Prospective study of sleep duration and glioma risk
Menée à l'aide de données de la "UK Biobank" et des cohortes "the Nurses’ Health Study" et "the Health Professionals Follow-Up Study", cette étude analyse l'association entre les heures de sommeil autodéclarées et l'incidence d'un gliome
Résumé en anglais
Purpose: Both long and short sleep duration have been linked with risk of some cancers, but evidence for glioma is lacking.
Methods: Using prospective data from the UK Biobank (UKB), the Nurses’ Health Study (NHS), and the Health Professionals Follow-Up Study (HPFS), we examined the association between self-reported hours of sleep and incident glioma in multivariable-adjusted Cox proportional hazards models.
Results: In the UKB, compared to 7 h, sleep durations of < 7 h (HR = 0.90; 95% CI 0.70–1.16) or > 7 h (HR = 1.05; 95% CI 0.85–1.30) were not significantly associated with glioma risk. Likewise, no significant associations were found between sleep duration and glioma risk in the NHS/HPFS for either < 7 h (HR = 0.93; 95% CI 0.69–1.26) or > 7 h (HR = 1.22; 95% CI 0.94–1.57), compared to 7 h. Results were similar for low-grade and high-grade glioma, did not materially change after lagging 2 years, or after accounting for factors known to disrupt sleep.
Conclusion: Sleep duration was not associated with incident glioma in either the UKB or the NHS/HPFS cohorts.