Cet article présente la mise à jour 2014 des recommandations de l'American Society of Clinical Oncology concernant la prévention et le traitement de la thromboembolie veineuse chez les patients atteints d'un cancer

Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update 2014

Lyman, Gary H. ; Bohlke, Kari ; Khorana, Alok A. ; Kuderer, Nicole M. ; Lee, Agnes Y. ; Arcelus, Juan Ignacio ; Balaban, Edward P. ; Clarke, Jeffrey M. ; Flowers, Christopher R. ; Francis, Charles W. ; Gates, Leigh E. ; Kakkar, Ajay K. ; Key, Nigel S. ; Levine, Mark N. ; Liebman, Howard A. ; Tempero, Margaret A. ; Wong, Sandra L. ; Somerfield, Mark R. ; Falanga, Anna

Purpose : To provide current recommendations about the prophylaxis and treatment of venous thromboembolism (VTE) in patients with cancer. Methods : PubMed and the Cochrane Library were searched for randomized controlled trials, systematic reviews, meta-analyses, and clinical practice guidelines from November 2012 through July 2014. An update committee reviewed the identified abstracts. Results : Of the 53 publications identified and reviewed, none prompted a change in the 2013 recommendations. [...]

A partir d'une revue systématique de la littérature (34 études), cette étude évalue l'efficacité d'une supplémentation en vitamine C pour augmenter l'efficacité et réduire la toxicité des traitements anticancéreux

Is There a Role for Oral or Intravenous Ascorbate (Vitamin C) in Treating Patients With Cancer?: A Systematic Review

Jacobs, Carmel ; Hutton, Brian ; Ng, Terry ; Shorr, Risa ; Clemons, Mark

Background. Many cancer patients receive supplemental ascorbate (vitamin C) in the belief that it synergizes the anticancer effects of chemotherapy and reduces its toxicity. Methods. A systematic review was performed to evaluate the antitumor effects and toxicity of ascorbate treatment. Medline (1946 to March 2014), EMBASE (1947 to March 2014), and the Cochrane central register (1993 to March 2014) were searched for randomized and observational studies. Results. Of 696 identified records, 61 [...]

Mené sur 253 patients atteints d'un lymphome non hodgkinien et inclus dans un essai évaluant deux schémas thérapeutiques avec rituximab, cette étude analyse, en fonction du traitement reçu, le niveau d'anxiété et la qualité de vie des patients

Anxiety and Health-Related Quality of Life Among Patients With Low–Tumor Burden Non-Hodgkin Lymphoma Randomly Assigned to Two Different Rituximab Dosing Regimens: Results From ECOG Trial E4402 (RESORT)

Wagner, Lynne I. ; Zhao, Fengmin ; Hong, Fangxin ; Williams, Michael E. ; Gascoyne, Randy D. ; Krauss, John C. ; Advani, Ranjana H. ; Go, Ronald S. ; Habermann, Thomas M. ; Leach, Joseph W. ; O'Connor, Brian ; Schuster, Stephen J. ; Cella, David ; Horning, Sandra J. ; Kahl, Brad S.

Purpose : The purpose of this study was to compare illness-related anxiety among participants in the Rituximab Extended Schedule or Retreatment Trial (RESORT) randomly assigned to maintenance rituximab (MR) versus rituximab re-treatment (RR). A secondary objective was to examine whether the superiority of MR versus RR on anxiety depended on illness-related coping style. Patients and Methods : Patients (N = 253) completed patient-reported outcome (PRO) measures at random assignment to MR or RR [...]

Menée en Allemagne auprès de 31 survivantes d'un cancer du sein, cette étude évalue l'efficacité d'un programme thérapeutique basé sur une approche psycho-éducative et artistique ainsi que sur des exercices de gymnastique pour réduire les symptômes de fatigue liée au cancer

Do we have predictors of therapy responsiveness for a multimodal therapy concept and aerobic training in breast cancer survivors with chronic cancer-related fatigue?

Kröz, M. ; Reif, M. ; Zerm, R. ; Winter, K. ; Schad, F. ; Gutenbrunner, C. ; Girke, M. ; Bartsch, C.

Cancer-related fatigue (CRF) is a burdensome symptom for breast cancer (BC) patients. In this pilot study, we tested several questionnaires as predictors for treatment responsiveness, along with the implementation of a multimodal therapy concept consisting of sleep, psycho-education, eurythmy, painting therapy and standard aerobic training. At the Community Hospital Havelhöhe and the Hannover Medical School, 31 BC patients suffering from CRF could be evaluated in a 10-week intervention study. [...]

Menée en Australie auprès de patients atteints d'un cancer de la tête et du cou, cette étude analyse leur façon de faire face à une santé buccale altérée ainsi que leurs besoins en soins de support après le traitement

Coping with an altered mouth and perceived supportive care needs following head and neck cancer treatment

Pateman, K. A. ; Ford, P. J. ; Batstone, M. D. ; Farah, C. S.

Purpose : Oral health is essential to general health and well-being and is severely impacted by head and neck cancer (HNC) and its treatment. This study aimed to describe how people who have been treated for HNC cope with altered oral health and function and to identify their supportive care needs. Methods : A qualitative, descriptive approach was used. Data was collected from individual interviews with six participants 6 months after treatment. Data analysis was performed by qualitative [...]

Cet article présente le rapport annuel de l'"American Society of Clinical Oncology" sur les principales avancées cliniques en 2015

Clinical Cancer Advances 2015: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology

Masters, Gregory A. ; Krilov, Lada ; Bailey, Howard H. ; Brose, Marcia S. ; Burstein, Harold ; Diller, Lisa R. ; Dizon, Don S. ; Fine, Howard A. ; Kalemkerian, Gregory P. ; Moasser, Mark ; Neuss, Michael N. ; O'Day, Steven J. ; Odenike, Olatoyosi ; Ryan, Charles J. ; Schilsky, Richard L. ; Schwartz, Gary K. ; Venook, Alan P. ; Wong, Sandra L. ; Patel, Jyoti D.

Clinical cancer research has yielded tremendous gains, leading to longer survival and better quality of life for the more than half a million Americans diagnosed with the disease each year. Great strides in cancer prevention have further decreased the burden of the disease. Cancer death rates in the United States have declined 20% from their peak in 1991 (215.1 per 100,000 population) to 2010 (171.8 per 100,000 population).1 Today, there are a record 14.5 million cancer survivors alive in the [...]

Menée à Taïwan, cette étude analyse l'évolution de l'incidence des cancers pédiatriques sur la période 1996-2010 (8 032 cas âgés de moins de 14 ans)

Incidence of cancer in children aged 0–14 years in Taiwan, 1996–2010

Liu, Yen-Lin ; Lo, Wei-Cheng ; Chiang, Chun-Ju ; Yang, Ya-Wen ; Lu, Meng-Yao ; Hsu, Wen-Ming ; Ho, Wan-Ling ; Li, Meng-Ju ; Miser, James S. ; Lin, Dong-Tsamn ; Lai, Mei-Shu

Studies have found lower risk of childhood cancer among Asian children. We aim to characterize the recent incidence and incidence-trend of childhood cancer in Taiwan after the National Health Insurance program was launched in March 1995. Data were extracted from the Taiwan Cancer Registry, a population-based database established in 1979. Cases diagnosed at age 0–14 from 1996 to 2010 were analyzed and categorized according to the International Classification of Childhood Cancer, Third Edition [...]

Menée aux Etats-Unis auprès de 21 031 participants, cette étude de cohorte analyse les disparités ethniques dans l'association entre des indicateurs de l'équilibre oxydant-antioxydant et le risque de décès, par cancer et autres causes

Oxidative Balance Score as Predictor of All-Cause, Cancer, and Non-cancer Mortality in a Biracial US Cohort

Kong, So Yeon ; Goodman, Michael ; Judd, Suzanne ; Bostick, Roberd M. ; Flanders, W. Dana ; McClellan, William

Purpose : We previously proposed an oxidative balance score (OBS) that combines pro- and anti-oxidant exposures to represent the overall oxidative balance status of an individual. In this study, we investigated associations of the OBS with all-cause and cause-specific mortality, and explored alternative OBS weighting methods in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study cohort. Methods : The OBS was calculated by combining information from 14 a priori selected [...]

A partir de données individuelles de patients inclus dans quatre essais randomisés et atteints d'un cancer du côlon de stade III, cette étude analyse l'impact de l'âge (moins de 70 ans, 70 ans ou plus) et des comorbidités médicales du patient sur l'efficacité d'un traitement adjuvant de type XELOX/FOLFOX ou de type LV/5-FU

Impact of age and medical comorbidity on adjuvant treatment outcomes for stage III colon cancer: a pooled analysis of individual patient data from four randomized controlled trials

Haller, D. G. ; O'Connell, M. J. ; Cartwright, T. H. ; Twelves, C.J. ; McKenna, E. F. ; Sun, W. ; Saif, M. W. ; Lee, S. ; Yothers, G. ; Schmoll, H.-J.

Background : Adjuvant oxaliplatin plus capecitabine or leucovorin/5-fluorouracil (LV/5-FU) (XELOX/FOLFOX) is the standard of care for stage III colon cancer (CC); however, there is disagreement regarding oxaliplatin benefit in patients aged >70. In most analyses the impact of medical comorbidity (MC) has not been assessed. Efficacy and safety of adjuvant XELOX/FOLFOX versus LV/5-FU were compared with respect to age and MC using pooled data from four randomized controlled trials, selected for [...]

Menée par entretiens auprès de 21 oncologues pédiatriques canadiens, cette étude analyse leurs difficultés à gérer les décisions thérapeutiques en fin de vie et à faire face aux décès de leurs patients

Challenging patient deaths in pediatric oncology

Granek, Leeat ; Bartels, Ute ; Scheinemann, Katrin ; Barrera, Maru

Purpose : Pediatric oncologists look after patients and their families for extended periods of time when they are diagnosed and treated for cancer. Twenty percent of these children will die while under their care. The purpose of this study was to explore what makes patient deaths challenging for pediatric oncologists. Methods : Twenty-one Canadian pediatric oncologists were interviewed about their experiences with patient death and were probed about the factors that make patient deaths [...]

Menée aux Etats-Unis par questionnaires auprès de patientes affectées par un lymphœdème consécutif à une opération pour un cancer du sein, cette étude transversale évalue la prévalence de symptômes dépressifs en fonction de l'intensité de la douleur et de la perception qu'ont les patientes de leur propre corps

Examining pain, body image, and depressive symptoms in patients with lymphedema secondary to breast cancer

Teo, Irene ; Novy, Diane M. ; Chang, David W. ; Cox, Matthew G. ; Fingeret, Michelle Cororve

Objective : Depression and reduced quality of life are often reported in patients with upper-extremity lymphedema secondary to breast cancer treatment. Little is known about how pain and body image influence depression in patients with lymphedema. The current study examined the association of pain intensity and body integrity beliefs with depressive symptoms and the extent to which body image dissatisfaction mediated these associations. Methods : A cross-sectional sample of patients with [...]

Menée à Taïwan auprès de 130 patients ayant été traités pour un cancer de la tête et du cou, cette étude transversale analyse leurs difficultés à parler selon la sévérité des symptômes et la perception qu'ils ont de leur propre corps

Communication dysfunction, body image, and symptom severity in postoperative head and neck cancer patients: factors associated with the amount of speaking after treatment

Chen, Shu-Ching ; Yu, Po-Jui ; Hong, Ming-Ying ; Chen, Mei-Hui ; Chu, Pen-Yuan ; Chen, Yen-Ju ; Wang, Chen-Ping ; Lai, Yeur-Hur

Purpose : The purpose of this study was to determine the relationships of communication dysfunction, body image, and amount of speaking in patients who were treated for head and neck cancers (HNCs). Methods : This was a cross-sectional study of postoperative HNC patients at the otolaryngology outpatient departments of two leading medical centers in northern Taiwan. Data were collected using questionnaires to assess perceived communication dysfunction, body image, symptom severity, and amount of [...]

Menée aux Etats-Unis, cette étude analyse l'intérêt de rappels téléphoniques ciblés pour s'assurer que les patients défavorisés et atteints de cancer adhèrent à un suivi médical régulier

Patient navigation based on predictive modeling decreases no-show rates in cancer care

Percac-Lima, Sanja ; Cronin, Patrick R. ; Ryan, David P. ; Chabner, Bruce A. ; Daly, Emily A. ; Kimball, Alexandra B.

BACKGROUND Patient adherence to appointments is key to improving outcomes in health care. “No-show” appointments contribute to suboptimal resource use. Patient navigation and telephone reminders have been shown to improve cancer care and adherence, particularly in disadvantaged populations, but may not be cost-effective if not targeted at the appropriate patients. METHODS In 5 clinics within a large academic cancer center, patients who were considered to be likely (the top 20th percentile) to [...]

Menée à Taïwan à partir de données portant sur 428 patients atteints d'un cancer de l'œsophage, cette étude analyse les coûts associés à une radiothérapie et les risques de décès, selon le niveau d'accréditation des établissements où sont pratiqués les traitements

Mortality and cost of radiation therapy for oesophageal cancer according to hospital accreditation level: a nationwide population-based study

Liu, S. H. ; Wu, J. N. ; Day, J. D. ; Muo, C. H. ; Sung, F. C. ; Kao, C. H. ; Liang, J. A.

This study examined and analysed the relationship between the cost-effectiveness and outcome of radiotherapy for oesophageal cancer among hospitals with varying accreditation levels. We selected 428 oesophageal cancer patients from medical and non-medical centres using the National Health Insurance Research Database, which is maintained by the Taiwanese National Health Research Institutes, and compared their medical expenditure and the outcome of their radiotherapy treatment. In this study [...]

Menée au Canada auprès de 37 patients atteints d'un cancer du poumon (âge de 56 à 93 ans ; âge médian : 76 ans), cette étude prospective analyse l'efficacité d'un outil pédagogique destiné à améliorer leurs connaissances sur la radiothérapie stéréotaxique du poumon

Development and Evaluation of Patient Education Materials for Elderly Lung Cancer Patients

Jewitt, Natalie ; Hope, AndrewJ ; Milne, Robin ; Le, LisaW ; Papadakos, Janet ; Abdelmutti, Nazek ; Catton, Pamela ; Giuliani, MeredithE

Patients treated for lung cancer are often elderly presenting a unique challenge for developing patient education materials. This study developed and evaluated a patient education pamphlet on lung stereotactic body radiotherapy (SBRT) designed specifically for an elderly population. The SBRT pamphlet was developed using a participatory design involving a convenience sample of patients. This prospective study assessed patient’s opinions of pamphlet effectiveness through self-report [...]

A partir des données des registres américains des cancers et de la base Medicare portant sur 174 patients atteints d'un cancer colorectal, cette étude analyse l'efficacité d'un algorithme permettant d'évaluer la récidive de cancer et d'estimer son association avec la survie globale

Development of a claims-based algorithm to identify colorectal cancer recurrence

Deshpande, Anjali D. ; Schootman, Mario ; Mayer, Allese

Purpose : To examine the validity of claims data to identify CRC recurrence and determine the extent to which misclassification of recurrence status affects estimates of its association with overall survival in a population-based administrative database. Methods : We calculated the accuracy of claims data relative to medical records from one large tertiary hospital to identify CRC recurrence. We estimated the effect of misclassifying recurrence on survival by applying these findings to the [...]