A partir des données des registres finlandais des cancers, cette étude de cohorte rétrospective analyse l'évolution de l'incidence de cancer chez une population de patients atteints de maladies hépatiques liée à une consommation d'alcool (11 873 patients atteints d'une cirrhose du foie ou d'une hépatite alcoolique), sur la période 1996-2013

Cancer incidence among alcoholic liver disease patients in Finland: A retrospective registry study during years 1996–2013

Sahlman, Perttu ; Nissinen, Markku ; Pukkala, Eero ; Färkkilä, Martti

Both alcohol abuse and liver cirrhosis are known risk factors for various cancers. This article was aimed to assess the long-term risk of malignancies among patients with severe alcoholic liver disease (ALD), i.e., alcoholic liver cirrhosis and alcoholic hepatitis. A cohort of 8,796 male and 3,077 female ALD patients from 1996 to 2012 was identified from the Finnish National Hospital Discharge Register. This nationwide cohort was combined with the data from the Finnish Cancer Registry for [...]

A partir des données de la cohorte "Sister Study cohort " incluant 50 844 participantes, cette étude prospective évalue l'association entre une exposition à des produits pesticides pendant l'enfance et l'adolescence et le risque de cancer du sein (durée moyenne de suivi : 5 ans, 2 134 cas)

Childhood and adolescent pesticide exposure and breast cancer risk

Niehoff, Nicole M. ; Nichols, Hazel B. ; White, Alexandra J. ; Parks, Christine G. ; D’Aloisio, Aimee A. ; Sandler, Dale P.

Background: To date, epidemiologic studies have not strongly supported an association between pesticide exposure and breast cancer. However, few previous studies had the ability to assess specific time periods of exposure. Studies that relied on adult serum levels of metabolites of organochlorine pesticides may not accurately reflect exposure during developmental periods. Further, exposure assessment often occurred after diagnosis and key tumor characteristics, such as hormone receptor status, [...]

A partir des données de la cohorte "Health Professionals' Follow-up Study" incluant 19 933 hommes n'ayant jamais fumé, cette étude évalue l'association entre une maladie parodontale et le risque de cancer (durée moyenne de suivi : 26 ans)

Periodontal disease and risk of all cancers among male never smokers: an updated analysis of the Health Professionals Follow-up Study

Michaud, D.S. ; Kelsey, K.T. ; Papathanasiou, E. ; Genco, C.A. ; Giovannucci, E.

Background : Periodontal disease has a direct impact on the immune response and has been linked to several chronic diseases, including atherosclerosis and stroke. Few studies have examined the association between periodontal disease and cancer. Methods : 19,933 men reported being never smokers (of cigarette, pipes or cigars) in the Health Professionals' Follow-up Study. Periodontal disease status and teeth number were self-reported at baseline and during follow-up. All cancers were ascertained [...]

A partir d'une revue systématique de la littérature (9 études), cette méta-analyse évalue l'association entre des symptômes de dépression et le risque de cancer

Risk of cancer among patients with depressive disorder: a meta-analysis and implications

Ahn, Hee Kyung ; Bae, Jeong Hun ; Ahn, Hong Yup ; Hwang, In Cheol

Objective : The question of cancer risk in individuals with depression is unclear, primarily because of the heterogeneity of the assessment of depression in the published literature. To clarify the mixed findings, this analysis was limited to articles that used a reliable method of ascertaining depressive disorder. Methods : We searched PubMed, EMBASE, and the Cochrane Library to identify studies investigating the effect of depression on subsequent risk of cancer, defining depression based on [...]

A partir de données portant sur 809 cas et 814 témoins, puis par réplication des résultats sur 691 autres cas et 775 témoins, cette étude évalue l'association entre des polymorphismes à simple nucléotide de 26 gènes liés à la voie de signalisation Wnt/bêta-caténine et le risque de cancer colorectal

Germline genetic variants in the Wnt/beta-catenin pathway as predictors of colorectal cancer risk

Hildebrandt, Michelle A.T. ; Reyes, Monica E. ; Lin, Moubin ; He, Yonggang ; Nguyen, Son V. ; Hawk, Ernest T. ; Wu, Xifeng

Background: The Wnt/beta-catenin signaling pathway plays a key role in stem cell maintenance in the colorectum. Rare high penetrance genetic mutations in components of this pathway result in familial colorectal cancer, yet the impact of common, germline variants remains unknown. Methods: We assessed 172 variants in 26 genes from the Wnt/beta-catenin pathway in 809 CRC cases and 814 healthy controls, followed by replication of the top findings in another 691 cases and 775 controls. In silico [...]

A partir de données d'études de cohorte conduites entre 1994 et 2010 et incluant un total de 143 477 participants, cette étude prospective norvégienne évalue l'association entre divers indicateurs anthropométriques de l'obésité et le risque d'adénocarcinome colorectal

Anthropometry-based obesity phenotypes and risk of colorectal adenocarcinoma: a large prospective cohort study in Norway

Lu, Yunxia ; Ness-Jensen, Eivind ; Martling, Anna ; Hveem, Kristian

Background: It is unclear whether obesity phenotypes measured by different anthropometric indices are associated with a risk of colorectal adenocarcinoma by anatomical location. Patients and Methods: We compiled harmonized population-based cohort studies (Cohort of Norway, CONOR) with 143,477 participants that were conducted between 1994 and 2010. General, abdominal, and gluteofemoral obesity were assessed by body mass index (BMI, kg/m2), waist circumference (cm) , and hip circumference (cm). [...]

A partir des données du registre suédois des cancers incluant 2 032 727 participants nés entre 1973 et 1995 et âgés de 15 à 37 ans, cette étude évalue l'association entre les caractéristiques anthropométriques à la naissance (taille, poids, tour de tête) et le risque de tumeurs cérébrales au début de l'âge adulte

Birth size characteristics and risk of brain tumors in early adulthood: results from a Swedish cohort study

Tettamanti, Giorgio ; Ljung, Rickard ; Mathiesen, Tiit ; Schwartzbaum, Judith ; Feychting, Maria

Background: Despite extensive research on the effect of birth size characteristics on childhood brain tumors, very few studies have evaluated the effect of birth size characteristics on the risk of adult brain tumor and they have provided inconsistent results. Methods: All individuals born in Sweden between 1973 and 1995 who were still alive and cancer free at their 15th birthday were included in the study (n = 2 032 727). At the end of the study period (31 December 2010), the study [...]

A partir des données de la cohorte "Black Women's Health Study" incluant 47 557 participantes, cette étude évalue l'association entre des indices mesurant la masse corporelle et l'adiposité, des facteurs métaboliques (diabète de type 2, hypertension) et le risque de cancer du corps de l'utérus chez les femmes noires (274 cas diagnostiqués entre 1995 et 2013)

Body Size, Metabolic Factors, and Risk of Endometrial Cancer in Black Women

Sponholtz, Todd R. ; Palmer, Julie R. ; Rosenberg, Lynn ; Hatch, Elizabeth E. ; Adams-Campbell, Lucile L. ; Wise, Lauren A.

Total and abdominal obesity, as well as metabolic factors such as type 2 diabetes, have been associated with a higher risk of endometrial cancer in white women. It remains unclear to what extent these factors influence the risk of endometrial cancer in black women. We followed 47,557 participants from the Black Women's Health Study for incident endometrial cancer from 1995 through 2013 (n = 274). We used Cox regression models to estimate incidence rate ratios and 95% confidence intervals while [...]

Menée à Taïwan auprès de 3 824 participants et portant sur 602 cas et 3 222 témoins, cette étude évalue l'association entre une consommation d'alcool, deux polymorphismes à simple nucléotide des gènes ADH1B et ALDH2 et le risque de carcinome hépatocellulaire chez des patients atteints d'une hépatite B chronique

Alcohol drinking mediates the association between polymorphisms of ADH1B and ALDH2 and hepatitis B related hepatocellular carcinoma

Liu, Jessica ; Yang, Hwai-I ; Lee, Mei-Hsuan ; Jen, Chin-Lan ; Hu, Hui-Han ; Lu, Sheng-Nan ; Wang, Li-Yu ; You, San-Lin ; Huang, Yen-Tsung ; Chen, Chien-Jen

Background:The role of polymorphisms on ADH1B and ALDH2 in patients with chronic hepatitis B is unclear. This study aims to examine whether alcohol drinking mediates the association between two ADH1B and ALDH2 polymorphisms and risk of HCC among chronic hepatitis B patients. Methods: A total of 3824 individuals were enrolled in this study. Two SNPs, rs1229984 (ADH1B) and rs671 (ALDH2) were genotyped using the Affymetrix Axiom Genome-wide CHB1 Array (Affymetrix, Inc. Santa Clara, CA). [...]