Menée auprès de 298 patients atteints d'un cancer, cette étude prospective évalue, par rapport aux soins standard en milieu hospitalier ou aux soins prodigués à domicile, l'intérêt d'une intervention infirmière téléphonique pour assister les malades recevant chez eux un traitement oral par capécitabine

Is a nurse-led telephone intervention a viable alternative to nurse-led home care and standard care for patients receiving oral capecitabine ? Results from a large prospective audit in patients with colorectal cancer

Craven, Olive ; Hughes, Carol Anne ; Burton, Amy ; Saunders, Mark P. ; Molassiotis, Alex

Home care nursing has been shown to be a valuable service for patients receiving oral chemotherapy; however, associated costs can be high and telephone-based services may be more cost-effective options. This prospective audit explored the usefulness of a nurse-led telephone intervention for supporting cancer patients treated with Capecitabine, comparing historical findings from a randomised trial evaluating a home-based intervention over standard care with a modified nurse-led telephone [...]

A partir d'une revue des sites web d'institutions membres du réseau "National Comprehensive Cancer Network", cette étude évalue les recommandations diététiques ciblant les patients traités pour un cancer ou ayant survécu à la maladie

Dietary Recommendations During and After Cancer Treatment: Consistently Inconsistent?

Champ, Colin E. ; Mishra, Mark V. ; Showalter, Timothy N. ; Ohri, Nitin ; Dicker, Adam P. ; Simone, Nicole L.

Recent data reveals that dietary factors may influence outcomes in patients undergoing cancer treatment. However, patient-centered information on dietary recommendations is limited. In this study, we assessed dietary recommendations for cancer patients during treatment and survivorship by evaluating the websites of all National Comprehensive Cancer Network (NCCN) member institutions. NCCN members were identified on www.nccn.org, and individual websites were reviewed for nutritional content. [...]

Menée sur 117 patients atteints d'un cancer de la tête et du cou ou de la région thoracique et traités par radiothérapie entre 2008 et 2010, cette étude rétrospective évalue l'efficacité de la glutamine administrée par voie orale pour prévenir la survenue d'une mucite de la cavité buccale ou d'une œsophagite aiguë

Efficacy of Glutamine in the Prevention of Oral Mucositis and Acute Radiation-Induced Esophagitis: A Retrospective Study

Vidal-Casariego, Alfonso ; Calleja-Fernández, Alicia ; Ballesteros-Pomar, María D. ; Cano-Rodríguez, Isidoro

Glutamine is a nutraceutic with antioxidant and immune functions that can protect from adverse effects associated with radiation therapy (RT). The aim of this study was to test whether oral glutamine prevents oral mucositis (OM) or acute radiation-induced esophagitis (ARIE) and favors nutritional status. This retrospective, cohort study included patients treated with RT for cancer on head and neck (HN) or chest areas during the 2008–2010 period. Data on glutamine treatment (initiated before RT, [...]

A partir de données anglaises portant sur 2 281 223 personnes décédées durant la période 1993-2010, cette étude analyse l'évolution des taux de décès à domicile et à l'hôpital et identifie les facteurs associés à cette évolution

Changing Patterns in Place of Cancer Death in England: A Population-Based Study

Gao, Wei ; Ho, Yuen K. ; Verne, Julia ; Glickman, Myer ; Higginson, Irene J. ; on behalf of the, Guide Care project

Background : Most patients with cancer prefer to die at home or in a hospice, but hospitals remain the most common place of death (PoD).This study aims to explore the changing time trends of PoD and the associated factors, which are essential for end-of-life care improvement. Methods and Findings : The study analysed all cancer deaths in England collected by the Office for National Statistics during 1993–2010 (n = 2,281,223). Time trends of age- and gender-standardised proportion of deaths in [...]

Menée sur 12 718 patients atteints d'un cancer du poumon diagnostiqué entre 2000 et 2010, cette étude multicentrique française analyse l'évolution sur les 10 dernières années des caractéristiques associées à la maladie et aux patients

Major changes in lung cancer over the last ten years in France: The KBP-CPHG studies

Locher, Chrystèle ; Debieuvre, Didier ; Coëtmeur, Daniel ; Goupil, François ; Molinier, Olivier ; Collon, Thierry ; Dayen, Charles ; Le Treut, Jacques ; Asselain, Bernard ; Martin, Francis ; Blanchon, François ; Grivaux, Michel

The incidence of lung cancer has dramatically increased in ten years, being now the most commonly diagnosed cancer in males and the fourth most commonly diagnosed cancer in females. Considering social and scientific evolution, the aim of the present study conducted by the French College of General Hospital Respiratory Physicians (CPHG) was to compare patient and lung cancer characteristics at a ten-year interval. Two epidemiological studies, KBP-2000-CPHG and KBP-2010-CPHG, were conducted at a [...]

Menée à partir de questionnaires auprès de 1 968 patients atteints d'un cancer du côlon de stade III et inclus dans un essai clinique évaluant une chimiothérapie de type FOLFOX (durée médiane de suivi :3,5 ans), cette étude évalue l'association entre le statut tabagique et la survie sans maladie

Associations Between Cigarette Smoking Status and Colon Cancer Prognosis Among Participants in North Central Cancer Treatment Group Phase III Trial N0147

Phipps, Amanda I. ; Shi, Qian ; Newcomb, Polly A. ; Nelson, Garth D. ; Sargent, Daniel J. ; Alberts, Steven R. ; Limburg, Paul J.

Purpose By using data from North Central Cancer Treatment Group Phase III Trial N0147, a randomized adjuvant trial of patients with stage III colon cancer, we assessed the relationship between smoking and cancer outcomes, disease-free survival (DFS), and time to recurrence (TTR), accounting for heterogeneity by patient and tumor characteristics.Patients and Methods Before random assignment to infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX) or FOLFOX plus cetuximab, 1,968 [...]

Cet article analyse l'évolution aux Etats-Unis de l'incidence du cancer du sein et de la mortalité spécifique puis identifie les facteurs associés à cette évolution afin d'améliorer la prévention primaire de la maladie

Trends in breast cancer incidence and mortality in the United States: implications for prevention

Toriola, AdetunjiT ; Colditz, GrahamA

While debate continues regarding short-term changes in breast cancer incidence and the impact of screening on mortality, a long-term view of trends in incidence and mortality may better inform our understanding of the changing patterns of disease and ultimately guide in population-based prevention. Although many factors have influenced breast cancer incidence over the past seven decades, some have played more prominent roles at various times. Changing reproductive patterns, greater longevity, [...]

A partir des données du registre américain des cancers portant sur 47 160 patientes atteintes d'un cancer épithélial invasif de l'ovaire diagnostiqué entre 1998 et 2002, cette étude analyse, en fonction de l'origine ethnique des patientes et de leur statut socioéconomique, les disparités en termes de survie et de qualité des soins

Disparities in Ovarian Cancer Care Quality and Survival According to Race and Socioeconomic Status

Bristow, Robert E. ; Powell, Matthew A. ; Al-Hammadi, Noor ; Chen, Ling ; Miller, J. Philip ; Roland, Phillip Y. ; Mutch, David G. ; Cliby, William A.

Background The relationship between racial and socioeconomic status (SES) disparities and the quality of epithelial ovarian cancer care and survival outcome are unclear.Methods A population-based analysis of National Cancer Data Base (NCDB) records for invasive primary epithelial ovarian cancer diagnosed in the period from 1998 to 2002 was done using data from patients classified as white or black. Adherence to National Comprehensive Cancer Network (NCCN) guideline care was defined by [...]

Menée à partir d'entretiens auprès de 94 patients âgés de 11 à 21 ans et ayant survécu à un cancer pédiatrique, cette étude analyse, en fonction de caractéristiques sociodémographiques, du type de cancer et du traitement reçu, leur développement personnel post-traumatique

Post-traumatic growth among an ethnically diverse sample of adolescent and young adult cancer survivors

Arpawong, T. Em ; Oland, Alyssa ; Milam, Joel E. ; Ruccione, Kathleen ; Meeske, Kathleen A.

Objective Although some survivors of childhood cancer report significant psychosocial distress, many also report having derived benefits, or post-traumatic growth (PTG), from their cancer experience. This study examines PTG and its correlates among an ethnically diverse sample of adolescent/young adult (AYA) cancer survivors who have recently completed treatment. Methods Survivors of childhood cancer (n = 94; 47% Hispanic), ages 11–21 and within 6 months of completing cancer therapy, were [...]

A partir d'une revue systématique de la littérature publiée entre 1990 et 2012 (12 études), cette étude évalue la qualité des interventions destinées à améliorer les connaissances et les pratiques des spécialistes en cancérologie

Systematic Review of Quality Improvement Interventions Directed at Cancer Specialists

Coory, Michael ; White, Victoria M. ; Johnson, Kristin S. ; Hill, David J. ; Jefford, Michael ; Harrison, Simon ; Winship, Ingrid ; Millar, Jeremy ; Giles, Graham G.

Purpose Summary evidence on the effectiveness of quality improvement interventions (QIIs) directed at cancer specialists is needed for two reasons. First, there are some innovations over which only cancer specialists have control (eg, surgical technique or chemotherapy regimen). Second, implementation of QIIs has opportunity costs; the time and money spent on an ineffective QII might be better spent on direct patient care.Methods Medical Subject Headings and text words for “quality improvement” [...]