Sublobar resection for small-sized non-small cell lung cancer: a comprehensive comparison between subsegmentectomy, segmentectomy and wedge resection

Menée à partir de données portant sur 1 440 patients atteints d'un cancer du poumon non à petites cellules (durée de suivi : 55,1 mois), cette étude analyse les résultats en fonction du traitement chirurgical reçu (sous-segmentectomie, segmentectomie ou résection cunéiforme)

Résumé en anglais

Objectives: Subsegmentectomy has been adopted for non-small cell lung cancer (NSCLC) for decades. This study aimed to compare the features between subsegmentectomy, segmentectomy and wedge resection for NSCLC.

Materials and Methods: NSCLC patients who underwent subsegmentectomy, segmentectomy, or wedge resection between 2014 and 2019 were retrospectively screened. Demographic, radiomic, and perioperative characteristics between patients were compared. Further, log-rank test, univariate and multivariate Cox regression were used for prognostic evaluation.

Results: There were 276, 670, and 494 patients undergoing subsegmentectomy, segmentectomy, and wedge resection, respectively. Patients with segmentectomy and subsegmentectomy had larger tumor sizes and greater distances to the pleura than those with wedge resection. Subsegmentectomy and segmentectomy were more likely to achieve adequate surgical margins than wedge resection (82.0% vs. 79.5% vs. 64.7%, P<0.001), which was especially true for nodules away from the pleura (80.2% vs. 81.4% vs. 55.8%, P<0.001). In addition, anatomic resection allowed for more lymph node dissection and required less preoperative localization than wedge reception. Subsegmentectomy preserved about two subsegments than segmentectomy (P<0.001). The incidence of prolonged air leakage after subsegmentectomy (3.3%) and wedge (1.8%) was similar (P=0.308). Notably, 66.8% of patients who underwent segmentectomy or subsegmentectomy were considered unsuitable for wedge. During the follow-up (55.1 months), no tumor recurrence or death occurred in patients undergoing subsegmentectomy. No significant recurrence-free survival (P=0.140) or overall survival (P=0.370) difference existed between these groups.

Conclusions: Subsegmentectomy could achieve more adequate surgical margins than wedge resection and showed superiority for deep nodules. Compared to segmentectomy, subsegmentectomy could preserve more lung parenchyma.