A partir des données de deux grandes cohortes américaines, cette méta-analyse évalue l'association entre le tabagisme et le risque de cancer de la peau

Smoking and risk of skin cancer: a prospective analysis and a meta-analysis

Song, Fengju ; Qureshi, Abrar A ; Gao, Xiang ; Li, Tricia ; Han, Jiali

Background The association between smoking and the risk of skin cancer has not been well established.Methods In two large cohorts in the USA, we prospectively examined the risks of melanoma, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) among participants grouped according to smoking variables.Results Among men, compared with never smokers, ever smokers had a significantly lower risk of melanoma [relative risk (RR) = 0.72; 95% confidence interval (CI): 0.58–0.86]; those who [...]

Menée dans l'Etat de Nouvelle-Angleterre, cette étude (1 046 cas et 1 239 témoins) évalue l'association entre l'utilisation de produits tabagiques sans fumée et le risque de cancer de la tête et du cou

Smokeless tobacco and risk of head and neck cancer: Evidence from a case–control study in New England

Zhou, Jiachen ; Michaud, Dominique S. ; Langevin, Scott M. ; McClean, Michael D. ; Eliot, Melissa ; Kelsey, Karl T.

Current studies suggesting that smokeless tobacco use increases the risk of head and neck cancer are hampered by small numbers. Consequently, there remains uncertainty in the magnitude and significance of this risk. We examined the relationship between smokeless tobacco use and head and neck squamous cell carcinoma (HNSCC) in a population-based case–control study with 1,046 cases and 1,239 frequency-matched controls. Logistic regression models were used to estimate odds ratios (OR) and 95% [...]

A partir des données de la cohorte "Nurses’ Health Study II" incluant 81 807 femmes suivies de 1989 à 2007, cette étude de cohorte prospective évalue l'association entre une mononucléose infectieuse et le risque de cancer du sein

Infectious mononucleosis and risk of breast cancer in a prospective study of women

Massa, J. ; Hamdan, A. ; Simon, K. ; Bertrand, K. ; Wulf, G. ; Tamimi, R. ; Ascherio, A.

Purpose The association between infectious mononucleosis (IM) and risk of breast cancer is unclear; no prospective studies have examined this relationship. We examined self-reported history and age at IM in relation to risk of invasive breast cancer. Methods Self-reported history and age at IM were examined in relation to risk of invasive breast cancer in a large cohort of women, the Nurses’ Health Study II (81,807 women followed from 1989 to 2007). Through questionnaires, women were asked [...]

Menée en Italie à partir des données de 3 études incluant 574 cas de cancer, cette étude analyse la prévalence du papillomavirus humain par sous-type histologique dans les cas de cancers invasifs du col de l'utérus diagnostiqués entre 1996 et 2007

HPV type distribution in invasive cervical cancers in Italy: pooled analysis of three large studies

Rossi, Paolo ; Sideri, Mario ; Carozzi, Francesca ; Vocaturo, Amina ; Buonaguro, Franco ; Tornesello, Maria ; Burroni, Elena ; Mariani, Luciano ; Boveri, Sara ; Zaffina, Leandra ; Chini, Francesco ; , the HPV Prevalence Italian Working Group

OBJECTIVE:The aim of this study is to describe the prevalence of HPV types in invasive cervical cancers in Italy from 1996 to 2008. METHODS:A pooled analysis of the three largest case series typed to date was performed. HPV typing was performed on paraffin-embedded slices. Molecular analyses were performed in four laboratories. Multivariate analyses were performed to test the associations between calendar time, age, and geographical area and the proportion of types 16/18. RESULTS:Out of 574 [...]

Menée en Italie sur la période 1997-2009, cette étude de cohorte incluant 7 217 participants analyse le risque de cancer après une greffe de rein

Risk of de novo cancers after transplantation: Results from a cohort of 7217 kidney transplant recipients, Italy 1997–2009

Piselli, Pierluca ; Serraino, Diego ; Segoloni, Giuseppe Paolo ; Sandrini, Silvio ; Piredda, Gian Benedetto ; Scolari, Maria Piera ; Rigotti, Paolo ; Busnach, Ghil ; Messa, Piergiorgio ; Donati, Donato ; Schena, Francesco Paolo ; Maresca, Maria Cristina ; Tisone, Giuseppe ; Veroux, Massimiliano ; Sparacino, Vito ; Pisani, Francesco ; Citterio, Franco

To assess incidence and risk factors for de novo cancers (DNCs) after kidney transplant (KT), we carried out a cohort investigation in 15 Italian KT centres. Seven thousand two-hundred seventeen KT recipients (64.2% men), transplanted between 1997 and 2007 and followed-up until 2009, represented the study group. Person years (PY) were computed from 30days after transplant to cancer diagnosis, death, return to dialysis or to study closure. The number of observed DNCs was compared to that [...]

Menée en Chine (1 438 cas et 860 témoins), cette étude en population évalue la relation entre 35 polymorphismes à simple nucléotide de 5 gènes associés au processus inflammatoire et le risque de cancer des voies biliaires ou de calculs biliaires

Inflammatory gene variants and the risk of biliary tract cancers and stones: a population-based study in China

Castro, Felipe ; Koshiol, Jill ; Hsing, Ann ; Gao, Yu-Tang ; Rashid, Asif ; Chu, Lisa ; Shen, Ming-Chang ; Wang, Bing-Shen ; Han, Tian-Qua ; Zhang, Bai-He ; Niwa, Shelley ; Yu, Kai ; Zhang, Hong ; Chanock, Stephen ; Andreotti, Gabriella

BACKGROUND:Genetic variants in inflammation-related genes have been associated with biliary stones and biliary tract cancers in previous studies.METHODS:To follow-up on these findings, we examined 35 single nucleotide polymorphism (SNPs) in 5 genes related to inflammation (IL8, NFKBIL, RNASEL, TNF, and VEGFA) in 456 participants with incident biliary tract cancer cases (262 gallbladder, 141 extrahepatic bile duct, 53 ampulla of Vater), 982 participants with biliary stones, and 860 healthy [...]

Menée sur 40 patients atteints d'un chordome et 358 témoins apparentés, cette étude met en évidence une association entre un polymorphisme à simple nucléotide du gène du facteur de transcription T et le risque de chordome

A common single-nucleotide variant in T is strongly associated with chordoma

Pillay, Nischalan ; Plagnol, Vincent ; Tarpey, Patrick S. ; Lobo, Samira B. ; Presneau, Nadege ; Szuhai, Karoly ; Halai, Dina ; Berisha, Fitim ; Cannon, Stephen R. ; Mead, Simon ; Kasperaviciute, Dalia ; Palmen, Jutta ; Talmud, Philippa J. ; Kindblom, Lars-Gunnar ; Amary, M. Fernanda ; Tirabosco, Roberto ; Flanagan, Adrienne M.

Chordoma is a rare malignant bone tumor that expresses the transcription factor T. We conducted an association study of 40 individuals with chordoma and 358 ancestry-matched controls, with replication in an independent cohort. Whole-exome and Sanger sequencing of T exons showed strong association of the common nonsynonymous SNP rs2305089 with chordoma risk (allelic odds ratio (OR) = 6.1, 95% confidence interval (CI) = 3.1–12.1; P = 4.4 × 10−9), a finding that is exceptional in cancers with a [...]

Menée sur 2 443 familles affectées par le cancer de la prostate, cette étude identifie la présence de la mutation G84E du gène HOXB dans 4,6% des familles

HOXB13 is a susceptibility gene for prostate cancer: results from the International Consortium for Prostate Cancer Genetics (ICPCG)

Xu, Jianfeng ; Lange, Ethan ; Lu, Lingyi ; Zheng, Siqun ; Wang, Zhong ; Thibodeau, Stephen ; Cannon-Albright, Lisa ; Teerlink, Craig ; Camp, Nicola ; Johnson, Anna ; Zuhlke, Kimberly ; Stanford, Janet ; Ostrander, Elaine ; Wiley, Kathleen ; Isaacs, Sarah ; Walsh, Patrick ; Maier, Christiane ; Luedeke, Manuel ; Vogel, Walther ; Schleutker, Johanna ; Wahlfors, Tiina ; Tammela, Teuvo ; Schaid, Daniel ; McDonnell, Shannon ; DeRycke, Melissa ; Cancel-Tassin, Geraldine ; Cussenot, Olivier ; Wiklund, Fredrik ; Gronberg, Henrik ; Eeles, Ros ; Easton, Doug ; Kote-Jarai, Zsofia ; Whittemore, Alice ; Hsieh, Chih-Lin ; Giles, Graham ; Hopper, John ; Severi, Gianluca ; Catalona, William ; Mandal, Diptasri ; Ledet, Elisa ; Foulkes, William ; Hamel, Nancy ; Mahle, Lovise ; Moller, Pal ; Powell, Isaac ; Bailey-Wilson, Joan ; Carpten, John ; Seminara, Daniela ; Cooney, Kathleen ; Isaacs, William ; International Consortium for Prostate Cancer Genetics

Prostate cancer has a strong familial component but uncovering the molecular basis for inherited susceptibility for this disease has been challenging. Recently, a rare, recurrent mutation (G84E) in HOXB13 was reported to be associated with prostate cancer risk. Confirmation and characterization of this finding is necessary to potentially translate this information to the clinic. To examine this finding in a large international sample of prostate cancer families, we genotyped this mutation and [...]

A patir des données de la cohorte "Malmö Diet and Cancer Study" incluant 4 632 participants, cette étude analyse l'association entre le niveau plasmatique de la neurotensine, le risque de diabète, de maladies cardiovasculaires, de cancer du sein et la mortalité

Plasma proneurotensin and incidence of diabetes, cardiovascular disease, breast cancer, and mortality

Melander O, Maisel A. S. Almgren P. ; et al.,

Context  Neurotensin regulates both satiety and breast cancer growth in the experimental setting, but little is known about its role in the development of breast cancer or cardiometabolic disease in humans.Objective  To test if fasting plasma concentration of a stable 117-amino acid fragment from the neurotensin precursor hormone proneurotensin is associated with development of diabetes mellitus, cardiovascular disease, breast cancer, and mortality.Design, Setting, and Participants  [...]

Cette étude (341 cas et 444 témoins) évalue la relation entre des polymorphismes à simple nucléotide de 23 gènes associés à l'obésité et le risque de cancer papillaire de la thyroïde

Common obesity-related genetic variants and papillary thyroid cancer risk

Kitahara, Cari M. ; Neta, Gila ; Pfeiffer, Ruth M. ; Kwon, Deukwoo ; Xu, Li ; Freedman, Neal D. ; Hutchinson, Amy ; Chanock, Stephen J. ; Sturgis, Erich M. ; Sigurdson, Alice J. ; Brenner, Alina V.

Background: Epidemiologic studies have shown consistent associations between obesity and increased thyroid cancer risk, but, to date, no studies have investigated the relationship between thyroid cancer risk and obesity-related single nucleotide polymorphisms (SNPs). Methods: We evaluated 575 tag SNPs in 23 obesity-related gene regions in a case-control study of 341 incident papillary thyroid cancer (PTC) cases and 444 controls of European ancestry. Logistic regression models, adjusted for [...]

A partir d'une revue systématique de la littérature, cette méta-analyse évalue l'association entre un polymorphisme du gène MTHFR et le risque de cancer du col de l'utérus

The association between MTHFR 677C>T polymorphism and cervical cancer: evidence from a meta-analysis

Mei, Qiang ; Zhou, Daijun ; Gao, Jinyu ; Shen, Shu ; Wu, Jinlin ; Guo, Linna ; Liang, Zhiqing

BACKGROUND:MTHFR 677C>T polymorphism is a genetic alteration in an enzyme involved in folate metabolism, but its effect on host susceptibility to cervical cancer is still uncertain. The aim of this study was to investigate the association between MTHFR 677C>T polymorphism and cervical cancer by performing a meta-analysis. METHODS:Pubmed, Embase, Web of Science, and the Chinese Biomedical Database (CBM) databases were searched for case--control studies investigating the association between MTHFR [...]