Menée à partir de données portant sur 13 935 participants à un essai évaluant l'efficacité du finastéride pour prévenir un cancer de la prostate (âge : 55 ans ou plus), cette étude évalue les effets secondaires et les effets bénéfiques à long terme du finastéride

Long-term Consequences of Finasteride vs Placebo in the Prostate Cancer Prevention Trial

Unger, Joseph M. ; Till, Cathee ; Thompson, Ian M. ; Tangen, Catherine M. ; Goodman, Phyllis J. ; Wright, Jason D. ; Barlow, William E. ; Ramsey, Scott D. ; Minasian, Lori M. ; Hershman, Dawn L.

Background : Finasteride has been found to reduce the risk of low-grade prostate cancer but to have no impact on overall survival. The long-term adverse and beneficial consequences of finasteride have not been examined. Methods : We used a linkage between data from the Prostate Cancer Prevention Trial (PCPT) and Medicare claims. Patients were examined by randomized study arm (finasteride vs placebo for 7 years) for long-term consequences of the intervention, including cardiac, endocrine, and [...]

Menée aux Etats-Unis à partir d'une enquête en ligne auprès de 2 448 adultes, cette étude analyse les raisons expliquant leur utilisation de la cigarette électronique

Reasons for current E-cigarette use among U.S. adults

Patel, Deesha ; Davis, Kevin C. ; Cox, Shanna ; Bradfield, Brian ; King, Brian A. ; Shafer, Paul ; Caraballo, Ralph ; Bunnell, Rebecca

E-cigarette use has increased rapidly among U.S. adults. However, reasons for use among adults are unclear. We assessed reasons for e-cigarette use among a national sample of U.S. adults. Data were collected via online surveys among U.S. adults aged 18 or older from April through June 2014. Descriptive and multivariate regression analyses were conducted to assess reasons for e-cigarette use among 2448 current e-cigarette users, by sociodemographic characteristics and product type. Assessed [...]

Menée auprès de 3 722 participantes (durée moyenne de suivi : 5,6 ans), cette étude internationale évalue l'effet d'une oophorectomie bilatérale sur le risque de cancer du sein chez les femmes porteuses d'une mutation BRCA1 ou BRCA2

Bilateral Oophorectomy and Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Kotsopoulos, Joanne ; Huzarski, Tomasz ; Gronwald, Jacek ; Singer, Christian F. ; Moller, Pal ; Lynch, Henry T. ; Armel, Susan ; Karlan, Beth ; Foulkes, William D. ; Neuhausen, Susan L. ; Senter, Leigha ; Tung, Nadine ; Weitzel, Jeffrey N. ; Eisen, Andrea ; Metcalfe, Kelly ; Eng, Charis ; Pal, Tuya ; Evans, Gareth ; Sun, Ping ; Lubinski, Jan ; Narod, Steven A. ; the Hereditary Breast Cancer Clinical Study Group

Background : Whether oophorectomy reduces breast cancer risk among BRCA mutation carriers is a matter of debate. We undertook a prospective analysis of bilateral oophorectomy and breast cancer risk in BRCA mutation carriers. Methods : Subjects had no history of cancer, had both breasts intact, and had information on oophorectomy status (n = 3722). Women were followed until breast cancer diagnosis, prophylactic bilateral mastectomy, or death. A Cox regression model was used to estimate the [...]