Menée dans 12 villes de Chine à partir de données portant sur 73 789 cas et 34 504 témoins, cette étude de cohorte rétrospective analyse l'incidence de cancers hématopoïétiques chez des salariés exposés à du benzène et évalue la mortalité spécifique

A retrospective cohort study of cause-specific mortality and incidence of hematopoietic malignancies in Chinese benzene-exposed workers

Linet, Martha S. ; Yin, Song-Nian ; Gilbert, Ethel S. ; Dores, Graça M. ; Hayes, Richard B. ; Vermeulen, Roel ; Tian, Hao-Yuan ; Lan, Qing ; Portengen, Lützen ; Ji, Bu-Tian ; Li, Gui-Lan ; Rothman, Nathaniel ; on behalf of the Chinese Center for Disease, Control ; Prevention—, U. S. National Cancer Institute Benzene Study Group

Benzene exposure has been causally linked with acute myeloid leukemia (AML), but inconsistently associated with other hematopoietic, lymphoproliferative and related disorders (HLD) or solid tumors in humans. Many neoplasms have been described in experimental animals exposed to benzene. We used Poisson regression to estimate adjusted relative risks (RR) and the likelihood ratio statistic to derive confidence intervals for cause-specific mortality and HLD incidence in 73,789 benzene-exposed [...]

A partir des données des deux cohortes "Nurses' Health Study" incluant un total de 181 771 participantes, cette étude évalue l'association entre l'utilisation d'une contraception orale et le risque de cancer colorectal

Oral Contraceptive Use and Colorectal Cancer in the Nurses' Health Study I and II

Charlton, Brittany M. ; Wu, Kana ; Zhang, Xuehong ; Giovannucci, Edward L. ; Fuchs, Charles S. ; Missmer, Stacey A ; Rosner, Bernard ; Hankinson, Susan E. ; Willett, Walter C. ; Michels, Karin B

Background: It remains unclear if oral contraceptive (OC) use is associated with the incidence of colorectal cancer. Few studies have examined this association by duration of OC use, time since last OC use, and different cancer subsites. Methods: Among 88,691 participants of the Nurses' Health Study I (NHSI) and 93,080 participants of the Nurses' Health Study II (NHSII), we assessed OC use every 2 years between 1976-2010 and categorized it as ever use, duration of use, and time since last use. [...]

Menée aux Etats-Unis et portant sur 359 cas et 391 témoins, cette étude évalue l'association entre l'utilisation de médicaments contre l'hypertension et le risque de second cancer primitif controlatéral chez des patientes ayant survécu à un cancer du sein invasif ER+

Use of antihypertensive medications not associated with risk of contralateral breast cancer among women diagnosed with estrogen-receptor positive invasive breast cancer

Chen, Lu ; Malone, Kathleen E ; Li, Christopher I

Background:Antihypertensive medications are widely used among adults in the U.S. and there is some evidence that certain classes may affect the risk of adverse breast cancer outcomes, but their impact on risk of second primary contralateral breast cancer is unclear. Methods:We used data from a population-based nested case-control study consisting of 359 women diagnosed with both a first primary breast cancer and a second primary contralateral breast cancer and 691 control women diagnosed with [...]

Couplée aux données de la cohorte "Framingham Heart Study" et incluant 396 cas et 1 475 témoins, cette étude évalue l'association entre 19 polymorphismes à simple nucléotide du gène du récepteur de l'insuline et le risque de cancers liés à l'obésité

Insulin receptor variants and obesity-related cancers in the Framingham Heart Study

Parekh, Niyati ; Guffanti, Guia ; Lin, Yong ; Ochs-Balcom, HeatherM ; Makarem, Nour ; Hayes, Richard

Purpose : The insulin-signaling pathway plays a pivotal role in cancer biology; however, evidence of genetic alterations in human studies is limited. This case–control study nested within the Framingham Heart Study (FHS) examined the association between inherited genetic variation in the insulin receptor (INSR) gene and obesity-related cancer risk. Methods : The study sample consisted of 1,475 controls and 396 cases from the second familial generation of the FHS. Participants who provided [...]

Menée sur 1 644 patientes atteintes d'un carcinome mucineux de l'ovaire et sur 21 693 témoins, cette étude identifie trois loci, situés sur les régions chromosomiques 2q13, 2q31.1 et 19q13.2, en association avec le risque de la maladie

Genome-wide significant risk associations for mucinous ovarian carcinoma

the Ovarian Cancer Association, Consortium

Genome-wide association studies have identified several risk associations for ovarian carcinomas but not for mucinous ovarian carcinomas (MOCs). Our analysis of 1,644 MOC cases and 21,693 controls with imputation identified 3 new risk associations: rs752590 at 2q13 (P = 3.3 [times] 10-8), rs711830 at 2q31.1 (P = 7.5 [times] 10-12) and rs688187 at 19q13.2 (P = 6.8 [times] 10-13). We identified significant expression quantitative trait locus (eQTL) associations for HOXD9 at 2q31.1 in ovarian (P = [...]

Couplée aux données de trois cohortes et portant sur 731 cas et 909 témoins, cette étude américaine évalue l'association entre le niveau de concentration sérique de leptine, mesuré avant le diagnostic, et le risque de cancer du pancréas

Circulating Leptin and Risk of Pancreatic Cancer: A Pooled Analysis From 3 Cohorts

Stolzenberg-Solomon, Rachael Z. ; Newton, Christina C. ; Silverman, Debra T. ; Pollak, Michael ; Nogueira, Leticia M. ; Weinstein, Stephanie J. ; Albanes, Demetrius ; Mannisto, Satu ; Jacobs, Eric J.

Adiposity is associated with pancreatic cancer; however, the underlying mechanism(s) is uncertain. Leptin is an adipokine involved in metabolic regulation, and obese individuals have higher concentrations. We conducted a pooled, nested case-control study of cohort participants from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, and the Cancer Prevention Study II Nutrition Cohort to investigate whether [...]

Couplée aux données de deux études de cohorte conduites à Shangaï et portant sur 271 cas et 2 693 témoins, cette étude évalue l'association, chez les hommes et chez les femmes, entre l'hypertension, l'obésité et le risque de carcinome à cellules rénales

Association of hypertension and obesity with renal cell carcinoma risk: a report from the Shanghai Men’s and Women’s Health Studies

Shen, Tian ; Shu, Xiao-Ou ; Xiang, Yong-Bing ; Li, Hong-Lan ; Cai, Hui ; Gao, Yu-Tang ; Zheng, Wei ; Lipworth, Loren

Purpose : Consistently reported associations between hypertension and obesity and renal cell carcinoma (RCC) risk have largely come from studies in Western populations. These associations were examined in a case–control study nested in the Shanghai Women’s Health Study (SWHS, 1996–2000) and Shanghai Men’s Health Study (SMHS, 2001–2006). Methods : Overall, 271 incident RCC cases (124 women, 147 men) were identified through 31 December 2011, and 2,693 controls were individually matched by sex, [...]

Menée sur 935 patients atteints d'un ostéosarcome métastatique au diagnostic, cette étude d'association sur le génome entier identifie un polymorphisme à simple nucléotide dans le gène NFIB associé au risque de métastases chez les patients d'origine européenne atteints d'un ostéosarcome

A genome-wide scan identifies variants in NFIB associated with metastasis in patients with osteosarcoma

Mirabello, Lisa ; Koster, Roelof ; Moriarity, Branden S. ; Spector, Logan G. ; Meltzer, Paul S. ; Gary, Joy ; Machiela, Mitchell J. ; Pankratz, Nathan ; Panagiotou, Orestis A. ; Largaespada, David ; Wang, Zhaoming ; Gastier-Foster, Julie M. ; Gorlick, Richard ; Khanna, Chand ; Caminada de Toledo, Silvia Regina ; Petrilli, Antonio S ; Patino-Garcia, Ana ; Sierrasesumaga, Luis ; Lecanda, Fernando ; Andrulis, Irene L. ; Wunder, Jay S. ; Gokgoz, Nalan ; Serra, Massimo ; Hattinger, Claudia ; Picci, Piero ; Scotlandi, Katia ; Flanagan, Adrienne M. ; Tirabosco, Roberto ; Fernanda Amary, Maria ; Halai, Dina ; Ballinger, Mandy L. ; Thomas, David M. ; Davis, Sean ; Barkauskas, Donald A. ; Marina, Neyssa ; Helman, Lee ; Otto, George M. ; Becklin, Kelsie L. ; Wolf, Natalie K. ; Weg, Madison T. ; Tucker, Margaret ; Wacholder, Sholom ; Fraumeni, Joseph F. ; Caporaso, Neil E. ; Boland, Joseph F. ; Hicks, Belynda D. ; Vogt, Aurelie ; Burdett, Laurie ; Yeager, Meredith ; Hoover, Robert N. ; Chanock, Stephen J. ; Savage, Sharon A.

Metastasis is the leading cause of death in osteosarcoma patients, the most common pediatric bone malignancy. We conducted a multi-stage genome-wide association study of osteosarcoma metastasis at diagnosis in 935 osteosarcoma patients to determine whether germline genetic variation contributes to risk of metastasis. We identified a SNP, rs7034162, in NFIB significantly associated with metastasis in European osteosarcoma cases, as well as in cases of African and Brazilian ancestry [...]

A partir des données de la cohorte "Nurses’ Health Study" incluant 51 948 participantes, cette étude prospective évalue l'association entre le rapport tour de taille/tour de hanches, pondéré par l'indice de masse corporelle, et le risque de cancer du corps de l'utérus

Prospective study of body fat distribution and the risk of endometrial cancer

Ju, Woong ; Kim, Hyun Ja ; Hankinson, Susan E. ; De Vivo, Immaculata ; Cho, Eunyoung

Background : Epidemiologic studies have found that overall obesity is positively related to endometrial cancer (EC) risk. However, data assessing the association between body fat distribution and risk of EC are still limited. Methods : We followed 51,948 women who first reported waist circumference (WC) and hip circumference in 1986 in the Nurses’ Health Study. Waist-to-hip ratio (WHR) was calculated. Results : During 24 years of follow-up, 449 incident invasive EC cases were diagnosed. In a [...]

Menée aux Etats-Unis à partir de données de 20 études de cohorte incluant 1 941 300 participants, cette étude évalue l'association entre des données anthropométriques et le risque de cancer de la tête et du cou (3 760 cas)

Anthropometry and head and neck cancer:a pooled analysis of cohort data

Gaudet, Mia M ; Kitahara, Cari M ; Newton, Christina C ; Bernstein, Leslie ; Reynolds, Peggy ; Weiderpass, Elisabete ; Kreimer, Aimée R ; Yang, Gong ; Adami, Hans-Olov ; Alavanja, Michael C ; Beane Freeman, Laura E ; Boeing, Heiner ; Buring, Julie ; Chaturvedi, Anil ; Chen, Yu ; D’Aloisio, Aimee A ; Freedman, Michal ; Gao, Yu-Tang ; Gaziano, J Michael ; Giles, Graham G ; Håkansson, Niclas ; Huang, Wen-Yi ; Lee, I-Min ; Linet, Martha S ; MacInnis, Robert J ; Park, Yikyung ; Prizment, Anna ; Purdue, Mark P ; Riboli, Elio ; Robien, Kim ; Sandler, Dale P ; Schairer, Catherine ; Sesso, Howard D ; Ou Shu, Xiao ; White, Emily ; Wolk, Alicja ; Xiang, Yong-Bing ; Zelenuich-Jacquotte, Anne ; Zheng, Wei ; Patel, Alpa V ; Hartge, Patricia ; Berrington de Gonzalez, Amy ; Gapstur, Susan M

Background: Associations between anthropometry and head and neck cancer (HNC) risk are inconsistent. We aimed to evaluate these associations while minimizing biases found in previous studies. Methods: We pooled data from 1 941 300 participants, including 3760 cases, in 20 cohort studies and used multivariable-adjusted Cox proportional hazard regression models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association of anthropometric measures with HNC risk overall and [...]

A partir de données portant sur 1 541 patients atteints d'un cancer du côlon et 1 934 témoins, cette étude présente un cadre d'analyse permettant d'identifier les interactions gènes-environnement dans le cancer du côlon, en prenant en compte l'association entre des polymorphismes à simple nucléotide de gènes et trois expositions liées au mode de vie (protéines alimentaires, tabagisme, consommation d'alcool)

A Candidate-Pathway Approach to Identify Gene-Environment Interactions: Analyses of Colon Cancer Risk and Survival

Sharafeldin, Noha ; Slattery, Martha L. ; Liu, Qi ; Franco-Villalobos, Conrado ; Caan, Bette J. ; Potter, John D. ; Yasui, Yutaka

Background: Genetic association studies have traditionally focused on associations between individual single nucleotide polymorphisms (SNPs) and disease. Standard analysis ignores interactions between multiple SNPs and environmental exposures explaining a small portion of disease heritability: the often-cited issue of “missing heritability.” Methods: We present a novel three-step analytic framework for modeling gene-environment interactions (GEIs) between an angiogenesis candidate-gene pathway [...]