Mené aux Etats-Unis, cet essai randomisé analyse et compare l'efficacité de quatre traitements pour prévenir les nausées des patients atteints de cancer et recevant une chimiothérapie

Prevention of Delayed Nausea: A University of Rochester Cancer Center Community Clinical Oncology Program Study of Patients Receiving Chemotherapy

Roscoe, Joseph A. ; Heckler, Charles E. ; Morrow, Gary R. ; Mohile, Supriya G. ; Dakhil, Shaker R. ; Wade, James L. ; Kuebler, J. Philip

Purpose We conducted a double-blind randomized clinical trial of the following four regimens for controlling delayed nausea (DN): group 1: palonosetron + dexamethasone on day 1 with prochlorperazine on days 2 and 3; group 2: granisetron + dexamethasone on day 1 with prochlorperazine on days 2 and 3; group 3: aprepitant + palonosetron + dexamethasone on day 1 with aprepitant + dexamethasone on days 2 and 3; and group 4: palonosetron + dexamethasone on day 1 with prochlorperazine + dexamethasone [...]

Cette étude de cohorte menée auprès de 160 participants (âge médian : 67 ans, 40 cas de cancer du poumon, 40 cas de cancer du sein, 40 cas de cancer du colon, 40 cas de cancer de la prostate) évalue l'utilisation des traitements de la fatigue chez des patients atteints d'un cancer de stade IV

Appropriateness of the treatment of fatigued patients with stage IV cancer

Cheville, Andrea ; Shen, Tiffany ; Chang, Megan ; Basford, Jeffrey

Background Fatigue among patients with cancer is prevalent, disabling, and treatable. While fatigue management guidelines have been in place for a decade, their use remains unclear. Methods We surveyed 160 patients with stage IV lung (40), breast (40), colon (40), and prostate (40) cancer who reported moderate to severe fatigue (i.e., > 5 of 10 on an 11-point numerical rating scale). Participants were queried about receipt of treatments in fatigue management domains emphasized in the [...]

Menée aux Etats-Unis, cette étude transversale incluant 114 participantes analyse la prévalence des symptômes d'épuisement et de fatigue des patientes atteintes d'un cancer du sein et traitées par chimiothérapie en ambulatoire

Definition, prevalence and characteristics of sudden exhaustion: a possible syndrome of fatigue in cancer?

Wu, Horng-Shiuann ; Davis, Jean

Purpose Although sudden fatigue/exhaustion is a symptom expression that oncology clinicians frequently hear from their patients, empirical information about this phenomenon is limited. This study investigated the occurrence and characteristics of sudden fatigue in patients treated for breast cancer. Methods This cross-sectional descriptive study enrolled 114 breast cancer chemotherapy outpatients from a cancer clinic and an urban teaching hospital in the Midwestern United States. Subjects were [...]

Menée en Californie, cette étude de cohorte prospective incluant 2 013 participantes évalue l'emploi et la qualité de vie de patientes ayant été récemment diagnostiquées avec un cancer du sein

Employment status and quality of life in recently diagnosed breast cancer survivors

Timperi, Allegra W. ; Ergas, Isaac Joshua ; Rehkopf, David H. ; Roh, Janise M. ; Kwan, Marilyn L. ; Kushi, Lawrence H.

Background Breast cancer survivors are less likely to be employed than similar healthy women, yet effects of employment on the well being of survivors are largely unknown. In a prospective cohort study of 2013 women diagnosed from 2006 to 2011 with invasive breast cancer in Kaiser Permanente Northern California, we describe associations between hours worked per week and change in employment with quality of life (QOL) from diagnosis through active treatment. Methods Participants completed [...]

Menée au Danemark, cette étude de cohorte incluant 11 580 participants analyse et compare, par rapport à la population générale, l'incidence de cancer dans une population baptiste et adventiste, ne consommant ni tabac, ni alcool, ni viande de porc, sur la période 1943 à 2008

Cancer incidence among Danish Seventh-day Adventists and Baptists

Thygesen, Lau Caspar ; Hvidt, Niels Christian ; Hansen, Helle Ploug ; Hoff, Andreas ; Ross, Lone ; Johansen, Christoffer

Introduction American Seventh-day Adventists have been reported to have lower cancer mortality and incidence than the general population. Adventists do not consume tobacco, alcohol or pork, and many adhere to a lacto-ovo-vegetarian lifestyle. Baptists discourage excessive use of alcohol and tobacco. In this study, we investigated whether the incidence of cancer in a large cohort of Danish Adventists and Baptists was different compared to the general Danish population. Material and methods We [...]

Menée par questionnaire en population danoise (13 777 participants), cette étude transversale évalue l'association entre des facteurs démographiques, socioéconomiques et la déclaration de symptômes conduisant à un diagnostic de cancer

Associations between reporting of cancer alarm symptoms and socioeconomic and demographic determinants: a population-based, cross-sectional study

Svendsen, Rikke ; Paulsen, Maja ; Larsen, Pia ; Hansen, Bjarne ; Stovring, Henrik ; Jarbol, Dorte ; Sondergaard, Jens

BACKGROUND:Reporting of symptoms which may signal cancer is the first step in the diagnostic pathway of cancer diseases. Cancer alarm symptoms are common in the general population. Public awareness and knowledge of cancer symptoms are sparse, however, and many people do not seek medical help when having possible cancer symptoms. As social inequality is associated with cancer knowledge, cancer awareness, and information-seeking, our hypothesis is that social inequality may also exist in the [...]

Menée aux Pays-Bas, cette étude de cohorte incluant 1 800 filles âgées de 14 à 16 ans analyse, avant vaccination, la prévalence des infections génitales par le papillomavirus humain, en fonction de son sous-type histologique

Prevalence of genital HPV infections and HPV serology in adolescent girls, prior to vaccination

Mollers, M. ; Scherpenisse, M. ; van der Klis, F. R. M. ; King, A. J. ; van Rossum, T. G. J. ; van Logchem, E. M. ; Feltkamp, M. C. ; Meijer, C. J. L. M. ; Snijders, P. J. F. ; Boot, H. J. ; de Melker, H. E.

Introduction: Monitoring the prevalence of type-specific HPV-DNA infections before and shortly after introduction of routine HPV vaccination offers the opportunity to evaluate early effects of the vaccination program. With this aim a cohort study was set up of 14- to 16-year-old girls eligible for HPV vaccination in the Netherlands. Annually, HPV-DNA and antibody status in vaginal self-samples and in serum respectively, will be studied among vaccinated (58%) and unvaccinated girls (42%). Here [...]

Mené sur 243 patients pédiatriques atteints d'une leucémie lymphoblastique aiguë, cet essai américain évalue leur état cognitif après une chimiothérapie sans irradiation crânienne prophylactique

Cognitive Outcomes Following Contemporary Treatment Without Cranial Irradiation for Childhood Acute Lymphoblastic Leukemia

Conklin, H. M. ; Krull, K. R. ; Reddick, W. E. ; Pei, D. ; Cheng, C. ; Pui, C. H.

Background Treatment of acute lymphoblastic leukemia (ALL) has included the use of prophylactic cranial irradiation in up to 20% of children with high-risk disease despite known cognitive risks of this treatment modality. Methods Patients enrolled on the St Jude ALL Total Therapy Study XV, which omitted prophylactic cranial irradiation in all patients, were assessed 120 weeks after completion of consolidation therapy (n = 243) using a comprehensive cognitive battery. χ2 analysis was used to [...]

A partir des données de 66 registres des cancers de 24 pays européens, cette étude analyse l'évolution de la survie des patients atteints d'un cancer de l'œsophage sur la période 1995 à 2003

Oesophageal cancer survival in Europe: A EUROCARE-4 study

Gavin, A. T. ; Francisci, S. ; Foschi, R. ; Donnelly, D. W. ; Lemmens, V. ; Brenner, H. ; Anderson, L. A.

Oesophageal cancer survival is poor with variation across Europe. No pan-European studies of survival differences by oesophageal cancer subtype exist. This study investigates rates and trends in oesophageal cancer survival across Europe. Data for primary malignant oesophageal cancer diagnosed in 1995–1999 and followed up to the end of 2003 was obtained from 66 cancer registries in 24 European countries. Relative survival was calculated using the Hakulinen approach. Staging data were available [...]

Menée au Danemark, cette étude de cohorte prospective analyse les caractéristiques des patients atteints d'un cancer du pancréas, leurs choix thérapeutiques et leur survie

Characteristics, therapy and outcome in an unselected and prospectively registered cohort of pancreatic cancer patients

Bjerregaard, J. K. ; Mortensen, M. B. ; Schønnemann, K. R. ; Pfeiffer, P.

Pancreatic cancer (PC) is associated with a dismal prognosis. Few studies have examined characteristics and outcome in an unselected population-based cohort of PC patients. Therefore, we investigated patient baseline characteristics, therapy choices and survival in a complete cohort of patients with PC. All cases diagnosed with PC between 2007 and 2009 in the Region of Southern Denmark (pop: 1,200,000) were prospectively registered. Patient characteristics including performance status, [...]

A partir des données de la cohorte "NHANES III", cette étude prospective évalue l'association entre le niveau sérique de calcium et le risque de décès par cancer de la prostate

A Prospective Study of Total and Ionized Serum Calcium and Time to Fatal Prostate Cancer

Schwartz, Gary G. ; Skinner, Halcyon G.

Background:Higher levels of total serum calcium and of ionized serum calcium have been shown to predict fatal prostate cancer in prospective studies. Because the length of follow-up in these studies was relatively short, these associations could reflect the effect of clinically significant but occult prostate tumors on serum calcium levels. If this were true, prostate cancer mortality rates among men with higher levels of serum calcium should be higher during the early follow-up period and [...]

A partir de données médicales portant sur 5 955 patients atteints d'un adénocarcinome localisé de la prostate traité par prostatectomie radicale ou radiothérapie (durée médiane de suivi : 70 mois), cette étude évalue l'association entre l'utilisation d'aspirine et le risque de décès lié à la maladie

Aspirin Use and the Risk of Prostate Cancer Mortality in Men Treated With Prostatectomy or Radiotherapy

Choe, Kevin S. ; Cowan, Janet E. ; Chan, June M. ; Carroll, Peter R. ; D'Amico, Anthony V. ; Liauw, Stanley L.

Purpose Experimental evidence suggests that anticoagulants (ACs) may inhibit cancer growth and metastasis, but clinical data have been limited. We investigated whether use of ACs was associated with the risk of death from prostate cancer.Patients and Methods This study comprised 5,955 men in the Cancer of the Prostate Strategic Urologic Research Endeavor database with localized adenocarcinoma of the prostate treated with radical prostatectomy (RP) or radiotherapy (RT). Of them, 2,175 (37%) were [...]

A partir des données du registre californien des cancers, cette étude évalue l'association entre le groupe ethnique et le statut socioéconomique des patients, le risque de cancer colorectal invasif ainsi que la mortalité

Examining the association between socioeconomic status and invasive colorectal cancer incidence and mortality in California

Steinbrecher, Astrid ; Fish, Kari ; Clarke, Christina A. ; West, Dee W. ; Gomez, Scarlett L. ; Cheng, Iona

Background: Colorectal cancer (CRC) incidence and mortality rates vary across race/ethnicity. Socioeconomic status (SES) also influences CRC rates; however, these associations might be inconsistent across racial/ethnic groups and tumor sub-site. We examined associations between area-level SES and CRC incidence and mortality in a population-based registry study of non-Hispanic Whites, African-Americans, Hispanics, and Asians/Pacific Islanders from California. Methods: Data on 52,608 incident CRC [...]

A partir des données d'un registre suisse des cancers, cette étude analyse, sur la période 1974 à 2008, l'évolution de l'incidence d'un second cancer colorectal primitif

High constant incidence of second primary colorectal cancer

Levi, Fabio ; Randimbison, Lalao ; Blanc-Moya, Rafael ; Maspoli-Conconi, Manuela ; Rosato, Valentina ; Bosetti, Cristina ; La Vecchia, Carlo

Patients who had a colorectal cancer have a 1.5 to 2-fold excess risk of a second colorectal cancer as compared to the general population, the excess being higher at younger age at diagnosis. To further investigate the risk and the age-relation of the incidence of second primary colorectal cancer, we considered 9,389 first colon and rectal cancers registered in the Vaud Cancer Registry, Switzerland, between 1974 and 2008, and followed-up to the end of 2008 for a total of 44,113 person-years. [...]

A partir d'une revue systématique de la littérature (17 études), cette méta-analyse évalue l'état des fonctions cognitives de survivantes d'un cancer du sein plus de 6 mois après leur chimiothérapie

Meta-Analysis of Cognitive Functioning in Breast Cancer Survivors Previously Treated With Standard-Dose Chemotherapy

Jim, Heather S.L. ; Phillips, Kristin M. ; Chait, Sari ; Faul, Leigh Anne ; Popa, Mihaela A. ; Lee, Yun-Hsiang ; Hussin, Mallory G. ; Jacobsen, Paul B. ; Small, Brent J.

Purpose Evidence is mixed regarding long-term cognitive deficits in patients treated with chemotherapy. Previous meta-analyses have not focused specifically on the postchemotherapy period and have not incorporated several recent studies. The goal of the current study was to conduct a meta-analysis of cognitive functioning in breast cancer survivors who were treated with chemotherapy ≥ 6 months previously.Methods A search of PubMed, PsycInfo, Cumulative Index to Nursing and Allied Health [...]

A partir des données de trois études, cette analyse menée en Inde évalue la prévalence des néoplasies cervicales intraépithéliales et des infections par le papillomavirus humain dans une population non dépistée

Prevalence of high risk human papillomavirus and cervical intraepithelial neoplasias in a previously unscreened population – a pooled analysis from three studies

Basu, Partha ; Mittal, Srabani ; Bhaumik, Suchismita ; Mandal, Shyam Sunder ; Samaddar, Anusree ; Ray, Chinmayi ; Siddiqi, Maqsood ; Biswas, Jaydip ; Sankaranarayanan, Rengaswamy

Population prevalence of Human Papillomavirus (HPV) and Cervical Intraepithelial Neoplasias (CIN) is an important indicator to judge the disease burden in the community, to monitor the performance of cervical cancer screening program and to assess the impact of HPV vaccination program. India being a country without any cervical cancer screening program has no published data on the population prevalence of CIN and only a few large community based studies to report the high risk HPV prevalence. [...]

Cette étude qualitative américaine analyse les méthodes et préférences masculines pour faire face à la maladie parmi un groupe de soutien dédié au cancer

Male coping processes as demonstrated in the context of a cancer-related social support group

Trapp, Stephen ; Woods, Jacqueline ; Grove, Alicia ; Stern, Marilyn

Purpose The coping styles of five adult men within the context of a cancer-related social support group and their preferences regarding group support were examined. Methods Considering the paucity of literature on male coping processes within a cancer-related social support group, qualitative methods were employed. Specifically, template analysis was used to analyze the range and quality of coping styles. Results In contrast to the commonly cited solitary and emotionally restricted coping [...]

Menée auprès de 48 jeunes enfants âgés de 8 à 48 mois et atteints de cancer, cette étude analyse leurs symptômes de stress post-traumatique

Posttraumatic stress in infants and preschoolers with cancer

Graf, Anna ; Bergstraesser, Eva ; Landolt, Markus A.

Objective This study is the first to assess posttraumatic stress disorder (PTSD) in young children with cancer and to examine individual, medical, and parent-related determinants. Methods Forty-eight patients with cancer, ages 8–48 months, were assessed in an average of 15 months after their diagnosis, using mothers as informants to complete the Posttraumatic Stress Disorder Semi-Structured Interview and Observational Record for Infants and Young Children. Additionally, mothers and the [...]

Menée au Royaume-Uni par entretiens auprès de 10 participants, cette étude qualitative analyse, trois mois après le diagnostic, l'expérience psychosociale des patients atteints d'un mésothéliome pleural malin

‘It's all bad news’: the first 3 months following a diagnosis of malignant pleural mesothelioma

Arber, Anne ; Spencer, Lesley

Objective This study explores patient's experience during the first 3 months following a diagnosis of malignant pleural mesothelioma. Methods This study uses a grounded theory approach with semi-structured, face-to-face interviews with 10 patients during the first 3 months following diagnosis. Results The key concept that emerged from the data was this: Uncertainty and lack of control leading to emotional, physical and psychosocial distress. Three themes informed the key concept: ‘ it's all bad [...]

Menée par questionnaire auprès de 84 adolescents de 12 à 18 ans et de 79 adultes de 19 à 30 ans, cette étude analyse l'efficacité et l'acceptabilité d'un dépistage des risques psychosociaux chez des survivants de tumeurs cérébrales pédiatriques

The feasibility of psychosocial screening for adolescent and young adult brain tumor survivors: the value of self-report

Liptak, Cori ; Manley, Peter ; Recklitis, Christopher

Purpose Psychosocial screening is increasingly applied to childhood cancer survivors generally, but less so with pediatric brain tumor survivors despite their psychosocial risks. This study examined the utility and acceptability of psychological screening in pediatric brain tumor survivors. Methods Eighty-four adolescents (age 12–18) completed the Beck Youth Inventory-II and 79 young adults (age 19–30) completed the Brief Symptom Inventory-18. Their scores were compared to clinician ratings on [...]

A partir de données européennes et australiennes, cette étude analyse les coûts d'une neutropénie fébrile induite par la chimiothérapie chez des patients atteints d'un lymphome non hodgkinien

Economic costs of chemotherapy-induced febrile neutropenia among patients with non-Hodgkins lymphoma in European and Australian clinical practice

Weycker, Derek ; Danel, Aurelie ; Marciniak, Anne ; Bendall, Kate ; Lipsitz, Michael ; Pettengell, Ruth

BACKGROUND:Economic implications of chemotherapy-induced febrile neutropenia (FN) in European and Australian clinical practice are largely unknown.METHODS:Data were obtained from a European (97%) and Australian (3%) observational study of patients with non-Hodgkin's lymphoma (NHL) receiving CHOP ([PLUS-MINUS SIGN]rituximab) chemotherapy. For each patient, each cycle of chemotherapy within the course, and each occurrence of FN within cycles, was identified. Patients developing FN in a given [...]

Cette étude passe en revue la nature et la qualité de l'information disponible en langue anglaise sur internet relative aux cancers de l'estomac, du pancréas et du colon-rectum

Relative Quality of Internet-Derived Gastrointestinal Cancer Information

Chan, David ; Willicombe, Anita ; Reid, Thomas ; Beaton, Ceri ; Arnold, David ; Ward, James ; Davies, I. ; Lewis, Wyn

Internet-derived health care information is increasingly accessed by patients, yet its quality and accuracy is variable and unregulated. The aim of this study was to assess the information available regarding common gastrointestinal cancers via three internet search engines (Google, Yahoo and Bing). The top 30 websites for each of the terms: oesophageal, gastric, pancreatic, colon and rectal cancer were evaluated (University of Michigan Consumer Health Website Checklist) and scored [−80 (poor) [...]

Mené aux Pays-Bas, cet essai randomisé incluant 6 600 participants âgés de 50 à 75 ans évalue et compare l'efficacité d'un entretien face à face ou d'un entretien téléphonique pour expliquer les risques et les bénéfices d'un dépistage du cancer colorectal par coloscopie

Face-to-face vs telephone pre-colonoscopy consultation in colorectal cancer screening; a randomised trial

Stoop, E. M. ; de Wijkerslooth, T. R. ; Bossuyt, P. M. ; Stoker, J. ; Fockens, P. ; Kuipers, E. J. ; Dekker, E. ; van Leerdam, M. E.

Background: A pre-colonoscopy consultation in colorectal cancer (CRC) screening is necessary to assess a screenee’s general health status and to explain benefits and risks of screening. The first option allows for personal attention, whereas a telephone consultation does not require travelling. We hypothesised that a telephone consultation would lead to higher response and participation in CRC screening compared with a face-to-face consultation. Methods: A total of 6600 persons (50–75 years) [...]

Cette étude passe en revue la nature et la qualité de l'information disponible en langue anglaise pour les patients atteints de tumeurs du cerveau ainsi que pour les familles

Quality and Readability of Information Materials for People with Brain Tumours and Their Families

Langbecker, Danette ; Janda, Monika

Written information is commonly used to inform patients about their disease and treatment but must be evidence-based and understandable to be useful. This study assessed the quality of the content and the readability of information brochures for people affected by brain tumours. We randomly selected 18 publicly available brochures. Brochures were assessed by criteria to assess the quality of content using the DISCERN instrument. Readability was tested using three commonly used formulas, which [...]

Cette étude présente un outil utilisant des données du systéme de santé, des variables socioéconomiques et démographiques pour estimer la survie des patients atteints de cancer au niveau de la province en Italie (équivalent du département en France)

Use of SERTS (Socio-Economic, health Resources and Technologic Supplies) models to estimate cancer survival at provincial geographical level

Vercelli, Marina ; Lillini, Roberto ; Capocaccia, Riccardo ; Quaglia, Alberto

Aim The main aim of this work is to compute expected cancer survival for Italian provinces by Socio-Economic and health Resources and Technologic Supplies (SERTS) models, based on demographic, socioeconomic variables and information describing the health care system (SEH). Methods Five-year age-standardised relative survival rates by gender for 11 cancer sites and all cancers combined of patients diagnosed in 1995–1999, were obtained from the Italian Association of Cancer Registries (CRs) [...]

A partir des données du registre national des tumeurs pédiatiques, cette étude analyse l'impact des changements de techniques de diagnostic et de procédures d'enregistrement de la maladie sur l'évolution de l'incidence des cancers pédiatriques en Grande-Bretagne sur la période 1966 à 2005

Effects of changes in diagnosis and registration on time trends in recorded childhood cancer incidence in Great Britain

Kroll, M. E. ; Carpenter, L. M. ; Murphy, M. F. G. ; Stiller, C. A.

Increases in recorded childhood cancer incidence are widely reported, but do not necessarily represent real increases in risk. Time trends might conceal underlying steps caused by changes in diagnosis and registration procedures. Methods: Using records from the National Registry of Childhood Tumours 1966–2005 (N=54 650), the age-sex-standardised rate for residents of Great Britain aged under 15 years was calculated by individual year of diagnosis for each cancer subtype, and the average annual [...]