Menée auprès de 452 269 participants de la cohorte EPIC, cette étude européenne évalue l'association entre la consommation d'une grande variété de légumes et de fruits et le risque de cancer de l'estomac ou de l'œsophage (573 cas ; durée moyenne de suivi : 8,4 ans)

Variety in vegetable and fruit consumption and the risk of gastric and esophageal cancer in the European Prospective investigation into cancer and nutrition (EPIC)

Jeurnink, S. ; Buchner, F. ; Bueno-de-Mesquita, H. ; Siersema, P. ; Boshuizen, H. ; Numans, M. ; Dahm, C. ; Overvad, K. ; Tjonneland, A. ; Roswall, N. ; Clavel-Chapelon, F. ; Boutron-Ruault, M. ; Morois, S. ; Kaaks, R. ; Teucher, B. ; Boeing, H. ; Buijsse, B. ; Trichopoulou, A. ; Benetou, V. ; Zylis, D. ; Palli, D. ; Sieri, S. ; Vineis, P. ; Tumino, R. ; Panico, S. ; Ocke, M. ; Peeters, P. ; Skeie, G. ; Brustad, M. ; Lund, E. ; Sanchez-Cantalejo, E. ; Navarro, C. ; Amiano, P. ; Ardanaz, E. ; Quiros, J. R. ; Hallmans, G. ; Johansson, I. ; Lindkvist, B. ; Regner, S. ; Khaw, K. ; Wareham, N. ; Key, T. ; Slimani, N. ; Norat, T. ; Vergnaud, A. ; Romaguera, D. ; Gonzalez, C.

BACKGROUND: Diets high in vegetables and fruits have been suggested to be inversely associated with risk of gastric cancer. However, the evidence of the effect of variety of consumption is limited. We therefore investigated whether consumption of a variety of vegetables and fruit is associated with gastric and esophageal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. METHODS: Data on food consumption and follow-up on cancer incidence was available for [...]

Cet article passe en revue le rôle des fibres alimentaires dans la prévention du diabète de type 2, des maladies cardiovasculaires et du cancer du côlon, décrit leurs fonctions physiologiques et analyse leurs actions immunitaires potentielles

The health benefits of dietary fiber: Beyond the usual suspects of type 2 diabetes mellitus, cardiovascular disease and colon cancer

Kaczmarczyk, M. M. ; Miller, M. J. ; Freund, G. G.

Dietary fiber (DF) is deemed to be a key component in healthy eating. DF is not a static collection of undigestible plant materials that pass untouched or unencumbered through the gastrointestinal (GI) tract; instead, DFs are a vast array of complex saccharide-based molecules that can bind potential nutrients and nutrient precursors to prevent their absorption. Some DFs are fermentable, and the GI tract catabolism leads to the generation of various bioactive materials, such as short-chain fatty [...]

Menée auprès de 62 284 femmes ménopausées d'origine italienne, espagnole ou grecque, cette étude prospective, couplée à l'étude EPIC, évalue l'association entre la consommation d'huile d'olive dans les pays méditerranéens et le risque de cancer du sein (1 256 cas ; durée moyenne de suivi : 9 ans)

Olive oil intake and breast cancer risk in the Mediterranean countries of the European prospective investigation into cancer and nutrition (EPIC) study

Buckland, G. ; Travier, N. ; Agudo, A. ; Fonseca-Nunes, A. ; Navarro, C. ; Lagiou, P. ; Demetriou, C. ; Amiano, P. ; Dorronsoro, M. ; Chirlaque, M. D. ; Huerta, J. M. ; Molina, E. ; Perez, M. J. ; Ardanaz, E. ; Moreno-Iribas, C. ; Quiros, J. R. ; Naska, A. ; Trichopoulos, D. ; Giurdanella, M. C. ; Tumino, R. ; Agnoli, C. ; Grioni, S. ; Panico, S. ; Mattiello, A. ; Masala, G. ; Sacerdote, C. ; Polidoro, S. ; Palli, D. ; Trichopoulou, A. ; Gonzalez, C. A.

Although there is some evidence suggesting that olive oil could reduce breast cancer risk, the epidemiological data is still relatively limited, not entirely consistent and mainly based on case-controls studies. Therefore, we prospectively assessed the association between olive oil and breast cancer risk in postmenopausal women from the Mediterranean cohorts within the European Prospective Investigation into Cancer and Nutrition (EPIC). The analysis included 62,284 postmenopausal women [...]

Menée en Chine à partir d'entretiens sur la période 2009-2011, cette étude cas-témoins montre qu'une grande consommation de fruits et de légumes réduit le risque de carcinome nasopharyngé chez l'adulte (600 cas : 448 hommes et 152 femmes ; 600 témoins)

Greater intake of fruit and vegetables is associated with lower risk of nasopharyngeal carcinoma in Chinese adults: a case–control study

Liu, Yuan-ting ; Dai, Jun-jin ; Xu, Chun-hua ; Lu, Yun-kai ; Fan, Yu-ying ; Zhang, Xing-lan ; Zhang, Cai-xia ; Chen, Yu-ming

Purpose The effect of fruit and vegetable intake on the risk of nasopharyngeal carcinoma (NPC) remains uncertain due to limited published evidence. We performed a matched case–control study to investigate the relationship between the intake of fruit and vegetables and the risk of NPC. Methods Between July 2009 and March 2011, 600 (448 male, 152 female), NPC incident cases from a single hospital in Guangzhou, Guangdong Province, China , a high-incidence area , were enrolled in the study. 600 [...]

Cet article passe en revue les propriétés chimiopréventives et thérapeutiques de triterpénoïdes pentacycliques d'origine végétale ciblant les molécules impliquées dans les processus de carcinogenèse et analyse le rôle potentiel de nouveaux triterpénoïdes synthétiques

Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer

Shanmugam, Muthu K. ; Nguyen, An H. ; Kumar, Alan P. ; Tan, Benny K. H. ; Sethi, Gautam

Over the last two decades, extensive research on plant-based medicinal compounds has revealed exciting and important pharmacological properties and activities of triterpenoids. Fruits, vegetables, cereals, pulses, herbs and medicinal plants are all considered to be biological sources of these triterpenoids, which have attracted great attention especially for their potent anti-inflammatory and anti-cancer activities. Published reports in the past have described the molecular mechanism(s) [...]

Menée sur un modèle murin, cette étude montre que l'acide 3-bromopyruvique administré sous forme d'aérosol inhibe la tumorigenèse du poumon sans présenter de toxicité pour le foie

Aerosolized 3-bromopyruvate inhibits lung tumorigenesis without causing liver toxicity

Zhang, Qi ; Pan, Jing ; North, Paula E. ; Yang, Shoua ; Lubet, Ronald A. ; Wang, Yian ; You, Ming

3-Bromopyruvate, an alkylating agent and a well-known inhibitor of energy metabolism, has been proposed as a specific anticancer agent. However, the chemopreventive effect s of 3-bromopyruvate in lung tumorigenesis has not been tested. In this study, we investigated the chemopreventive activity of 3-bromopyruvate in a mouse lung tumor model. Benzo(a)pyrene was used to induce lung tumors, and 3-bromopyruvate was given administered by oral gavage to female A/J mice. We found that 3-Bromopyruvate [...]

Menée sur des lignées cellulaires de carcinome du côlon, cette étude montre que l'acide ursodésoxycholique inhibe la prolifération des cellules tumorales en supprimant l'expression de la protéine c-Myc

The chemopreventive agent ursodeoxycholic acid inhibits proliferation of colon carcinoma cells by suppressing c-Myc expression

Peiró-Jordán, Roser ; Krishna-Subramanian, Santosh ; Hanski, Marie-Luise ; Lüscher-Firzlaff, Juliane ; Zeitz, Martin ; Hanski, Christoph

Ursodeoxycholic acid (UDCA) can prevent chemical and colitis-associated colon carcinogenesis by unknown mechanism(s). One of the processes underlying the chemopreventive action could be the inhibition of proliferation by UDCA. To clarify the antiproliferative mechanism of UDCA, we used p53wt colon carcinoma cell lines HCT8 and HCT116. UDCA-induced inhibition of proliferation was reversible and was associated with a decrease of the S-phase and an increase of G1 phase population, but not with [...]

Menée in vitro et in vivo, cette étude montre que l'aspirine inhibe la signalisation de la protéine kinase mTOR, active la protéine AMPK et induit l'autophagie dans les cellules de cancer colorectal

Aspirin Inhibits mTOR Signaling, Activates AMP-Activated Protein Kinase, and Induces Autophagy in Colorectal Cancer Cells

Din, Farhat V. N. ; Valanciute, Asta ; Houde, Vanessa ; Zibrova, Daria ; Green, Kevin A. ; Sakamoto, Kei ; Alessi, Dario R. ; Dunlop, Malcolm G.

Aspirin reduces the incidence of and mortality from colorectal cancer (CRC) by unknown mechanisms. Cancer cells have defects in signaling via the mechanistic target of rapamycin (mTOR), which regulates proliferation. We investigated whether aspirin affects AMP-activated protein kinase (AMPK) and mTOR signaling in CRC cells The effects of aspirin on mTOR signaling, the ribosomal protein S6, S6 kinase (S6K1), and eukaryotic translation initiation factor 4E binding protein (4E-BP)1 were examined [...]

Menée sur un modèle murin, cette étude montre qu'un acide triterpénoïde synthétique peut retarder le développement de tumeurs mammaires ER-

The Synthetic Triterpenoid CDDO-Methyl Ester Delays Estrogen Receptor-Negative Mammary Carcinogenesis in Polyoma Middle T Mice

Tran, Kim M. ; Risingsong, Renee ; Royce, Darlene B. ; Williams, Charlotte R. ; Sporn, Michael B. ; Liby, Karen T.

Novel drugs are needed for the prevention and treatment of breast cancer. Synthetic triterpenoids are a promising new class of compounds with activity in a variety of preclinical cancer models. We tested activity of the methyl ester derivative of the synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO-Me), in a relevant model of ER-negative breast cancer, the polyoma-middle T (PyMT), in which the oncoprotein drives carcinogenesis. The developing tumors recapitulate [...]