A partir d'une revue systématique de la littérature publiée entre 2010 et 2021 (22 études incluant un total de 1 992 patients), cette méta-analyse évalue l'efficacité d'interventions de kinésithérapie pour réduire la fatigue pendant des traitements cytotoxiques chez des patients atteints d'un cancer

Physical rehabilitation for the management of cancer-related fatigue during cytotoxic treatment: a systematic review with meta-analysis

Penna, Giana Berleze ; Otto, Douglas Maquart ; da Silva, Tassiana Costa ; Pedroni, Anderson Sartor ; Macagnan, Fabricio Edler

Objective: To assess the effect of physical therapy on cancer-related fatigue (CRF) during cytotoxic anticancer treatment. Methods: Systematic review with meta-analysis of randomized clinical trials published from 2010 to 2021 (EMBASE, MEDLINE, PEDro; SciELO, and LILACS). Studies assessing the effect of supervised physical therapy (IG) for the management of CRF on adults undergoing anticancer treatment compared with a control group (CG) covering usual care or any uncontrolled practice, such as [...]

A partir d'une revue systématique de la littérature publiée jusqu'en juin 2022 (53 essais incluant un total de 22 228 patients), cette méta-analyse évalue l'efficacité, du point de vue du taux de réponse complète globale, et la toxicité de différents traitements pour prévenir et traiter les nausées et vomissements induits par des chimiothérapies hautement émétisantes

Efficacy and safety of Antiemetic Regimens for Highly Emetogenic Chemotherapy-Induced Nausea and Vomiting: A Systematic Review and Network Meta-Analysis

Filetti, Marco ; Lombardi, Pasquale ; Giusti, Raffaele ; Falcone, Rosa ; Scotté, Florian ; Giannarelli, Diana ; Carcagnì, Antonella ; Altamura, Valeria ; Scambia, Giovanni ; Daniele, Gennaro

Background: Several regimens have been introduced in clinical practice in the last twenty years to treat chemotherapy-induced nausea and vomiting (CINV). However, direct comparative data remain insufficient, as many new regimes lack head-to-head comparisons. In this study, through an indirect comparison, we overcome this limit by providing the most up-to-date estimate of the efficacy and safety of all combinations used for HEC-induced nausea and vomiting. Patients and methods: We retrieved [...]

Cette étude met à jour les recommandations concernant la prise en charge de la fièvre et d'une neutropénie chez des patients pédiatriques atteints d'un cancer et des patients recevant une greffe de cellules souches hématopoïétiques

Guideline for the Management of Fever and Neutropenia in Pediatric Patients With Cancer and Hematopoietic Cell Transplantation Recipients: 2023 Update

Thomas Lehrnbecher ; Paula D. Robinson ; Roland A. Ammann ; Brian Fisher ; Priya Patel ; Robert Phillips ; Melissa P. Beauchemin ; Fabianne Carlesse ; Elio Castagnola ; Bonnie L. Davis ; Caitlin W. Elgarten ; Andreas H. Groll ; Gabrielle M. Haeusler ; Christa Koenig ; Maria E. Santolaya ; Wim J.E. Tissing ; Joshua Wolf ; Sarah Alexander ; Helen Hu ; L. Lee Dupuis ; Lillian Sung

PURPOSE: To update a clinical practice guideline (CPG) for the empiric management of fever and neutropenia (FN) in pediatric patients with cancer and hematopoietic cell transplantation recipients. METHODS: The International Pediatric Fever and Neutropenia Guideline Panel reconvened to conduct the second update of this CPG. We updated the previous systematic review to identify new randomized controlled trials (RCTs) evaluating any strategy for the management of FN in pediatric patients. Using [...]

Menée par enquête aux Etats-Unis, cette étude analyse les pratiques des kinésithérapeutes pour traiter un lymphoedème chez des patientes atteintes d'un cancer du sein

Practice patterns of physical therapists and physical therapist assistants treating patients with breast cancer related lymphedema

Wampler, Meredith ; Campione, Elizabeth ; Bolch, Charlotte A.

Abstract: Clinical Practice Guidelines (CPGs) aim to improve patient outcomes through implementation of proven interventions and decrease variation in practices. The relevance of this article is to describe the current state practice of physical therapists who diagnose and treat patients with Breast Cancer Related Lymphedema (BCRL). It also provides a description of physical therapist-reported adherence to the BCRL CPG recommendations which establishes the need for implementation interventions [...]

A partir d'une revue systématique de la littérature publiée entre 2014 et 2021 (8 études, 539 patientes), cette étude met à jour les données concernant la prise en charge des symptômes génito-urinaires chez des patientes atteintes d'un cancer du sein

Management of genitourinary symptoms in patients with breast cancer: an updated systematic review of available evidence from randomized trials

Fallah, Parvaneh ; Wolfe, Dianna ; Hutton, Brian ; Clemons, Mark ; Shorr, Risa ; Vandermeer, Lisa ; Rushton, Moira

Purpose: The purpose of this systematic review update is to synthesize available data on management of genitourinary symptoms (GUS) in breast cancer patients, a common and challenging clinical scenario. Methods: EMBASE, Ovid Medline, and the Cochrane Library were searched from September 2014 to December 2021 for randomized controlled trials which examined various interventions for GUS in breast cancer patients. Outcomes of interest included improvements in vaginal symptoms (e.g., dryness, pain, [...]

A partir d'une revue systématique de la littérature (27 essais randomisés incluant un total de 4 120 patientes), cette méta-analyse examine, chez des patientes atteintes d'un cancer du sein, le maintien d'une activité physique après des interventions comportant des exercices physiques

Long-term effects of exercise interventions on physical activity in breast cancer patients: a systematic review and meta-analysis of randomized controlled trials

Goldschmidt, Siri ; Schmidt, Martina E. ; Steindorf, Karen

Background: Benefits of exercise interventions for cancer patients are well established. This systematic review aimed to investigate the sustainability of exercise interventions with respect to physical activity behaviour of breast cancer patients in the longer term. Methods: The databases Pubmed, Cochrane, Embase, and Web of Science were systematically searched for randomized controlled trials (RCTs) investigating aerobic exercise, resistance exercise, or combined exercise interventions in [...]

Menée au Canada à partir de données 1987-2015 portant sur 1 150 témoins et sur 230 patients ayant survécu plus de 5 ans à un médulloblastome diagnostiqué avant l'âge de 18 ans, cette étude analyse la présence de différentes séquelles et la mortalité toutes causes confondues

The Burden of Surviving Childhood Medulloblastoma: A Population-Based, Matched Cohort Study in Ontario, Canada

Hallie Coltin ; Priscila Pequeno ; Ning Liu ; Derek S. Tsang ; Sumit Gupta ; Michael D. Taylor ; Eric Bouffet ; Paul C. Nathan ; Vijay Ramaswamy

PURPOSE: Survivors of childhood medulloblastoma suffer from substantial late effects. We characterized these sequelae using real-world health services data in a population-based cohort of medulloblastoma survivors. METHODS: All 5-year medulloblastoma survivors diagnosed age < 18 years between 1987 and 2015 in Ontario, Canada, were identified and matched 1:5 with population controls. Index date was 5 years from latest pediatric cancer event. Linkage to provincial administrative health data [...]

Menée à partir des données des registres américains des cancers portant sur 268 501 adolescents et jeunes adultes atteints d'un cancer diagnostiqué entre 2000 et 2016, cette étude analyse les facteurs associés au risque de décès prématuré

Risk of early death in adolescents and young adults with cancer: a population-based study

Berkman, Amy M ; Andersen, Clark R ; Hildebrandt, Michelle A T ; Livingston, J A ; Green, Adam L ; Puthenpura, Vidya ; Peterson, Susan K ; Milam, Joel ; Miller, Kimberly A ; Freyer, David R ; Roth, Michael E

Background: Advancements in treatment and supportive care have led to improved survival for adolescents and young adults (AYAs) with cancer; however, a subset of those diagnosed remain at risk for early death (within 2 months of diagnosis). Factors that place AYAs at increased risk of early death have not been well studied. Methods: The Surveillance, Epidemiology, and End Results registry was used to assess risk of early death in AYAs with hematologic malignancies, central nervous system [...]

Menée aux Etats-Unis à partir de données portant sur 9 203 femmes âgées ayant survécu à un cancer (âge moyen au diagnostic : 73 ans) et sur 45 358 témoins, cette étude de cohorte prospective analyse l'évolution de leurs fonctions physiques

Long-term Trajectories of Physical Function Decline in Women With and Without Cancer

Cespedes Feliciano, Elizabeth M. ; Vasan, Sowmya ; Luo, Juhua ; Binder, Alexandra M. ; Chlebowski, Rowan T. ; Quesenberry, Charles ; Banack, Hailey R. ; Caan, Bette J. ; Paskett, Electra D. ; Williams, Grant R. ; Barac, Ana ; LaCroix, Andrea Z. ; Peters, Ulrike ; Reding, Kerryn W. ; Pan, Kathy ; Shadyab, Aladdin H. ; Qi, Lihong ; Anderson, Garnet L.

Importance: Patients with cancer experience acute declines in physical function, hypothesized to reflect accelerated aging driven by cancer-related symptoms and effects of cancer therapies. No study has examined long-term trajectories of physical function by cancer site, stage, or treatment compared with cancer-free controls. Objective : Examine trajectories of physical function a decade before and after cancer diagnosis among older survivors and cancer-free controls. Design, Setting, and [...]

Menée à partir de données portant sur 718 patients âgés atteints d'un cancer de stade avancé (âge moyen : 77 ans), cette étude de cohorte analyse l'association entre une polypharmacie et les interactions médicamenteuses, les toxicités, les hospitalisations non programmées ainsi que l'abandon précoce du traitement anticancéreux

Association of polypharmacy and potential drug-drug interactions with adverse treatment outcomes in older adults with advanced cancer

Mohamed, Mostafa R. ; Mohile, Supriya G. ; Juba, Katherine M. ; Awad, Hala ; Wells, Megan ; Loh, Kah Poh ; Flannery, Marie ; Culakova, Eva ; Tylock, Rachael G. ; Ramsdale, Erika E.

Background: Polypharmacy is common in older adults who are starting cancer treatment and is associated with an increased risk of potentially inappropriate medications (PIMs) and potential drug-drug interactions (PDIs). The authors evaluated the association of medication measures with adverse outcomes in older adults with advanced cancer who were receiving systemic therapy. Methods: This secondary analysis from GAP 70+ Trial (ClinicalTrials.gov identifier NCT02054741; principal investigator, [...]

Menée aux Etats-Unis, cette étude transversale analyse les disparités, selon les Etats, dans l'utilisation des thérapies ciblées chez des patients atteints d'un cancer du poumon non à petites cellules présentant des altérations au niveau du gène EGFR ou ALK et bénéficiant de la couverture Medicaid

Variation in Use of Lung Cancer Targeted Therapies Across State Medicaid Programs, 2020-2021

Roberts, Thomas J. ; Kesselheim, Aaron S. ; Avorn, Jerry

Importance : Targeted therapies for EGFR (OMIM 131550)– and ALK (OMIM 105590)–altered metastatic non–small cell lung cancer (NSCLC) substantially improve outcomes for some patients. However, use of these therapies is lower among Medicaid patients, and access to oncology care varies across state Medicaid programs. Evidence is lacking on how use of targeted therapies for metastatic NSCLC varies across state Medicaid programs. Objectives : To characterize state-level variation in the use of [...]

Menée aux Etats-Unis à partir de données portant sur 2 008 patients ayant survécu à une tumeur de Wilms, cette étude de cohorte analyse les morbidités à long terme et la mortalité tardive (au moins 5 ans après le diagnostic ; 142 décès) en lien avec les traitements reçus

Late Health Outcomes Among Survivors of Wilms Tumor Diagnosed Over Three Decades: A Report From the Childhood Cancer Survivor Study

Brent R. Weil ; Andrew J. Murphy ; Qi Liu ; Rebecca M. Howell ; Susan A. Smith ; Christopher B. Weldon ; Elizabeth A. Mullen ; Arin L. Madenci ; Wendy M. Leisenring ; Joseph P. Neglia ; Lucie M. Turcotte ; Kevin C. Oeffinger ; Amanda M. Termuhlen ; Sogol Mostoufi-Moab ; Jennifer M. Levine ; Kevin R. Krull ; Yutaka Yasui ; Leslie L. Robison ; Gregory T. Armstrong ; Eric J. Chow ; Saro H. Armenian

PURPOSE: To evaluate long-term morbidity and mortality among unilateral, nonsyndromic Wilms tumor (WT) survivors according to conventional treatment regimens. METHODS: Cumulative incidence of late mortality (≥ 5 years from diagnosis) and chronic health conditions (CHCs) were evaluated in WT survivors from the Childhood Cancer Survivor Study. Outcomes were evaluated by treatment, including nephrectomy combined with vincristine and actinomycin D (VA), VA + doxorubicin + abdominal radiotherapy [...]

Menée en France à partir de données portant sur 3 227 adolescents et jeunes adultes atteints d'un sarcome diagnostiqué entre 2010 et 2017 (âge : 15-30 ans), cette étude analyse les traitements reçus, le lieu de la prise en charge (centres de référence ou ailleurs) et la survie

Management and outcomes of adolescent and young adult sarcoma patients: results from the French nationwide database NETSARC

Kubicek, Pierre ; Cesne, Axel Le ; Lervat, Cyril ; Toulmonde, Maud ; Chevreau, Christine ; Duffaud, Florence ; Le Nail, Louis-Romee ; Morelle, Magali ; Gaspar, Nathalie ; Vérité, Cecile ; Castex, Marie-Pierre ; Penel, Nicolas ; Saada, Esma ; Causeret, Sylvain ; Bertucci, François ; Perrin, Christophe ; Bompas, Emmanuelle ; Orbach, Daniel ; Laurence, Valérie ; Piperno-Neumann, Sophie ; Anract, Philippe ; Rios, Maria ; Gentet, Jean-Claude ; Mascard, Eric ; Pannier, Stéphanie ; Blouin, Pascale ; Carrère, Sébastien ; Chaigneau, Loïc ; Soibinet-Oudot, Pauline ; Corradini, Nadège ; Boudou-Rouquette, Pascaline ; Ruzic, Jean-Christophe ; Lebrun-Ly, Valérie ; Dubray-Longeras, Pascale ; Varatharajah, Sharmini ; Lebbé, Celeste ; Ropars, Mickaël ; Kurtz, Jean-Emmanuel ; Guillemet, Cécile ; Lotz, Jean-Pierre ; Berchoud, Juliane ; Cherrier, Grégory ; Ducimetiere, Francoise ; Chemin, Claire ; Italiano, Antoine ; Honoré, Charles ; Désandes, Emmanuel ; Blay, Jean-Yves ; Gouin, Francois ; Marec-Bérard, Perrine

Background: The initial management of patients with sarcoma is a critical issue. We used the nationwide French National Cancer Institute-funded prospective sarcoma database NETSARC to report the management and oncologic outcomes in adolescents and young adults (AYAs) patients with sarcoma at the national level. Patients and methods: NETSARC database gathers regularly monitored and updated data from patients with sarcoma. NETSARC was queried for patients (15–30 years) with sarcoma diagnosed from [...]

Menée à Hong Kong auprès de 125 aidants familiaux de patients atteints d'un cancer recevant des soins palliatifs, cette étude analyse l'impact de leur sentiment d'auto-efficacité sur l'association entre leurs besoins en soins de support et leur qualité de vie

Mediating role of self-efficacy between unmet needs and quality of life in palliative cancer caregivers

CHENG, Hui-Lin ; LEUNG, Doris Yin Ping ; KO, Po Shan ; LAM, Wai Man ; LAM, Po Tin ; LUK, Andrew Leung ; CHUNG, Ming Wai ; LAM, Simon Ching

Objective: Although unmet support needs are associated with health-related quality of life (HRQOL) in cancer caregivers, little is known about the mechanism underlying the relationship between two variables. The self-efficacy (SE) theory and literature suggest that caregiving SE is important in the perception of and reaction to caregiving demands, which in turn affects HRQOL. The aim of this study was to examine whether caregiving SE mediates the relationship between unmet support needs and [...]

Menée à Taïwan à partir de données portant sur 5 121 enfants et adolescents ayant survécu à un cancer (âge moyen : 9 ans) et sur 51 210 témoins, cette étude longitudinale analyse le risque de développer des troubles psychiatriques

Risk of Major Psychiatric Disorders Among Children and Adolescents Surviving Malignancies: A Nationwide Longitudinal Study

Tien-Wei Hsu ; Chih-Sung Liang ; Shih-Jen Tsai ; Ya-Mei Bai ; Tung-Ping Su ; Tzeng-Ji Chen ; Mu-Hong Chen

PURPOSE: Evidence suggests an increased long-term risk of major psychiatric disorders (MPDs) in childhood and adolescent cancer survivors (CACSs). However, definitive conclusions regarding such associations and whether such associations vary for different types of cancers remain unclear. METHODS: Using a nationwide data set from 2001 to 2011, we enrolled CACSs and likewise randomly selected individuals without cancer from the general population (1:10 ratio) who were matched to the CACSs with [...]

A partir d'une revue de la littérature (55 articles, 12 976 patients), cette méta-analyse évalue l'association entre l'empathie du médecin et la survie du patient atteint d'un cancer

The association of physician empathy with cancer patient outcomes: A meta-analysis

LELORAIN, Sophie ; GEHENNE, Lucie ; Christophe, Véronique ; DUPREZ, Christelle

Objective: In oncology, research remains unclear as to whether physician empathy is associated with patient outcomes. Our goal was to answer this question and explore potential moderators of the association. Methods: In this meta-analysis on adult cancer care, we excluded randomised controlled trials, and studies of survivors without active disease or involving analogue patients. Eight databases were searched, in addition to reference lists of relevant articles and grey literature. Two [...]

A partir d'une revue de la littérature publiée entre 2000 et 2021 (51 études), cette méta-analyse évalue l'effet, sur les fonctions neurocognitives des enfants et adolescents atteints d'une leucémie lymphoblastique aiguë, d'une chimiothérapie en combinaison ou non avec une radiothérapie

Effect of chemotherapy (with and without radiotherapy) on the intelligence of children and adolescents treated for acute lymphoblastic leukemia; a meta-analysis

Cao, Shu-Chun ; Legerstee, Jeroen S. ; van Bellinghen, Marc ; Lemiere, Jurgen ; Sleurs, Charlotte ; Segers, Heidi ; Danckaerts, Marina ; Dierckx, Bram

Objective: This meta-analysis assesses cognitive functioning in children with acute lymphoblastic leukemia (ALL) post-treatment who were treated with either chemotherapy-only (CT-only) or in combination with radiation therapy (CTRT). Methods: The databases Pubmed and PsychInfo were searched between 1-1-2000 and 31-12-2021. Data were analyzed using Comprehensive Meta-Analysis (version 2). Results: Mean weighted intelligence after treatment was 100.2 (number of studies n=51, 95%CI: 98.8 to [...]

Menée en Suède par questionnaire auprès de 481 patientes atteintes d'un cancer du sein traité par mastectomie, cette étude analyse les facteurs associés à la satisfaction vis-à-vis de leur vie et de leur image corporelle

Life satisfaction, body image and associated factors among women with breast cancer after mastectomy

Phoosuwan, Nitikorn ; Lundberg, Pranee C.

Background : Women having undergone mastectomy due to breast cancer have experiences which are very much individual and contextual. In order to understand the women and improve their quality of life, the aim of this study was to investigate life satisfaction, body image and associated factors among Swedish women with breast cancer after mastectomy. Methods : This descriptive cross-sectional study enrolled 481 Swedish women with breast cancer after mastectomy who completed a questionnaire [...]

Menée dans 17 pays d'Amérique latine par enquête auprès de 831 médecins d'enfants atteints d'un cancer, cette étude analyse leurs points de vue concernant le moment idéal pour intégrer ces patients dans un programme de soins palliatifs et les facteurs entravant cette intégration

Ideal vs Actual Timing of Palliative Care Integration for Children With Cancer in Latin America

McNeil, Michael J. ; Ehrlich, Bella ; Wang, Huiqi ; Bustamante, Marisol ; Dussel, Veronica ; Friedrich, Paola ; Garcia Quintero, Ximena ; Gillipelli, Srinithya R. ; Gomez Garcia, Wendy ; Graetz, Dylan ; Kaye, Erica C. ; Metzger, Monika ; Sabato Danon, Carla Vittoria ; Devidas, Meenakshi ; Baker, Justin N. ; Agulnik, Asya ; Assessing Doctors’ Attitudes on Palliative Treatment Latin America Study Group

Early integration of pediatric palliative care (PPC) for children with cancer is critical for the quality of life of both patient and family. To improve access to PPC in resource-limited settings, barriers to early integration must be understood.To evaluate the ideal vs actual timing of PPC integration for children with cancer and to uncover barriers to early integration identified by physicians in Latin America.The Assessing Doctors’ Attitudes on Palliative Treatment (ADAPT) survey was [...]