Menée à partir de données chinoises 2000-2019 portant sur 538 147 utilisateurs d'aspirine et 968 378 non-utilisateurs, cette étude analyse l'effet chimioprotecteur de l'aspirine sur le risque de cancer et la mortalité spécifique en fonction de la durée d'utilisation

Long-term use of low-dose aspirin for cancer prevention: A 20-year longitudinal cohort study of 1,506,525 Hong Kong residents

Lam, Amy ; Hao, Ziyu ; Yiu, Karen ; Chan, Stephen ; Chan, Francis ; Sung, Joseph ; Tsoi, Kelvin

Long-term use of low-dose aspirin has been demonstrated to reduce cancer risk, but the duration of necessary medication use remains uncertain. This study aimed to investigate the long-term chemoprotective effect of aspirin among the Chinese population. This population-based study included all aspirin users between 2000 and 2019. Aspirin users were age-sex matched with non-users at a 1:2 ratio. Cancer incidence and mortality were the main outcomes measured. Survival analyses with the Fine–Gray [...]

Menée à partir de données portant sur 1 360 230 enfants danois nés entre 1997 et 2018, cette étude analyse l'association entre les vaccinations infantiles et le risque de leucémie (771 cas)

Childhood vaccinations and the risk of leukemia: A nationwide cohort study

Alberts, Aya ; Kjaer, Susanne K. ; Søegaard, Signe H. ; Winther, Jeanette F. ; Schmiegelow, Kjeld ; Sopina, Liza ; Erdmann, Friederike ; Hargreave, Marie

A protective effect of childhood vaccinations on leukemia risk, particularly acute lymphoblastic leukemia (ALL), has been hypothesized, though findings are inconsistent. We used a nationwide cohort of Danish children born 1997–2018 (n = 1,360,230), to examine associations between childhood vaccinations and leukemia (<20 years) using registry data (follow-up: December 31, 2018). Cox proportional hazard models with age as the underlying time estimated hazard ratios (HRs) for leukemia (any, ALL, [...]

A partir d'une revue systématique de la littérature publiée jusqu'en novembre 2023 (36 études), cette méta-analyse évalue l'efficacité d'interventions impliquant activement les parents pour la prévention du tabagisme ou le sevrage tabagique auprès des enfants et adolescents

Smoking Prevention and Cessation Programs for Children and Adolescents Focusing on Parental Involvement: A Systematic Review and Meta-Analysis

Rifat, M. A. ; Orsini, Nicola ; Qazi, Basra ; Galanti, Maria Rosaria

This study aims to determine the effect and equity outcomes of smoking prevention or smoking cessation interventions for children and adolescents involving parents. A systematic literature search was conducted between 24 November 2022 and 27 November 2023 in PubMed, Medline, Web of Science, Embase, PsycINFO, Google Scholar, ClinicalTrials.gov, EU Clinical Trials Register, and the WHO international clinical trials registry. Experimental or quasi-experimental studies reporting smoking initiation [...]

Menée sur le réseau social Instagram, cette étude évalue le rapport coût-efficacité de messages de prévention anticancer abordant 5 facteurs de risque modifiables (tabac, alimentation, alcool, exposition au soleil, papillomavirus humain) et diffusés par un influenceur virtuel généré à l'aide d'une intelligence artificielle

AI-generated cancer prevention influencers can target risk groups on social media at low cost

Winterstein, Jana T. ; Abels, Julia ; Kuehn, Arlene ; Carl, Nicolas ; Wies, Christoph ; Brinker, Titus J.

Background: This study explores the potential of Artificial Intelligence (AI)-generated social media influencers to disseminate cancer prevention messages. Utilizing a Generative AI (GenAI) application, we created a virtual persona, "Wanda", to promote cancer awareness on Instagram. Methods: We created five posts, addressing the five most modifiable risk factors for cancer: tobacco consumption, unhealthy diet, sun exposure, alcohol consumption, and Human Papillomavirus (HPV) infection. To [...]