Bariatric Surgery and Cancer Risk

Menée aux Etats-Unis à partir de données 2004-2017 portant sur 30 318 personnes ayant un indice de masse corporelle supérieur ou égal à 35 (âge médian : 46 ans ; 77 % de femmes ; durée médiane de suivi : 6,1 ans), cette étude analyse l'effet de la chirurgie bariatrique sur l'association entre l'obésité et le risque de cancer ainsi que la mortalité spécifique

Résumé en anglais

Approximately 42% of adults in the US have obesity, with a body mass index of 30 or greater. Obesity has been shown to be associated with multiple types of cancer (including postmenopausal breast, endometrial or uterine, ovarian, esophageal adenocarcinoma, gallbladder, gastric cardia, colorectal, renal cell, liver, pancreas, thyroid, meningioma, multiple myeloma) and these are referred to as obesity-associated cancers. Obesity promotes and accelerates cancer by multiple mechanisms, including increases in circulating adipokines, insulin and insulin growth factor, circulating estrogens, inflammatory cytokines, changes in microbiota, and epigenetic changes.