Menée auprès de 181 survivants d'un cancer ayant reçu une greffe de moelle osseuse, cette étude américaine analyse l'impact de facteurs économiques, de difficultés liées à l'emploi et à la couverture sociale sur leur stress et leur qualité de vie

Economic survivorship stress is associated with poor health-related quality of life among distressed survivors of hematopoietic stem cell transplantation

Hamilton, Jada G. ; Wu, Lisa M. ; Austin, Jane E. ; Valdimarsdottir, Heiddis ; Basmajian, Katie ; Vu, AnnaMarie ; Rowley, Scott D. ; Isola, Luis ; Redd, William H. ; Rini, Christine

Background Hematopoietic stem cell transplantation is a demanding cancer treatment associated with enduring physical and psychological complications. Survivors' well-being may be further compromised by exposure to chronic stressors common to this population, including difficulties arising from costly medical care, changes in employment status, and health insurance coverage. Thus, we hypothesized that financial, employment, and insurance stressors (collectively referred to as economic [...]

Mené sur 27 patients atteints d'un cancer localement avancé et/ou métastatique de la région pelvienne (11 hommes, 16 femmes ; âge : 47 à 86 ans ; durée médiane de suivi : 6 mois), cet essai de phase 1 évalue l'efficacité et la toxicité d'une radiothérapie accélérée de courte durée sur le contrôle des symptômes et la qualité de vie des patients

Short-Course Accelerated Radiotherapy in Palliative Treatment of Advanced Pelvic Malignancies: A Phase I Study

Caravatta, Luciana ; Padula, Gilbert D. A. ; Macchia, Gabriella ; Ferrandina, Gabriella ; Bonomo, Pierluigi ; Deodato, Francesco ; Massaccesi, Mariangela ; Mignogna, Samantha ; Tambaro, Rosa ; Rossi, Marco ; Flocco, Mariano ; Scapati, Andrea ; Scambia, Giovanni ; Pacelli, Fabio ; Valentini, Vincenzo ; Cellini, Numa ; Morganti, Alessio G.

To define the maximum tolerated dose of a conformal short-course accelerated radiotherapy in patients with symptomatic advanced pelvic cancer. A phase I trial in 3 dose-escalation steps was designed: 14 Gy (3.5-Gy fractions), 16 Gy (4-Gy fractions), and 18 Gy (4.5-Gy fractions). The eligibility criteria included locally advanced and/or metastatic pelvic cancer and Eastern Cooperative Oncology Group performance status of ≤3. Treatment was delivered in 2 days with twice-daily fractionation and at [...]

Menée en population européenne, cette étude analyse et compare, chez des survivants d'un cancer du colon ou du rectum et en population saine, la prévalence des dysfonctionnements sexuels

Higher prevalence of sexual dysfunction in colon and rectal cancer survivors compared with the normative population: A population-based study

Den Oudsten, B. L. ; Traa, M. J. ; Thong, M. S. Y. ; Martijn, H. ; De Hingh, I. H. J. T. ; Bosscha, K. ; van de Poll-Franse, L. V.

Background To compare colorectal cancer survivors with a normative population regarding erectile dysfunction, ejaculation problems, dyspareunia, dry vagina, sexual functioning (SF) and enjoyment (SE). In addition, the sociodemographic, clinical and psychological correlates of (dys)function in survivors are examined. Patients and methods The European Organisation for Research and Treatment of Cancer (EORTC) QLQ-CR38 sexuality subscales were completed by survivors (n = 1371; response [...]

A partir de questionnaires auprès de 440 patientes atteintes d'un cancer du sein en rémission (âge médian : 52 ans), cette étude analyse la relation entre le profil psychosocial des patientes, leur niveau réel d'activité physique et leurs besoins en soins de support

Physical activity levels and supportive care needs for physical activity among breast cancer survivors with different psychosocial profiles: a cluster-analytical approach

Charlier, C. ; Pauwels, E. ; Lechner, L. ; Spittaels, H. ; Bourgois, J. ; De Bourdeaudhuij, I. ; Van Hoof, E.

The transition from breast cancer patient to survivor is associated with many treatment-related and psychosocial factors, which can influence health behaviour and associated needs. First, this study aimed to identify clusters of treatment-related and psychosocial factors among breast cancer survivors. Second, clusters' physical activity levels and care needs for physical activity were evaluated. Breast cancer survivors (n= 440; 52 ± 8 years) (3 weeks to 6 months post treatment) completed [...]

Menée sur la période 1964-2008, cette étude de cohorte en population suédoise évalue le risque de cancer du moignon gastrique après une gastrectomie pour traiter un ulcère bénin de l'estomac

Gastric stump cancer after distal gastrectomy for benign gastric ulcer in a population-based study

Lagergren, Jesper ; Lindam, Anna ; Mason, Robert M.

The risk of cancer in the gastric remnant after distal gastrectomy for benign ulcer disease has been assessed mainly in studies of small sample size, selected series and limited follow-up time. This was a population-based cohort study of patients who had undergone distal gastrectomy for benign ulcer disease in 1964–2008 in Sweden. Data for follow-up for cancer and censoring for death were obtained from nationwide registries of Cancer and Population, respectively. The number of observed cancer [...]

A partir de questionnaires auprès de 7 414 patients ayant survécu à un cancer pédiatrique (âge : 21,2 à 58,8 ans ; durée médiane de suivi : 22,7 ans) et de 2 374 témoins frères et soeurs (âge : 18,4 à 62,6 ans), cette étude évalue la prévalence de fractures dans cette population et identifie les facteurs de risques associés

Fractures among long-term survivors of childhood cancer

Wilson, Carmen L. ; Dilley, Kimberley ; Ness, Kirsten K. ; Leisenring, Wendy L. ; Sklar, Charles A. ; Kaste, Sue C. ; Stovall, Marilyn ; Green, Daniel M. ; Armstrong, Gregory T. ; Robison, Leslie L. ; Kadan-Lottick, Nina S.

BACKGROUND: Although reductions in bone mineral density are well documented among children during treatment for cancer and among childhood cancer survivors, little is known about the long-term risk of fracture. The objective of this study was to ascertain the prevalence of and risk factors for fractures among individuals participating in the Childhood Cancer Survivor Study (CCSS). METHODS: Analyses included 7414 ≥5-year survivors of childhood cancer diagnosed between 1970 and 1986 who completed [...]

A partir des données du registre breton des cancers pédiatriques, cette étude évalue l'incidence des cancers de l'enfant sur la période 1991-2005 et analyse ses fluctuations temporelles et géographiques

Childhood cancer incidence in French Brittany, 1991–2005

Gagnière, B. ; Tron, I. ; Guillois-Bécel, Y. ; Gourvellec, G. ; Le Gall, E. ; Gandemer, V.

Background : The aim of this study was to describe childhood cancer incidence in French Brittany from 1991 to 2005, as well as its temporal and geographical variations. Methods : Childhood cancer incidence was analyzed from the data from the Brittany child tumor registry. Crude rates, world age standardized rates and cumulative rates were estimated for all cancers and for each diagnosis group. Standardized rates were also estimated for each of the four Brittany districts. Poisson regressions [...]

A partir de données médicales de Caroline du Nord portant sur la période 1998-2010, cette étude analyse l'évolution de l'incidence des adénocarcinomes colorectaux et de la mortalité spécifique chez les patients atteints d'une maladie inflammatoire de l'intestin (82 cas)

Incidence and Mortality of Colorectal Adenocarcinoma in Persons with Inflammatory Bowel Disease from 1998 to 2010

Herrinton, Lisa J. ; Liu, Liyan ; Levin, Theodore R. ; Allison, James E. ; Lewis, James D. ; Velayos, Fernando

The relationship between inflammatory bowel disease (IBD) and incidence and mortality of colorectal adenocarcinoma (CRC) has not been recently evaluated. We calculated the incidence and standardized incidence and mortality rate ratios (SMR) of CRC among adult individuals with intact colons using Kaiser Permanente of Northern California’s database of members with IBD and general membership data for the period of 1998–June 2010 (data through 2008 was used to calculate mortality). We also [...]

A partir d'une revue de la littérature et des données d'une cohorte incluant 1 543 participants, cette méta-analyse évalue l'impact de l'obésité sur la survie des patients atteints d'un carcinome à cellules rénales

Body mass index and survival in patients with renal cell carcinoma: a clinical-based cohort and meta-analysis

Choi, Yuni ; Park, Bumsoo ; Jeong, Byong Chang ; Seo, Seong Il ; Jeon, Seong Soo ; Choi, Han Yong ; Adami, Hans-Olov ; Lee, Jung Eun ; Lee, Hyun Moo

Growing evidence suggests that obesity, an established cause of renal cell cancer (RCC), may also be associated with a better prognosis. To evaluate the association between RCC survival and obesity, we analyzed a large cohort of patients with RCC and undertook a meta-analysis of the published evidence. We collected clinical and pathologic data from 1,543 patients who underwent nephrectomy for RCC between 1994 and 2008 with complete follow-up through 2008. Patients were grouped according to BMI [...]

A partir des données des registres américains du cancer portant sur la période 1973-2007, cette étude évalue le risque, les caractéristiques et le pronostic d'un cancer du sein chez les survivantes d'un lymphome hodgkinien

Risk, Characteristics, and Prognosis of Breast Cancer after Hodgkin's Lymphoma

Veit-Rubin, Nikolaus ; Rapiti, Elisabetta ; Usel, Massimo ; Benhamou, Simone ; Vinh-Hung, Vincent ; Vlastos, Georges ; Bouchardy, Christine

Abstract Purpose. To assess breast cancer (BC) risk after Hodgkin's lymphoma (HL) and compare characteristics, risk of second BC, and prognosis of patients with these BCs with patients with first primary BC.Patients and Methods. We considered all 9,620 women with HL recorded in the Surveillance, Epidemiology and End Results dataset in 1973–2007. We calculated age-period standardized incidence ratios of BC. We compared patient, tumor, and treatment characteristics, risk of second BC, and [...]

Menée dans quatre comtés norvégiens, cette étude analyse l'évolution de la mortalité par cancer du sein dans le contexte du déploiement progressif d'un programme de dépistage de la maladie entre 1996 et 2004 (durée moyenne de suivi : 5,9 ans)

Breast cancer mortality in Norway after the introduction of mammography screening

Olsen, Anne Helene ; Lynge, Elsebeth ; Njor, Sisse H. ; Kumle, Merethe ; Waaseth, Marit ; Braaten, Tonje ; Lund, Eiliv

An organized mammography screening program was gradually implemented in Norway during the period 1996–2004. Norwegian authorities have initiated an evaluation of the program. Our study focused on breast cancer mortality. Using Poisson regression, we compared the change in breast cancer mortality from before to during screening in four counties starting the program early controlling for change in breast cancer mortality during the same time in counties starting the program late. A follow-up [...]

A partir des données des registres néerlandais du cancer entre 1994 et 2008, cette étude analyse l'évolution des disparités socioéconomiques dans le recours à une biopsie du ganglion sentinelle et à une chirurgie conservatrice chez les patientes atteintes d'un cancer du sein

Small but significant socioeconomic inequalities in axillary staging and treatment of breast cancer in the Netherlands

Aarts, M. J. ; Hamelinck, V. C. ; Bastiaannet, E. ; Coebergh, J. W. W. ; Liefers, G. J. ; Voogd, A. C. ; van der Sangen, M. ; Louwman, W. J.

Background: The use of sentinel node biopsy (SNB), lymph node dissection, breast-conserving surgery, radiotherapy, chemotherapy and hormonal treatment for breast cancer was evaluated in relation to socioeconomic status (SES) in the Netherlands, where access to care was assumed to be equal. Methods: Female breast cancer patients diagnosed between 1994 and 2008 were selected from the nationwide population-based Netherlands Cancer Registry (N=176 505). Socioeconomic status was assessed based on [...]

Menée au Vénézuéla à partir de 329 échantillons inclus en paraffine, cette étude transversale évalue la prévalence d'une infection par différents types de papillomavirus humain dans les néoplasies intraépithéliales cervicales de grade 2 et 3

Human papillomavirus in invasive cervical cancer and cervical intraepithelial neoplasia 2 and 3 in Venezuela: A cross-sectional study

Sánchez-Lander, Jorge ; Cortiñas, Paula ; Loureiro, Carmen Luisa ; Pujol, Flor Helene ; Medina, Francisco ; Capote-Negrín, Luis ; Bianchi, Gino ; García-Barriola, Victoria ; Ruiz-Benni, Angela ; Avilán-Rovira, José ; Acosta, Humberto

Background This study investigated the distribution of human papillomavirus (HPV) types in invasive cervical cancer (ICC), cervical intraepithelial neoplasia 2 (CIN2) and cervical intraepithelial neoplasia 3 (CIN3) in Venezuela. Methods Paraffin-embedded samples from 329 women from 29 medical centers of the 24 states of Venezuela were analyzed to determine the distribution of HPV types for ICC, CIN2, and CIN3, the prevalence of single and multiple infection, and the association of HPV types [...]

A partir d'entretiens semi-dirigés auprès de 16 femmes ayant apporté un soutien psychologique par téléphone à des patientes atteintes, comme elles, d'un cancer gynécologique, cette étude analyse leur intérêt et les problèmes rencontrés au cours de l'intervention

Telephone peer support for women with gynaecological cancer: benefits and challenges for supporters

Pistrang, Nancy ; Jay, Zara ; Gessler, Sue ; Barker, Chris

Objective Despite the prevalence of one-to-one peer support programmes for people with cancer, little research has examined its impact on the supporters themselves. This qualitative study examined a telephone-delivered one-to-one peer support intervention for women with gynaecological cancer, focussing on supporters' subjective experiences of benefits or costs to themselves and challenges arising in the support process. Methods Semi-structured interviews (N = 24) were conducted with 16 women [...]

A partir d'une revue systématique de la littérature (15 études), cette étude analyse l'impact d'une stigmatisation de patients, atteints d'un cancer du poumon, sur leur qualité de vie

A Systematic Review of the Impact of Stigma and Nihilism on Lung Cancer Outcomes

Chambers, Suzanne ; Dunn, Jeffrey ; Occhipinti, Stefano ; Hughes, Suzanne ; Baade, Peter ; Sinclair, Sue ; Aitken, Joanne ; Youl, Pip ; O'Connell, Dianne

BACKGROUND:This study systematically review the evidence on the influence of stigma and nihilism on lung cancer patterns of care; patients' psychosocial and quality of life (QOL) outcomes; and how this may link to public health programs.METHODS:Medline, EMBASE, ProQuest, CINAHL and PsycINFO databases were searched. The inclusion criteria were: included lung cancer patients and/or partners or caregivers and/or health professionals (either at least 80% of participants had lung cancer or were [...]

A partir des données des registres danois et de celles de 1 208 participantes, cet essai analyse les facteurs d'inclusion et de participation des patientes atteintes d'un cancer du sein à des essais randomisés portant sur des psychothérapies de gestion du stress

Who participates in a randomized trial of mindfulness-based stress reduction (MBSR) after breast cancer? A study of factors associated with enrollment among Danish breast cancer patients

Würtzen, Hanne ; Dalton, Susanne Oksbjerg ; Andersen, Klaus Kaae ; Elsass, Peter ; Flyger, Henrik Lavlund ; Sumbundu, Antonia ; Johansen, Christoffer

Background Discussion regarding the necessity to identify patients with both the need and motivation for psychosocial intervention is ongoing. Evidence for an effect of mindfulness-based interventions among cancer patients is based on few studies with no systematic enrollment. Methods We used Danish population-based registries and clinical databases to determine differences in demographics, breast cancer and co-morbidity among 1208 women eligible for a randomized controlled trial [...]

Cette étude américaine (57 cas et 30 témoins) analyse les capacités cognitives de survivantes d'un cancer du sein à 10 ans ou plus, en fonction de leur âge et du traitement reçu

Cognitive features 10 or more years after successful breast cancer survival: comparisons across types of cancer interventions

Nguyen, Christopher M. ; Yamada, Torricia H. ; Beglinger, Leigh J. ; Cavanaugh, Joseph E. ; Denburg, Natalie L. ; Schultz, Susan K.

Background The present study examined the long-term cognitive implications of cancer treatment among breast cancer survivors aged 65 years and older to better understand the long term implications of cancer treatment. Methods Fifty-seven women survivors were compared with 30 healthy older female adult comparisons, matched in terms of age and education, with no history of cancer. Cancer survivors were also compared on the basis of treatment intervention, involving chemotherapy (n = 27) versus [...]

A partir d'une revue systématique de la littérature, cette étude analyse les caractéristiques et l'efficacité d'interventions ciblées permettant d'améliorer la participation et l'implication du patient lors des consultations en oncologie

Enhancing patient participation in oncology consultations: a best evidence synthesis of patient-targeted interventions

Henselmans, Inge ; de Haes, Hanneke C. J. M. ; Smets, Ellen M. A.

Objective Because of the complexity of cancer consultations, the contribution of patients is often limited. This systematic review examined the characteristics and effectiveness of patient-targeted interventions that aim to enhance cancer patients' participation in the consultation. Methods Relevant studies were selected by a search of databases until mid-2010 (Pubmed, PsycINFO and CINAHL), citations in relevant reviews as well as backward/forward citations. A Best Evidence Synthesis was [...]

A partir d'une revue de la littérature, cette étude analyse les recommandations concernant l'intensité et la durée du suivi des patients après cystectomie radicale pour un cancer de la vessie

Follow-up After Surgical Treatment of Bladder Cancer: A Critical Analysis of the Literature

Viktor, Soukup ; Marko, Babjuk ; Joaquim, Bellmunt ; Guido, Dalbagni ; Gianluca, Giannarini ; Oliver, W. Hakenberg ; Harry, Herr ; Eric, Lechevallier ; Maria, J. Ribal

Context : Follow-up of patients treated for bladder cancer (BCa) is of great importance for both non–muscle-invasive BCa (NMIBC) and muscle-invasive BCa (MIBC) because of the high incidence of recurrence and progression. The schedule and methods of follow-up should reflect the individual clinical situation. Objective : To evaluate the existing evidence for intensity and duration of follow-up recommendations in patients after surgical treatment of BCa. Evidence acquisition : We searched the [...]