Menée entre 2006 et 2008 dans le Sud de la Chine, cette étude cas-témoins montre que la pratique habituelle d'activité physique réduit le risque de cancer de l'ovaire (500 cas et 500 témoins ; âge moyen : 59 ans)

Habitual physical activity reduces risk of ovarian cancer: A case–control study in southern China

Lee, Andy H. ; Su, Dada ; Pasalich, Maria ; Wong, Yut Lin ; Binns, Colin W.

Objective To ascertain the relationship between habitual physical activity and the risk of ovarian cancer among southern Chinese women. Method A case–control study was conducted in Guangzhou, Guangdong Province, during 2006–2008. Information on physical activity exposure and lifestyle characteristics was obtained from 500 incident ovarian cancer patients and 500 hospital-based controls (mean age 59 years) using a validated and reliable questionnaire. Logistic regression analyses were performed [...]

Menée auprès de 22 participants (parents au premier degré de patients ayant survécu à un cancer colorectal), cette étude évalue l'efficacité d'un programme d'interventions téléphoniques pour réduire les facteurs de risque comportementaux associés à la maladie

CanPrevent: a telephone-delivered intervention to reduce multiple behavioural risk factors for colorectal cancer

Hawkes, Anna ; Patrao, Tania ; Green, Anita ; Aitken, Joanne

BACKGROUND:This pilot study aimed to test the acceptability and short-term effectiveness of a telephone-delivered multiple health behaviour change intervention for relatives of colorectal cancer survivors.METHODS:A community-based sample of 22 first-degree relatives of colorectal cancer survivors were recruited via a media release. Data were collected at baseline and at six weeks (post-intervention). Outcome measures included health behaviours (physical activity, television viewing, diet, [...]

Menée en 2008 à partir d'un questionnaire auprès de 1 478 femmes âgées de 18 à 65 ans et d'entretiens semi-dirigés auprès de 32 participantes, cette étude transversale française évalue leurs connaissances sur le cancer du col de l'utérus et ses moyens de prévention, puis analyse l'attitude de femmes, mères d'une adolescente âgée entre14 et 18 ans, vis-à-vis de la vaccination contre le papillomavirus humain

French women's knowledge of and attitudes towards cervical cancer prevention and the acceptability of HPV vaccination among those with 14 -- 18 year old daughters: a quantitative-qualitative study

Haesebaert, Julie ; Lutringer-Magnin, Delphine ; Kalecinski, Julie ; Barone, Giovanna ; Jacquard, Anne-Carole ; Regnier, Veronique ; Leocmach, Yann ; Vanhems, Philippe ; Chauvin, Franck ; Lasset, Christine

BACKGROUND:In France, it is recommended that girls and women aged 14--23 are vaccinated against the human papillomavirus (HPV). However, French women's knowledge of and attitude towards the vaccine has been little studied.METHODS:Thirty-nine general practitioners, representative of those working in the large Rhone-Alpes region, offered a self-administered questionnaire on cervical cancer (CC) prevention to all 18--65 year-old women who came for consultation during June and July 2008. In [...]

A partir de questionnaires auprès de 81 670 participants (durée moyenne de suivi : 9,9 ans), cette étude de cohorte suédoise évalue l'association entre la consommation de lignanes d'origine alimentaire et le risque d'adénocarcinome gastrique ou œsophagien (211 cas au total)

Dietary intake of lignans and risk of esophageal and gastric adenocarcinoma: a cohort study in Sweden

Lin, Yulan ; Wolk, Alicja ; Håkansson, Niclas ; Lagergren, Jesper ; Lu, Yunxia

Background:High intake of phytoestrogen lignans has been found to be associated with decreased risk of esophageal adenocarcinoma in our previous population-based case-control study in Sweden. Methods:In a population-based cohort study in Sweden, 81,670 participants who were cancer-free at baseline were followed up during 1998-2009. All participants completed a 96-item food-frequency questionnaire (FFQ), which was used to assess dietary exposure to lignans (secoisolariciresinol, matairesinol, [...]

Menée in vitro et à l'aide d'un modèle murin de carcinome hépatocellulaire induit par le N-Nitrosodiéthylamine, cette étude évalue les effets chimiopréventifs de la lutéine, un caroténoïde, sur les cellules tumorales et identifie son mécanisme d'action

Effect of carotenoid lutein on N-nitrosodiethylamine-induced hepatocellular carcinoma and its mechanism of action

Sindhu, Edakkadath R. ; Firdous, Alikkunjhi P. ; Ramnath, Viswanathan ; Kuttan, Ramadasan

Oxycarotenoid lutein (3,3'-dihydroxy-[beta],[epsilon]-carotene) was checked for anticarcinogenic activity against N-nitrosodiethylamine-induced hepatocellular carcinoma (HCC) in rats. Lutein could significantly reduce the altered morphological and pathological changes in the liver induced by N-nitrosodiethylamine. Biochemical analysis of serum and tissues indicated that alanine transaminase, aspartate transaminase, and alkaline phosphatase were significantly elevated in the control group and [...]

Cet article passe en revue les études récentes concernant la formulation et l'administration de composés d'origine naturelle au moyen des nanotechnologies dans la chimioprévention et le traitement du cancer de la prostate

Nanoformulation of natural products for prevention and therapy of prostate cancer

Sanna, Vanna ; Siddiqui, Imtiaz A. ; Sechi, Mario ; Mukhtar, Hasan

There is a need for developing improved therapeutic options for the management of prostate cancer, able to inhibit proliferation of precancerous and malignant lesions and/or to improve the effectiveness of conventional chemopreventive and chemotherapeutic agents. In this perspective, application of nanotechnology based strategies for the delivery of natural compounds for effective management of the disease is being actively researched. Here, after highlighting the most promising natural [...]

A partir d'une revue systématique de la littérature publiée jusqu'en mai 2012 (5 études, plus de 9 000 participants), cette méta-analyse évalue l'efficacité d'interventions d’aide à l’arrêt du tabagisme délivrées par SMS

Can interventions delivered by mobile phones help people to stop smoking? Updated

Whittaker R; ; McRobbie H; ; Bullen C; ; Borland R; ; Rodgers A; ; Gu Y;

Background: Innovative and effective smoking cessation interventions are required to appeal to those who are not accessing traditional cessation services. Mobile phones are widely used and are now well-integrated into the daily lives of many, particularly young adults. Mobile phones are a potential medium for the delivery of health programmes such as smoking cessation. Objectives: To determine whether mobile phone-based interventions are effective at helping people who smoke, to quit. Search [...]

A partir des données d'une enquête nationale réalisée en 2010 auprès de 17 284 participants, cette étude américaine identifie, en fonction de l'appartenance ethnique, les facteurs socio-économiques associés aux comportements tabagiques, à la morbidité liée au cancer du poumon et à la mortalité

Socioeconomic Disparities in Tobacco-Related Health Outcomes Across Race/Ethnic Groups in the United States: National Health Interview Survey 2010

Margerison-Zilko, Claire ; Cubbin, Catherine

Introduction: Existing research documents strong inverse socioeconomic gradients in current smoking and lung cancer morbidity and mortality; these gradients appear stronger among non-Hispanic Whites and Blacks compared with Hispanics. We sought to examine a broader range of outcomes across the tobacco use continuum, examining socioeconomic gradients separately among the 3 largest racial/ethnic groups in the United States.Methods: We used data from the 2010 National Health Interview Survey (n = [...]

Menée auprès de 50 femmes obèses ou en surpoids ayant un risque accru de cancer du sein, cette étude pilote évalue l'efficacité d'un programme en ligne pour les aider à perdre du poids

Web-based self-monitoring for weight loss among overweight/obese women at increased risk for breast cancer: the HELP pilot study

Cadmus-Bertram, Lisa ; Wang, Julie B. ; Patterson, Ruth E. ; Newman, Vicky A. ; Parker, Barbara A. ; Pierce, John P.

Objective Excess weight and physical inactivity are modifiable risk factors for breast cancer. Training women to use self-help resources over the internet has potential for reducing intervention costs and enhancing maintenance. Methods A total of 50 overweight/obese women at increased breast cancer risk were randomized to a 12-week intervention or a comparison group. Telephone-based sessions trained participants to use web-based self-monitoring tools to set goals and track diet and exercise. [...]