A partir d'une revue systématique de la littérature publiée jusqu'en avril 2023 (6 études), cette étude analyse l'intérêt de la pratique collective du chant pour améliorer le bien-être (émotionnel, physique, social, spirituel) et la qualité de vie des aidants et des patients atteints d'un cancer

A systematic review of change in symptoms, well-being and quality of life with group singing in people with cancer and their caregivers

Bains, Kuljit Kaur ; Jennings, Sophie ; Bull, Caitlin ; Tilley, Louise ; Montgomery, Laura ; Lee, Annemarie L.

Purpose: This systematic review aimed to assess the impact of group singing on physical function, cancer-related symptoms, well-being (emotional, physical, social, spiritual), and health-related quality of life in individuals with cancer and their caregivers. Methods: A search was performed using Ovid MEDLINE, Embase, Scopus and Web of Science from inception to April 2023; key words included cancer, choir, and group singing. Observational cohort, prospective or retrospective studies, randomized [...]

A partir d'une revue de la littérature (60 articles), cette étude analyse l'efficacité des stratégies de prise en charge d'une neuropathie périphérique induite par la chimiothérapie chez les patients atteints d'un cancer

Summary of evidence on comprehensive healthcare for chemotherapy-induced peripheral neuropathy in cancer patients

Dan, Xin ; He, Ya-Lin ; Tian, Ya-Lin ; Huang, Yan ; Ren, Jian-Hua

Objective: This paper aims to provide an evidence-based summary of the most effective strategies for comprehensive healthcare of chemotherapy-induced peripheral neuropathy (CIPN) in cancer patients. Method: Following the “6S” model, relevant evidence on CIPN management was collected from reputable evidence-based resource websites and databases nationally and internationally. The included articles were evaluated for methodological quality, and evidence was extracted using the Australian JBI [...]

A partir d'une revue de la littérature publiée jusqu'en mai 2023 (32 études), cette étude analyse les interactions entre les symptômes somatiques et psychologiques chez les patients atteints d'un cancer ou ayant survécu à la maladie

Network analysis used to investigate the interplay among somatic and psychological symptoms in patients with cancer and cancer survivors: a scoping review

Doppenberg-Smit, G. Elise ; Lamers, Femke ; van Linde, Myra E. ; Braamse, Annemarie M. J. ; Sprangers, Mirjam A. G. ; Beekman, Aartjan T. F. ; Verheul, Henk M. W. ; Dekker, Joost

Purpose: Patients with cancer often experience multiple somatic and psychological symptoms. Somatic and psychological symptoms are thought to be connected and may reinforce each other. Network analysis allows examination of the interconnectedness of individual symptoms. The aim of this scoping review was to examine the current state of knowledge about the associations between somatic and psychological symptoms in patients with cancer and cancer survivors, based on network analysis. Methods: [...]

Cette étude passe en revue les données évaluant l'impact du jeûne intermittent sur les symptômes et la qualité de vie des patients traités pour un cancer

Intermittent fasting and its impact on Toxicities, symptoms and quality of life in patients on active cancer treatment

Li Sucholeiki, Robert ; Propst, Casey L. ; Hong, David S. ; George, Goldy C.

We examine in this review the impact of intermittent fasting on symptoms, toxicities, and quality of life in patients undergoing cancer therapy and highlight unmet investigative areas to prompt future research.?While current evidence is preliminary and conclusions mixed, some promising clinical studies suggest that intermittent fasting interventions may improve fatigue and reduce gastrointestinal toxicities in certain patients with cancer.?Emerging clinical evidence also demonstrates that [...]

A partir d'une revue systématique de la littérature (10 études, 495 patients), cette étude évalue l'intérêt de l'art-thérapie pour soulager, pendant la chimiothérapie, les symptômes psychiques (anxiété, dépression) et améliorer la qualité de vie des patients atteints d'un cancer

The effectiveness of therapeutic artmaking on depression, anxiety, quality of life, and psychological distress in cancer patients on chemotherapy: a systematic review of the literature

Peng, Juan ; Cheng, Dan

Objectives: The purpose of this study was to evaluate the evidence of art therapy on depression, anxiety, quality of life, and mental distress in cancer patients undergoing chemotherapy. Methods: A systematic literature search was conducted. A systematic search of online electronic databases including, PubMed/MEDLINE, Scopus Web of Science, PsycINFO, and EMBASE was performed using keywords extracted from Medical Subject Headings such as “Art Therapy,” and “Neoplasms,” “Cancer,” and [...]

Mené sur 71 patients atteints d'un cancer, cet essai randomisé évalue l'intérêt d'une application mobile pour déclarer et prendre en charge les symptômes liés à l'utilisation d'immunothérapies et améliorer la qualité de vie

Electronic health intervention to manage symptoms of immunotherapy in patients with cancer (SOFIA): Results from a randomized controlled pilot trial

Sauer, Christina ; Zschäbitz, Stefanie ; Krauss, Jürgen ; Walle, Thomas ; Haag, Georg Martin ; Jäger, Dirk ; Hiller, Kiriaki ; Bugaj, Till Johannes ; Friederich, Hans-Christoph ; Maatouk, Imad

Background: For patients receiving immune checkpoint inhibitors, early detection of immune-related adverse events (irAEs) is critical for one’s safety. To this end, a smartphone app (SOFIA) was developed that featured the assessment of electronic patient-reported outcomes (ePROs) focusing on irAEs as well as a set of comprehensive supportive information. Its feasibility and preliminary efficacy were evaluated in a randomized controlled trial (RCT). Methods: Patients who received immune [...]

Menée aux Etats-Unis par questionnaire auprès de 1 515 patients ayant survécu à un cancer, cette étude analyse les facteurs associés à leur utilisation récréative ou thérapeutique de cannabis

Cannabis use after a cancer diagnosis in a population-based sample of cancer survivors

Ton, Mimi ; Newcomb, Polly A. ; Jones, Salene ; Malen, Rachel C. ; Heffner, Jaimee L.

Purpose: This study aimed to characterize the prevalence and correlates of cannabis use and the methods and reasons for use among recently diagnosed cancer survivors in a population sample within Washington state. Methods: We identified individuals diagnosed with invasive cancers in the prior 6 to 17 months from April 2020 to December 2020 using the Seattle-Puget Sound Surveillance, Epidemiology, and End Results (SEER) cancer registry. Participants (n = 1,515) completed a questionnaire, [...]

Mené sur 96 patients atteints d'un cancer, cet essai randomisé évalue l'intérêt d'une application mobile destinée à améliorer l'auto-prise en charge de la douleur liée à la maladie

Randomized controlled trial of an app for cancer pain management

Weng, Lizhu ; Lin, Wanlong ; Lin, Xiuxian ; Liu, Maobai ; Yang, Jing

Purpose: The primary objective of this investigation was to devise a mobile application for self-management of cancer-related discomfort, with the overarching goal of enhancing patients’ overall well-being. Would the utilization of the self-management application result in an amelioration of life quality compared to conventional follow-up procedures? Methods: Modules were meticulously devised with the collaborative expertise of oncology pain specialists employing the Delphi technique. [...]

Mené sur 59 patients atteints d'un cancer de la prostate traité par thérapie anti-androgénique (âge moyen : 67,7 ans), cet essai de phase II évalue l'intérêt d'une supplémentation en vitamine D pour réduire la perte de densité osseuse liée au traitement anticancéreux

High-dose vitamin D to attenuate bone loss in patients with prostate cancer on androgen deprivation therapy: A phase 2 RCT

Peppone, Luke J. ; Kleckner, Amber S. ; Fung, Chunkit ; Puzas, J. Edward ; Reschke, Jennifer E. ; Culakova, Eva ; Inglis, Julia ; Kamen, Charles ; Friedberg, Jonathan W. ; Janelsins, Michelle ; Mustian, Karen ; Heckler, Charles E. ; Mohile, Supriya

Background: Androgen deprivation therapy (ADT) inhibits prostate cancer growth. However, ADT causes loss of bone mineral density (BMD) and an increase in fracture risk; effective interventions for ADT-induced bone loss are limited. Methods: A phase 2 randomized controlled trial investigated the feasibility, safety, and preliminary efficacy of high-dose weekly vitamin D (HDVD, 50,000 IU/week) versus placebo for 24 weeks in patients with prostate cancer receiving ADT, with all subjects receiving [...]

Mené sur 303 patientes ayant survécu à un cancer du sein, cet essai randomisé évalue l'intérêt d'une intervention de réadaptation menée par téléphone pour améliorer leur participation à des activités de loisirs ou à des activités sociales ou familiales

Telephone-Based Rehabilitation Intervention to Optimize Activity Participation After Breast Cancer: A Randomized Clinical Trial

Lyons, Kathleen Doyle ; Wechsler, Stephen B. ; Ejem, Deborah B. ; Stevens, Courtney J. ; Azuero, Andres ; Khalidi, Sarah ; Hegel, Mark T. ; dos Anjos, Sarah M. ; Codini, Megan E. ; Chamberlin, Mary D. ; Morency, Jamme L. ; Coffee-Dunning, Jazmine ; Thorp, Karen E. ; Cloyd, Danielle Z. ; Goedeken, Susan ; Newman, Robin ; Muse, Colleen ; Rocque, Gabrielle ; Keene, Kimberly ; Pisu, Maria ; Echols, Jennifer ; Bakitas, Marie A.

Importance : Following treatment, breast cancer survivors face challenges participating in valued activities. Objective : To determine whether a telephone-based coaching rehabilitation intervention enhances activity participation in the year following breast cancer treatment. Design, Setting, and Participants : In this multisite, single-blind randomized clinical trial (Optimizing Functional Recovery of Breast Cancer Survivors), recruitment occurred between August 28, 2019, and April 30, 2022. [...]

A partir d'une revue systématique de la littérature (21 études), cette étude identifie les facteurs associés aux besoins en soins de support des patients atteints d'un cancer de la vessie sans envahissement musculaire

Identifying the supportive care needs of people affected by non-muscle invasive bladder cancer: An integrative systematic review

Schubach, Kathryn ; Niyonsenga, Theo ; Turner, Murray ; Paterson, Catherine

Purpose: To understand supportive care needs among people with non-muscle invasive bladder cancer (NMIBC). Methods: An integrative systematic review was reported using the Preformed Reporting Items for Systematic Review and Meta-analyses (PRISMA) guidelines. Seven electronic databases were searched for relevant studies, including all quantitative, qualitative, and mixed methods studies, irrespective of research design. The review process was managed by Covidence systematic review software. Two [...]

Menée à partir de données portant sur 1 293 patients atteints d'un adénocarcinome de l'estomac ou de la jonction oesogastrique traité par gastrectomie radicale et présentant une infection par Hélicobacter pylori (âge médian : 59 ans), cette étude de cohorte rétrospective évalue l'effet, sur la survie globale et la survie sans maladie, d'un traitement anti-Hélicobacter pylori par amoxicilline, clarithromycine et oméprazole

Anti–Helicobacter pylori Treatment in Patients With Gastric Cancer After Radical Gastrectomy

Zhao, Zhoukai ; Zhang, Ruopeng ; Chen, Guoming ; Nie, Man ; Zhang, Feiyang ; Chen, Xiaojiang ; Lin, Jun ; Chen, Zewei ; Lin, Feizhi ; Wei, Chengzhi ; Zheng, Ziqi ; Ruan, Shenghang ; Huang, Bowen ; Chen, Yingbo ; Nie, Runcong

Importance : Whether anti–Helicobacter pylori treatment can provide survival benefits for patients with gastric cancer who are diagnosed with H pylori infection is an area with limited research. Objective : To explore the potential survival benefits of anti–H pylori treatment after radical gastrectomy in patients with gastric cancer and presurgical confirmation of H pylori infection. Design, Setting, and Participants : This retrospective cohort study was conducted using data from patients with [...]

Menée aux Etats-Unis à partir de données portant sur 3 698 patients atteints d'une leucémie aiguë, cette étude de cohorte rétrospective analyse leur participation à un essai clinique en fonction de l'origine ethnique

Race/ethnic associations with comprehensive cancer center access and clinical trial enrollment for acute leukemia

Hantel, Andrew ; Brunner, Andrew M ; Plascak, Jesse J ; Uno, Hajime ; Varela, Juan C ; Luskin, Marlise R ; Rebbeck, Timothy R ; Stone, Richard M ; Lathan, Christopher S ; DeAngelo, Daniel J ; Abel, Gregory A

Background: Clinical trial participation at Comprehensive Cancer Centers (CCC) is inequitable for minoritized race/ethnic groups with acute leukemia. CCCs care for a high proportion of adults with acute leukemia. It is unclear if participation inequities are due to CCC access, post-access enrollment, or both. Methods: We conducted a retrospective cohort study of adults with acute leukemia (2010-2019) residing within Massachusetts, the designated catchment area of the Dana-Farber/Harvard Cancer [...]

Menée aux Etats-Unis à partir de données 1999-2018 d'une enquête portant sur 317 patients ayant survécu à un cancer et connaissant une insécurité alimentaire, cette étude analyse l'association entre divers régimes alimentaires et le risque de décès

Dietary patterns among U.S. food insecure cancer survivors and the risk of mortality: NHANES 1999–2018

Maino Vieytes, Christian A. ; Zhu, Ruoqing ; Gany, Francesca ; Koester, Brenda D. ; Arthur, Anna E.

Purpose: Food insecurity—the lack of unabated access to nutritious foods—is a consequence many cancer survivors face. Food insecurity is associated with adverse health outcomes and lower diet quality in the general public. The goal of this analysis was to extract major and prevailing dietary patterns among food insecure cancer survivors from observed 24-h recall data and evaluate their relationship to survival after a cancer diagnosis. Methods: We implemented two dietary patterns analysis [...]

Menée aux Etats-Unis sur la période 2001-2019, cette étude analyse l'évolution des traitements anticancéreux reçus par les patients atteints d'un cancer et infectés par le VIH

Cancer Treatment Disparities in People With HIV in the United States, 2001-2019

Jennifer K. McGee-Avila ; Gita Suneja ; Eric A. Engels ; Anne F. Rositch ; Marie-Josephe Horner ; Qianlai Luo ; Meredith S. Shiels ; Jessica Y. Islam

PURPOSE: People with HIV (PWH) have worse cancer outcomes, partially because of inequities in cancer treatment. We evaluated cancer treatment disparities among PWH, including an assessment of changes in disparities over time. METHODS: We used data from the HIV/AIDS Cancer Match Study, a population-based HIV and cancer registry linkage to examine diffuse large B-cell lymphoma (DLBCL), Hodgkin lymphoma (HL), and cancers of the cervix, lung, anus, prostate, colon, and female breast. Outcomes [...]

Menée en France par enquête auprès de 115 professionnels en oncologie (chirurgiens en oncologie gynécologique, radiothérapeutes oncologiques, oncologues médicaux), cette étude analyse leurs pratiques pour traiter un cancer du col de l'utérus de stade localement avancé et évalue le respect des recommandations européennes par les équipes pluridisciplinaires

Variability of treatment of locally advanced cervical cancer: How French multidisciplinary teams follow European guidelines?

Sabah, Jonathan ; Menoux, Ines ; Eberst, Lauriane ; Lodi, Massimo ; Gantzer, Justine ; Azais, Henri ; El Hajj, Houssein ; Balaya, Vincent ; Babin, Guillaume ; Espenel, Sophie ; Dabi, Yohann ; Kissel, Manon ; Phuong Lien, Tran ; Angeles Fité, Martina ; Margueritte, Francois ; Deluche, Elise ; Marouk, Alexis ; Le borgne, Pierrick ; Apithy, Mah-Soune ; Laas-Faron, Enora ; Akladios, Cherif ; Lecointre, Lise

Introduction: Cervical cancer is a global public health concern. Despite ESGO recommendations and FIGO classification changes, management of locally advanced cervical cancer (LACC) remains debated in France. Our study aimed to review LACC treatment practices and assess adherence to ESGO recommendations among different practitioners. Methods: From February 2021 to August 2022, we conducted a survey among gynecologic oncology surgeons, radiation oncologists, and medical oncologists practicing in [...]

Menée à partir des données 2006-2017 des registres américains des cancers portant sur 90 631 patients atteints d'un cancer de la cavité buccale ou du pharynx, cette étude analyse l'incidence de la maladie, la survie relative à 5 ans, la stade au diagnostic et la mortalité en fonction de la persistance de la pauvreté

Persistent poverty disparities in incidence and outcomes among oral and pharynx cancer patients

Karanth, Shama ; Mistry, Shilpi ; Wheeler, Meghann ; Akinyemiju, Tomi ; Divaker, Joel ; Yang, Jae Jeong ; Yoon, Hyung-Suk ; Braithwaite, Dejana

Purpose: Disparities in oral cavity and pharyngeal cancer based on race/ethnicity and socioeconomic status have been reported, but the impact of living within areas that are persistently poor at the time of diagnosis and outcome is unknown. This study aimed to investigate whether the incidence, 5-year relative survival, stage at diagnosis, and mortality among patients with oral cavity and pharyngeal cancers varied by persistent poverty. Methods: Data were drawn from the SEER database [...]

Mené sur 132 patients ayant survécu à un cancer (âge moyen : 60 ans), cet essai randomisé évalue l'intérêt d'une thérapie cognitive et comportementale pour soulager la sévérité de l'insomnie et réduire les déficiences cognitives perçues et liées à la maladie

Randomized Controlled Trial of Virtually Delivered Cognitive Behavioral Therapy for Insomnia to Address Perceived Cancer-Related Cognitive Impairment in Cancer Survivors

Sheila N. Garland ; Joshua Tulk ; Josée Savard ; Joshua A. Rash ; Sondria Browne ; Robin Urquhart ; Melanie Seal ; John Thoms ; Kara Laing

PURPOSE: Comorbid insomnia and cancer-related cognitive impairment (CRCI) are experienced by up to 26% of individuals diagnosed with cancer. This study examined the efficacy and durability of cognitive behavioral therapy for insomnia (CBT-I) on perceived CRCI in cancer survivors. METHODS: Atlantic Canadian cancer survivors with insomnia and CRCI were randomly assigned to receive seven weekly virtual CBT-I sessions (n = 63) or placed in a waitlist control group (n = 69) to receive treatment [...]

Menée aux Etats-Unis auprès de 4 837 parents d'un enfant atteint d'un cancer (âge de l'enfant : inférieur ou égal à 21 ans) et de 24 185 témoins, cette étude transversale analyse leur utilisation de soins psychiques pendant l'année suivant le diagnostic de la maladie

Mental Health Care Utilization Among Parents of Children With Cancer

Hu, Xin ; Grosse, Scott D. ; Han, Xuesong ; Marchak, Jordan Gilleland ; Ji, Xu

Importance: Caring for children diagnosed with cancer may adversely affect the mental health (MH) of parents. Objective : To characterize utilization of MH services among parents of children with vs without cancer using nationwide commercial claims data. Design, Setting, and Participants : For this cross-sectional study, the Merative MarketScan Commercial Claims Database was used to identify continuously insured families of children treated for cancer (aged ≤21 years at diagnosis) during 2010 [...]

A partir d'une revue systématique de la littérature publiée jusqu'en septembre 2023 (17 articles, 555 patients), cette méta-analyse évalue l'intérêt des psychothérapies basées sur le sens (ou logothérapie) pour améliorer la croissance post-traumatique et réduire la peur de la mort chez les patients atteints d'un cancer

Effects of meaning-based psychotherapy on post-traumatic growth and death anxiety in patients with cancer: a systematic review and meta-analysis

Shaygan, Maryam ; Khaki, Sahar ; Zarei, Davood ; Moshfeghinia, Reza ; Beheshtaeen, Fateme ; Sadeghi, Yasin

Introduction: Cancer is one of the leading causes of mortality in the world which imposes numerous psychological burdens on the patients. Psycho-spiritual interventions such as meaning-based therapies may help decrease these challenges. This systematic review and meta-analysis aim to investigate the effects of meaning-based psychotherapy on post-traumatic growth and death anxiety of patients with cancer. Methods: PubMed, Scopus, Proquest, Web of Science, and Google Scholar were searched until [...]

A partir d'une revue systématique de la littérature publiée jusqu'en décembre 2022 (9 études), cette méta-analyse évalue l'intérêt des interventions psychosociales numériques pour prendre en charge la détresse psychique, les symptômes de dépression et d'anxiété des patientes atteintes d'un cancer gynécologique et améliorer leur qualité de vie

The effectiveness of digital psychosocial interventions on psychological distress, depression, anxiety, and health-related quality of life in patients with gynaecological cancer: a systematic review and meta-analysis

Yen, Kai Yoong ; Cheng, Jing Ying ; Li, Jin-Qiu ; Toh, Zheng An ; He, Hong-Gu

Purpose: Patients with gynaecological cancer often experience psychological issues due to multiple stressors. Psychological disturbances have debilitating effects on patients with gynaecological cancer. In recent decades, digital psychosocial interventions have rapidly advanced and been incorporated into mental health interventions. Digital psychosocial interventions could provide patients with several benefits over traditional in-person interventions, including convenience, anonymity, flexible [...]

Menée auprès de 133 patients âgés atteints d'un cancer de la prostate (âge moyen : 72 ans), cette étude analyse les effets à long terme de l'utilisation d'une thérapie anti-androgénique sur leurs fonctions cognitives

Cognitive effects of long-term androgen deprivation therapy in older men with prostate cancer

Pergolizzi, Denise ; Flaherty, Kathleen R. ; Saracino, Rebecca M. ; Root, James C. ; Schofield, Elizabeth ; Cassidy, Caroline ; Katheria, Vani ; Patel, Sunita K. ; Dale, William ; Nelson, Christian J.

Objective: Androgen deprivation therapy (ADT) is a common treatment for prostate cancer (PCa), with increasing numbers of men on ADT for longer. Limited evidence suggests ADT impacts cognition. This study addressed gaps in the literature by focusing on older men with PCa and assessing ADT usage longer than 1 year. Methods: This study of 133 men ≥65 years of age with PCa included two groups: (1) men on ADT for 1–3 years (ADT-exposed), and (2) a comparison group of men with PCa not on ADT [...]

Menée auprès de patientes âgées ayant survécu à un cancer du sein, cette étude prospective évalue l'intérêt d'un outil permettant de prédire le risque de déclin de leurs fonctions cognitives après les traitements systémiques

Prediction of cognitive decline in older breast cancer survivors: the thinking and living with cancer study

Mcdeed, Arthur Patrick ; Van Dyk, Kathleen ; Zhou, Xingtao ; Zhai, Wanting ; Ahles, Tim A ; Bethea, Traci N ; Carroll, Judith E ; Cohen, Harvey Jay ; Nakamura, Zev M ; Rentscher, Kelly E ; Saykin, Andrew J ; Small, Brent J ; Root, James C ; Jim, Heather ; Patel, Sunita K ; McDonald, Brenna C ; Mandelblatt, Jeanne S ; Ahn, Jaeil

Purpose: Cancer survivors commonly report cognitive declines after cancer therapy. Due to the complex etiology of cancer-related cognitive decline (CRCD), predicting who will be at risk of CRCD remains a clinical challenge. We developed a model to predict breast cancer survivors who would experience CRCD after systematic treatment. Patients and Methods: We used the Thinking and Living with Cancer study, a large ongoing multisite prospective study of older breast cancer survivors with complete [...]

Mené aux Etats-Unis, cet essai évalue la faisabilité et l'intérêt d'une intervention financière et juridique de coordination du parcours de soins pour réduire les difficultés financières et améliorer la qualité de vie des enfants, adolescents et jeunes adultes atteints d'un cancer et de leurs aidants

Financial-Legal navigation reduces financial toxicity of pediatric and AYA cancers

Edward, Jean ; Northrip, Kimberly D ; Rayens, Mary Kay ; Welker, Andrea ; O’Farrell, Rachel ; Knuf, Jennifer ; Fariduddin, Haafsah ; Costich, Julia ; D’Orazio, John

Background: Pediatric and Adolescent and Young Adult (AYA) cancer patients and caregivers are at high risk for financial toxicity and few evidence-based oncology financial and legal navigation programs exist to address it. We tested the feasibility, acceptability, and preliminary effectiveness of FINassist (Financial and Insurance Navigation Assistance), a novel interdisciplinary financial and legal navigation intervention for pediatric oncology patients and caregivers. Methods: We used a [...]

Menée en Italie dans un contexte de vie réelle à partir de données portant sur 189 patients d'origine caucasienne atteints d'un cancer du poumon non à petites cellules avec mutations de l'EGFR (durée de suivi : 20,7 mois), cette étude prospective compare le rapport coût-efficacité de l'osimertinib, du géfitinib et de l'erlotinib

Osimertinib in Patients With Treatment-Naive EGFR-Mutant Non-small Cell Lung Cancer: Overall Survival, Post-progression Management and Budget Impact Analysis in Real-World

Pasello, Giulia ; Lorenzi, Martina ; Scattolin, Daniela ; Del Conte, Alessandro ; Cecere, Fabiana ; Pavan, Alberto ; Macerelli, Marianna ; Polo, Valentina ; Pilotto, Sara ; Santarpia, Mariacarmela ; Cumerlato, Enrico ; Da Ros, Valentina ; Targato, Giada ; Bortolami, Alberto ; Bonanno, Laura ; Ferro, Alessandra ; Dal Maso, Alessandro ; Frega, Stefano ; Guarneri, Valentina

Introduction: The observational multicenter prospective FLOWER study (NCT04965701) confirmed effectiveness and safety of osimertinib in the real-world (RW) management of untreated EGFR-mutant advanced non-small cell lung cancer (aNSCLC) patients. Methods: Herein, we report updated survival data, post-progression management, cost/effectiveness and budget impact (BI) of osimertinib compared with a RW population receiving gefitinib or erlotinib. Results: Overall, 189 Caucasian patients receiving [...]

Mené au Mexique sur 146 patients atteints d'un cancer du poumon non à petites cellules de stade métastatique, cet essai randomisé évalue l'intérêt, du point de vue de la survie globale et de l'amélioration de la qualité de vie, de soins palliatifs dispensés précocement

Early Incorporation to Palliative Care (EPC) in Patients With Advanced Non-Small Cell Lung Cancer: The PACO Randomized Clinical Trial

Allende, Silvia ; Turcott, Jenny G ; Verástegui, Emma ; Rodriguez-Mayoral, Oscar ; Flores-Estrada, Diana ; Pérez Camargo, Dana Aline ; Ramos-Ramírez, Maritza ; Martínez-Hernández, Jorge-Negueb ; Oñate-Ocaña, Luis F ; Pina, Pamela Soberanis ; Cardona, Andrés F ; Arrieta, Oscar

Background: Patients with non-small cell lung cancer (NSCLC) experience a considerable disease burden, evident in symptomatic and psychological spheres. Advanced cancer represents a complex scenario for patients and the healthcare team. Early palliative care (EPC) has been proven as a clinically meaningful strategy in this context by several randomized trials but not in a resource-limited setting. This study aimed to evaluate the effect of EPC compared with standard oncological care (SOC) in [...]

Menée en Italie par enquête en ligne auprès de 320 professionnels en hématologie (personnel médical et infirmier), cette étude multicentrique analyse leurs perceptions des facteurs facilitant ou entravant l'accès aux soins palliatifs des patients atteints d'un cancer hématologique

A multicentre survey on the perception of palliative care among health professionals working in haematology

Di Lorenzo, Sara ; Mozzi, Lisa ; Salmaso, Flavia ; Silvagni, Claudia ; Soffientini, Silvia ; Valenti, Vanessa ; Zagonel, Vittorina

Purpose: Patients with haematologic malignancies have less access to palliative care and are referred later than patients with solid tumours. We developed a survey to investigate this phenomenon, with the intention of analysing palliative care perceptions among health professionals who treat haematology patients and identifying barriers and facilitators to referrals to palliative care services. Methods: This was a multicentre exploratory descriptive web-based survey. A questionnaire was [...]

Menée aux Etats-Unis par enquête transversale auprès de 204 oncologues, cette étude analyse leurs perceptions des enjeux éthiques liés à l'utilisation de l'intelligence artificelle pour le choix des traitements anticancéreux

Perspectives of Oncologists on the Ethical Implications of Using Artificial Intelligence for Cancer Care

Hantel, Andrew ; Walsh, Thomas P. ; Marron, Jonathan M. ; Kehl, Kenneth L. ; Sharp, Richard ; Van Allen, Eliezer ; Abel, Gregory A.

Importance : Artificial intelligence (AI) tools are rapidly integrating into cancer care. Understanding stakeholder views on ethical issues associated with the implementation of AI in oncology is critical to optimal deployment. Objective : To evaluate oncologists’ views on the ethical domains of the use of AI in clinical care, including familiarity, predictions, explainability (the ability to explain how a result was determined), bias, deference, and responsibilities. Design, Setting, and [...]

Mené en Allemagne sur 359 enfants, adolescents et jeunes adultes ayant survécu à un cancer (âge médian : 25 ans), cet essai randomisé multicentrique évalue l'intérêt d'un programme de conseils et d'informations en matière d'activité physique, de nutrition et de psycho-oncologie

A Multimodal Lifestyle Psychosocial Survivorship Program in Young Cancer Survivors: The CARE for CAYA Program—A Randomized Clinical Trial Embedded in a Longitudinal Cohort Study

von Grundherr, Julia ; Elmers, Simon ; Koch, Barbara ; Hail, Lesley-Ann ; Mann, Julia ; Escherich, Gabriele ; Bergelt, Corinna ; Samland, Luisa ; Jensen, Wiebke ; Vettorazzi, Eik ; Stark, Maria ; Valentini, Luzia ; Baumann, Freerk T. ; Singer, Susanne ; Reer, Rüdiger ; Beller, Ronja ; Calaminus, Gabriele ; Faber, Jörg ; Classen, Carl Friedrich ; Gebauer, Judith ; Hilgendorf, Inken ; Koehler, Michael ; Puzik, Alexander ; Salzmann, Nicole ; Sander, Annette ; Schiffmann, Lisa ; Sokalska-Duhme, Magdalena ; Schuster, Sonja ; Kock-Schoppenhauer, Ann-Kristin ; Bokemeyer, Carsten ; Sinn, Marianne ; Stein, Alexander ; Dwinger, Sarah ; Salchow, Jannike

Importance : There is a lack of trials examining the effect of counseling interventions for child, adolescent, and younger adult (CAYA) cancer survivors. Objective : To assess lifestyle habits and the psychosocial situation of CAYAs to determine the efficacy of needs-based interventions in the CARE for CAYA program (CFC-P). Design, Setting, and Participants : The CFC-P was conducted as a multicenter program in 14 German outpatient clinics, mainly university cancer centers. Recruitment began [...]