Oncogenic activity of the regulatory subunit p85beta of phosphatidylinositol 3-kinase (PI3K)
Menée in vitro, cette étude met en évidence le rôle joué par une sous-unité régulatrice du gène PI3K dans la transformation maligne
Proceedings of the National Academy of Sciences, sous presse, 2014, résumé
Résumé en anglais
Expression of the regulatory subunit p85β of PI3K induces oncogenic transformation of primary avian fibroblasts. The transformed cells proliferate at an increased rate compared with nontransformed controls and show elevated levels of PI3K signaling. The oncogenic activity of p85β requires an active PI3K-TOR signaling cascade and is mediated by the p110α and p110β isoforms of the PI3K catalytic subunit. The data suggest that p85β is a less effective inhibitor of the PI3K catalytic subunit than p85α and that this reduced level of p110 inhibition accounts for the oncogenic activity of p85β.
