A partir des données de deux cohortes européennes incluant 459 cas et 3 024 témoins, cette étude évalue les interactions entre le tabagisme, une infection par le papillomavirus de type 16 et le risque de cancer de l'oropharynx

Combined effects of smoking and HPV16 in oropharyngeal cancer

Anantharaman, Devasena ; Muller, David C. ; Lagiou, Pagona ; Ahrens, Wolfgang ; Holcatova, Ivana ; Merletti, Franco ; Kjærheim, Kristina ; Polesel, Jerry ; Simonato, Lorenzo ; Canova, Cristina ; Castellsagué, Xavier ; Macfarlane, Tatiana V. ; Znaor, Ariana ; Thomson, Peter ; Robinson, Max ; Conway, David I. ; Healy, Claire M. ; Tjønneland, Anne ; Westin, Ulla ; Ekström, Johanna ; Chang-Claude, Jenny ; Kaaks, Rudolf ; Overvad, Kim ; Drogan, Dagmar ; Hallmans, Göran ; Laurell, Göran ; Bueno-de-Mesquita, H.B. ; Peeters, Petra H. ; Agudo, Antonio ; Larranaga, Nerea ; Travis, Ruth C. ; Palli, Domenico ; Barricarte, Aurelio ; Trichopoulou, Antonia ; George, Saitakis ; Trichopoulos, Dimitrios ; Quirós, J.Ramón ; Grioni, Sara ; Sacerdote, Carlotta ; Navarro, Carmen ; Sánchez, María-José ; Tumino, Rosario ; Severi, Gianluca ; Boutron-Ruault, Marie-Christine ; Clavel-Chapelon, Françoise ; Panico, Salvatore ; Weiderpass, Elisabete ; Lund, Eiliv ; Gram, Inger T. ; Riboli, Elio ; Pawlita, Michael ; Waterboer, Tim ; Kreimer, Aimee R. ; Johansson, Mattias ; Brennan, Paul

Background: Although smoking and HPV infection are recognized as important risk factors for oropharyngeal cancer, how their joint exposure impacts on oropharyngeal cancer risk is unclear. Specifically, whether smoking confers any additional risk to HPV-positive oropharyngeal cancer is not understood. Methods: Using HPV serology as a marker of HPV-related cancer, we examined the interaction between smoking and HPV16 in 459 oropharyngeal (and 1445 oral cavity and laryngeal) cancer patients and [...]

Menée en France à partir des données de la cohorte "E3N" incluant 57 403 participantes, cette étude évalue les interactions entre une supplémentation en vitamine C, une consommation de vitamine C d'origine alimentaire et le risque de cancer du sein après la ménopause (2 482 cas sur la période 1995-2008)

Vitamin C supplement intake and postmenopausal breast cancer risk: interaction with dietary vitamin C

Cadeau, Claire ; Fournier, Agnès ; Mesrine, Sylvie ; Clavel-Chapelon, Françoise ; Fagherazzi, Guy ; Boutron-Ruault, Marie-Christine

Background: Experimental and epidemiologic studies have yielded conflicting results on the relation between vitamin C intake and breast cancer risk. Objective: We investigated the relation between vitamin C supplement intake and breast cancer risk while considering dietary vitamin C intake. Design: Between 1995 and 2008, 2482 invasive breast cancer cases occurred in 57,403 postmenopausal women from the Etude Epidémiologique auprès de femmes de la Mutuelle Générale de l'Education Nationale (E3N) [...]

Menée aux Etats-Unis auprès de 177 femmes âgées de 25 à 29 ans, cette étude prospective évalue l'association entre une consommation de graisses d'origine alimentaire pendant l'adolescence (entre 10 et 18 ans) et la densité mammaire, un facteur de risque de cancer du sein

Dietary Fat Intake During Adolescence and Breast Density Among Young Women

Jung, Seungyoun ; Goloubeva, Olga ; Klifa, Catherine ; LeBlanc, Erin S. ; Snetselaar, Linda G. ; Van Horn, Linda ; Dorgan, Joanne F.

Background: Lack of association between fat intake and breast cancer risk in cohort studies might be attributed to the disregard of temporal effects during adolescence when breasts develop and are particularly sensitive to stimuli. We prospectively examined associations between adolescent fat intakes and breast density. Method: Among 177 women who participated in the Dietary Intervention Study in Children, dietary intakes at ages 10–18 years were assessed on five occasions by 24-hour recalls [...]

Menée en Californie à partir de données portant sur 5 788 cas de leucémie pédiatrique entre 1986 et 2008, cette étude évalue l'association entre une exposition à des lignes à haute tension à proximité du lieu de résidence et le risque de la maladie

Childhood leukaemia and distance from power lines in California: a population-based case-control study

Crespi, Catherine M. ; Vergara, Ximena P. ; Hooper, Chris ; Oksuzyan, Sona ; Wu, Sheng ; Cockburn, Myles ; Kheifets, Leeka

Background: Studies have reported an increased risk of childhood leukaemia associated with living near high-voltage electric power transmission lines that extend to distances at which magnetic fields from lines are negligible. We conducted a large records-based case-control study of childhood leukaemia risk in the population living near power lines in California. Methods: The study included 5788 childhood leukaemia and 3308 central nervous system (CNS) cancer cases (for comparison) born in and [...]

A partir des données du registre du Texas des cancers portant sur 308 cas et 1 202 témoins, cette étude évalue l'association entre le niveau de fluoration de l'eau potable et le risque d'ostéosarcome chez les enfants et adolescents âgés de moins de 20 ans

Fluoride exposure in public drinking water and childhood and adolescent osteosarcoma in Texas

Archer, Natalie P. ; Napier, Thomas S. ; Villanacci, John F.

Purpose : The purpose of this study was to examine the association between fluoride levels in public drinking water and childhood and adolescent osteosarcoma in Texas; to date, studies examining this relationship have been equivocal. Using areas with high and low naturally occurring fluoride, as well as areas with optimal fluoridation, we examined a wide range of fluoride levels in public drinking water. Methods : This was a population-based case–control study, with both cases and controls [...]

Menée aux Etats-Unis, cette étude évalue l'association entre une infection par les sous-types 31, 33, 45, 56 et 58 du papillomavirus humain, la persistance de l'infection et le risque de néoplasie cervicale intraépithéliale

Variant-specific persistence of infections with human papillomavirus Types 31, 33, 45, 56 and 58 and risk of cervical intraepithelial neoplasia

Xi, Long Fu ; Schiffman, Mark ; Koutsky, Laura A. ; Hughes, James P. ; Hulbert, Ayaka ; Shen, Zhenping ; Galloway, Denise A. ; Kiviat, Nancy B.

In our previous study of the etiologic role of oncogenic human papillomavirus (HPV) types other than HPV16 and 18, we observed a significantly higher risk of cervical intraepithelial neoplasia Grades 2–3 (CIN2/3) associated with certain lineages of HPV types 31/33/45/56/58 [called high-risk (HR) variants] compared with non-HR variants. This study was to examine whether these intra-type variants differ in persistence of the infection and persistence-associated risk of CIN2/3. Study subjects were [...]

Menée au Royaume-Uni à partir de données portant sur 1 195 cas et 4 640 témoins, cette étude évalue l'association entre une utilisation d'antibiotiques et le risque de cancer primitif du foie

Associations of antibiotic use with risk of primary liver cancer in the Clinical Practice Research Datalink

Yang, Baiyu ; Hagberg, Katrina Wilcox ; Chen, Jie ; Sahasrabuddhe, Vikrant V. ; Graubard, Barry I. ; Jick, Susan ; McGlynn, Katherine A.

Background: Use of antibiotics could alter human microbiota composition and decrease bacterial diversity. Such microbial dysbiosis may have implications in hepatocarcinogenesis; however, the association between antibiotic use and liver cancer risk has been minimally examined in humans. Methods: We performed a nested case–control study (1195 primary liver cancer cases and 4640 matched controls) within the United Kingdom’s Clinical Practice Research Datalink. Antibiotic use was obtained from [...]

Couplée aux données de trois études de cohorte incluant 1 063 cas et 5 556 témoins en population chinoise, cette méta-analyse évalue l'association entre des indicateurs de la santé buccale (perte de dents, caries, etc) et le risque de cancer colorectal

Oral health and risk of colorectal cancer: results from three cohort studies and a meta-analysis

Ren, H. G. ; Luu, H. N. ; Cai, H. ; Xiang, Y. B. ; Steinwandel, M. ; Gao, Y. T. ; Hargreaves, M. ; Zheng, W. ; Blot, W. J. ; Long, J. R. ; Shu, X. O.

Background While studies have shown that poor oral health status may increase the risk of cancer, evidence of a specific association with the risk of colorectal cancer (CRC) is inconclusive. We evaluated the association between oral health and CRC risk using data from three large cohorts: the Shanghai Men's Health Study (SMHS), the Shanghai Women's Health Study (SWHS), and the Southern Community Cohort Study (SCCS), and carried out a meta-analysis of results from other relevant published [...]

A partir des données des registres américains des cancers portant sur la période 1998-2002 et incluant 7 955 patientes ayant bénéficié d'une reconstruction mammaire après une mastectomie, cette étude évalue l'association entre des implants mammaires et le risque de second cancer

A population-based analysis of secondary malignancies in breast cancer patients receiving breast reconstruction

Warschkow, Rene ; Cerny, Thomas ; Schmied, Bruno M. ; Guller, Ulrich ; Thuerlimann, Beat ; Joerger, Markus

Background: There is an ongoing debate about the relationship between breast implants and secondary malignancies. Methods: Breast cancer patients undergoing surgical reconstruction after mastectomy by either implants or autologous flap were identified in the Surveillance, Epidemiology and End Results registry between 1998 and 2002. The occurrence of secondary malignancies at least 1 year after diagnosis was compared between breast reconstruction with implants vs autologous flap. Results: Of [...]

Menée en Chine à partir de données portant sur 2 528 cas et 2 596 témoins, cette étude évalue l'association entre des indicateurs de la santé buccale (nombre de brossages dentaires par jour, perte de dents, etc) et le risque de carcinome du rhinopharynx

Oral hygiene and risk of nasopharyngeal carcinoma - a population-based case-control study in China

Liu, Zhiwei ; Chang, Ellen T ; Liu, Qing ; Cai, Yonglin ; Zhang, Zhe ; Chen, Guomin ; Xie, Shang-Hang ; Cao, Su-Mei ; Shao, Jian-Yong ; Jia, Wei-Hua ; Zheng, Yuming ; Liao, Jian ; Chen, Yufeng ; Ernberg, Ingemar ; Vaughan, Thomas L ; Adami, Hans-Olov ; Huang, Guangwu ; Zeng, Yi ; Zeng, Yi-Xin ; Ye, Weimin

Background:The association between oral health and risk of nasopharyngeal carcinoma (NPC) is largely unknown. Further understanding could shed light on potential pathogenic mechanisms and preventive measures. Methods:We conducted a population-based case-control study in southern China between 2010 and 2014. We enrolled 2528 incident NPC cases aged 20-74 years, and 2596 controls, randomly selected from the total population registers, with frequency matching to the 5-year age and sex distribution [...]

A partir de données portant sur 273 cas et 5 725 témoins, cette étude évalue l'association entre 8 polymorphismes à simple nucélotide de gènes liés à la longueur des télomères des leucocytes, et précédemment identifiés dans des études d'association sur le génome entier, et le risque de leucémie lymphocytaire chronique

Genetic variation associated with longer telomere length increases risk of chronic lymphocytic leukemia

Ojha, Juhi ; Codd, Veryan ; Nelson, Christopher P ; Samani, Nilesh J ; Smirnov, Ivan V. ; Madsen, Nils R ; Hansen, Helen M. ; de Smith, Adam J ; Bracci, Paige M. ; Wiencke, John K. ; Wrensch, Margaret R. ; Wiemels, Joseph L. ; Walsh, Kyle M.

Background: Chronic lymphocytic leukemia (CLL) is the most common leukemia in the western world. Shorter mean telomere length in leukemic cells has been associated with more aggressive disease. Germline polymorphisms in telomere maintenance genes impact telomere length and may contribute to CLL susceptibility. Methods: We collected genome-wide data from two groups of patients with CLL (N=273) and two control populations (N=5725). In ancestry-adjusted case-control comparisons, we analyzed eight [...]

Menée aux Etats-Unis à partir de données portant sur 985 cas et 877 témoins, cette étude analyse l'association entre des variants génétiques précédemment associés au risque de cancer du pancréas, du sein, de l'ovaire ou de la prostate, et le risque de cancer du pancréas chez une population à haut risque (histoire familiale ou apparition précoce de la maladie)

Association of common susceptibility variants of pancreatic cancer in higher risk patients: A PACGENE study

Childs, Erica J. ; Chaffee, Kari G. ; Gallinger, steven ; Syngal, Sapna ; Schwartz, Ann G. ; Coté, Michele L. ; Bondy, Melissa L. ; Hruban, Ralph H. ; Chanock, Stephen J. ; Hoover, Robert N. ; Fuchs, Charles S. ; Rider, David N. ; Amundadottir, Laufey T. ; Stolzenberg-Solomon, Rachael ; Wolpin, Brian M. ; Risch, Harvey A. ; Goggins, Michael G. ; Petersen, Gloria M. ; Klein, Alison P.

Individuals from pancreatic cancer families are at increased risk, not only of pancreatic cancer, but also of melanoma, breast, ovarian, and colon cancers. While some of the increased risk may be due to mutations in high-penetrance genes (i.e. BRCA2, PALB2, ATM, p16/CDKN2A or DNA mismatch-repair genes), common genetic variants may also be involved. In a high-risk population of cases with either a family history of pancreatic cancer or early-onset pancreatic cancer (diagnosis before age 50), we [...]

A partir de données issues d'études d'association sur le génome entier, cette étude met en évidence des mécanismes par lesquels une mutation constitutionnelle du gène d'un long ARN non codant (LINC00673) confère une susceptibilité au cancer du pancréas

Pancreatic cancer risk variant in LINC00673 creates a miR-1231 binding site and interferes with PTPN11 degradation

Zheng, Jian ; Huang, Xudong ; Tan, Wen ; Yu, Dianke ; Du, Zhongli ; Chang, Jiang ; Wei, Lixuan ; Han, Yaling ; Wang, Chengfeng ; Che, Xu ; Zhou, Yifeng ; Miao, Xiaoping ; Jiang, Guoliang ; Yu, Xianjun ; Yang, Xianghong ; Cao, Guangwen ; Zuo, Chaohui ; Li, Zhaoshen ; Wang, Chunyou ; Cheung, Siu Tim ; Jia, Yongfeng ; Zheng, Xiongwei ; Shen, Hongbing ; Wu, Chen ; Lin, Dongxin

Genome-wide association studies have identified several loci associated with pancreatic cancer risk; however, the mechanisms by which genetic factors influence the development of sporadic pancreatic cancer remain largely unknown. Here, by using genome-wide association analysis and functional characterization, we identify a long intergenic noncoding RNA (lincRNA), LINC00673, as a potential tumor suppressor whose germline variation is associated with pancreatic cancer risk. LINC00673 is able to [...]

Couplée aux données de la cohorte "Shanghai Women’s Health Study" et menée à partir d'échantillons urinaires prélevés sur 399 participantes et sur 399 témoins, cette étude évalue l'association entre le niveau de concentration des œstrogènes, de métabolites des œstrogènes et le risque de cancer du sein après la ménopause

Endogenous Estrogens, Estrogen Metabolites, and Breast Cancer Risk in Postmenopausal Chinese Women

Moore, Steven C. ; Matthews, Charles E. ; Ou Shu, Xiao ; Yu, Kai ; Gail, Mitchell H. ; Xu, Xia ; Ji, Bu-Tian ; Chow, Wong-Ho ; Cai, Qiuyin ; Li, Honglan ; Yang, Gong ; Ruggieri, David ; Boyd-Morin, Jennifer ; Rothman, Nathaniel ; Hoover, Robert N. ; Gao, Yu-Tang ; Zheng, Wei ; Ziegler, Regina G.

Background: The role of estrogen metabolism in determining breast cancer risk and differences in breast cancer rates between high-incidence and low-incidence nations is poorly understood. Methods: We measured urinary concentrations of estradiol and estrone (parent estrogens) and 13 estrogen metabolites formed by irreversible hydroxylation at the C-2, C-4, or C-16 positions of the steroid ring in a nested case-control study of 399 postmenopausal invasive breast cancer case participants and 399 [...]