A partir d'une revue systématique de la littérature (60 études anglaises et chinoises), cette méta-analyse évalue l'association entre une consommation d'aliments et de légumes macérés dans le vinaigre et le risque de cancer de l'estomac en Asie de l'est

Pickled Food and Risk of Gastric Cancer - A Systematic Review and Meta-Analysis of English and Chinese Literature

Ren, Jian-Song ; Kamangar, Farin ; Forman, David ; Islami, Fahrad

Background: Ecological and experimental studies have suggested an increased risk of gastric cancer in relation to consumption of pickled vegetables in East Asia. Methods: We conducted a meta-analysis of epidemiologic observational studies to evaluate the existing evidence. Searching PubMed, Vip Chinese Periodical and China National Knowledge Infrastructure databases, we found a total of 60 studies, 50 case-control and 10 prospective. We compared gastric cancer risk in pickled vegetable/food [...]

Menée aux Etats-Unis, cette étude (1 433 cas et 1 350 témoins) évalue l'association entre une exposition aux rayonnements de radiographies dentaires et le risque de méningiome

Dental x-rays and risk of meningioma

Claus, Elizabeth B. ; Calvocoressi, Lisa ; Bondy, Melissa L. ; Schildkraut, Joellen M. ; Wiemels, Joseph L. ; Wrensch, Margaret

BACKGROUND: Ionizing radiation is a consistently identified and potentially modifiable risk factor for meningioma, which is the most frequently reported primary brain tumor in the United States. The objective of this study was to examine the association between dental x-rays—the most common artificial source of ionizing radiation—and the risk of intracranial meningioma. METHODS: This population-based case-control study included 1433 patients who had intracranial meningioma diagnosed at ages 20 [...]

A partir des données des registres suédois des cancers, cette étude analyse l'association entre des maladies à polyglutamine, comprenant notamment la chorée de Huntington, et le risque de cancer

Cancer incidence in patients with polyglutamine diseases: a population-based study in Sweden

Ji, Jianguang ; Sundquist, Kristina ; Sundquist, Jan

Polyglutamine (polyQ) diseases are characterised by the expansion of CAG triplet repeats in specific genes. The accumulated encoded proteins affect the transcription of numerous transcription factors. We investigated whether polyQ diseases reduce the risk of cancer development. Data on patients with the polyQ diseases Huntington's disease (HD), spinobulbar muscular atrophy (SBMA), and hereditary ataxia (HA) in Sweden were linked to the Swedish Cancer Registry. We calculated standardised [...]

A partir d'une revue systématique de la littérature (13 études cas-témoins et 13 études de cohorte), cette méta-analyse évalue l'association entre un diabète de type 2 et le risque de lymphome non hodgkinien, de leucémie et de myélome

Increased incidence of non-Hodgkin lymphoma, leukemia and myeloma in patients with diabetes mellitus type 2: a meta-analysis of observational studies

Castillo, Jorge J. ; Mull, Nikhil ; Reagan, John L. ; Nemr, Saed ; Mitri, Joanna

Hematologic malignancies are a heterogeneous group of conditions with an unclear etiology. We hypothesized that diabetes mellitus type 2 (DM2) is associated with increased risk of developing leukemia, lymphoma and myeloma. A literature search identified 26 studies (13 case-control and 13 cohort studies) evaluating such association. Outcome was calculated as odds ratio (OR) using a random effects model. Heterogeneity and publication bias were evaluated using the I2 index and the trim-and-fill [...]

Couplée à la cohorte "Health Professionals Follow-up Study", cette étude prospective (1 260 cas et 1 331 témoins) évalue l'association entre des variants des gènes associés à la vitamine D, le niveau sanguin de vitamine D et le risque de cancer létal de la prostate

Vitamin D–Related Genetic Variation, Plasma Vitamin D, and Risk of Lethal Prostate Cancer: A Prospective Nested Case–Control Study

Shui, Irene M. ; Mucci, Lorelei A. ; Kraft, Peter ; Tamimi, Rulla M. ; Lindström, Sara ; Penney, Kathryn L. ; Nimptsch, Katharina ; Hollis, Bruce W. ; DuPre, Natalie ; Platz, Elizabeth A. ; Stampfer, Meir J. ; Giovannucci, Edward

Background The association of vitamin D status with prostate cancer is controversial; no association has been observed for overall incidence, but there is a potential link with lethal disease.Methods We assessed prediagnostic 25-hydroxyvitamin D [25(OH)D] levels in plasma, variation in vitamin D–related genes, and risk of lethal prostate cancer using a prospective case–control study nested within the Health Professionals Follow-up Study. We included 1260 men who were diagnosed with prostate [...]

Menée sur deux cohortes de 1 903 et 800 hommes participant à des études sur le dépistage du cancer de la prostate à l'aide du PSA, cette étude identifie deux variants du nombre de copies de gènes, situés sur les chromosomes 15q21.3 and 12q21.31, en association avec le risque de cancer de la prostate

Identification of functionally active, low frequency copy number variants at 15q21.3 and 12q21.31 associated with prostate cancer risk

Demichelis, Francesca ; Setlur, Sunita R. ; Banerjee, Samprit ; Chakravarty, Dimple ; Chen, Jin Yun Helen ; Chen, Chen X. ; Huang, Julie ; Beltran, Himisha ; Oldridge, Derek A. ; Kitabayashi, Naoki ; Stenzel, Birgit ; Schaefer, Georg ; Horninger, Wolfgang ; Bektic, Jasmin ; Chinnaiyan, Arul M. ; Goldenberg, Sagit ; Siddiqui, Javed ; Regan, Meredith M. ; Kearney, Michale ; Soong, T. David ; Rickman, David S. ; Elemento, Olivier ; Wei, John T. ; Scherr, Douglas S. ; Sanda, Martin A. ; Bartsch, Georg ; Lee, Charles ; Klocker, Helmut ; Rubin, Mark A.

Copy number variants (CNVs) are a recently recognized class of human germ line polymorphisms and are associated with a variety of human diseases, including cancer. Because of the strong genetic influence on prostate cancer, we sought to identify functionally active CNVs associated with susceptibility of this cancer type. We queried low-frequency biallelic CNVs from 1,903 men of Caucasian origin enrolled in the Tyrol Prostate Specific Antigen Screening Cohort and discovered two CNVs strongly [...]

A partir des données d'une étude chinoise (641 cas et 1 037 témoins) et d'une méta-analyse (29 859 cas et 29 696 témoins), cette étude montre une association entre un polymorphisme à simple nucléotide localisé sur le chromosome 20p12.3 et le risque de cancer colorectal

The SNP rs961253 in 20p12.3 Is Associated with Colorectal Cancer Risk: A Case-Control Study and a Meta-Analysis of the Published Literature

Zheng, Xiawen ; Wang, Li ; Zhu, Yaowu ; Guan, Qing ; Li, Huijun ; Xiong, Zhigang ; Deng, Lingyan ; Lu, Jie ; Miao, Xiaoping ; Cheng, Liming

Background : Colorectal cancer (CRC) is the third common cancer and the fourth leading cause of cancer death worldwide. A single nucleotide polymorphism (SNP), rs961253 located in 20p12, was firstly described to be associated with the increased risk of CRC in a genome-wide association study; however, more recent replication studies yielded controversial results. Methodology/Principal Findings : A hospital-based case-control study in a Chinese population was firstly performed, and then a [...]

Cet article présente un outil de fouille textuelle (text mining) pour évaluer les risques de cancer associés à des substances chimiques

Text Mining for Literature Review and Knowledge Discovery in Cancer Risk Assessment and Research

Korhonen, Anna ; Ó Séaghdha, Diarmuid ; Silins, Ilona ; Sun, Lin ; Högberg, Johan ; Stenius, Ulla

Research in biomedical text mining is starting to produce technology which can make information in biomedical literature more accessible for bio-scientists. One of the current challenges is to integrate and refine this technology to support real-life scientific tasks in biomedicine, and to evaluate its usefulness in the context of such tasks. We describe CRAB – a fully integrated text mining tool designed to support chemical health risk assessment. This task is complex and time-consuming, [...]