A partir des données du registre néo-zélandais des cancers, cette étude évalue l'association entre le tabagisme et le risque de divers cancers, en prenant en compte les biais de classification induits par d'autres facteurs de risque (consommation d'alcool et obésité)

The association of active smoking with multiple cancers: national census-cancer registry cohorts with quantitative bias analysis

Blakely, Tony ; Barendregt, JanJ ; Foster, RachelH ; Hill, Sarah ; Atkinson, June ; Sarfati, Diana ; Edwards, Richard

Purposes : (1) Determine the association of multiple cancers with smoking, focusing on cancers with an uncertain association; and (2) illustrate quantitative bias analysis as applied to registry data, to adjust for misclassification of smoking and residual confounding by alcohol and obesity. Methods : New Zealand 1981 and 1996 censuses, including smoking questions, were linked to cancer registry data giving 14.8 million person-years of follow-up. Rate ratios (RR) for current versus never [...]

A partir de données historiques portant sur 155 patients traités pour un cholangiocarcinome entre 2006 et 2010, cette étude italienne évalue l'association entre une exposition professionnelle à l'amiante et le risque de la maladie

Asbestos: a hidden player behind the cholangiocarcinoma increase? Findings from a case–control analysis

Brandi, Giovanni ; Girolamo, Stefania ; Farioli, Andrea ; Rosa, Francesco ; Curti, Stefania ; Pinna, AntonioDaniele ; Ercolani, Giorgio ; Violante, FrancescoSaverio ; Biasco, Guido ; Mattioli, Stefano

Purposes : We conducted a case–control analysis to explore the association between occupational exposure to asbestos and cholangiocarcinoma (CC). Methods : The study was based on historical data from 155 consecutive patients with CC [69 intrahepatic CC (ICC) and 86 extrahepatic CC (ECC)] referred to Sant’Orsola-Malpighi University Hospital between 2006 and 2010. The cases were individually matched by calendar period of birth, sex, and region of residence to historical hospital and population [...]

A partir des données du registre géorgien des cancers portant sur 34 053 cas et 14 458 témoins, cette étude évalue l'association entre une exposition nocturne à la lumière artificielle et le risque de cancer du sein

A case-referent study: Light at night and breast cancer risk in Georgia

Bauer, Sarah ; Wagner, Sara ; Burch, Jim ; Bayakly, Rana ; Vena, John

BACKGROUND:Literature has identified detrimental health effects from the indiscriminate use of artificial nighttime light. We examined the co-distribution of light at night (LAN) and breast cancer (BC) incidence in Georgia, with the goal to contribute to the accumulating evidence that exposure to LAN increases risk of BC. METHODS:Using Georgia Comprehensive Cancer Registry data (2000--2007), we conducted a case-referent study among 34,053 BC cases and 14,458 lung cancer referents. Individuals [...]

A partir des données du registre finlandais des cancers portant sur 3 958 cas (pour chaque cas, trois témoins), cette étude en population évalue l'association entre divers traitements hormonaux substitutifs de la ménopause et le risque de cancer de l'ovaire, par sous-type histologique

Effect of various forms of postmenopausal hormone therapy on the risk of ovarian cancer—A population-based case control study from Finland

Koskela-Niska, Virpi ; Pukkala, Eero ; Lyytinen, Heli ; Ylikorkala, Olavi ; Dyba, Tadeusz

Postmenopausal hormone therapy (HT) associates with an increased risk of ovarian cancer, but its' influence on tumor histology is not as well known. Therefore, we evaluated the effect of various types of HT on the risk of epithelial ovarian cancer by histological subtype. All Finnish women diagnosed with ovarian cancer (n= 3,958) aged over 50 during 1995–2007 were identified from the Finnish Cancer Registry. For each case, three controls, matched for age and place of residence, were recruited [...]

A partir d'une méta-analyse de la littérature et des données de population américaine portant sur 1 408 cas et 1 408 témoins, cette étude évalue l'association entre une infection par des papillomavirus de type alpha, beta ou gamma et le risque de carcinome épidermoïde de la peau

Cutaneous alpha, beta and gamma human papillomaviruses in relation to squamous cell carcinoma of the skin: A population-based study

Farzan, Shohreh F. ; Waterboer, Tim ; Gui, Jiang ; Nelson, Heather H. ; Li, Zhongze ; Michael, Kristina M. ; Perry, Ann E. ; Spencer, Steven K. ; Demidenko, Eugene ; Green, Adèle C. ; Pawlita, Michael ; Karagas, Margaret R.

Human papillomavirus (HPV) infection is common worldwide and, in immunodeficient populations, may contribute to the pathogenesis of keratinocyte cancers, particularly squamous cell carcinomas (SCC). However, their role in SCC in the general population is less clear. We conducted a comprehensive analysis to investigate the independent effects of seropositivity for cutaneous alpha, beta and gamma HPV types on risk of SCC, and a meta-analysis of the available literature. In a population-based [...]

Menée en Finlande auprès de 94 349 participantes, cette étude de cohorte évalue l'association entre des infections par le papillomavirus humain ou par Chlamydia trachomatis, en fonction de l'ordre dans lequel elles surviennent, et le risque de lésions cervicales précancéreuses de haut grade

Order of HPV/Chlamydia infections and cervical high-grade precancer risk: A case-cohort study

Luostarinen, Tapio ; Namujju, Proscovia B. ; Merikukka, Marko ; Dillner, Joakim ; Hakulinen, Timo ; Koskela, Pentti ; Paavonen, Jorma ; Surcel, Helja-Marja ; Lehtinen, Matti

Interactions of carcinogenic human papillomaviruses (most notably HPV types 16/18/31/33/45), and HPV6 or Chlamydia trachomatis are not well understood. We have used seroconversions to study effects the order of these infections has on the risk of high-grade cervical precancer. In a cohort of 94,349 Finnish women with paired sera from consecutive pregnancies within an average of 2.4 years, 490 were diagnosed with cervical CIN3/AIS. Serum antibodies to HPV6/16/18/31/33/45 and C. trachomatis were [...]

Menée à partir d'échantillons tumoraux inclus en paraffine, cette étude multicentrique transversale évalue la prévalence d'une infection par le papillomavirus humain parmi les cas de cancer de la tête et du cou au Sénégal

The role of human papillomavirus in head and neck cancer in Senegal

Ndiaye, Cathy ; Alemany, Laia ; Diop, Yankhoba ; Ndiaye, Nafissatou ; Dieme, Marie-Joseph ; Tous, Sara ; Klaustermeier, Jo ; Alejo, Maria ; Castellsagué, Xavier ; Bosch, F ; Trottier, Helen ; Sanjosé, Silvia

BACKGROUND:Exploring the presence and role of human papillomavirus (HPV) in head and neck cancer (HNC) is a necessary step to evaluate the potential impact of HPV prophylactic vaccines. OBJECTIVE:To assess the prevalence and oncogenic role of HPV in HNC in Senegal. METHODS:This is a multicenter cross-sectional study. Paraffin-embedded blocks of cases diagnosed with invasive HNC between 2002 and 2010 were collected from 4 pathology laboratories in Senegal. Presence of HPV DNA was determined by [...]

A partir d'une revue systématique de la littérature, cette méta-analyse évalue l'association entre une histoire de carcinome d'origine kératinocytaire et le risque de carcinome basocellualire, de carcinome épidermoïde ou de mélanome

Risk of subsequent cutaneous malignancy in patients with prior keratinocyte carcinoma: A systematic review and meta-analysis

Flohil, Sophie C. ; van der Leest, Robert J. T. ; Arends, Lidia R. ; de Vries, Esther ; Nijsten, Tamar

In this systematic review and meta-analysis the risk of a subsequent basal cell carcinoma (BCC), squamous cell carcinoma (SCC) or melanoma in patients with a previous keratinocyte carcinoma (KC) was investigated. PubMed, Embase, Web of Science and the Cochrane library were searched for studies published before 1st January 2012 that reported risks (i.e. proportions, cumulative risks or standardised incidence ratios [SIR]) of developing a subsequent BCC, SCC or melanoma in patients with prior KC. [...]

Menée en population britannique auprès de 21 503 patients atteints d'un cancer de la prostate, cette étude de cohorte évalue l'association entre une hormonothérapie anti-androgénique et le risque de cancer colorectal

Androgen deprivation therapy and the risk of colorectal cancer in patients with prostate cancer

Assayag, Jonathan ; Yin, Hui ; Benayoun, Serge ; Pollak, MichaelN ; Suissa, Samy ; Azoulay, Laurent

Purpose : Androgens are known to play an important protective role on colorectal carcinogenesis, and thus the objective of this study was to determine whether androgen deprivation therapy (ADT) is associated with an increased risk of incident colorectal cancer in patients with prostate cancer. Methods : We conducted a population-based cohort study within the UK General Practice Research Database population which included all patients newly diagnosed with prostate cancer between 1 January 1988 [...]

Menée auprès de 431 patients et de 605 témoins non malades, cette étude néerlandaise évalue la relation entre des polymorphismes des gènes MHC and FOXF1, déjà identifiés comme étant associés à un endobrachyœsophage, et le risque de carcinome de l'œsophage

Barrett associated MHC and FOXF1 variants also increase esophageal carcinoma risk

Dura, Polat ; van Veen, Elke M. ; Salomon, Jody ; te Morsche, Rene H. M. ; Roelofs, Hennie M. J. ; Kristinsson, Jon O. ; Wobbes, Theo ; Witteman, Ben J. M. ; Tan, Adriaan C. I. T. L. ; Drenth, Joost P. H. ; Peters, Wilbert H. M.

Barrett's esophagus, with gastroesophageal reflux disease and obesity as risk factors, predisposes to esophageal adenocarcinoma (EAC). Recently a British genome wide association study identified two Barrett's esophagus susceptibility loci mapping within the major histocompatibility complex (MHC; rs9257809) and closely to the Forkhead-F1 (FOXF1; rs9936833) coding gene. An interesting issue is whether polymorphisms associated with Barrett's esophagus, are also implicated in esophageal carcinoma [...]

Menée en Chine auprès de 267 400 salariées de l'industrie du textile, cette étude de cohorte évalue l'association entre des facteurs reproductifs et le risque de cancer du poumon

Reproductive factors and risk of lung cancer in female textile workers in Shanghai, China

Gallagher, LisaG ; Rosenblatt, KarinA ; Ray, RobertaM ; Li, Wenjin ; Gao, DaoL ; Applebaum, KatieM ; Checkoway, Harvey ; Thomas, DavidB

Purpose : Hormonal factors may play a role in the development of lung cancer in women. This study examined the relationship between lung cancer and reproductive factors in a large cohort of women, most of whom never smoked (97 %). Methods : A cohort of 267,400 female textile workers in Shanghai, China, enrolled in a trial of breast self-examination provided information on reproductive history, demographical factors, and cigarette smoking at enrollment in 1989–91. The cohort was followed until [...]

A partir des données de l'étude "Nurses' Health Study" incluant 1 028 cas et 1 780 témoins, cette étude évalue l'association entre la densité mammaire et le risque de cancer du sein chez des femmes ménopausées selon le temps écoulé depuis leur dernière mammographie

Mammographic Breast Density and Subsequent Risk of Breast Cancer in Postmenopausal Women according to the Time Since the Mammogram

Yaghjyan, Lusine ; Colditz, Graham ; Rosner, Bernard A. ; Tamimi, Rulla M.

Background. Few studies have shown that the association between mammographic breast density and breast cancer persists for up to 10 years after the mammogram. We investigated associations of percent density, absolute dense and non-dense areas with breast cancer risk according to the time since the mammogram. Methods. This study included 1,028 incident breast cancer cases diagnosed within the Nurses' Health Study and 1,780 matched controls. Breast density was measured from digitized film images [...]

Menée au Canada auprès de 3 101 cas et de 3 471 témoins, cette étude évalue l'association entre des allergies, de l'asthme, le rhume des foins et le risque de cancer du sein

Association between allergies, asthma, and breast cancer risk among women in Ontario, Canada

Lowcock, ElizabethC ; Cotterchio, Michelle ; Ahmad, Noor

Purpose : To investigate the association between allergies, asthma, and breast cancer risk in a large, population-based case–control study. Methods : Breast cancer cases (n = 3,101) were identified using the Ontario Cancer Registry and population controls (n = 3,471) through random digit dialing. Self-reported histories of allergies, hay fever, and asthma were collected by questionnaire. Logistic regression was used to assess associations between breast cancer risk and history of allergy/hay [...]

Couplée à la cohorte européenne EPIC et incluant 1 391 cas et 1 391 témoins, cette étude évalue l'association entre le niveau sanguin d'hydrovitamine D circulante et le risque de cancer du sein

Plasma 25-hydroxyvitamin D and the risk of breast cancer in the European prospective investigation into cancer and nutrition: A nested case–control study

Kühn, Tilman ; Kaaks, Rudolf ; Becker, Susen ; Eomois, Piia-Piret ; Clavel-Chapelon, Françoise ; Kvaskoff, Marina ; Dossus, Laure ; Tjønneland, Anne ; Olsen, Anja ; Overvad, Kim ; Chang-Claude, Jenny ; Lukanova, Annekatrin ; Buijsse, Brian ; Boeing, Heiner ; Trichopoulou, Antonia ; Lagiou, Pagona ; Bamia, Christina ; Masala, Giovanna ; Krogh, Vittorio ; Sacerdote, Carlotta ; Tumino, Rosario ; Mattiello, Amalia ; Buckland, Genevieve ; Sánchez, María-José ; Menéndez, Virginia ; Chirlaque, María-Dolores ; Barricarte, Aurelio ; Bueno-de-Mesquita, H. Bas ; van Duijnhoven, Fränzel J. B. ; van Gils, Carla H. ; Bakker, Marije F. ; Weiderpass, Elisabete ; Skeie, Guri ; Brustad, Magritt ; Andersson, Anne ; Sund, Malin ; Wareham, Nick ; Khaw, Kay Tee ; Travis, Ruth C. ; Schmidt, Julie A. ; Rinaldi, Sabina ; Romieu, Isabelle ; Gallo, Valentina ; Murphy, Neil ; Riboli, Elio ; Linseisen, Jakob

Experimental evidence suggests that vitamin D might play a role in the development of breast cancer. Although the results of case–control studies indicate that circulating 25-hydroxyvitamin D [25(OH)D] is inversely associated with the risk of breast cancer, the results of prospective studies are inconsistent. A case–control study embedded in the European Prospective Investigation into Cancer and Nutrition (EPIC) was carried out comprising 1,391 incident breast cancer cases and 1,391 controls. [...]

A partir d'une revue systématique de la littérature (6 études, 1 890 cas), cette méta-analyse fait le point sur l'association entre le niveau sérique d'insuline, de peptide C et le risque de cancer du sein

Serum insulin and C-peptide concentration and breast cancer: a meta-analysis

Autier, Philippe ; Koechlin, Alice ; Boniol, Mathieu ; Mullie, Patrick ; Bolli, Geremia ; Rosenstock, Julio ; Boyle, Peter

Purpose : Chronic hyperinsulinemia may play a role in breast cancer etiology. We performed a meta-analysis examining whether serum concentrations of insulin and C-peptide are associated with increased breast cancer risk. Methods : We restricted our analyses to prospective studies. After a systematic literature search, we computed summary relative risks (SRRs) and 95 % confidence intervals (95 % CIs) using random effect models applied to the relative risk associated with the highest versus [...]

A partir de données australiennes, canadiennes, françaises, israëliennes et néo-zélandaises portant sur 2 113 cas et 2 520 témoins de la cohorte Interphone, cette étude évalue l'association entre des allergies et le risque de tumeurs cérébrales

Allergy and brain tumors in the INTERPHONE study: pooled results from Australia, Canada, France, Israel, and New Zealand

Turner, MichelleC ; Krewski, Daniel ; Armstrong, BruceK ; Chetrit, Angela ; Giles, GrahamG ; Hours, Martine ; McBride, MaryL ; Parent, Marie-Élise ; Sadetzki, Siegal ; Siemiatycki, Jack ; Woodward, Alistair ; Cardis, Elisabeth

Purpose : A history of allergy has been inversely associated with several types of cancer although the evidence is not entirely consistent. We examined the association between allergy history and risk of glioma, meningioma, acoustic neuroma, and parotid gland tumors using data on a large number of cases and controls from five INTERPHONE study countries (Australia, Canada, France, Israel, New Zealand), to better understand potential sources of bias in brain tumor case–control studies and to [...]

Menée en Australie auprès de 1 538 cas et de 1 538 témoins, cette étude en population évalue l'association entre des variations de poids au cours de la vie et le risque, par sous-type histologique, de cancer de l'endomètre

Impact of weight change and weight cycling on risk of different subtypes of endometrial cancer

Nagle, C. M. ; Marquart, L. ; Bain, C. J. ; O’Brien, S. ; Lahmann, P. H. ; Quinn, M. ; Oehler, M. K. ; Obermair, A. ; Spurdle, A. B. ; Webb, P. M.

Obesity is an established risk factor for endometrial cancer. Associations tend to be stronger for the endometrioid subtype. The role of adult weight change and weight cycling is uncertain. Our study aimed to determine whether there is an association between different adult weight trajectories, weight cycling and risk of endometrial cancer overall, and by subtype. We analysed data from the Australian National Endometrial Cancer study, a population-based case–control study that collected [...]