Menée auprès de 240 patients atteints d'un cancer localisé de la prostate, cette étude analyse et compare, en fonction du traitement reçu (prostatectomie radicale, radiothérapie externe, brachythérapie) la qualité de vie des patients

Quality of life after prostate cancer treatments in patients comparable at baseline

van Tol-Geerdink, J. J. ; Leer, J. W. H. ; van Oort, I. M. ; van Lin, E. J. N. T. ; Weijerman, P. C. ; Vergunst, H. ; Witjes, J. A. ; Stalmeier, P. F. M.

Background: Previous studies on the effects of different prostate cancer treatments on quality of life, were confounded because patients were not comparable. This study examined treatment effects in more comparable groups. Methods: From 2008–2011, 240 patients with localised prostate cancer were selected to be eligible for both radical prostatectomy (RP) and external beam radiotherapy (EBRT). Brachytherapy (BT) was a third option for some. Health-related quality of life was measured by expanded [...]

Menée sur 167 patientes atteintes d'un cancer du sein de stade précoce et recevant une polychimiothérapie sur une période de 3 semaines, cette étude multicentrique évalue l'intérêt de poursuivre durant tous les cycles de la chimiothérapie un premier traitement prophylactique par facteur de stimulation des colonies de granulocytes pour réduire le risque de neutropénie fébrile

Primary Granulocyte Colony-Stimulating Factor Prophylaxis During the First Two Cycles Only or Throughout All Chemotherapy Cycles in Patients With Breast Cancer at Risk for Febrile Neutropenia

Aarts, Maureen J. ; Peters, Frank P. ; Mandigers, Caroline M. ; Dercksen, M. Wouter ; Stouthard, Jacqueline M. ; Nortier, Hans J. ; van Laarhoven, Hanneke W. ; van Warmerdam, Laurence J. ; van de Wouw, Agnes J. ; Jacobs, Esther M. ; Mattijssen, Vera ; van der Rijt, Carin C. ; Smilde, Tineke J. ; van der Velden, Annette W. ; Temizkan, Mehmet ; Batman, Erdogan ; Muller, Erik W. ; van Gastel, Saskia M. ; Borm, George F. ; Tjan-Heijnen, Vivianne C.G.

Purpose : Early breast cancer is commonly treated with anthracyclines and taxanes. However, combining these drugs increases the risk of myelotoxicity and may require granulocyte colony-stimulating factor (G-CSF) support. The highest incidence of febrile neutropenia (FN) and largest benefit of G-CSF during the first cycles of chemotherapy lead to questions about the effectiveness of continued use of G-CSF throughout later cycles of chemotherapy. Patients and Methods : In a multicenter study, [...]

Menée auprès de 1 064 adolescents ou jeunes adultes atteints de cancer et de 13 206 témoins, cette étude analyse la fréquence de leurs consultations chez le médecin généraliste trois mois avant le diagnostic

Features of cancer in teenagers and young adults in primary care: a population-based nested case-control study

Dommett, R. M. ; Redaniel, M. T. ; Stevens, M. C. G. ; Hamilton, W. ; Martin, R. M.

Background: Teenagers and young adults (TYA, 15–24 years) diagnosed with cancer report repeated visits to primary care before referral. We investigated associations of symptoms and consultation frequency in primary care with TYA cancers. Methods : Population-based, case–control study was carried out using data from the Clinical Practice Research Datalink (CPRD). A total of 1064 TYA diagnosed with cancer were matched to 13 206 controls. Symptoms independently associated with specific cancers [...]

Menée à partir de données de 4 registres américains du cancer, cette étude évalue, sur la période 2001-2008, l'incidence de cancers parmi les professionnels ayant participé aux opérations de sauvetage au World Trade Center le 11 septembre 2001

Cancer Incidence in World Trade Center Rescue and Recovery Workers, 2001-2008

Samara Solan; ; Sylvan Wallenstein; ; Moshe Shapiro; ; Susan L. Teitelbaum; ; Lori Stevenson; ; Anne Kochman; ; Julia Kaplan; ; Cornelia Dellenbaugh; ; Amy Kahn; ; F. Noah Biro; ; Michael Crane; ; Laura Crowley; ; Janice Gabrilove; ; Lou Gonsalves; ; Denise Harrison; ; Robin Herbert; ; Benjamin Luft; ; Steven B. Markowitz; ; Jacqueline Moline; ; Xiaoling Niu; ; Henry Sacks; ; Gauri Shukla; ; Iris Udasin; ; Roberto G. Lucchini; ; Paolo Boffetta; ; Philip J. Landrigan1

Background : World Trade Center rescue and recovery workers were exposed to a complex mix of pollutants and carcinogens. The purpose of this investigation was to evaluate cancer incidence in responders during the first seven years after September 11, 2001. Methods : Cancers among 20,984 consented participants in the WTC Health Program were identified through linkage to state tumor registries in New York, New Jersey, Connecticut, and Pennsylvania. Standardized incidence ratios (SIRs) were [...]

Menée sur 153 patients atteints d'un lymphome périphérique à cellules T et n'ayant pas reçu de greffe de cellules souches hématopoïétiques, cette étude évalue, après première récidive ou progression de la maladie et en fonction de trois sous-types, la survie des patients

Survival of Patients With Peripheral T-Cell Lymphoma After First Relapse or Progression: Spectrum of Disease and Rare Long-Term Survivors

Mak, Vivien ; Hamm, Jeremey ; Chhanabhai, Mukesh ; Shenkier, Tamara ; Klasa, Richard ; Sehn, Laurie H. ; Villa, Diego ; Gascoyne, Randy D. ; Connors, Joseph M. ; Savage, Kerry J.

Introduction : A number of novel therapies are under investigation in relapsed or refractory peripheral T-cell lymphoma (PTCL); however, their relative impact on outcome is unknown. We examined the survival of patients with PTCL after relapse or progression in the absence of hematopoietic stem-cell transplantation and explored factors influencing survival. The three most common subtypes encountered in North America were evaluated: PTCL not otherwise specified (PTCL-NOS), angioimmunoblastic [...]

Menée à partir de données américaines portant sur 143 548 patients atteints d'un cancer du poumon non à petites cellules de stade IIIB/IV diagnostiqué entre 1988 et 2005, cette étude montre que les agents systémiques actuellement sur le marché (platine, docétaxel, pemetrexed et bévacizumab) améliorent la survie des patients

Real-World Effectiveness of Systemic Agents Approved for Advanced Non-Small Cell Lung Cancer: A SEER–Medicare Analysis

Owonikoko, Taofeek K. ; Ragin, Camille ; Chen, Zhengjia ; Kim, Sungjin ; Behera, Madhusmita ; Brandes, Johann C. ; Saba, Nabil F. ; Pentz, Rebecca ; Ramalingam, Suresh S. ; Khuri, Fadlo R.

Objectives : Disparity exists between patients with lung cancer enrolled in clinical trials and patients treated in the community setting. This study assessed the real-world effectiveness of cytotoxic agents that became available for the treatment of non-small cell lung cancer (NSCLC) in the last 2 decades. Methods : We employed the linked Surveillance, Epidemiology, and End Results (SEER)–Medicare database for patients diagnosed with stage IIIB/IV NSCLC between 1988 and 2005 to assess the [...]

A partir des données du registre français des cancers portant sur 1 840 cas de cancer de la prostate diagnostiqués en 2001, cette étude analyse le phénomène de sur-diagnostic et de l'éventuel sur-traitement, en prenant en compte les comorbidités

Life expectancy estimates as a key factor in over-treatment: The case of prostate cancer

Delpierre, Cyrille ; Lamy, Sébastien ; Kelly-Irving, Michelle ; Molinié, Florence ; Velten, Michel ; Tretarre, Brigitte ; Woronoff, Anne-Sophie ; Buemi, Antoine ; Lapôtre-Ledoux, Bénédicte ; Bara, Simona ; Guizard, Anne-Valérie ; Colonna, Marc ; Grosclaude, Pascale

Objective: To estimate the magnitude of over-diagnosis and of potential and actual over-treatment regarding prostate cancer, taking comorbidities into account. Materials and methods: We used a sample collected by the French cancer registries of 1840 cases (T1: 583; T2: 1257) diagnosed in 2001. The proportion of over-diagnosed and over-treated patients was estimated by comparing life expectancy (LE), including or not comorbidities, with natural LE with cancer, using several assumptions from the [...]

A partir des données de deux études prospectives de cohortes incluant 605 patients atteints d'un cancer du côlon ou du rectum de stade I-III, cette étude évalue l'association entre le niveau d'activité physique après le diagnostic de la maladie, l'expression tumorale de la cyclooxygénase PTGS2 et la survie des patients

Physical Activity, Tumor PTGS2 Expression, and Survival in Patients with Colorectal Cancer

Yamauchi, Mai ; Lochhead, Paul ; Imamura, Yu ; Kuchiba, Aya ; Liao, Xiaoyun ; Qian, Zhi Rong ; Nishihara, Reiko ; Morikawa, Teppei ; Shima, Kaori ; Wu, Kana ; Giovannucci, Edward ; Meyerhardt, Jeffrey A. ; Fuchs, Charles S. ; Chan, Andrew T. ; Ogino, Shuji

Background : Higher levels of physical activity are associated with lower colorectal cancer incidence and mortality, perhaps through influencing energy balance, cellular prostaglandin biosynthesis and systemic inflammation. Although evidence suggests interactive effects of energetics, sedentary lifestyle, and tumor CTNNB1 (beta-catenin) or CDKN1B (p27) status on colon cancer prognosis, interactive effects of physical activity and tumor PTGS2 (the official symbol for cyclooxygenase-2) status on [...]

Menée à partir des données américaines portant sur la période 1931-2007, cette étude évalue l'évolution du taux de mortalité par cancer colorectal en fonction de catégories d'âge et compare cette évolution à celle de l'utilisation des techniques de dépistage du cancer colorectal

Time trends of mortality from colorectal cancer in the united states: A birth-cohort analysis

Lee By, Sonnenberg A.

The occurrence of colorectal cancer in the United States is decreasing. We sought to determine whether the decrease began prior to increased colorectal cancer screening.

Menée auprès d'un groupe de 20 patients âgés de 5 à 58 ans, cette étude rétrospective allemande analyse, depuis 1977, la prévalence des ostéosarcomes de la colonne vertébrale mobile ainsi que la survie

Osteosarcoma of the mobile spine

Zils, K. ; Bielack, S. ; Wilhelm, M. ; Werner, M. ; Schwarz, R. ; Windhager, R. ; Hofmann-Wackersreuther, G. ; Andus, T. ; Kager, L. ; Kuehne, T. ; Reichardt, P. ; von Kalle, T.

Background : The aims of this analysis were to investigate features and outcome of high-grade osteosarcomas of the mobile spine. Patients and methods : Since 1977, 20 Cooperative Osteosarcoma Study Group patients had a diagnosis of high-grade osteosarcomas of the mobile spine and were included in this retrospective analysis of patient-, tumor- and treatment-related variables and outcome. Results : The median age was 29 years (range 5–58). Most frequent tumor sites were thoracic and lumbar [...]

A partir des données de 11 registres allemands des cancers et celles des registres américains portant sur la période 2002-2006, cette étude analyse et compare, pour ces deux pays, la survie des patients atteints d'un cancer du testicule à cellules germinales, par sous-type histologique

Survival after a diagnosis of testicular germ cell cancers in Germany and the United States, 2002–2006: A high resolution study by histology and age

Stang, A. ; Jansen, L. ; Trabert, B. ; Rusner, C. ; Eberle, A. ; Katalinic, A. ; Emrich, K. ; Holleczek, B. ; Brenner, H.

Introduction: The aim of this study was to provide detailed age-specific (5-year age groups) and histology-specific (histologic subtypes of seminoma and nonseminoma) relative survival estimates of testicular germ cell cancer patients in Germany and the United States (U.S.) for the years 2002–2006 and to compare these estimates between countries. Methods: We pooled data from 11 cancer registries of Germany and used data from the U.S. (SEER-13 database) including 11,508 and 10,774 newly diagnosed [...]

Mené auprès de 260 participants, cet essai multicentrique australien analyse le rapport coût-efficacité d'une intervention psychosociale destinée à apprendre aux survivants d'un cancer à gérer leur peur de la récidive

Conquer fear: protocol of a randomised controlled trial of a psychological intervention to reduce fear of cancer recurrence

Butow, Phyllis ; Bell, Melanie ; Smith, Allan ; Fardell, Joanna ; Thewes, Belinda ; Turner, Jane ; Gilchrist, Jemma ; Beith, Jane ; Girgis, Afaf ; Sharpe, Louise ; Shih, Sophy ; Mihalopoulos, Cathrine

BACKGROUND:Up to 70% of cancer survivors report clinically significant levels of fear of cancer recurrence (FCR). Despite the known negative impact of FCR on psychological wellbeing and quality of life, little research has investigated interventions for high FCR. Our team has developed and piloted a novel intervention (Conquer Fear) based on the Self-Regulatory Executive Function Model and Relational Frame Theory and is evaluating Conquer Fear in a randomised controlled trial (RCT). We aim to [...]

Menée au Royaume-Uni dans des zones rurales, cette étude qualitative analyse les expériences de patients recevant leur chimiothérapie dans une unité mobile gérée par des infirmières

Patients' experiences of receiving chemotherapy in outpatient clinic and/or onboard a unique nurse-led mobile chemotherapy unit: a qualitative study

Mitchell, T.

There is a drive in the UK to revise chemotherapy provision for people living in rural communities. Using a different model of treatment delivery might impact positively upon the experience of receiving chemotherapy. In 2007 the first nurse-led mobile chemotherapy unit (MCU) in the UK was launched in the South West of England with the intention of providing treatment closer to home. The aim of the research was to explore experiences of people with cancer who received chemotherapy treatment in [...]

Signé par plus de 100 spécialistes de la leucémie myéloïde chronique, cet article passe en revue les multiples facteurs qui interviennent dans le prix des médicaments contre le cancer, leur impact sur les patients et les politiques de santé, et plaide pour la nécessité d'abaisser le prix de ces médicaments

Price of drugs for chronic myeloid leukemia (CML), reflection of the unsustainable cancer drug prices: perspective of CML Experts

Experts in chronic myeloid leukemia

As a group of more than 100 experts in chronic myeloid leukemia (CML), we draw attention to the high prices of cancer drugs, with the particular focus on the prices of approved tyrosine kinase inhibitors for the treatment of CML. This editorial addresses the multiple factors involved in cancer drug pricing, their impact on individual patients and healthcare policies, and argues for the need to lower the prices of cancer drugs to allow more patients to afford them and to maintain sound long-term [...]

Menée auprès de 1 498 patients atteints de cancer, cette étude néerlandaise présente un outil destiné à évaluer, du point de vue des patients, la qualité des soins hospitaliers

Improving cancer patient care: development of a generic cancer consumer quality index questionnaire for cancer patients

Booij, Judith ; Zegers, Marieke ; Evers, Pauline ; Hendriks, Michelle ; Delnoij, Diana ; Rademakers, Jany

BACKGROUND:To develop a Consumer Quality Index (CQI) Cancer Care questionnaire for measuring experiences with hospital care of patients with different types of cancer. METHODS:We derived quality aspects from focus group discussions, existing questionnaires and literature. We developed an experience questionnaire and sent it to 1,498 Dutch cancer patients. Another questionnaire measuring the importance of the quality aspects was sent to 600 cancer patients. Data were psychometrically analysed. [...]

A partir des données issues de la base américaine Medicare, cette étude analyse le rapport coût-efficacité du remboursement complet des inhibiteurs de l'aromatase pour les femmes atteintes d'un cancer du sein de stade précoce

Cost-effectiveness of full coverage of aromatase inhibitors for Medicare beneficiaries with early breast cancer

Ito, Kouta ; Elkin, Elena ; Blinder, Victoria ; Keating, Nancy ; Choudhry, Niteesh

BACKGROUND : Rates of nonadherence to aromatase inhibitors (AIs) among Medicare beneficiaries with hormone receptor-positive early breast cancer are high. Out-of-pocket drug costs appear to be an important contributor to this and may be addressed by eliminating copayments and other forms of patient cost sharing. The authors estimated the incremental cost-effectiveness of providing Medicare beneficiaries with full prescription coverage for AIs compared with usual prescription coverage under the [...]