Menée au Canada auprès de 1 076 cas et de 1 439 témoins, cette étude en population évalue l'association entre l'indice de masse corporelle, les pratiques tabagiques tout au long de la vie et le risque de cancer du poumon

Body mass index, lifetime smoking intensity and lung cancer risk

El-Zein, Mariam ; Parent, Marie-Élise ; Nicolau, Belinda ; Koushik, Anita ; Siemiatycki, Jack ; Rousseau, Marie-Claude

There is as yet no generally accepted explanation for the common finding that low body mass index (BMI) is associated with an increased risk of lung cancer. We investigated this association in a Canadian population-based case–control study (1996–2002) with a particular view to assessing the hypothesis that the observed association was due to residual confounding by smoking. Analyses were based on 1,076 cases and 1,439 controls who provided their height at enrollment and their weight at two [...]

Menée aux Pays-Bas auprès de 120 852 participants, cette étude de cohorte évalue l'association entre une consommation d'alcool et le risque de tumeurs lymphoïdes ou myéloïdes

Alcohol consumption and risk of lymphoid and myeloid neoplasms: Results of the Netherlands cohort study

Heinen, Mirjam M. ; Verhage, Bas A. J. ; Schouten, Leo J. ; Goldbohm, R. Alexandra ; Schouten, Harry C. ; van den Brandt, Piet A.

Results from epidemiological studies suggest that alcohol drinkers have a decreased risk of lymphoid neoplasms, whereas results for myeloid neoplasms are inconsistent. However, most of these studies have used retrospective data. We examined prospectively whether alcohol consumption decreases the risk of both lymphoid and myeloid neoplasms, including most common subtypes. Moreover, we investigated whether this decreased risk is due to ethanol or other contents of specific alcoholic beverages [...]

Menée auprès de 858 cas et de 806 témoins, cette étude américaine évalue l'association entre une exposition au tabagisme passif pendant l'enfance et le risque de cancer de la tête et du cou à l'âge adulte

Childhood passive smoke exposure is associated with adult head and neck cancer

Troy, Jesse D. ; Grandis, Jennifer R. ; Youk, Ada O. ; Diergaarde, Brenda ; Romkes, Marjorie ; Weissfeld, Joel L.

Introduction: Passive smoke is carcinogenic but its association with head and neck squamous cell carcinoma (HNSCC) is uncertain. Methods: We conducted a case-control study of childhood passive smoke exposure (CPSE) and HNSCC in 858 cases and 806 frequency-matched controls using an interviewer-administered questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated with logistic regression controlling for adult smoking in the total study population, and in never-smokers only [...]

Menée en Norvège à partir des données du registre des cancers et de 856 000 échantillons provenant d'une biobanque, cette étude prospective évalue l'association entre une infection par les souches 16 et 18 du papillomavirus humain et le risque de cancer de la peau hors mélanome

Prospective study of genital human papillomaviruses and nonmelanoma skin cancer

Andersson, Kristin ; Luostarinen, Tapio ; Strand, Anna Söderlund ; Langseth, Hilde ; Gislefoss, Randi E. ; Forslund, Ola ; Pawlita, Michael ; Waterboer, Tim ; Dillner, Joakim

Genital high-risk human papillomaviruses (HPVs) cause cervical cancer and are also found in a small proportion of nonmelanoma skin cancers (NMSCs). We used cancer registry linkages to follow the 856,000 serum donors included in the Southern Sweden Microbiology Biobank or the Janus Biobank in Norway, for incident skin cancers occurring up to 30 years after serum donation. Serum samples taken before diagnosis of squamous cell carcinoma (SCC) (N = 633), basal cell carcinoma (BCC) (N = 1990) or [...]

A partir des données du registre britannique des tumeurs pédiatriques portant sur la période 1962-2006, cette étude cas-témoins évalue l'association entre le métier et le statut socioéconomique du père et le risque de tumeurs du système nerveux central chez l'enfant

Case-control study of paternal occupation and social class with risk of childhood central nervous system tumours in Great Britain, 1962-2006

Keegan, T. J. ; Bunch, K. J. ; Vincent, T. J. ; King, J. C. ; O'Neill, K. A. ; Kendall, G. M. ; MacCarthy, A. ; Fear, N. T. ; Murphy, M. F. G.

Background: Paternal occupational exposures have been proposed as a risk factor for childhood central nervous system (CNS) tumours. This study investigates possible associations between paternal occupational exposure and childhood CNS tumours in Great Britain. Methods: The National Registry of Childhood Tumours provided all cases of childhood CNS tumours born and diagnosed in Great Britain from 1962 to 2006. Controls without cancer were matched on sex, period of birth and birth registration [...]

A partir de données portant sur 885 236 patients atteints d'un diabète de type 2, cette étude taïwanaise évalue l'association entre l'utilisation de rosiglitazone, un agent ani-diabétique, et le risque de cancer de la vessie

Rosiglitazone is not associated with an increased risk of bladder cancer

Tseng, Chin-Hsiao

Background : Whether rosiglitazone may increase bladder cancer risk has not been extensively investigated. Methods : The reimbursement databases of all Taiwanese diabetic patients under oral anti-diabetic agents or insulin from 1996 to 2009 were retrieved from the National Health Insurance. An entry date was set at 1 January 2006 and a total of 885,236 patients with type 2 diabetes were followed up for bladder cancer incidence till end of 2009. Incidences for ever-users, never-users and [...]

A partir des données de deux cohortes américaines incluant 153 576 participants, cette étude prospective analyse l'association entre des antécédents de cancer de la peau hors mélanome et le risque de second cancer primitif dans d'autres localisations

Risk of a Second Primary Cancer after Non-melanoma Skin Cancer in White Men and Women: A Prospective Cohort Study

Song, Fengju ; Qureshi, Abrar A. ; Giovannucci, Edward L. ; Fuchs, Charlie S. ; Chen, Wendy Y. ; Stampfer, Meir J. ; Han, Jiali

Background : Previous studies suggest a positive association between history of non-melanoma skin cancer (NMSC) and risk of subsequent cancer at other sites. The purpose of this study is to prospectively examine the risk of primary cancer according to personal history of NMSC. Methods and Findings : In two large US cohorts, the Health Professionals Follow-up Study (HPFS) and the Nurses' Health Study (NHS), we prospectively investigated this association in self-identified white men and women. In [...]

Menée sur 292 patients atteints d'un cancer de la prostate et sur 278 témoins, cette étude néerlandaise évalue l'association entre des marqueurs microsatellitaires de la région chromosomique

Prostate cancer susceptibility genes on 8p21-23 in a Dutch population

Zeegers, M. P. ; Nekeman, D. ; Khan, H. S. ; van Dijk, B. A. C. ; Goldbohm, R. A. ; Schalken, J. ; Shajahan, S. ; Pearlman, A. ; Oddoux, C. ; van den Brandt, P. A. ; Schouten, L. J. ; Ostrer, H.

Background : Prostate cancer is the most commonly diagnosed cancer in men in Europe and the United States. Numerous studies have indicated genetics to have a major role in the aetiology of this disease; as much as 42% of the risk may be explained by heritable factors. Genome-wide association studies have detected an association between prostate cancer and chromosome 8p21–23. In this study, we analysed eight microsatellite (MS) markers in that region in order to confirm previous results and [...]

Nichée dans une étude de cohorte incluant 6 692 hommes ayant subi une biopsie de la prostate n'ayant pas révélé de malignité, cette étude menée auprès de 494 cas et de 494 témoins évalue l'association entre l'obésité et le risque de cancer de la prostate

Obesity and Future Prostate Cancer Risk among Men after an Initial Benign Biopsy of the Prostate

Rundle, Andrew ; Jankowski, Michelle ; Kryvenko, Oleksandr N. ; Tang, Deliang ; Rybicki, Benjamin A.

Background: In general population studies, obesity has been associated with risk of high-grade prostate cancer, but little is known about obesity and future prostate cancer risk among men with an initial benign biopsy of the prostate; a high-risk population. Methods: Within a cohort of 6,692 men followed up after a biopsy or transurethral resection of the prostate (TURP) with benign findings, a nested case–control study was conducted of 494 prostate cancer cases and controls matched on age, [...]

A partir des données taïwanaises d'assurance maladie portant sur 1 184 patients sur la période 1997-2008, cette étude évalue l'association entre une hyperplasie bénigne de la prostate, une prostatite et le risque de cancer de la prostate

Synergistic interaction of benign prostatic hyperplasia and prostatitis on prostate cancer risk

Hung, S. C. ; Lai, S. W. ; Tsai, P. Y. ; Chen, P. C. ; Wu, H. C. ; Lin, W. H. ; Sung, F. C.

Background: The incidence of prostate cancer is much lower in Asian men than in Western men. This study investigated whether prostate cancer is associated with prostatitis, benign prostatic hyperplasia (BPH), and other medical conditions in the low-incidence population. Methods: From the claims data obtained from the universal National Health Insurance of Taiwan, we identified 1184 patients with prostate cancer diagnosed from 1997 to 2008. Controls comprised 4736 men randomly selected from a [...]

A partir des données de deux grandes cohortes prospectives américaines incluant 283 952 participantes sur la période 1993-2010, cette étude évalue l'association entre des facteurs reproductifs et le risque de cancer du rein

Reproductive Factors and Kidney Cancer Risk in 2 US Cohort Studies, 1993–2010

Karami, Sara ; Daugherty, Sarah E. ; Schonfeld, Sara J. ; Park, Yikyung ; Hollenbeck, Albert R. ; Grubb, Robert L. ; Hofmann, Jonathan N. ; Chow, Wong-Ho ; Purdue, Mark P.

Clinical and experimental findings suggest that female hormonal and reproductive factors could influence kidney cancer development. To evaluate this association, we conducted analyses in 2 large prospective cohorts (the National Institutes of Health–AARP Diet and Health Study (NIH-AARP), 1995–2006, and the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial (PLCO), 1993–2010). Cohort-specific and aggregated hazard ratios and 95% confidence intervals relating reproductive factors and [...]

Menée au Royaume-Uni sur 2 cohortes incluant au total 1 887 participantes dont 651 atteintes d'un cancer du sein et 378 atteintes d'un cancer de l'ovaire, cette étude évalue l'association entre une mutation du gène BRCA1 ou du gène BRCA2 et le risque de cancer du sein ou de l'ovaire

Cancer Risks for BRCA1 and BRCA2 Mutation Carriers: Results From Prospective Analysis of EMBRACE

Mavaddat, Nasim ; Peock, Susan ; Frost, Debra ; Ellis, Steve ; Platte, Radka ; Fineberg, Elena ; Evans, D. Gareth ; Izatt, Louise ; Eeles, Rosalind A. ; Adlard, Julian ; Davidson, Rosemarie ; Eccles, Diana ; Cole, Trevor ; Cook, Jackie ; Brewer, Carole ; Tischkowitz, Marc ; Douglas, Fiona ; Hodgson, Shirley ; Walker, Lisa ; Porteous, Mary E. ; Morrison, Patrick J. ; Side, Lucy E. ; Kennedy, M. John ; Houghton, Catherine ; Donaldson, Alan ; Rogers, Mark T. ; Dorkins, Huw ; Miedzybrodzka, Zosia ; Gregory, Helen ; Eason, Jacqueline ; Barwell, Julian ; McCann, Emma ; Murray, Alex ; Antoniou, Antonis C. ; Easton, Douglas F. ; on behalf of EMBRACE

Background : Reliable estimates of cancer risk are critical for guiding management of BRCA1 and BRCA2 mutation carriers. The aims of this study were to derive penetrance estimates for breast cancer, ovarian cancer, and contralateral breast cancer in a prospective series of mutation carriers and to assess how these risks are modified by common breast cancer susceptibility alleles. Methods : Prospective cancer risks were estimated using a cohort of 978 BRCA1 and 909 BRCA2 carriers from the United [...]

Menée sur 60 patients atteints d'un syndrome de Li-Fraumeni sans mutation détectable du gène TP53, cette étude met en évidence des variants du nombre de copies de gènes associés à une susceptibilité au cancer, notamment aux cancers du cerveau

Germline copy number variation of genes involved in chromatin remodelling in families suggestive of Li-Fraumeni syndrome with brain tumours

Aury-Landas, Juliette ; Bougeard, Gaelle ; Castel, Helene ; Hernandez-Vargas, Hector ; Drouet, Aurelie ; Latouche, Jean-Baptiste ; Schouft, Marie-Therese ; Ferec, Claude ; Leroux, Dominique ; Lasset, Christine ; Coupier, Isabelle ; Caron, Olivier ; Herceg, Zdenko ; Frebourg, Thierry ; Flaman, Jean-Michel

Germline alterations of the tumour suppressor TP53 gene are detected approximately in 25% of the families suggestive of Li-Fraumeni syndrome (LFS), characterised by a genetic predisposition to a wide tumour spectrum, including soft-tissue sarcomas, osteosarcomas, premenopausal breast cancers, brain tumours, adrenocortical tumours, plexus choroid tumours, leukaemia and lung cancer. The aim of this study was to determine the contribution of germline copy number variations (CNVs) to LFS in [...]

Menée auprès de 1 007 patients atteints d'un cancer de la vessie et auprès de 1 299 témoins, cette étude évalue l'association entre la consommation totale de divers liquides, des variants du gène codant pour l'UDP-glucuronosyltransférase et le risque de développer la maladie

Fluid intake, genetic variants of UDP-glucuronosyltransferases, and bladder cancer risk

Wang, J. ; Wu, X. ; Kamat, A. ; Barton Grossman, H. ; Dinney, C. P. ; Lin, J.

Background : Results of studies of fluid consumption and its association with bladder cancer have been inconsistent. Few studies have considered modification effects from genetic variants that may interact with the type of consumed fluids. UDP-glucuronosyltransferases (UGTs), which are membrane-bound conjugating enzymes, catalyse the transformation of hydrophobic substrates to more water-soluble glucuronides to facilitate renal or biliary excretion. Whether genetic variants in UGTs could [...]

Menée à partir de données portant sur 1 227 patients de type caucasien ou africain et atteints d'un carcinome épidermoïde de la tête et du cou, cette étude américaine identifie des polymorphismes à simple nucléotide de gènes du métabolisme de l'alcool et du stress oxydant en association avec la survie des patients

Effects of polymorphisms in alcohol metabolism and oxidative stress genes on survival from head and neck cancer

Hakenewerth, Anne M. ; Millikan, Robert C. ; Rusyn, Ivan ; Herring, Amy H. ; Weissler, Mark C. ; Funkhouser, William K. ; North, Kari E. ; Barnholtz-Sloan, Jill S. ; Olshan, Andrew F.

Background : Heavy alcohol consumption increases risk of developing squamous cell carcinoma of the head and neck (SCCHN). Alcohol metabolism to cytotoxic and mutagenic intermediates acetaldehyde and reactive oxygen species is critical for alcohol-drinking-associated carcinogenesis. We hypothesized that polymorphisms in alcohol metabolism-related and antioxidant genes influence SCCHN survival. Methods : Interview and genotyping data (64 polymorphisms in 12 genes) were obtained from 1227 white [...]