A partir des données de 20 études observationnelles, cette méta-analyse évalue l'association entre la consommation d'alcool et le risque de carcinome à cellules rénales

Alcohol drinking and risk of renal cell carcinoma: results of a meta-analysis

Bellocco, R. ; Pasquali, E. ; Rota, M. ; Bagnardi, V. ; Tramacere, I. ; Scotti, L. ; Pelucchi, C. ; Boffetta, P. ; Corrao, G. ; La Vecchia, C.

Background: The role of alcohol consumption in relation with renal cell carcinoma is still unclear; a few studies have reported a beneficial effect of moderate levels of alcohol consumption, whereas it remains still under debate whether there is a dose–response association.Materials and methods: Twenty observational studies (4 cohort, 1 pooled and 15 case–control) reporting results on at least three levels of alcohol consumption were selected through a combined search with PubMed and EMBASE of [...]

Menée au Japon auprès de 393 femmes non ménopausées, cette étude analyse l'impact d'une consommation d'alcool, de graisses, de fibres, d'isoflavones de soja, sur le niveau de prolactine et d'hormones sexuelles mesurées dans le sang, et évalue leur rôle dans l'étiologie du cancer du sein

Associations of intakes of fat, dietary fiber, soy isoflavones, and alcohol with levels of sex hormones and prolactin in premenopausal Japanese women

Tsuji, Michiko ; Tamai, Yuya ; Wada, Keiko ; Nakamura, Kozue ; Hayashi, Makoto ; Takeda, Noriyuki ; Yasuda, Keigo ; Nagata, Chisato

Objective Endogenous sex hormones have been implicated in the etiology of breast cancer. Dietary factors such as fat, dietary fiber, soy isoflavones, and alcohol have been suggested to influence endogenous estrogen and other steroid hormone levels. We examined the relationship among these dietary factors and plasma sex hormone levels in premenopausal Japanese women. Methods We measured the plasma concentrations of estradiol, estrone, testosterone, dehydroepiandrosterone sulfate, sex [...]

Menée auprès de 49 884 fermiers masculins de la cohorte "Agricultural Health Study", cette étude analyse l'association entre une exposition professionnelle à des volailles et du bétail et le risque de cancer

Poultry and livestock exposure and cancer risk among farmers in the agricultural health study

Beane Freeman, Laura ; DeRoos, Anneclaire ; Koutros, Stella ; Blair, Aaron ; Ward, Mary ; Alavanja, Michael ; Hoppin, Jane

Purpose The purpose of this study is to evaluate cancer risk associated with raising animals as commodities, which is associated with a variety of exposures, such as infectious agents and endotoxins. Methods Information was available for 49,884 male farmers in the Agricultural Health Study, who reported livestock and poultry production at enrollment (1993–1997). Cancer incidence data were obtained through annual linkage to state registries. Using Poisson regression analyses, we evaluated [...]

Menée dans six provinces du Canada, cette étude (513 cas et 1 506 témoins) évalue l'association entre l'utilisation de produits pesticides, des maladies allergiques et le risque de lymphome non hodgkinien

Pesticide use, immunologic conditions, and risk of non-hodgkin lymphoma in Canadian men in six provinces

Pahwa, Manisha ; Harris, Shelley A. ; Hohenadel, Karin ; McLaughlin, John R. ; Spinelli, John J. ; Pahwa, Punam ; Dosman, James A. ; Blair, Aaron

Pesticide exposures and immune suppression have been independently associated with the risk of non-Hodgkin lymphoma (NHL), but their joint effect has not been well explored. Data from a case-control study of men from six Canadian provinces were used to evaluate the potential effect modification of asthma, allergies, or asthma and allergies and hay fever combined on NHL risk from use of: (1) any pesticide; (2) any organochlorine insecticide; (3) any organophosphate insecticide; (4) any phenoxy [...]

A partir des données de 12 registres américains du cancer, cette étude évalue la pertinence de deux estimations du risque de gliome lié à l'usage du téléphone portable (l'étude Interphone et une étude suédoise) pour rendre compte de l'évolution de l'incidence de la maladie entre 1997 et 2008

Mobile phone use and glioma risk: comparison of epidemiological study results with incidence trends in the United States

M P Little ; P Rajaraman ; R E Curtis ; S S Devesa ; P D Inskip ; D P Check ; M S Linet

Objective In view of mobile phone exposure being classified as a possible human carcinogen by the International Agency for Research on Cancer (IARC), we determined the compatibility of two recent reports of glioma risk (forming the basis of the IARC’s classification) with observed incidence trends in the United States. Design Comparison of observed rates with projected rates of glioma incidence for 1997-2008. We estimated projected rates by combining relative risks reported in the 2010 [...]

Menée aux Etats-Unis, cette étude évalue l'association entre une infection par des variants du type 31 du papillomavirus humain et le risque de néoplasies cervicales intra-épithéliales de grade 2 à 3

Association of human papillomavirus type 31 variants with risk of cervical intraepithelial neoplasia grades 2-3

Xi, Long Fu ; Schiffman, Mark ; Koutsky, Laura A. ; Hulbert, Ayaka ; Lee, Shu-Kuang ; DeFilippis, Victor ; Shen, Zhenping ; Kiviat, Nancy B.

Although the lineages of human papillomavirus type 31 (HPV31) variants are recognized, their clinical relevance is unknown. The purpose of the present study was to examine risk of cervical intraepithelial neoplasia grades 2-3 (CIN2/3) by HPV31 variants. Study subjects were women who participated in the Atypical Squamous Cells of Undetermined Significance and Low-Grade Squamous Intraepithelial Lesion Triage Study and who had HPV31 infections detected at one or more visits. They were followed [...]

A partir d'une revue systématique de la littérature (22 études, 3 852 cas et 5 604 témoins), cette méta-analyse évalue l'association entre des polymorphismes du gène UGT1A7 et le risque de cancer

The association between UGT1A7 polymorphism and cancer risk: A meta-analysis

Han, Shuang-Xi ; Wang, Li ; Wu, De-Quan

Background: studies investigating the associations between UDP-glucuronosyltransferase 1A7 (UGT1A7) gene polymorphisms and various carcinomas risk reported conflicting results. To derive a more precise estimation of the association, we have conducted a meta-analysis. Methods: data were collected from the following electronic databases: PubMed, Medline and Chinese Biomedical Literature Database, with the last report up to September 2011. Case–control studies containing available genotype [...]

Menée à la Barbade, cette étude (963 cas et 941 témoins) évalue l'association entre l'adiposité centrale et le risque de cancer de la prostate dans une population noire

Central Adiposity and Prostate Cancer in a Black Population

Nemesure, Barbara ; Wu, Suh-Yuh ; Hennis, Anselm ; Leske, M. Cristina

Background: The relationship between central adiposity and prostate cancer remains unclear. Methods: This report includes 963 newly diagnosed cases of histologically-confirmed prostate cancer and 941 randomly selected controls ascertained from the population-based Prostate Cancer in a Black Population study conducted between July, 2002 and January, 2011 in Barbados, West Indies. Trained nurse-interviewers obtained data on height, weight, waist and hip circumferences, family and medical history, [...]

Menée en Allemagne, cette étude de cas incluant 2 410 patientes atteintes d'un cancer du sein évalue l'association entre la densité mammaire et l'expression des récepteurs hormonaux

Association of mammographic density with hormone receptors in invasive breast cancers — results from a case-only study

Heusinger, Katharina ; Jud, Sebastian M. ; Häberle, Lothar ; Hack, Carolin ; Adamietz, Boris R. ; Meier-Meitinger, Martina ; Lux, Michael P. ; Wagner, Florian ; Loehberg, Christian R. ; Uder, Michael ; Hartmann, Arndt ; Schulz-Wendtland, Rüdiger ; Beckmann, Matthias W. ; Fasching, Peter A.

Introduction For many breast cancer (BC) risk factors, there is growing evidence concerning molecular subtypes for which the risk factor is specific. With regard to mammographic density (MD), there are inconsistent data concerning its association with estrogen receptor (ER) and progesterone receptor (PR) expression. The aim of this study was to analyze the association between ER and PR expression and MD. Methods In this case-only study, data on BC risk factors, hormone receptor expression, and [...]

A partir des données portant sur 1 034 patientes, cette étude analyse les différents facteurs de risque de cancer du sein par sous-type dans 3 groupes ethniques distincts de l'Asie du sud-est

Incidence and risk factors for breast cancer subtypes in three distinct South-East Asian ethnic groups: Chinese, Malay and natives of Sarawak, Malaysia

Devi, C. R. Beena ; Tang, Tieng Swee ; Corbex, Marilys

Introduction: We determined the incidences of the ER, PR and HER2 subtypes among breast cancer cases in Sarawak, Malaysia, and their correlation with various risk factors in the three ethnic groups: Chinese, Malay and native. Methods: Subtype status was ascertained for 1034 cases of female breast cancer (93% of all cases diagnosed since 2003), and the age-standardized incidence rates (ASRs) of each subtype were inferred. Case–case comparisons across subtypes were performed for reproductive risk [...]

Cette étude (393 cas et 359 témoins) analyse l'association entre des polymorphismes du gène DR4, une infection par le virus de l'hépatite C et le risque de carcinome hépatocellulaire

TRAIL receptor I (DR4) polymorphisms C626G und A638C are associated with an increased risk for hepatocellular carcinoma (HCC) in HCV-infected patients

Korner, Christian ; Riesner, Katarina ; Kramer, Benjamin ; Eisenhardt, Marianne ; Glassner, Andreas ; Wolter, Franziska ; Berg, Thomas ; Muller, Tobias ; Sauerbruch, Tilman ; Nattermann, Jacob ; Spengler, Ulrich ; Nischalke, Hans Dieter

BACKGROUND:Tumour surveillance via induction of TRAIL-mediated apoptosis is a key mechanism, how the immune system prevents malignancy. To determine if gene variants in the TRAIL receptor I (DR4) gene affect the risk of hepatitis C virus-(HCV)-induced liver cancer (HCC), we analysed DR4 mutations C626G (rs20575) and A683C (rs20576) in HCV-infected patients with and without HCC.METHODS:Frequencies of DR4 gene polymorphisms were determined by LightSNiP assays in 159 and 234 HCV-infected patients [...]