Menée sur 104 patients pédiatriques atteints d'un cancer de stade avancé et âgés de plus de deux ans (durée de suivi : 9 mois), cette étude décrit les symptômes de détresse associés à la maladie

Symptoms and Distress in Children With Advanced Cancer: Prospective Patient-Reported Outcomes From the PediQUEST Study

Wolfe, Joanne ; Orellana, Liliana ; Ullrich, Christina ; Cook, E. Francis ; Kang, Tammy I. ; Rosenberg, Abby ; Geyer, Russ ; Feudtner, Chris ; Dussel, Veronica

Purpose : Thousands of children are living with advanced cancer; yet patient-reported outcomes (PROs) have rarely been used to describe their experiences. We aimed to describe symptom distress in 104 children age 2 years or older with advanced cancer enrolled onto the Pediatric Quality of Life and Evaluation of Symptoms Technology (PediQUEST) Study (multisite clinical trial evaluating an electronic PRO system). Methods : Symptom data were collected using age- and respondent-adapted versions of [...]

Mené au Japon sur 413 patients atteints d'un cancer traité par chimiothérapie à base d'oxaliplatine, cet essai multicentrique de phase III évalue l'efficacité de l'aprépitant oral ou du fosaprépitant, en combinaison avec la dexaméthasone et un antagoniste du récepteur 5-HT 3, pour prévenir le risque de vomissement lié à la chimiothérapie

Combination antiemetic therapy with aprepitant/fosaprepitant in patients with colorectal cancer receiving oxaliplatin-based chemotherapy (SENRI trial): A multicentre, randomised, controlled phase 3 trial

Nishimura, Junichi ; Satoh, Taroh ; Fukunaga, Mutsumi ; Takemoto, Hiroyoshi ; Nakata, Ken ; Ide, Yoshihito ; Fukuzaki, Takayuki ; Kudo, Toshihiro ; Miyake, Yasuhiro ; Yasui, Masayoshi ; Morita, Shunji ; Sakai, Daisuke ; Uemura, Mamoru ; Hata, Taishi ; Takemasa, Ichiro ; Mizushima, Tsunekazu ; Ohno, Yuko ; Yamamoto, Hirofumi ; Sekimoto, Mitsugu ; Nezu, Riichiro ; Doki, Yuichiro ; Mori, Masaki

Introduction : The oral neurokinin-1 antagonist aprepitant is recommended in several guidelines for preventing chemotherapy-induced nausea & vomiting (CINV) due to highly emetogenic cancer chemotherapy. Little is known about the feasibility and safety of aprepitant in patients treated with oxaliplatin. Methods : In this multicentre, open label, randomised, phase 3 trial, we recruited patients with colorectal cancer who underwent an oxaliplatin-based chemotherapy. Patients were centrally [...]

Menée auprès d'une cohorte de 1 917 patients ayant survécu à un cancer de la prostate non métastatique, cette étude évalue l'association entre la durée hebdomadaire et l'intensité de l'activité physique pratiquée et la qualité de vie des patients

Physical activity, sedentary behavior, and health-related quality of life in prostate cancer survivors in the health professionals follow-up study

Phillips, SiobhanM ; Stampfer, MeirJ ; Chan, JuneM ; Giovannucci, EdwardL ; Kenfield, StaceyA

Purpose : Many prostate cancer survivors experience compromised health-related quality of life (HRQOL) as a result of prostate cancer. We examined relationships between types and intensities of activity and sedentary behavior and prostate cancer-related HRQOL, overall, and by demographic, disease, and treatment characteristics. Methods : Associations between post-diagnosis activity and sedentary behavior and HRQOL domains (urinary incontinence, urinary irritation/obstruction, bowel, sexual, and [...]

Menée à partir de questionnaires auprès de100 patients ayant survécu à un cancer de la prostate (âge moyen : 71,7 ans), cette étude évalue l'efficacité d'un programme d'exercices physiques pour améliorer leur qualité de vie, puis identifie les facteurs influençant l'efficacité de ce programme

The effect, moderators, and mediators of resistance and aerobic exercise on health-related quality of life in older long-term survivors of prostate cancer

Buffart, Laurien M. ; Newton, Robert U. ; Chinapaw, Mai J. ; Taaffe, Dennis R. ; Spry, Nigel A. ; Denham, James W. ; Joseph, David J. ; Lamb, David S. ; Brug, Johannes ; Galvão, Daniel A.

BACKGROUND : The current study examined effects, moderators (for whom), and mediators (working mechanisms) of 12 months of exercise on health-related quality of life (HRQoL) in older long-term survivors of prostate cancer. METHODS : In total, 100 men aged 71.7 years (standard deviation, 6.4 years) were randomly assigned to 6 months of supervised aerobic and resistance exercise followed by 6 months of a home-based exercise maintenance program (EX group) or printed education material regarding [...]

Mené sur 230 patientes atteintes d'un cancer du sein et recevant une chimiothérapie adjuvante, cet essai évalue l'efficacité d'un programme d'exercices physiques de faible et de haute intensité pour améliorer la qualité de vie des patientes et leur tolérance au traitement

Effect of Low-Intensity Physical Activity and Moderate- to High-Intensity Physical Exercise During Adjuvant Chemotherapy on Physical Fitness, Fatigue, and Chemotherapy Completion Rates: Results of the PACES Randomized Clinical Trial

van Waart, Hanna ; Stuiver, Martijn M. ; van Harten, Wim H. ; Geleijn, Edwin ; Kieffer, Jacobien M. ; Buffart, Laurien M. ; de Maaker-Berkhof, Marianne ; Boven, Epie ; Schrama, Jolanda ; Geenen, Maud M. ; Meerum Terwogt, Jetske M. ; van Bochove, Aart ; Lustig, Vera ; van den Heiligenberg, Simone M. ; Smorenburg, Carolien H. ; Hellendoorn-van Vreeswijk, Jeannette A.J.H. ; Sonke, Gabe S. ; Aaronson, Neil K.

Purpose : We evaluated the effectiveness of a low-intensity, home-based physical activity program (Onco-Move) and a moderate- to high-intensity, combined supervised resistance and aerobic exercise program (OnTrack) versus usual care (UC) in maintaining or enhancing physical fitness, minimizing fatigue, enhancing health-related quality of life, and optimizing chemotherapy completion rates in patients undergoing adjuvant chemotherapy for breast cancer. Patients and Methods : We randomly assigned [...]

Menée à l'aide d'un modèle mathématique intégrant les données GLOBOCAN de l'année 2012, cette étude évalue le nombre de cas de carcinome hépatocellulaire non détectés dans les pays en voie de développement

Global and country underestimation of hepatocellular carcinoma (HCC) in 2012 and its implications

Sartorius, K. ; Sartorius, B. ; Aldous, C. ; Govender, P. S. ; Madiba, T. E.

Purpose : The problems of screening costs, as well as poor data, potentially lead to the underestimation of the incidence of hepatocellular carcinoma (HCC). In particular, this is problematic in developing countries with limited resources and poor data. The study develops a model to inform policy makers of the true incidence and potential extra cost of HCC in a developing country context. Methods : Using Globocan 2012 data, we employed an ecological correlation design at country level to [...]

Cette étude identifie les registres des cancers collectant des données sur les cancers pédiatriques, évalue leur taux de couverture de la population pédiatrique de l'Union Européenne et des régions de l'Organisation Mondiale de la Santé, puis compare la qualité de leurs données et leur rapport coût-efficacité

Registration of childhood cancer: Moving towards pan-European coverage?

Steliarova-Foucher, Eva ; Stiller, Charles ; Colombet, Murielle ; Kaatsch, Peter ; Zanetti, Roberto ; Peris-Bonet, Rafael

Cancer is relatively rare in childhood, but it contributes considerably to childhood mortality, years of life lost per person and late effects in survivors. Large populations need to be covered to set up meaningful studies of these rare conditions. Cancer registries ensure cancer surveillance, thus providing the basis for research as well as policy decisions. In this paper we examine coverage of childhood population by cancer registries in Europe and encourage national cancer registration. Over [...]

Menée à partir des données des registres médicaux danois portant sur 28 997 patients atteints d'un cancer, cette étude analyse la relation entre une infection par l'herpès zoster avant le diagnostic de cancer (2 754 cas) et la mortalité

Mortality in cancer patients previously diagnosed with herpes zoster in the hospital setting: a nationwide cohort study

Schmidt, S. A. J. ; Sorensen, G. V. ; Horvath-Puho, E. ; Pedersen, L. ; Obel, N. ; Petersen, K. L. ; Schonheyder, H. C. ; Sorensen, H. T.

Background : Herpes zoster (HZ) is associated with underlying immunodeficiency and may thereby predict mortality of subsequent cancer. Methods : By using Danish nationwide medical databases, we identified all cancer patients with a prior hospital-based HZ diagnosis during 1982–2011 (n=2754) and a matched cancer cohort without prior HZ (n=26 243). We computed adjusted mortality rate ratios (aMRRs) associating prior HZ with mortality following cancer. Results : Prior HZ was associated with [...]

A partir des données de 9 essais de phase II ou III évaluant l'efficacité et la toxicité du pazopanib en monothérapie et incluant au total 2 080 patients atteints d'un cancer de stade avancé, cette méta-analyse identifie et caractérise les anomalies de la fonction hépatique liées au traitement

Characterisation of liver chemistry abnormalities associated with pazopanib monotherapy: A systematic review and meta-analysis of clinical trials in advanced cancer patients

Powles, Thomas ; Bracarda, Sergio ; Chen, Mei ; Norry, Elliot ; Compton, Natalie ; Heise, Mark ; Hutson, Thomas ; Harter, Philipp ; Carpenter, Christopher ; Pandite, Lini ; Kaplowitz, Neil

Drug-induced liver chemistry abnormalities, primarily transaminase elevations, are commonly observed in pazopanib-treated patients. This meta-analysis characterises liver chemistry abnormalities associated with pazopanib. Data of pazopanib-treated patients from nine prospective trials were integrated (N = 2080). Laboratory datasets were used to characterise the incidence, timing, recovery and patterns of liver events, and subsequent rechallenge with pazopanib. Severe cases of liver chemistry [...]

Menée auprès de 2 549 femmes et 4 274 hommes ayant une pratique tabagique, cette étude évalue l'incidence du cancer du poumon et la survie en fonction de la présence d'une infection par le VIH

Lung cancer incidence and survival among HIV-infected and uninfected women and men

Hessol, Nancy A. ; Martinez-Maza, Otoniel ; Levine, Alexandra M. ; Morris, Alison ; Margolick, Joseph B. ; Cohen, Mardge H. ; Jacobson, Lisa P. ; Seaberg, Eric C.

Objectives: To determine the lung cancer incidence and survival time among HIV-infected and uninfected women and men. Design: Two longitudinal studies of HIV infection in the United States. Methods: Data from 2549 women in the Women's Interagency HIV Study (WIHS) and 4274 men in the Multicenter AIDS Cohort Study (MACS), all with a history of cigarette smoking, were analyzed. Lung cancer incidence rates and incidence rate ratios were calculated using Poisson regression analyses. Survival time [...]

A partir d'une revue systématique de la littérature publiée entre 1948 et 2013 (29 études), cette étude évalue la prévalence à l'autopsie des cancers de la prostate, puis identifie les facteurs prédictifs associés à la détection post mortem de la maladie

Prevalence of incidental prostate cancer: A systematic review of autopsy studies

Bell, Katy J. L. ; Del Mar, Chris ; Wright, Gordon ; Dickinson, James ; Glasziou, Paul

Prostate cancer screening may detect nonprogressive cancers, leading to overdiagnosis and overtreatment. The potential for overdiagnosis can be assessed from the reservoir of prostate cancer in autopsy studies that report incidental prostate cancer rates in men who died of other causes. We aimed to estimate the age-specific incidental cancer prevalence from all published autopsy studies. We identified eligible studies by searches of Medline and Embase, forward and backward citation searches and [...]

Menée à partir de données portant sur 210 femmes atteintes d'un cancer inflammatoire métastatique ou non de stade III ou IV diagnostiqué entre 1997 et 2011, cette étude évalue l'incidence cumulée à 1, 2 ou 3 ans de métastases cérébrales, puis identifie les facteurs de risque associés

Inflammatory breast cancer and development of brain metastases: risk factors and outcomes

Warren, LauraE G. ; Guo, Hao ; Regan, MeredithM ; Nakhlis, Faina ; Yeh, ErenD ; Jacene, HeatherA ; Hirshfield-Bartek, Judi ; Overmoyer, BethA ; Bellon, JenniferR

Brain metastases are associated with significant morbidity. Minimal research has been conducted on the risk factors for and incidence of brain metastases in women with inflammatory breast cancer (IBC). 210 women with Stage III or IV IBC diagnosed from 1997–2011 were identified. Competing risk analysis and competing risks regression were used to calculate the incidence of brain metastases and identify significant risk factors. After a median follow-up in surviving patients of 2.8 years (range [...]

Menée à partir d'un modèle mathématique incorporant des données statistiques sur la période 1986-2010, cette étude analyse, dans 50 provinces espagnoles, l'évolution de la mortalité par cancer du cerveau chez les jeunes de moins de 20 ans

Analyzing the evolution of young people brain cancer mortality in Spanish provinces

Ugarte, M. D. ; Adin, A. ; Goicoa, T. ; López-Abente, G.

Objectives : To analyze the spatio-temporal evolution of brain cancer relative mortality risks in young population (under 20 years of age) in Spanish provinces during the period 1986–2010. Methods : A new and flexible conditional autoregressive spatio-temporal model with two levels of spatial aggregation was used. Results : Brain cancer relative mortality risks in young population in Spanish provinces decreased during the last years, although a clear increase was observed during the 1990s. The [...]

A partir d'une revue systématique de la littérature (13 études), cette méta-analyse évalue l'association entre les niveaux sériques de l'adiponectine, de la leptine ou du rapport adiponectine/leptine et le risque de cancer de l'endomètre (1 963 cas et 3 503 témoins)

Circulating adiponectin, leptin and adiponectin–leptin ratio and endometrial cancer risk: Evidence from a meta-analysis of epidemiologic studies

Gong, Ting-Ting ; Wu, Qi-Jun ; Wang, Yong-Lai ; Ma, Xiao-Xin

We performed this meta-analysis of epidemiologic studies to investigate the associations between circulating adiponectin, leptin and adiponectin–leptin (A/L) ratio and endometrial cancer risk. Relevant manuscripts were identified by searching PubMed and ISI Web of Science databases as well as by manual searching the references cited in retrieved manuscripts. Random-effects models were used to estimate summary odds ratio (SOR) and 95% confidence intervals (CIs) for aforementioned associations. [...]

A partir d'une revue systématique de la littérature publiée jusqu'en février 2014 (12 études), cette méta-analyse évalue l'effet d'interventions psychosociales (interventions pédagogiques, conseils, exercices physiques, ...) sur la santé psychique des adolescents et jeunes adultes atteints d'un cancer

Psychosocial interventions for adolescents and young adult cancer patients: A systematic review and meta-analysis

Richter, Diana ; Koehler, Michael ; Friedrich, Michael ; Hilgendorf, Inken ; Mehnert, Anja ; Weißflog, Gregor

Adolescent and young adult (AYA) cancer patients experience unique psychosocial needs and developmental challenges. A cancer diagnosis can stress this development and disrupt AYAs in their normal life. The aim of this systematic review and meta-analysis was to assess the impact of psychosocial interventions on mental health in AYAs. A literature research was conducted, which resulted in twelve eligible studies. The standardized mean difference between intervention and control conditions was [...]

A partir d'une revue systématique de la littérature publiée entre 2000 et 2014 (10 revues systématiques), cette étude évalue le rapport coût-efficacité des hormonothérapies, chimiothérapies et thérapies ciblées dans le cancer du sein

A review of systematic reviews of the cost-effectiveness of hormone therapy, chemotherapy, and targeted therapy for breast cancer

Diaby, Vakaramoko ; Tawk, Rima ; Sanogo, Vassiki ; Xiao, Hong ; Montero, AlbertoJ

Breast cancer is a global health concern. In fact, breast cancer is the primary cause of death among women worldwide and constitutes the most expensive malignancy to treat. As health care resources are finite, decisions regarding the adoption and coverage of breast cancer treatments are increasingly being based on “value for money,” i.e., cost-effectiveness. As the evidence about the cost-effectiveness of breast cancer treatments is abundant, therefore difficult to navigate, systematic reviews [...]

Cet article fait le point sur les indications et les aspects techniques de la sédation continue dans les soins de fin de vie puis aborde une réflexion éthique sur son utilisation

End-of-life sedation: is there an alternative?

Lossignol, Dominique

Purpose of review : To evaluate the place and the usefulness of sedation in medical practice at the end of life. Recent findings : Continuous sedation is an acknowledged medical practice for the management of refractory symptoms at the end of life. Guidelines and recommendations have been proposed in palliative care. Although considered as a good medical practice at the end of life, sedation is neither the only option nor the best. Summary : This article presents the state-of-the-art [...]