Menée au Brésil auprès de patients atteints d'un cancer de stade avancé et traités à domicile, cette étude identifie les facteurs prédictifs de la fatigue et suggère qu'un état inflammatoire chronique joue un rôle dans la survenue d'une fatigue associée au cancer

Prevalence, predictors, and prognostic impact of fatigue among Brazilian outpatients with advanced cancers

Paiva, Carlos ; Paiva, Bianca

Purposes The purposes of this study are to evaluate the impact of cancer-related fatigue (CRF) on quality of life (QoL), and to identify its clinical predictors. In addition, the authors investigated the prognostic impact of CRF and its relationship with the inflammatory marker C-reactive protein. Method Data regarding patient characteristics, symptom scores, and QoL indices were collected at the initial evaluation. At the same time, blood samples were collected in order to evaluate some [...]

A partir d'une revue systématique de la littérature publiée entre 2004 et 2011 (23 études), cette étude analyse l'impact d'un lymphœdème sur des indicateurs psychosociaux (image de soi, apparence, sexualité, détresse émotionnelle...)

Psychosocial impact of lymphedema: a systematic review of literature from 2004 to 2011

Fu, Mei R. ; Ridner, Sheila H. ; Hu, Sophia H. ; Stewart, Bob R. ; Cormier, Janice N. ; Armer, Jane M.

Objective This systematic review aimed to evaluate the level of evidence of contemporary peer-reviewed literature published from 2004 to 2011 on the psychosocial impact of lymphedema. Methods Eleven electronic databases were searched and 1311 articles retrieved; 23 met inclusion criteria. Twelve articles utilized qualitative methodology and 11 used quantitative methodology. An established quality assessment tool was used to assess the quality of the included studies. Results The overall quality [...]

Menée auprès de patients atteints de tumeurs solides, cette étude identifie les facteurs prédictifs d'une infection sanguine associée à l'usage d'un cathéter à chambre implantable

Predictors of bloodstream infection associated with permanently implantable venous port in solid cancer patients

Chen, I. C. ; Hsu, C. ; Chen, Y. C. ; Chien, S. F. ; Kao, H. F. ; Chang, S. Y. ; Hu, F. C. ; Yeh, K. H.

Background The purpose of this study is to characterize the risk factors of bloodstream infection (BSI) associated with the use of permanent implantable venous ports (Port-A) in solid cancer patients. Methods Solid cancer patients implanted with a Port-A were prospectively observed for the occurrence of Port-A-associated BSI (PABSI), defined as BSI without other identifiable infection foci. A PABSI risk score was developed using the Cox proportional hazards model. Results A total of 415 [...]

Menée auprès de 61 patients adultes atteints d'un cancer avancé, cet essai clinique multicentrique évalue l'efficacité de la cryochirurgie percutanée guidée par imagerie pour soigner la douleur associée à des métastases osseuses

Percutaneous image-guided cryoablation of painful metastases involving bone

Callstrom, Matthew R. ; Dupuy, Damian E. ; Solomon, Stephen B. ; Beres, Robert A. ; Littrup, Peter J. ; Davis, Kirkland W. ; Paz-Fumagalli, Ricardo ; Hoffman, Cheryl ; Atwell, Thomas D. ; Charboneau, J. William ; Schmit, Grant D. ; Goetz, Matthew P. ; Rubin, Joseph ; Brown, Kathy J. ; Novotny, Paul J. ; Sloan, Jeff A.

BACKGROUND: This study sought to describe the results of a single-arm multicenter clinical trial using image-guided percutaneous cryoablation for the palliation of painful metastatic tumors involving bone. METHODS: Over a 44-month period, 61 adult patients with 1 or 2 painful bone metastases with a score of 4 or more on a scale of 0 to 10 (≥4/10) worst pain in a 24-hour period who had failed or refused conventional treatment were treated with percutaneous image-guided cryoablation. Patient pain [...]

A partir des données des registres américains des cancers (28 960 hommes de plus de 65 ans diagnostiqués avec un cancer de la prostate entre 2001 et 2007), cette étude analyse l'intérêt de mesurer et de contrôler la densité osseuse chez des survivants d'un cancer de la prostate ayant reçu une hormonothérapie anti-androgénique

Bone density testing among prostate cancer survivors treated with androgen-deprivation therapy

Morgans, Alicia K. ; Smith, Matthew R. ; O'Malley, A. James ; Keating, Nancy L.

BACKGROUND. Androgen-deprivation therapy (ADT) causes bone loss and fractures. Guidelines recommend bone density testing before and during ADT to characterize fracture risk. The authors of the current report assessed bone density testing among men who received ADT for ≥ 1 year. METHODS. Surveillance, Epidemiology, and End Results/Medicare data were used to identify 28,960 men aged > 65 years with local/regional prostate cancer diagnosed from 2001 to 2007 who were followed through 2009 and who [...]

Menée auprès de 60 patientes atteintes d'un cancer du sein, cette étude analyse l'impact d'une mastectomie sans reconstruction mammaire sur leur sexualité et leur relation maritale

Partner relationships after mastectomy in women not offered breast reconstruction

Andrzejczak, Ewa ; Markocka-Mączka, Krystyna ; Lewandowski, Andrzej

Backgroud The present study assessed the degree to which undergoing a mastectomy without reconstructive surgery negatively impacts the patient's psychological state. We focus on body image and self-esteem as well as the influence of mastectomy on patient sex lives and partnership relations. Methods The participants were 60 women, either married or in a relationship, who had had a mastectomy because of breast cancer and no subsequent reconstructive surgery. A marital happiness questionnaire was [...]

Menée auprès de 2 029 patients atteints d'une compression médullaire métastatique, cette étude américaine développe et évalue un système de scoring permettant d'identifier les patients susceptibles de bénéficier d'un traitement intensif ou de soins de support

A score to identify patients with metastatic spinal cord compression who may be candidates for best supportive care

Rades, Dirk ; Hueppe, Michael ; Schild, Steven E.

BACKGROUND: The objective of the current study was to develop a scoring system that identifies those patients with metastatic spinal cord compression who may be candidates for best supportive care or single-fraction radiotherapy. METHODS: Ten potential prognostic factors were retrospectively analyzed in 2029 patients, including age, gender, Eastern Cooperative Oncology Group performance status, tumor type, number of involved vertebrae, further bone metastases, visceral metastases, interval from [...]

Menée aux Etats-Unis et au Canada auprès de survivants d'un cancer du cerveau pendant l'enfance, cette étude (164 cas et 164 témoins) identifie les facteurs familiaux, éducatifs et socioéconomiques, ayant un impact sur leurs compétences et performances scolaires

Family factors associated with academic achievement deficits in pediatric brain tumor survivors

Ach, Emily ; Gerhardt, Cynthia A. ; Barrera, Maru ; Kupst, Mary Jo ; Meyer, Eugene A. ; Patenaude, Andrea F. ; Vannatta, Kathryn

Purpose The purpose of this study is to examine whether parental education, socioeconomic status, or family environment moderate the extent of academic achievement deficits in pediatric brain tumor survivors (PBTS) relative to classmate case-controls. PBTS are known to be at risk for cognitive and academic impairment; however, the degree of impairment varies. Prior research has focused on treatment risk, and efforts to examine the protective role of family resources and relationships have been [...]

Menée auprès de 33 patients atteints d'un cancer des voies aérodigestives supérieures et recevant une radiothérapie, cette étude analyse l'association entre l'indice de masse corporelle et le risque de mucite orale

Low body mass index as a risk factor of moderate to severe oral mucositis in oral cancer patients with radiotherapy

Saito, Nobue ; Imai, Yutaka ; Muto, Takashi ; Sairenchi, Toshimi

Purpose The association between body mass index (BMI) and oral mucositis in oral cancer patients receiving radiotherapy is unclear. This study examined whether low BMI could be a risk factor for oral mucositis in oral cancer patients receiving radiotherapy. Methods Between April 2007 and March 2011, a total of 33 inpatients with oral cancer receiving radiotherapy were recruited. They were followed from the beginning of radiotherapy to discharge from hospital. All patients had no mucositis when [...]

A partir des données d'un registre australien des cancers, cette étude analyse la survie relative à 5 ans de patients atteints d'un cancer diagnostiqué entre 1972 et 2006

Conditional survival of cancer patients: an Australian perspective

Yu, Xue Qin ; Baade, Peter ; O'Connell, Dianne

BACKGROUND:Estimated conditional survival for cancer patients diagnosed at different ages and disease stage provides important information for cancer patients and clinicians in planning follow-up, surveillance and ongoing management. METHODS:Using population-based cancer registry data for New South Wales Australia, we estimated conditional 5-year relative survival for 11 major cancers diagnosed 1972--2006 by time since diagnosis and age and stage at diagnosis. RESULTS:193,182 cases were [...]

A partir des données du registre national anglais des cancers, cette étude analyse, sur la période 1986-2004, l'évolution de l'incidence du cancer chez une population immigrante d'origine asiatique en fonction d'un indicateur socioéconomique

Cancer incidence in South Asian migrants to England, 1986–2004: Unraveling ethnic from socioeconomic differentials

Maringe, Camille ; Mangtani, Punam ; Rachet, Bernard ; Leon, David A. ; Coleman, Michel P. ; dos Santos Silva, Isabel

Studies on cancer in migrants are informative about the relative influence of environmental and genetic factors on cancer risk. This study investigates trends in incidence from colorectal, lung, breast and prostate cancer in England among South Asians and examines the influence of deprivation, a key environmental exposure. South Asian ethnicity was assigned to patients recorded in the population-based National Cancer Registry of England during 1986–2004, using the computerized algorithm SANGRA: [...]

A partir des données des registres américains des cancers portant sur la période 1992-2009 et incluant des adultes âgés de 25 à 84 ans, cette étude analyse l'évolution de l'incidence de leucémie chez l'adulte en fonction de l'année de naissance

Are Incidence rates of adult leukemia in the United States significantly associated with birth cohort?

Rosenberg, Philip S. ; Wilson, Katherine L. ; Anderson, William F.

BACKGROUND: Leukemia is a common cancer among United States adults but there are few established risk factors. If leukemia risks are substantially influenced by exposures that vary in prevalence across generations, then population incidence rates should vary significantly by birth cohort. However, prior studies have not examined leukemia birth cohort effects using contemporary data and methods. METHODS: We used incidence data from the National Cancer Institute's Surveillance, Epidemiology and [...]

A partir des données des registres américains des cancers portant sur la période 1992-2005, cette étude analyse et compare, pour les Etats-Unis et pour Porto-Rico, l'évolution de l'incidence du cancer de l'œsophage en fonction du sous-type histologique

Esophageal cancer incidence rates by histological type and overall: Puerto Rico versus the United States Surveillance, Epidemiology, and End Results population, 1992–2005

González, Lorena ; Magno, Priscilla ; Ortiz, Ana P. ; Ortiz-Ortiz, Karen ; Hess, Kenneth ; Nogueras-González, Graciela M. ; Suárez, Erick

Objective: The aim of our study was to compare the age-standardized incidence of esophageal cancer (EC) in Puerto Ricans (PRs) with that for non-Hispanic White (NHW), non-Hispanic Black (NHB), and Hispanic (USH), groups in the United States (US) as reported by the Surveillance, Epidemiology, and End Results program for the 1992–2005 period. Methods: We computed the age-standardized and age-specific incidence (per 100,000 individuals) of EC during 1992–2005 using the World Standard Population as [...]

A partir des données de statistiques hospitalières portant sur la période 2001-2007, cette étude analyse les disparités ethniques dans l'incidence du cancer de l'œsophage et du cancer de l'estomac en Angleterre

Ethnicity in relation to incidence of oesophageal and gastric cancer in England

Coupland, V. H. ; Lagergren, J. ; Konfortion, J. ; Allum, W. ; Mendall, M. A. ; Hardwick, R. H. ; Linklater, K. M. ; Moller, H. ; Jack, R. H.

Background: This study investigated the variation in incidence of all, and six subgroups of, oesophageal and gastric cancer between ethnic groups. Methods: Data on all oesophageal and gastric cancer patients diagnosed between 2001 and 2007 in England were analysed. Self-assigned ethnicity from the Hospital Episode Statistics dataset was used. Male and female age-standardised incidence rate ratios (IRRs) were calculated for each ethnic group, using White groups as the references. Results: [...]

En comparant les données de deux systèmes d’assurance maladie dédiée aux anciens combattants américains, cette étude analyse, à 3 ans, la survie globale des patients atteints d'un cancer colorectal non métastatique

Reduced Overall and Event-Free Survival Among Colon Cancer Patients Using Dual System Care

Tarlov, Elizabeth ; Lee, Todd A. ; Weichle, Thomas ; Durazo-Arvizu, Ramon ; Zhang, Qiuying ; Perrin, Ruth ; Bentrem, David J. ; Hynes, Denise M.

Background:Many veterans have dual Veterans Administration (VA) and Medicare healthcare coverage. We compared 3-year overall and cancer event-free survival (OS; EFS) among patients with non-metastatic colon cancer who obtained substantial portions of their care in both systems and those whose care was obtained predominantly in the VA or in the Medicare fee-for-service system. Methods:Many veterans have dual Veterans Administration (VA) and Medicare healthcare coverage. We compared 3-year [...]

A partir de données à l'échelle mondiale sur la période 1988-2002, cette étude analyse l'évolution de l'incidence du cancer du sein sur les cinq continents, pour les femmes et les hommes

An international comparison of male and female breast cancer incidence rates

Ly, Diana ; Forman, David ; Ferlay, Jacques ; Brinton, Louise A. ; Cook, Michael B.

Global international trends in female breast cancer incidence have been described previously but no comparable analysis of male breast cancer incidence rates has been conducted. We obtained male and female case and population data using Cancer Incidence in Five Continents (CI5). We calculated age-adjusted, sex-specific incidence rates and female-to-male incidence rate ratios (FMIRRs) and compared trends of such for the period 1988–2002. This analysis included 8,681 male breast cancer cases and [...]

Menée au Royaume-Uni à partir des données de patientes diagnostiquées avec un cancer du sein entre 2005 et 2007, cette étude en population analyse les disparités ethniques dans l'incidence du cancer du sein triplement négatif

Differences in breast cancer hormone receptor status in ethnic groups: A London population

Jack, Ruth H. ; Davies, Elizabeth A. ; Renshaw, Christine ; Tutt, Andrew ; Grocock, Melanie J. ; Coupland, Victoria H. ; Møller, Henrik

Triple negative breast cancer (TNBC) is associated with different ethnic groups in the United States (US), however this has not previously been examined in a population-based study within the United Kingdom (UK). Electronic pathology reports from the North East London Cancer Network (NELCN) on women diagnosed with breast cancer between 2005 and 2007 were collated. The statuses of oestrogen receptor, progesterone receptor and HER-2 were extracted. Women were classified as having TNBC if all [...]

Cette étude évalue un modèle permettant de prédire l'incidence du cancer du col de l'utérus dans les pays qui ne possèdent pas de registres des cancers

Using HPV prevalence to predict cervical cancer incidence

Sharma, Monisha ; Bruni, Laia ; Diaz, Mireia ; Castellsagué, Xavier ; Sanjosé, Silvia de ; Bosch, F. Xavier ; Kim, Jane J.

Knowledge of a country's cervical cancer (CC) burden is critical to informing decisions about resource allocation to combat the disease; however, many countries lack cancer registries to provide such data. We developed a prognostic model to estimate CC incidence rates in countries without cancer registries, leveraging information on human papilloma virus (HPV) prevalence, screening, and other country-level factors. We used multivariate linear regression models to identify predictors of CC [...]

A partir d'une revue de la littérature, cette méta-analyse (83 études, plus de 100 000 femmes) évalue la prévalence et la durée d'une infection génitale par le papillomavirus humain

Patterns of persistent genital human papillomavirus infection among women worldwide: A literature review and meta-analysis

Rositch, Anne F. ; Koshiol, Jill ; Hudgens, Michael G. ; Razzaghi, Hilda ; Backes, Danielle M. ; Pimenta, Jeanne M. ; Franco, Eduardo L. ; Poole, Charles ; Smith, Jennifer S.

Persistent high-risk human papillomavirus (HR-HPV) infection is the strongest risk factor for high-grade cervical precancer. We performed a systematic review and meta-analysis of HPV persistence patterns worldwide. Medline and ISI Web of Science were searched through January 1, 2010 for articles estimating HPV persistence or duration of detection. Descriptive and meta-regression techniques were used to summarize variability and the influence of study definitions and characteristics on duration [...]

Menée sur la période 2000-2009, cette étude (506 cas et 3 036 témoins) analyse, du point de la mortalité, l'efficacité du programme national finlandais de dépistage du cancer du col de l'utérus

Mortality audit of the Finnish cervical cancer screening program

Lönnberg, Stefan ; Nieminen, Pekka ; Luostarinen, Tapio ; Anttila, Ahti

Incidence-based evaluations of cervical cancer screening programs have suggested age-specific impacts and there is uncertainty regarding the effectiveness of screening outside the ages of 30–60 years. We audited the screening histories of cervical cancer deaths and conducted a case-control evaluation of the effectiveness of organized screening in different ages with mortality as outcome. We included all 506 cervical cancer deaths in Finland in 2000–2009 due to cancers diagnosed in 1990 or [...]

Menée auprès de 250 survivants d'un cancer âgés de 18 à 55 ans, cette étude américaine analyse les facteurs prédictifs des aspects émotionnels et cognitifs de la peur d'une récidive de la maladie

Cognitive and emotional aspects of fear of recurrence: predictors and relations with adjustment in young to middle-aged cancer survivors

Park, Crystal L. ; Cho, Dalnim ; Blank, Thomas O. ; Wortmann, Jennifer H.

Objective We investigated predictors of emotional (worry) and cognitive (perceived risk) dimensions of fear of recurrence (FOR) and their relationships with psychological well-being in a sample of young and middle-aged adult cancer survivors. Methods Eligible participants were survivors between 18 and 55 years old and diagnosed from 1 to 3 years prior. A total of 250 participants were recruited, and 167 responded to a 1-year follow-up. Demographic and psychosocial variables were assessed at [...]

Menée auprès de 14 médecins généralistes norvégiens, cette étude qualitative analyse leur vécu et leur relation avec leurs patients atteints de cancer

‘I deal with the small things’: The doctor–patient relationship and professional identity in GPs’ stories of cancer care

Johansen, May-Lill ; Holtedahl, Knut Arne ; Davidsen, Annette Sofie ; Rudebeck, Carl Edvard

An important part of GPs’ work consists of attending to the everyday and existential conditions of human being. In these life world aspects, biomedicine is often not the relevant theory to guide the GP; nevertheless they are a part of GPs’ professional domain. In cancer care, previous studies have shown that GPs with a biomedical perspective on medicine could feel subordinate to specialists, and that doctors with a curative focus could see disease progression as a personal failure. The aim of [...]

A partir de données de prescription issues de 173 cabinets de médecine générale en Ecosse, cette étude (7 298 cas et 14 596 témoins) analyse, un an après un diagnostic de cancer, l'incidence des symptômes d'anxiété, de dépression et d'alcoolisme

Incidence and drug treatment of emotional distress after cancer diagnosis: a matched primary care case-control study

Desplenter, F. ; Bond, C. ; Watson, M. ; Burton, C. ; Murchie, P. ; Lee, A. J. ; Lefevre, K. ; Simoens, S. ; Laekeman, G.

Background: Emotional distress is common in cancer patients. This study aimed to describe, in the year after a cancer diagnosis: the incidence of anxiety, depression and excessive alcohol use; the pattern of these diagnoses and treatment over time; and the nature and duration of the prescribed treatment. Methods: A matched case–control study was conducted using routinely collected primary care data from 173 Scottish general practices. A presumptive diagnosis of emotional distress (anxiety, [...]

A partir d'une revue systématique de la littérature (23 études, 2 645 participants), cette méta-analyse évalue l'efficacité de psychothérapies destinées aux couples dont l'un des partenaires est atteint de cancer

A systematic review and meta-analysis of psychosocial interventions for couples coping with cancer

Badr, Hoda ; Krebs, Paul

Objective Quality of life (QOL) is a multidimensional construct that includes physical, psychological, and relationship well-being. Methods We conducted a systematic review and meta-analysis of randomized controlled studies published between 1980 and 2012 of interventions conducted with both cancer patients and their partners that were aimed at improving QOL. Using bibliographic software and manual review, two independent raters reviewed 752 articles with a systematic process for reconciling [...]

Menée aux Etats-Unis, cette étude analyse l'efficacité d'un protocole d'identification de symptômes d'angoisse et de détresse spirituelle et religieuse (sentiments d'abondon ou de punition par Dieu) chez 178 patients ayant reçu une greffe de sang ou de moelle osseuse

Screening for religious/spiritual struggle in blood and marrow transplant patients

King, Stephen ; Fitchett, George ; Berry, Donna

Purpose A growing body of research documents the harmful effects of religious/spiritual (R/S) struggle (e.g., feeling abandoned or punished by God) among patients with a wide variety of diagnoses. Documented effects include poorer quality of life, greater emotional distress, poorer recovery, and increased disability. This study reports the use of a screening protocol that identified patients who may have been experiencing R/S struggle. We also examined the prevalence and correlates of possible [...]

Menée aux Etats-Unis auprès de 653 participantes, cette étude analyse les facteurs associés à la survenue d'une dépression après un diagnostic de cancer du sein en fonction de l'âge des patientes

Explaining age-related differences in depression following breast cancer diagnosis and treatment

Avis, Nancy ; Levine, Beverly ; Naughton, Michelle ; Case, Douglas ; Naftalis, Elizabeth ; Van Zee, Kimberly

Younger women with breast cancer consistently show greater psychological distress than older women. This study examined a range of factors that might explain these age differences. A total of 653 women within 8 months of a first-time breast cancer diagnosis provided data on patient characteristics, symptoms, and psychosocial variables. Chart reviews provided cancer and treatment-related data. The primary outcome was depressive symptomatology assessed by the Beck Depression Inventory. A [...]