Menée auprès de 6 560 participants positifs au VIH et 36 821 négatifs, cette étude de cohorte américaine évalue l'association entre une infection par le VIH, une immunodéficience et le risque de cancer de la peau hors mélanome

HIV Infection Status, Immunodeficiency, and the Incidence of Non-Melanoma Skin Cancer

Silverberg, Michael J. ; Leyden, Wendy ; Warton, E. Margaret ; Quesenberry , Charles P. ; Engels, Eric A. ; Asgari, Maryam M.

Background The incidence of non-melanoma skin cancers (NMSCs), including basal cell (BCC) or squamous cell carcinoma (SCC), is not well documented among HIV-positive (HIV+) individuals.Methods We identified 6560 HIV+ and 36 821 HIV-negative (HIV−) non-Hispanic white adults who were enrolled and followed up in Kaiser Permanente Northern California from 1996 to 2008. The first biopsy-proven NMSCs diagnosed during follow-up were identified from pathology records. Poisson models estimated rate [...]

A partir des données de la cohorte "Women’s Health Initiative Observational Study" incluant 75 828 participantes, cette étude analyse l'association entre la durée du sommeil et le risque de cancer colorectal chez les femmes ménopausées

Sleep duration and incidence of colorectal cancer in postmenopausal women

Jiao, L. ; Duan, Z. ; Sangi-Haghpeykar, H. ; Hale, L. ; White, D. L. ; El-Serag, H. B.

Background: Sleep duration is dependent on circadian rhythm that controls a variety of key cellular functions. Circadian disruption has been implicated in colorectal tumorigenesis in experimental studies. We prospectively examined the association between sleep duration and risk of colorectal cancer (CRC). Methods: In the Women’s Health Initiative Observational Study, 75 828 postmenopausal women reported habitual sleep duration at baseline 1993–1998. We used Cox proportional hazards regression [...]

Menée en Finlande, cette étude (4 000 cas et 5 000 témoins) évalue l'association entre la mutation germinale G84E du gène HOXB13 et le risque de cancer de la prostate, du sein ou du côlon-rectum

HOXB13 G84E mutation in Finland; population-based analysis of prostate, breast and colorectal cancer risk

Laitinen, Virpi H ; Wahlfors, Tiina ; Saaristo, Leena ; Rantapero, Tommi ; Pelttari, Liisa M ; Kilpivaara, Outi ; Laasanen, Satu-Leena ; Kallioniemi, Anne ; Nevanlinna, Heli ; Aaltonen, Lauri A ; Vessella, Robert L. ; Auvinen, Anssi ; Visakorpi, Tapio ; Tammela, Teuvo L.J ; Schleutker, Johanna

Background: A recently identified germline mutation G84E in HOXB13 was shown to increase the risk of prostate cancer (PrCa). In a family-based analysis by The International Consortium for Prostate Cancer Genetics, the proportion of G84E mutation was highest in families from the Nordic countries of Finland (22.4%) and Sweden (8.2%). Methods: To further investigate the importance of G84E in the Finns, we determined its frequency in over 4000 PrCa cases and 5000 controls. In addition, the [...]

Menée auprès d'une population chinoise (2 918 cas et 2 324 témoins), cette étude montre une absence de variants de susceptibilité génétique communs au cancer du sein et au cancer de l'ovaire

No Association between Ovarian Cancer Susceptibility Variants and Breast Cancer Risk among Chinese Women

Ma, Xiangyu ; Cai, Qiuyin ; Delahanty, Ryan ; Shu, Xiao-Ou ; Zhang, Ben ; Lu, Wei ; Gao, Yu-Tang ; Zheng, Wei ; Long, Jirong ; Beeghly-Fadiel, Alicia

Background: As breast and ovarian cancers may have similar etiologies, this study aimed to evaluate the hypothesis that breast cancer shares common genetic susceptibility variants with ovarian cancer. Methods: Ten genetic variants in 9 loci were previously identified to be associated with ovarian cancer risk among Caucasian women; an additional 353 variants in high linkage disequilibrium (r2≥0.6) among Han Chinese were identified. Data were available from the Affymetrix Genome Wide Array (6.0) [...]

Menée en population taïwanaise, cette étude de cohorte évalue l'association entre une hyperplasie bénigne de la prostate et le risque de cancer de la vessie chez des patients diabétiques

Benign prostatic hyperplasia is a significant risk factor for bladder cancer in diabetic patients: a population-based cohort study using the National Health Insurance in Taiwan

Tseng, Chin-Hsiao

BACKGROUND:Diabetic patients have a higher risk of bladder cancer and benign prostatic hyperplasia (BPH). Theoretically, BPH patients may have an increased risk of bladder cancer because residual urine in the bladder surely increases the contact time between urinary excreted carcinogens and the urothelium. However, whether BPH increases bladder cancer risk in patients with type 2 diabetes has not been studied. METHODS:The reimbursement databases of all Taiwanese diabetic patients under oral [...]

Mené sur 551 fumeurs d'ascendance européenne et 548 témoins, cette étude multicentrique ne montre pas d'association entre un polymorphisme fonctionnel à simple nucléotide du gène codant pour la catéchol-O-méthyltransférase et le comportement tabagique des participants

Lack of Association of a Functional Catechol-O-Methyltransferase Gene Polymorphism With Risk of Tobacco Smoking: Results From a Multicenter Case–Control Study

Mutschler, Jochen ; Abbruzzese, Elvira ; von der Goltz, Christoph ; Dinter, Christina ; Mobascher, Arian ; Thiele, Holger ; Diaz-Lacava, Amalia ; Dahmen, Norbert ; Gallinat, Jürgen ; Majic, Tomislav ; Petrovsky, Nadine ; Thuerauf, Norbert ; Kornhuber, Johannes ; Gründer, Gerhard ; Rademacher, Lena ; Brinkmeyer, Juergen ; Wienker, Thomas ; Wagner, Michael ; Winterer, Georg ; Kiefer, Falk

Background: The catechol-O-methyltransferase (COMT) modulates dopaminergic neurotransmission in the prefrontal cortex as well as in the mesolimbic reward system. Since the reward system mediates addictive behavior, the COMT gene is a strong candidate gene regarding the pathophysiology of tobacco dependence and smoking behavior. Because of rather conflicting results in previous studies, the purpose of the present study was to test for association between a functional genetic variant in the COMT [...]

A partir des données de 7 études incluant 5 026 cas et 4 630 témoins, cette étude analyse l'association entre le tabagisme, des variants des gènes NAT1 et NAT2, et le risque de lymphome non hodgkinien

Smoking, variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma: a pooled analysis within the InterLymph consortium

Gibson, ToddM ; Smedby, KarinE ; Skibola, ChristineF ; Hein, DavidW ; Slager, SusanL ; Sanjosé, Silvia ; Vajdic, ClaireM ; Zhang, Yawei ; Chiu, BrianC H. ; Wang, SophiaS ; Hjalgrim, Henrik ; Nieters, Alexandra ; Bracci, PaigeM ; Kricker, Anne ; Zheng, Tongzhang ; Kolar, Carol ; Cerhan, JamesR ; Darabi, Hatef ; Becker, Nikolaus ; Conde, Lucia ; Holford, TheodoreR ; Weisenburger, DennisD ; Roos, AnneclaireJ ; Butterbach, Katja ; Riby, Jacques ; Cozen, Wendy ; Benavente, Yolanda ; Palmers, Casey ; Holly, ElizabethA ; Sampson, JoshuaN ; Rothman, Nathaniel ; Armstrong, BruceK ; Morton, LindsayM

Purpose: Studies of smoking and risk of non-Hodgkin lymphoma (NHL) have yielded inconsistent results, possibly due to subtype heterogeneity and/or genetic variation impacting the metabolism of tobacco-derived carcinogens, including substrates of the N-acetyltransferase enzymes NAT1 and NAT2. Methods : We conducted a pooled analysis of 5,026 NHL cases and 4,630 controls from seven case–control studies in the international lymphoma epidemiology consortium to examine associations between smoking, [...]