheet, the Mishel [...]

Menée au Japon à partir de données d'enquêtes et d'entretiens, cette étude analyse l'efficacité d'un programme regional composé de divers types d'interventions visant à développer et améliorer l'organisation des soins palliatifs pour les patients atteints de cancer

Effects of a programme of interventions on regional comprehensive palliative care for patients with cancer: a mixed-methods study

Morita, Tatsuya ; Miyashita, Mitsunori ; Yamagishi, Akemi ; Akiyama, Miki ; Akizuki, Nobuya ; Hirai, Kei ; Imura, Chizuru ; Kato, Masashi ; Kizawa, Yoshiyuki ; Shirahige, Yutaka ; Yamaguchi, Takuhiro ; Eguchi, Kenji

Background : Improvement of palliative care is an important public health issue, but knowledge about how to deliver palliative care throughout a region remains inadequate. We used surveys and in-depth interviews to assess changes in the quality of palliative care after regional interventions and to gain insights for improvement of palliative care at a regional level. Methods : In this mixed-methods study, a comprehensive programme of interventions for regional palliative care for patients with [...]

Menée par enquête auprès de 66 oncologues et 202 patientes, cette étude britannique analyse leurs points de vue et leurs expériences relatifs aux traitements d'un cancer de l'ovaire
de stade avancé ainsi qu'aux soins de support

Patients' and oncologists' views on the treatment and care of advanced ovarian cancer in the UK: results from the ADVOCATE study

Jenkins, V. ; Catt, S. ; Banerjee, S. ; Gourley, C. ; Montes, A. ; Solis-Trapala, I. ; Monson, K. ; Fallowfield, L.

Background: Most patients presenting with advanced ovarian cancer (AOC) eventually relapse. Symptom palliation, maintenance of quality of life (QoL) and prolongation of life are primary therapeutic goals. Methods: Sixty-six UK oncologists completed an online survey about AOC management. Two hundred and two patients were interviewed about care, treatment experiences and expectations. Results: Prior to diagnosis, 34% (69 out of 202) of women had 3 symptoms associated with AOC. Twenty-one per cent [...]

Cette étude fait le point sur les données publiées relatives à l'utilisation de la sédation palliative dans le cadre des soins de fin de vie dispensés aux patients atteints de cancer et passe en revue les difficultés cliniques, relationnelles et éthiques qui y sont associées

Palliative sedation in end-of-life care

Maltoni, Marco ; Scarpi, Emanuela ; Nanni, Oriana

Purpose of review: The aim of this review was to present and comment on recent data published on palliative sedation in palliative and end-of-life care. Palliative sedation is a medical procedure used to deal with the refractory symptoms occurring in the advanced stages of cancer. It has clinical, nursing, relational and ethical implications, making it a highly sensitive issue. Recent findings: Over the last 12 months, a number of authors have published interesting new findings on different [...]

A partir des données des registres américains des cancers, cette étude analyse l'impact de différentes règles de déclaration et d'enregistrement des cancers primitifs multiples sur l'estimation de la survie

The effect of multiple primary rules on population-based cancer survival

Weir, HannahK ; Johnson, ChristopherJ ; Thompson, TrevorD

Purpose : Different rules for registering multiple primary (MP) cancers are used by cancer registries throughout the world, making international data comparisons difficult. This study evaluates the effect of Surveillance, Epidemiology, and End Results (SEER) and International Association of Cancer Registries (IACR) MP rules on population-based cancer survival estimates. Methods : Data from five US states and six metropolitan area cancer registries participating in the SEER Program were used to [...]

Cette étude présente un modèle permettant d'évaluer, dans le monde entier, l'évolution temporelle de la mortalité par cancer de la prostate

Model-based patterns in prostate cancer mortality worldwide

Fontes, F. ; Severo, M. ; Castro, C. ; Lourenco, S. ; Gomes, S. ; Botelho, F. ; La Vecchia, C. ; Lunet, N.

Background: Prostate cancer mortality has been decreasing in several high income countries and previous studies analysed the trends mostly according to geographical criteria. We aimed to identify patterns in the time trends of prostate cancer mortality across countries using a model-based approach. Methods: Model-based clustering was used to identify patterns of variation in prostate cancer mortality (1980–2010) across 37 European, five non-European high-income countries and four leading [...]