A partir des données de 12 études européennes de cohorte incluant 116 056 participants âgés de 17 à 70 ans, cette méta-analyse évalue l'association entre un stress d'origine professionnelle et le risque de cancer

Work stress and risk of cancer: meta-analysis of 5700 incident cancer events in 116 000 European men and women

Katriina Heikkilä ; Solja T Nyberg ; Töres Theorell ; Eleonor I Fransson ; Lars Alfredsson ; Jakob B Bjorner ; Sébastien Bonenfant ; Marianne Borritz ; Kim Bouillon ; Herman Burr ; Nico Dragano ; Goedele A Geuskens ; Marcel Goldberg ; Mark Hamer ; Wendela E Hooftman ; Irene L Houtman ; Matti Joensuu ; Anders Knutsson ; Markku Koskenvuo ; Aki Koskinen ; Anne Kouvonen ; Ida E H Madsen ; Linda L Magnusson Hanson ; Michael G Marmot ; Martin L Nielsen ; Maria Nordin ; Tuula Oksanen ; Jaana Pentti ; Paula Salo ; Reiner Rugulies ; Andrew Steptoe ; Sakari Suominen ; Jussi Vahtera ; Marianna Virtanen ; Ari Väänänen ; Peter Westerholm ; Hugo Westerlund ; Marie Zins ; Jane E Ferrie ; Archana Singh-Manoux ; G David Batty ; Mika Kivimäki

Objective To investigate whether work related stress, measured and defined as job strain, is associated with the overall risk of cancer and the risk of colorectal, lung, breast, or prostate cancers. Design Meta-analysis of pooled prospective individual participant data from 12 European cohort studies including 116 056 men and women aged 17-70 who were free from cancer at study baseline and were followed-up for a median of 12 years. Work stress was measured and defined as job strain, which was [...]

A partir des données de cinq études (1 959 cas et 6 192 témoins), cette étude évalue l'association entre diverses expositions professionnelles et le risque de myélome multiple

Multiple myeloma and occupation: A pooled analysis by the International Multiple Myeloma Consortium

Perrotta, Carla ; Kleefeld, Silke ; Staines, Anthony ; Tewari, Prerna ; De Roos, Anneclaire J. ; Baris, Dalsu ; Birmann, Brenda ; Chiu, Brian ; Cozen, Wendy ; Becker, Nikolaus ; Foretova, Lenka ; Maynadie, Marc ; Nieters, Alexandra ; de Sanjose, Silvia ; Miligi, Lucia ; Seniori Costantini, Adele ; Purdue, Mark ; Spinelli, John ; Cocco, Pierluigi

Objective: We investigated occupational risk of multiple myeloma (MM) in a pooled analysis of five international case–control studies. Methods: We calculated the odds ratio and its 95% confidence interval for selected occupations with unconditional regression analysis in 1959 MM cases and 6192 controls, by pooling study-specific risks using random-effects meta-analysis. Exposure to organic solvents was assessed with a job-exposure matrix (JEM). Results: Gardeners and nursery workers combined, [...]

A partir d'une revue systématique de la littérature (8 études cas-téloins et 5 études de cohorte), cette méta-analyse évalue l'association entre un travail de nuit et le risque de cancer du sein

Does night work increase the risk of breast cancer? A systematic review and meta-analysis of epidemiological studies

Jia, Yijun ; Lu, Yunshu ; Wu, Kejin ; Lin, Qing ; Shen, Wei ; Zhu, Mingjie ; Huang, Shuo ; Chen, Jian

Objective: To conduct a systematic review, with meta-analysis, of studies assessing the association between night work and the risk of breast cancer, using available epidemiological evidence. Method: Relevant studies were identified by searching several databases and the reference lists of retrieved articles. We combined the relative risks (RR) from individual studies using a random-effects model. Subgroup analysis was carried out as the data showed statistically significant heterogeneity. [...]

Menée en Italie et en Australie auprès de 627 cas et de 782 témoins, cette étude analyse l'association entre la charge virale de papillomavirus humain de type bêta, mesurée dans des follicules pileux des sourcils, et le risque de carcinome épidermoïde de la peau

Human Papilloma Virus load in eyebrow hair follicles and risk of cutaneous squamous cell carcinoma

Neale, Rachel E ; Weissenborn, Soenke ; Abeni, Damiano ; Bouwes Bavinck, Jan Nico ; Euvrad, Sylvie ; Feltkamp, Mariet C. ; Green, Adele C ; Harwood, Catherine A ; de Koning, Maurits NC ; Naldi, Luigi ; Nindl, Ingo ; Pawlita, Michael ; Proby, Charlotte ; Quint, Wim ; Waterboer, Tim ; Wieland, Ulrike ; Pfister, Herbert J

Background: Beta HPV (betaPV) may play a role in the development of cutaneous squamous cell carcinoma (SCC). However betaPV is highly prevalent, and it may only be people with a higher viral load that have increased risk of SCC. We therefore examined the association between betaPV load and SCC. Methods: We recruited 448 immunocompetent cases with SCC and 464 controls from Italy and Australia, and 497 immunosuppressed organ transplant recipients (OTR) (179 cases and 318 controls) from Europe. We [...]

A partir des données de deux cohortes incluant un total de 2 665 participants américains d'origine européenne, cette étude analyse l'association entre une mutation du gène HOXB13 et le risque de cancer de la prostate

HOXB13 Mutation and Prostate Cancer: Studies of Siblings and Agressive Disease

Witte, John S. ; Mefford, Joel ; Plummer, Sarah ; Liu, Jinghua ; Cheng, Iona ; Klein, Eric A ; Rybicki, Benjamin A ; Casey, Graham

Background: Recent work detected for the first time a high-risk prostate cancer mutation, in homeobox B13 (HOXB13) among European-Americans. Methods: We further evaluated this G84E missense mutation (rs138213197) in two genetic association studies of prostate cancer: a family-based study of brothers and a case-control study of more aggressive disease (N=2,665 total). We then calculated overall impact of this mutation by pooling all published studies of European-Americans. Results: In our [...]

Incluant sept études cas-témoins, cette méta-analyse évalue la relation entre des polymorphismes à simple nucléotide de deux gènes associés aux allergies, IL-4Rα et IL-13, et le risque de gliome

Association between polymorphisms in interleukin-4Rα and interleukin-13 and glioma risk: A meta-analysis

Sun, Guan ; Wang, Xiefeng ; Shi, Lei ; Yue, Xiao ; Fu, Linshan ; Chen, Chen ; Li, Zhengyi ; Pan, Tianhong ; Wan, Zhengqiang

Introduction: It has been suggested that allergies are inversely associated with glioma risk. Single nucleotide polymorphisms in two allergy-related genes [interleukin (IL)-4Rα, IL-13] have been implicated in susceptibility to glioma; however, results from the published studies remained inconclusive. Methods: To derive a more precise relationship, we conducted a meta-analysis including seven case–control studies that investigated the influence of IL-4Rα rs1801275 and IL13 rs20541 polymorphisms [...]

Menée en hôpital auprès de 252 cas et de 236 témoins et complétée par les données de 13 études précédemment publiées (9 études de cohorte et 5 études cas-témoins), cette méta-analyse évalue l'association entre des allergies et le risque d'un cancer de la tête et du cou

Allergies and Risk of Head and Neck Cancer: An Original Study plus Meta-Analysis

Hsiao, Jenn-Ren ; Ou, Chun-Yen ; Lo, Hung- I. ; Huang, Cheng-Chih ; Lee, Wei-Ting ; Huang, Jehn-Shyun ; Chen, Ken-Chung ; Wong, Tung-Yiu ; Tsai, Sen-Tien ; Yen, Chia-Jui ; Wu, Yuan-Hua ; Hsueh, Wei-Ting ; Yang, Ming-Wei ; Wu, Shang-Yin ; Chang, Jang-Yang ; Chang, Kwang-Yu ; Lin, Chen-Lin ; Wang, Fang-Ting ; Wang, Yi-Hui ; Weng, Ya-Ling ; Yang, Han-Chien ; Chang, Jeffrey S.

Backround : Although the relationship between allergy and cancer has been investigated extensively, the role of allergy in head and neck cancer (HNC) appears less consistent. It is not clear whether allergies can independently influence the risk of HNC in the presence of known strong environmental risk factors, including consumption of alcohol, betel quid, and cigarette. Methods: The current paper reports results from: 1) an original hospital-based case-control study, which included 252 [...]