A partir d'une revue systématique de la littérature (16 études), cette méta-analyse évalue l'association entre divers régimes alimentaires, certains riches en fruits et légumes, d'autres riches en viandes et en graisses, et le risque de cancer de l'estomac

Dietary patterns and gastric cancer risk: a systematic review and meta-analysis

Bertuccio, P. ; Rosato, V. ; Andreano, A. ; Ferraroni, M. ; Decarli, A. ; Edefonti, V. ; La Vecchia, C.

Background Declines in gastric cancer (GC) incidence and mortality have been related to improvements in diet. It is therefore important to consider dietary patterns. Design We conducted a systematic review and meta-analysis of the literature through Medline and Embase databases. Results We identified 16 papers, of these 9 derived dietary patterns through an a posteriori method, 5 through a priori scores, and 2 used both approaches. Eight studies that used the a posteriori approach were [...]

A partir de données de six pays européens (Espagne, France, Allemagne, Italie, Irlande, République tchèque) et menée auprès de 2 205 cas et 2 296 témoins, cette étude analyse l'association entre une exposition professionnelle à des agents allergènes et le risque de lymphome

Occupational exposure to immunologically active agents and risk for lymphoma: The European Epilymph case–control study

Espinosa, Ana ; Zock, Jan-Paul ; Benavente, Yolanda ; Boffetta, Paolo ; Becker, Nikolaus ; Brennan, Paul ; Cocco, Pierluigi ; Foretova, Lenka ; Maynadie, Marc ; Staines, Anthony ; Nieters, Alexandra ; Kogevinas, Manolis ; de Sanjose, Silvia

Objectives Allergies and asthma may be protective for the development of lymphoma. We evaluated whether occupational allergens that provoke immune reactivity and asthma through an IgE-mediated pathway are protective for lymphoma. Methods The Epilymph study includes histologically or cytologically confirmed Hodgkin, B-cell, and T-cell lymphoma cases from six European countries (Spain, France, Germany, Italy, Ireland, and Czech Republic) recruited in 1998–2004. Controls were frequency matched to [...]

Cette étude passe en revue les facteurs de risque du carcinome épidermoïde de la tête et du cou, autres que le tabagisme et la consommation d'alcool

Epidemiology of head and neck squamous cell carcinoma not related to tobacco or alcohol

Curado, Maria P. ; Boyle, Peter

Purpose of review: This review intends to present some epidemiological findings regarding the epidemiology of head and neck squamous cell carcinoma not related to alcohol or tobacco (HNSCCNAT). Recent findings: Twenty-five percent of squamous cell carcinomas of head and neck are not related to tobacco or alcohol consumption. The risk factors for this group of malignancies are not very well established yet. HNSCCNAT are more likely to occur in the oropharynx. The diagnosis is more frequent at [...]

Menée au Danemark auprès de 45 986 patients ayant une maladie inflammatoire de l'intestin, cette étude de cohorte historique (1997-2008) évalue l'association entre l'utilisation de l'azathioprine et le risque de cancer

Use of Azathioprine and the Risk of Cancer in Inflammatory Bowel Disease

Pasternak, Björn ; Svanström, Henrik ; Schmiegelow, Kjeld ; Jess, Tine ; Hviid, Anders

Increased risks of lymphoma and skin cancer associated with thiopurine use among patients with inflammatory bowel disease have been shown, but data on the overall cancer risk are limited. We conducted a historical cohort study of 45,986 patients with inflammatory bowel disease (of whom, 5,197 (11%) used azathioprine) in Denmark from 1997 to 2008. We linked registry data on filled drug prescriptions, cancer diagnoses, and covariates and compared rates of overall incident cancer and cancer [...]

Menée aux Etats-Unis auprès de 14 358 survivants d'un cancer pédiatrique diagnostiqué entre 1970 et 1986, cette étude analyse les facteurs de risque et l'incidence d'un carcinome rénal secondaire

Renal Carcinoma After Childhood Cancer: A Report From the Childhood Cancer Survivor Study

Wilson, Carmen L. ; Ness, Kirsten K. ; Neglia, Joseph P. ; Hammond, Sue ; Shnorhavorian, Margarett ; Leisenring, Wendy L. ; Stovall, Marilyn ; Robison, Leslie L. ; Armstrong, Gregory T.

Adult survivors of childhood cancer are known to be at increased risk of subsequent malignancy, but only limited data exist describing the incidence and risk factors for secondary renal carcinoma. Among 14 358 5-year survivors diagnosed between 1970 and 1986, we estimated standardized incidence ratios (SIRs) for subsequent renal carcinoma and identified associations with primary cancer therapy using Poisson regression. Twenty-six survivors were diagnosed with renal carcinoma (median = 22.6 [...]

Menée aux Etats-Unis, cette étude de cohorte prospective évalue l'association entre une exposition à des rayons X lors d'un examen médical et le risque de cancer de la thyroïde

A Prospective Study of Medical Diagnostic Radiography and Risk of Thyroid Cancer

Neta, Gila ; Rajaraman, Preetha ; Berrington de Gonzalez, Amy ; Doody, Michele M. ; Alexander, Bruce H. ; Preston, Dale ; Simon, Steven L. ; Melo, Dunstana ; Miller, Jeremy ; Freedman, D. Michal ; Linet, Martha S. ; Sigurdson, Alice J.

Although diagnostic x-ray procedures provide important medical benefits, cancer risks associated with their exposure are also possible, but not well characterized. The US Radiologic Technologists Study (1983–2006) is a nationwide, prospective cohort study with extensive questionnaire data on history of personal diagnostic imaging procedures collected prior to cancer diagnosis. We used Cox proportional hazard regressions to estimate thyroid cancer risks related to the number and type of selected [...]

Menée aux Etats-Unis auprès de 1 605 cas et 6 661 témoins, puis validée par des séries de réplication incluant 845 cas et 4 316 témoins, cette étude multiethnique évalue, en fonction de l'origine ethnique, l'association entre des variants des gènes ARID5B, IKZF1, CEBPE, et BMI1-PIP4K2A et le risque de leucémie lymphoblastique aiguë chez l'enfant

Novel Susceptibility Variants at 10p12.31-12.2 for Childhood Acute Lymphoblastic Leukemia in Ethnically Diverse Populations

Xu, Heng ; Yang, Wenjian ; Perez-Andreu, Virginia ; Devidas, Meenakshi ; Fan, Yiping ; Cheng, Cheng ; Pei, Deqing ; Scheet, Paul ; Burchard, Esteban González ; Eng, Celeste ; Huntsman, Scott ; Torgerson, Dara G. ; Dean, Michael ; Winick, Naomi J. ; Martin, Paul L. ; Camitta, Bruce M. ; Bowman, W. Paul ; Willman, Cheryl L. ; Carroll, William L. ; Mullighan, Charles G. ; Bhojwani, Deepa ; Hunger, Stephen P. ; Pui, Ching-Hon ; Evans, William E. ; Relling, Mary V. ; Loh, Mignon L. ; Yang, Jun J.

Background Acute lymphoblastic leukemia (ALL) is the most common cancer in children and the incidence of ALL varies by ethnicity. Although accumulating evidence indicates inherited predisposition to ALL, the genetic basis of ALL susceptibility in diverse ancestry has not been comprehensively examined. Methods We performed a multiethnic genome-wide association study in 1605 children with ALL and 6661 control subjects after adjusting for population structure, with validation in three replication [...]

Menée auprès de 519 cas et de 372 témoins sains, cette étude évalue l'association entre la longueur des télomères et le risque de mélanome, de carcinome épidermoïde et de carcinome basocellulaire

Telomere length and risk of melanoma, squamous cell carcinoma, and basal cell carcinoma

Anic, Gabriella M. ; Sondak, Vernon K. ; Messina, Jane L. ; Fenske, Neil A. ; Zager, Jonathan S. ; Cherpelis, Basil S. ; Lee, Ji-Hyun ; Fulp, William J. ; Epling-Burnette, Pearlie K. ; Park, Jong Y. ; Rollison, Dana E.

Background: Telomeres help maintain chromosomal structure and may influence tumorigenesis. We examined the association between telomere length and skin cancer in a clinic-based case-control study of 198 melanoma cases, 136 squamous cell carcinoma (SCC) cases, 185 basal cell carcinoma (BCC) cases, and 372 healthy controls. Methods: Cases were histologically confirmed patients treated at the Moffitt Cancer Center and University of South Florida Dermatology Clinic in Tampa, FL. Controls [...]

A partir de données américaines incluant 10 084 cas, cette étude conclut à une absence d'association entre 27 polymorphismes précédemment identifiés et la survie des patientes atteintes d'un cancer de l'ovaire

Analysis of Over 10,000 Cases Finds No Association between Previously-Reported Candidate Polymorphisms and Ovarian Cancer Outcome

White, Kristin L. ; Vierkant, Robert A. ; Fogarty, Zachary ; Charbonneau, Bridget ; Block, Matthew S ; Pharoah, Paul D.P. ; Chenevix-Trench, Georgia ; Rossing, Mary Anne ; Cramer, Daniel W. ; Pearce, Leigh ; Schildkraut, Joellen M. ; Menon, Usha ; Kruger Kjær, Susanne ; Levine, Douglas A. ; Gronwald, Jacek ; Anton-Culver, Hoda ; Whittemore, Alice S. ; Karlan, Beth Y. ; Lambrechts, Diether ; Wentzensen, Nicolas ; Kupryjanczyk, Jolanta ; Chang-Claude, Jenny ; Bandera, Elisa V. ; Hogdall, Estrid V. ; Heitz, Florian ; Kaye, Stan ; Fasching, Peter A. ; Campbell, Ian G ; Goodman, Marc T. ; Pejovic, Tanja ; Bean, Yukie T ; Lurie, Galina ; Eccles, Diana ; Hein, Alexander ; Beckmann, Matthias W. ; Ekici, Arif B. ; Paul, James ; Brown, Robert ; Flanagan, James M. ; Harter, Philipp ; du Bois, Andreas ; Schwaab, Ira ; Hogdall, Claus K. ; Lundvall, Lene ; Olson, Sara H. ; Orlow, Irene ; Paddock, Lisa E. ; Rudolph, Anja ; Eilber, Ursula ; Dansonka-Mieszkowska, Agnieszka ; Rzepecka, Iwona K. ; Ziolkowska-Seta, Izabela ; Brinton, Louise A. ; Yang, Hannah P. ; Garcia-Closas, Montserrat ; Despierre, Evelyn ; Lambrechts, Sandrina ; Vergote, Ignace ; Walsh, Christine ; Lester, Jenny ; Sieh, Weiva ; McGuire, Valerie ; Rothstein, Joseph H. ; Ziogas, Argyrios ; Lubinski, Jan ; Cybulski, Cezary ; Menkiszak, Janusz ; Jensen, Allan ; Gayther, Simon A. ; Ramus, Susan J. ; Gentry-Maharaj, Aleksandra ; Berchuck, Andrew ; Wu, Anna H. ; Pike, Malcolm C. ; Van Den Berg, David ; Terry, Kathryn L. ; Vitonis, Allison F ; Doherty, Jennifer A. ; Johnatty, Sharon E ; Defazio, Anna ; Song, Honglin ; Tyrer, Jonathan ; Sellers, Thomas A. ; Phelan, Catherine M. ; Kalli, Kimberly R. ; Cunningham, Julie M. ; Fridley, Brooke L. ; Goode, Ellen L.

Background: Ovarian cancer is a leading cause of cancer-related death among women. In an effort to understand contributors to disease outcome, we evaluated single-nucleotide polymorphisms (SNPs) previously associated with ovarian cancer recurrence or survival, specifically in angiogenesis, inflammation, mitosis, and drug disposition genes. Methods: Twenty-seven SNPs in VHL, HGF, IL18, PRKACB, ABCB1, CYP2C8, ERCC2, and ERCC1 previously associated with ovarian cancer outcome were genotyped in [...]

A partir de données américaines incluant 9 226 cas et 10 420 témoins, cette étude évalue l'association entre quatre polymorphismes à simple nucléotide de BCMO1, un gène impliqué dans la production de vitamine A à partir des caroténoïdes d'origine alimentaire, et le risque de cancer du sein

Plasma carotenoid- and retinol-weighted gene scores and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium

Hendrickson, Sara J. ; Lindström, Sara ; Eliassen, A. Heather ; Rosner, Bernard A. ; Chen, Constance ; Barrdahl, Myrto ; Brinton, Louise A. ; Buring, Julie E. ; Canzian, Federico ; Chanock, Stephen J. ; Clavel-Chapelon, Françoise ; Figueroa, Jonine D. ; Gapstur, Susan M. ; Garcia-Closas, Montserrat ; Gaudet, Mia M. ; Haiman, Christopher ; Hazra, Aditi ; Henderson, Brian E. ; Hoover, Robert ; Hüsing, Anika ; Johansson, Mattias ; Kaaks, Rudolf ; Khaw, Kay-Tee ; Kolonel, Laurence ; Le Marchand, Loic ; Lissowska, Jolanta ; Lund, Eiliv ; McCullough, Marjorie ; Peplonska, Beata ; Riboli, Elio ; Sacerdote, Carlotta ; Sánchez, María-José ; Tjonneland, Anne ; Trichopoulos, Dimitrios ; van Gils, Carla H. ; Yeager, Meredith ; Kraft, Peter ; Hunter, David J. ; Ziegler, Regina G. ; Willett, Walter C.

Background: Dietary and circulating carotenoids have been inversely associated with breast cancer risk, but observed associations may be due to confounding. Single nucleotide polymorphisms (SNPs) in β-carotene 15,15′-monooxygenase 1 (BCMO1), a gene encoding the enzyme involved in the first step of synthesizing vitamin A from dietary carotenoids, have been associated with circulating carotenoid concentrations and may serve as unconfounded surrogates for those biomarkers. We determined [...]

Menée aux Etats-Unis auprès de 159 patients atteints d'un cancer de la cavité buccale ou de l'oropharynx avec antécédents tabagiques ou alcooliques, cette étude évalue l'association entre des polymorphismes des gènes NAT2 et GSTP1 et la survie des patients

Polymorphisms in NAT2 and GSTP1 are associated with survival in oral and oropharyngeal cancer

Troy, Jesse D. ; Weissfeld, Joel L. ; Diergaarde, Brenda ; Youk, Ada O. ; Buch, Shama C. ; Romkes, Marjorie ; Grandis, Jennifer R.

Introduction: Functional polymorphisms in drug metabolizing enzymes (DMEs) may be determinants of survival in oral and oropharyngeal squamous cell carcinoma (OOSCC). Methods: OOSCC cases (N = 159) with a history of either tobacco or alcohol use were genotyped for polymorphisms in eight DMEs. Overall and disease-specific survival were analyzed using Kaplan–Meier plots and the log-rank test. Cox proportional hazards regression was used to calculate hazard ratios (HR) and 95% confidence intervals [...]