Menée auprès de 13 personnes utilisant la cigarette et la pipe à eau, cette étude américaine transversale analyse et compare, pour les deux produits, le niveau d'exposition des consommateurs à la nicotine et à des produits carcinogènes

Comparison of Nicotine and Carcinogen Exposure with Water pipe and Cigarette Smoking

Jacob, Peyton ; Abu Raddaha, Ahmad H. ; Dempsey, Delia ; Havel, Chis ; Peng, Margaret ; Yu, Lisa ; Benowitz, Neal L.

Background Smoking tobacco preparations in a water pipe (hookah) is widespread in many places of the world and is perceived by many as relatively safe. We investigated biomarkers of toxicant exposure with water pipe compared to cigarette smoking. Methods We conducted a cross-over study to assess daily nicotine and carcinogen exposure with water pipe and cigarette smoking in 13 people who were experienced in using both products. Results While smoking an average of 3 water pipe sessions compared [...]

A partir des données de 21 études (14 724 cas et 19 066 témoins), cette étude évalue l'association entre le tabagisme et le risque de cancer de l'ovaire

Cigarette smoking and risk of ovarian cancer: a pooled analysis of 21 case–control studies

Faber, MetteT ; Kjær, SusanneK ; Dehlendorff, Christian ; Chang-Claude, Jenny ; Andersen, KlausK ; Høgdall, Estrid ; Webb, PenelopeM ; Jordan, SusanJ ; Rossing, MaryAnne ; Doherty, JenniferA ; Lurie, Galina ; Thompson, PamelaJ ; Carney, MichaelE ; Goodman, MarcT ; Ness, RobertaB ; Modugno, Francesmary ; Edwards, RobertP ; Bunker, ClareannH ; Goode, EllenL ; Fridley, BrookeL ; Vierkant, RobertA ; Larson, MelissaC ; Schildkraut, Joellen ; Cramer, DanielW ; Terry, KathrynL ; Vitonis, AllisonF ; Bandera, ElisaV ; Olson, SaraH ; King, Melony ; Chandran, Urmila ; Kiemeney, LambertusA ; Massuger, LeonF A. G. ; Altena, AnneM ; Vermeulen, SitaH ; Brinton, Louise ; Wentzensen, Nicolas ; Lissowska, Jolanta ; Yang, HannahP ; Moysich, KirstenB ; Odunsi, Kunle ; Kasza, Karin ; Odunsi-Akanji, Oluwatosin ; Song, Honglin ; Pharaoh, Paul ; Shah, Mitul ; Whittemore, AliceS ; McGuire, Valerie ; Sieh, Weiva ; Sutphen, Rebecca ; Menon, Usha ; Gayther, SimonA ; Ramus, SusanJ ; Gentry-Maharaj, Aleksandra ; Pearce, CelesteLeigh ; Wu, AnnaH ; Pike, MalcolmC ; Risch, HarveyA ; Jensen, Allan

Purpose : The majority of previous studies have observed an increased risk of mucinous ovarian tumors associated with cigarette smoking, but the association with other histological types is unclear. In a large pooled analysis, we examined the risk of epithelial ovarian cancer associated with multiple measures of cigarette smoking with a focus on characterizing risks according to tumor behavior and histology. Methods : We used data from 21 case–control studies of ovarian cancer (19,066 controls, [...]

A partir d'une revue systématique de la littérature, cette méta-analyse fait le point sur l'association entre carcinome urothélial des voies urinaires supérieures et une exposition à l'acide aristolochique présent dans des plantes utilisées en médecine traditionnelle chinoise

Risk Assessment of Upper Tract Urothelial Carcinoma Related to Aristolochic Acid

Wu, Felicia ; Wang, Tianxiu

Background: Aristolochic acid (AA) is a toxin found in plants of the genus Aristolochia, to which humans can be exposed either through certain Chinese herbal medicines or through inadvertent commingling with food crops. Our objective was to estimate cumulative exposures of AA associated with increased risk of end stage renal disease (ESRD), and to conduct a systematic review and meta-analysis on AA-induced upper tract urothelial carcinoma (UUC). Methods: Using epidemiological studies on [...]

A partir des données des cohortes américaines "Nurses’ Health Study" incluant 88 173 femmes et "Health Professionals Follow-up Study" incluant 23 722 hommes, cette étude prospective évalue l'association entre la fréquence des selles, l'utilisation de laxatifs et le risque de cancer colorectal

Prospective cohort studies of bowel movement frequency and laxative use and colorectal cancer incidence in US women and men

Zhang, Xuehong ; Wu, Kana ; Cho, Eunyoung ; Ma, Jing ; Chan, AndrewT ; Gao, Xiang ; Willett, WalterC ; Fuchs, CharlesS ; Giovannucci, EdwardL

Purpose : The associations between bowel movement frequency, laxative use, and colorectal cancer incidence remain uncertain. No published studies have accounted for potential latency between these factors and colorectal cancer onset. Methods : We prospectively examined these associations among 88,173 women in the Nurses’ Health Study (NHS, 1982–2010) and 23,722 men in the Health Professionals Follow-up Study (HPFS, 2000–2010). Cox proportional hazards regression models were used to estimate [...]

A partir d'une revue systématique de la littérature (96 études, 40 585 cas et 48 320 témoins), cette méta-analyse évalue l'association entre deux polymorphismes du gène XPC et le risque de cancer

Associations of Lys939Gln and Ala499Val polymorphisms of the XPC gene with cancer susceptibility: A meta-analysis

He, Jing ; Shi, Ting-Yan ; Zhu, Mei-Ling ; Wang, Meng-Yun ; Li, Qiao-Xin ; Wei, Qing-Yi

XPC polymorphisms may alter DNA repair capacity, thus leading to genetic instability and carcinogenesis. Numerous studies have investigated the associations of XPC Lys939Gln (rs2228001) and Ala499Val (rs2228000) polymorphisms with cancer susceptibility; however, the findings are inconclusive. We searched literature from MEDLINE and EMBASE for eligible publications that assessed the associations between these two polymorphisms and cancer risk. We also assessed genotype-mRNA expression [...]

Couplée aux données de cinq cohortes américaines (470 cas et 1 094 témoins), cette étude prospective évalue l'association entre des marqueurs d'une inflammation chronique mesurés dans le plasma et le risque de cancer du pancréas

Inflammatory Plasma Markers and Pancreatic Cancer Risk: a Prospective Study of 5 U.S. Cohorts

Bao, Ying ; Giovannucci, Edward ; Kraft, Peter ; Qian, Zhi Rong ; Wu, Chen ; Ogino, Shuji ; Gaziano, John Michael ; Stampfer, Meir J. ; Ma, Jing ; Buring, Julie E. ; Sesso, Howard ; Lee, I-Min ; Rifai, Nader ; Pollak, Michael N. ; Jiao, Li ; Lessin, Lawrence S ; Cochrane, Barbara B. ; Manson, JoAnn E. ; Fuchs, Charles S. ; Wolpin, Brian M.

Background: Chronic inflammation may play a role in the development of pancreatic cancer. However, few prospective studies have examined the association between plasma inflammatory markers and pancreatic cancer risk. Methods: In a prospective, nested case-control study of 470 cases and 1094 controls from Health Professionals Follow-up Study, Nurses' Health Study, Physicians' Health Study, Women's Health Initiative, and Women's Health Study, we investigated the association of prediagnostic [...]

Menée en Suède auprès de 117 328 cas et de 562 644 témoins, cette étude en population analyse l'association entre le nombre d'enfants, le statut marital et le risque de cancer de la prostate

Fatherhood status and risk of prostate cancer: Nationwide, population-based case–control study

Wirén, Sara M. ; Drevin, Linda I. ; Carlsson, Sigrid V. ; Akre, Olof ; Holmberg, Erik C. ; Robinson, David E. ; Garmo, Hans G. ; Stattin, Pär E.

Previous studies have shown a decreased risk of prostate cancer for childless men; however, the cause of the association remains to be elucidated. The aim of our study was to assess the risk of prostate cancer by fatherhood status, also considering potential confounding factors. In a case–control study in Prostate Cancer data Base Sweden 2.0, a nationwide, population-based cohort, data on number of children, marital status, education, comorbidity and tumor characteristics obtained through [...]

Menée en population australienne auprès de 690 participants, cette étude analyse l'association entre une histoire familiale de cancer colorectal et le risque de cancer colorectal chez des membres de la famille porteurs de la mutation p.V600E du gène BRAF

Family History of Colorectal Cancer in BRAF p.V600E mutated Colorectal Cancer Cases

Buchanan, Daniel D. ; Win, Aung Ko ; Walsh, Michael D. ; Walters, Rhiannon J. ; Clendenning, Mark ; Nagler, Belinda N. ; Pearson, Sally-Ann ; Macrae, Finlay ; Parry, Susan ; Arnold, Julie ; Winship, Ingrid ; Giles, Graham G. ; Lindor, Noralane M. ; Potter, John D. ; Hopper, John L. ; Rosty, Christophe ; Young, Joanne P. ; Jenkins, Mark A.

Background: Previous reports suggest that relatives of CRC-affected probands carrying the BRAF p.V600E mutation are at an increased risk of colorectal (CRC) and extracolonic cancers (ECCs). In this study, we estimated the association between a family history (FH) of either CRC or ECC and risk of CRC with a BRAF p.V600E mutation. Methods: Population-based CRC cases (probands; aged 18-59years at diagnosis), recruited irrespective of family cancer history, were characterised for BRAF p.V600E [...]

Couplée à la cohorte "Nurses' Health Study II" et incluant 634 cas et 1 264 témoins, cette étude évalue l'association entre le niveau d' hormones sexuelles stéroïdiennes avant la ménopause et le risque de cancer du sein

Premenopausal endogenous steroid hormones and breast cancer risk: results from the Nurses' Health Study II

Fortner, Renee ; Eliassen, A Heather ; Spiegelman, Donna ; Willett, Walter ; Barbieri, Robert ; Hankinson, Susan

INTRODUCTION:Prior research supports an association between endogenous sex steroids and breast cancer among postmenopausal women; the association is less clear among premenopausal women. METHODS:We evaluated the associations between estrogens, androgens, progesterone, and sex hormone binding globulin (SHBG) and breast cancer in a nested case-control study in the Nurses' Health Study II. Between 1996-1999, 29,611 participants provided blood samples; 18,521 provided samples timed in early [...]

Menée aux Etats-Unis auprès de 1 111 cas et de 1 096 témoins, cette étude évalue l'association entre des facteurs anthropométriques (taille, poids) et le risque de gliome

Anthropometric factors in relation to risk of glioma

Little, RebeccaB ; Madden, MelissaH ; Thompson, ReidC ; Olson, JeffreyJ ; LaRocca, RenatoV ; Pan, Edward ; Browning, JamesE ; Egan, KathleenM ; Nabors, L. Burton

Introduction : Increased height and greater adiposity have been linked to an increased risk of many cancer types, though few large studies have examined these associations in glioma. We examined body weight and height as potential risk factors for glioma in a large US-based case–control study. Methods : The analysis included 1,111 glioma cases and 1,096 community controls. In a structured interview, participants reported their height and weight at 21 years of age, lowest and highest weight in [...]

Menée en Chine auprès de 1 538 cas et 1 260 témoins, cette étude évalue l'association entre le groupe sanguin A, B, O et le risque de carcinome du rhinopharynx

ABO blood group and nasopharyngeal carcinoma risk in a population of Southeast China

Sheng, Liming ; Sun, Xiaojiang ; Zhang, Lizhen ; Su, Dan

Previous studies found that the ABO blood type alters the individual susceptibility of some malignancies. However, whether such an association exists between ABO blood type and nasopharyngeal carcinoma (NPC) remains unknown. A case-control study was conducted, with 1,538 patients who had NPC and 1,260 cancer-free controls. The association between ABO blood type and NPC incidence was evaluated using unconditional logistic regression analysis. Compared with subjects with blood type O, a [...]

A partir des données de 14 études (5 566 cas et 7 374 témoins), cette étude fait le point sur l'association entre des facteurs de risque déjà identifiés dans des études d'association sur le génome entier, des facteurs de risques environnementaux et le risque de cancer de l'ovaire

Combined and interactive effects of environmental and GWAS-identified risk factors in ovarian cancer

Pearce, Celeste Leigh ; Rossing, Mary Anne ; Lee, Alice W. ; Ness, Roberta B. ; Webb, Penelope M. ; Chenevix-Trench, Georgia ; Jordan, Susan J. ; Stram, Douglas A. ; Chang-Claude, Jenny ; Hein, Rebecca ; Nickels, Stefan ; Lurie, Galina ; Thompson, Pamela J. ; Carney, Michael E. ; Goodman, Marc T. ; Moysich, Kirsten B. ; Hogdall, Estrid V. ; Jensen, Allan ; Goode, Ellen L. ; Fridley, Brooke L. ; Cunningham, Julie M. ; Vierkant, Robert A. ; Weber, Rachel Palmieri ; Ziogas, Argyrios ; Anton-Culver, Hoda ; Gayther, Simon A. ; Gentry-Maharaj, Aleksandra ; Menon, Usha ; Ramus, Susan J. ; Brinton, Louise A. ; Wentzensen, Nicolas ; Lissowska, Jolanta ; Garcia-Closas, Montserrat ; Massuger, Leon ; Kiemeney, Lambertus A. ; van Altena, Anne M. ; Aben, Katja K.H. ; Berchuck, Andrew ; Doherty, Jennifer A. ; Iversen, Edwin ; McGuire, Valerie ; Moorman, Patricia G. ; Pharoah, Paul D. P. ; Pike, Malcolm C. ; Risch, Harvey A. ; Sieh, Weiva ; Stram, Daniel O. ; Terry, Kathryn L. ; Whittemore, Alice S. ; Wu, Anna ; Schildkraut, Joellen M. ; Kjaer, Susanne K.

Background: There are several well-established environmental risk factors for ovarian cancer, and recent genome-wide association studies have also identified six variants that influence disease risk. However, the interplay between such risk factors and susceptibility loci has not been studied. Methods: Data from 14 ovarian cancer case-control studies were pooled, and stratified analyses by each environmental risk factor with tests for heterogeneity were conducted to determine the presence of [...]