The dynamic effects of nutritional status on chemotherapy-related toxicity in patients with non-Hodgkin’s lymphoma
Menée auprès de 143 patients atteints d'un lymphome non hodgkinien récemment diagnostiqué (âge médian : 50,2 ans ; durée médiane de suivi : 18,8 mois), cette étude multicentrique évalue l'influence de l'état nutritionel sur la toxicité de la chimiothérapie et la survie
Résumé en anglais
Background/Objectives: Understanding the dynamic changes in nutritional status of patients with non-Hodgkin’s lymphoma (NHL) during chemotherapy is crucial, as it significantly impacts chemotherapy-related toxicity and survival outcomes.
Subjects/Methods: This multi-center study included newly diagnosed NHL patients. Nutritional status and chemotherapy-related toxic effects were assessed over the first five chemotherapy sessions, with follow-ups conducted every 3 months. Patients were categorized into three groups based on pre-chemotherapy Patient-Generated Subjective Global Assessment (PG-SGA) scores: Group A (0–1), Group B (2–8), and Group C (>9). Repeated-measures ANOVA and Generalized Estimating Equations (GEE) models were used for analysis, with survival outcomes evaluated via Kaplan–Meier and Cox regression.
Results: A total of 143 patients (mean age 50.26 ± 15.02 years) completed the study, over a median follow-up of 18.8 months. PG-SGA scores were highest in Group C during chemotherapy (P < 0.001), with significant time-group interaction effects (P < 0.001). Liver and kidney impairments worsened across all groups (P < 0.05), while gastrointestinal toxicity and bone marrow suppression initially decreased before increasing. GEE analysis showed that nutritional status positively influenced gastrointestinal toxicity (
