A partir de données internationales collectées jusqu'en décembre 2006 au sein de 3 études cas-témoins (Australie, Canada, Royaume-Uni), cette étude évalue l'association entre une exposition professionnelle à de faibles concentrations de benzène et le risque de développer un cancer lympho-hématopoïétique chez des travailleurs du secteur de la distribution des produits pétroliers (370 cas et 1 587 témoins)

Myelodysplastic Syndrome and Benzene Exposure Among Petroleum Workers: An International Pooled Analysis

Schnatter, A. Robert ; Glass, Deborah C. ; Tang, Gong ; Irons, Richard D. ; Rushton, Lesley

Background Benzene at high concentrations is known to cause acute myeloid leukemia (AML), but its relationship with other lymphohematopoietic (LH) cancers remains uncertain, particularly at low concentrations. In this pooled analysis, we examined the risk of five LH cancers relative to lower levels of benzene exposure in petroleum workers.Methods We updated three nested case–control studies from Australia, Canada, and the United Kingdom with new incident LH cancers among petroleum distribution [...]

A partir des données d'une étude européenne portant sur 2 348 patients atteints d'un lymphome et sur 2 462 témoins, cette étude évalue l'association entre une exposition professionnelle aux pesticides (organiques ou inorganiques) et le risque global de lymphome, de lymphome à cellules B ou de leucémie lymphoïde chronique

Lymphoma risk and occupational exposure to pesticides: results of the Epilymph study

Cocco, Pierluigi ; Satta, Giannina ; Dubois, Stefania ; Pili, Claudia ; Pilleri, Michela ; Zucca, Mariagrazia ; ‘t Mannetje, Andrea Martine ; Becker, Nikolaus ; Benavente, Yolanda ; de Sanjose, Silvia ; Foretova, Lenka ; Staines, Anthony ; Maynadie, Marc ; Nieters, Alexandra ; Brennan, Paul ; Miligi, Lucia ; Ennas, Maria Grazia ; Boffetta, Paolo

Objectives We investigated the role of occupational exposure to specific groups of agrochemicals in the aetiology of lymphoma overall, B cell lymphoma and its most prevalent subtypes.Methods In 1998–2003, 2348 incident lymphoma cases and 2462 controls were recruited to the EPILYMPH case-control study in six European countries. A detailed occupational history was collected in cases and controls. Job modules were applied for farm work including specific questions on type of crop, farm size, pests [...]

Menée sur 2 348 éleveurs atteints d'un lymphome et sur 2 462 témoins, cette étude évalue l'association entre le contact avec les animaux et le risque de développer la maladie en fonction de ses sous-types et de l'âge du début de l'activité professionnelle

Lymphoma risk in livestock farmers: Results of the Epilymph study

Cocco, Pierluigi ; Satta, Giannina ; D'Andrea, Ileana ; Nonne, Tinucia ; Udas, Giuseppe ; Zucca, Mariagrazia ; Mannetje, Andrea 't ; Becker, Nikolaus ; Sanjosé, Silvia de ; Foretova, Lenka ; Staines, Anthony ; Maynadie, Marc ; Nieters, Alexandra ; Brennan, Paul ; Ennas, Maria G. ; Boffetta, Paolo

We explored the risk of lymphoma and its most prevalent subtypes associated with occupational contact with livestock, and whether risk was modified by age at first contact, in 2,348 incident lymphoma cases and 2,462 controls who participated in the EPILYMPH case–control study. A detailed occupational history was collected in cases and controls, including working in a livestock farm, species of livestock, its approximate number and circumstances of contact. For each disease outcome, and each [...]

A partir de données du système d'assurance maladie de Taïwan, cette étude en population montre une association entre une infection par le virus herpes zoster (42 498 cas et 169 983 témoins) et le risque de tumeur maligne lymphoïde (154 cas dont 48 parmi les patients infectés par le virus)

Herpes zoster is associated with an increased risk of subsequent lymphoid malignancies - A nationwide population-based matched-control study in Taiwan

Liu, Yi-Chang ; Yang, Yi-Hsin ; Hsiao, Hui-Hua ; Yang, Wen-Chi ; Liu, Ta-Chih ; Chang, Chao-Sung ; Yang, Ming-Yu ; Lin, Pai-Mei ; Hsu, Jui-Feng ; Chang, Pi-Yu ; Lin, Sheng-Fung

BACKGROUND:Infectious agents have been shown to contribute to the development of lymphoid malignancies. The different distribution of lymphoid malignancies in Asian and Western populations suggests possibly different etiologies in Asian populations. Herpes zoster infection, commonly seen in immunocompromised persons, has been reported to be associated with lymphoid malignancies in retrospective case--control studies from Western populations, but the results are controversial and large-scale [...]

Grâce à un nouvel anticorps permettant d'améliorer la détection de l'antigène grand T du polyomavirus dans des échantillons tumoraux prélevés sur des patients atteints d'un carcinome à cellules de Merkel, cette étude montre la présence du virus dans toutes les tumeurs

Improved detection suggests all Merkel cell carcinomas harbor Merkel polyomavirus

Rodig, Scott J. ; Cheng, Jingwei ; Wardzala, Jacek ; DoRosario, Andrew ; Scanlon, Jessica J. ; Laga, Alvaro C. ; Martinez-Fernandez, Alejandro ; Barletta, Justine A. ; Bellizzi, Andrew M. ; Sadasivam, Subhashini ; Holloway, Dustin T. ; Cooper, Dylan J. ; Kupper, Thomas S. ; Wang, Linda C. ; DeCaprio, James A.

A human polyomavirus was recently discovered in Merkel cell carcinoma (MCC) specimens. The Merkel cell polyomavirus (MCPyV) genome undergoes clonal integration into the host cell chromosomes of MCC tumors and expresses small T antigen and truncated large T antigen. Previous studies have consistently reported that MCPyV can be detected in approximately 80% of all MCC tumors. We sought to increase the sensitivity of detection of MCPyV in MCC by developing antibodies capable of detecting large T [...]

A partir des données de registres allemands du cancer et à l'aide d'entretiens auprès de 427 patients atteints d'un cancer du nez (âge moyen : 62,1 ans) et auprès de 2 401 témoins (âge moyen : 60,8 ans), cette étude identifie les facteurs de risque associés à la survenue d'un carcinome nasal

Risk factors for nasal malignancies in German men: the South-German Nasal Cancer Study

Greiser, Eberhard ; Greiser, Karin ; Ahrens, Wolfgang ; Hagen, Rudolf ; Lazszig, Roland ; Maier, Heinz ; Schick, Bernhard ; Zenner, Hans

BACKGROUND:There are few studies of the effects of nasal snuff and environmental factors on the risk of nasal cancer. This study aimed to investigate the impact of using nasal snuff and of other risk factors on the risk of nasal cancer in German men.METHODS:A population-based case--control study was conducted in the German Federal States of Bavaria and Baden-Wurttemberg. Tumor registries and ear, nose and throat departments provided access to patients born in 1926 or later.RESULTS:Telephone [...]

Menée sur 237 patients (70% d'hommes, 30% de femmes) atteints d'un endobrachyœsophage et sur 247 témoins, cette étude évalue, en fonction du sexe, l'association entre l'obésité abdominale et le risque de développer la maladie

The risk of Barrett's esophagus associated with abdominal obesity in males and females

Kendall, Bradley J. ; Macdonald, Graeme A. ; Hayward, Nicholas K. ; Prins, Johannes B. ; O'Brien, Suzanne ; Whiteman, David C. ; for the Study of Digestive, Health

Esophageal adenocarcinoma arises from Barrett's esophagus (BE). Both occur predominantly in males. The role of abdominal obesity in this sex distribution is uncertain. Our study aimed to determine whether there is an association between abdominal obesity and risk of BE and if present was it modified by sex. A structured interview and anthropometric measures were conducted within a population-based case–control study. We recruited 237 BE cases (70% male) and 247 population controls, frequency [...]

Menée sur une cohorte initiale de 914 patients atteints d'un cancer du poumon et 860 témoins, puis sur une cohorte de 679 cas et 695 témoins, cette étude d'association sur le génome entier identifie des loci génétiques liés aux mécanismes de réparation de l'ADN et associés au risque de cancer du poumon

Genome-wide association study reveals novel genetic determinants of DNA repair capacity in lung cancer

Wang, Li-E ; Gorlova, Olga Y. ; Ying, Jun ; Qiao, Yawei ; Weng, Shih-Feng ; Lee, Annette T ; Gregersen, Peter K. ; Spitz, Margaret R. ; Amos, Christopher I. ; Wei, Qingyi

Suboptimal cellular DNA repair capacity (DRC) has been shown to be associated with enhanced cancer risk, but genetic variants affecting the DRC phenotype have not been comprehensively investigated. In this study, with the available DRC phenotype data, we analyzed correlations between the DRC phenotype and genotypes detected by the Illumina 317K platform in 1,774 individuals of European ancestry from a Texas lung cancer genome-wide association study. The discovery phase was followed by a [...]

Couplée à deux cohortes américaines, cette étude montre une association entre un polymorphisme à simple nucléotide nouvellement identifié sur le chromosome 6q25.1 (rs2046211) et le risque de cancer du sein chez les femmes afro-américaines (2 530 cas et 2 762 témoins au total)

Fine-mapping of the 6q25 locus identifies a novel SNP associated with breast cancer risk in African American women

Ruiz-Narváez, Edward A. ; Rosenberg, Lynn ; Yao, Song ; Rotimi, Charles N. ; Cupples, L. Adrienne ; Bandera, Elisa V. ; Ambrosone, Christine B. ; Adams-Campbell, Lucile L. ; Palmer, Julie R.

The rs2046210 single nucleotide polymorphism (SNP) in the 6q25.1 region was identified in a breast cancer genome-wide association study of Chinese women. The SNP has been replicated in European ancestry populations but replication efforts have failed in African ancestry populations. We evaluated a total of 13 tagging SNPs in the linkage disequilibrium block around rs2046210 in a case-control study of breast cancer nested within the Black Women’s Health Study (BWHS), which included 1,191 cases [...]

Menée au Royaume-Uni à partir de données d'un registre médical portant sur 52 657 patientes atteintes d'un diabète de type 2 diagnostiqué sur la période 1987-2007 et sur 30 210 témoins, cette étude évalue l'association entre la maladie, les traitements utilisés et les risques de cancer du sein et de décès toutes causes confondues

Associations of type 2 diabetes and diabetes treatment with breast cancer risk and mortality: a population-based cohort study among British women

Redaniel, MariaTheresaM ; Jeffreys, Mona ; May, MargaretT ; Ben-Shlomo, Yoav ; Martin, RichardM

Purpose : There is great interest in whether type 2 diabetes and its treatments alter breast cancer risk and prognosis, but previous studies are inconclusive. We conducted a cohort study within the UK General Practice Research Database to investigate associations of type 2 diabetes and patterns of diabetes treatment with breast cancer risk and all-cause mortality. Methods : We identified 52,657 women with type 2 diabetes, diagnosed between 1987 and 2007, and 30,210 randomly selected women [...]

Menée sur 1 125 patients atteints d'un cancer urothélial de la vessie et sur 1 028 témoins, cette étude analyse, en fonction du stade de la tumeur, du sous-type de récepteur FGFR3 qu'elle exprime et du statut tabagique des patients, l'association entre le niveau plasmatique de la 25-hydroxy-vitamine D3 et le risque de développer la maladie

Plasma 25-Hydroxyvitamin D3 and Bladder Cancer Risk According to Tumor Stage and FGFR3 Status: A Mechanism-Based Epidemiological Study

Amaral, André FS ; Méndez-Pertuz, Marinela ; Munoz, Alberto ; Silverman, Debra T. ; Allory, Yves ; Kogevinas, Manolis ; Lloreta, Josep ; Rothman, Nathaniel ; Carrato, Alfredo ; Rivas del Fresno, Manuel ; Real, Francisco X. ; Malats, Nuria

Background Previous evidence suggests that 25-hydroxyvitamin D3 [25(OH)D3] protects against several cancers. However, little is known regarding urothelial bladder cancer (UBC). We analyzed the association between plasma 25(OH)D3 and overall risk of UBC, as well as according to stage and FGFR3 molecular subphenotypes.Methods Plasma concentrations of 25(OH)D3 in 1125 cases with UBC and 1028 control subjects were determined by a chemiluminescence immunoassay. FGFR3 mutational status and expression [...]

A partir d'une revue de la littérature publiée jusqu'en mars 2012 (24 études cas-témoins, 3 022 cas et 4 635 témoins), cette méta-analyse évalue l'association entre des polymosphismes du gène codant pour la protéine CYP2E1 et une susceptibilité au cancer de l'estomac en fonction du statut tabagique des patients, de leur consommation d'alcool et de leur appartenance ethnique

CYP2E1 RsaI/PstI Polymorphism and Gastric Cancer Susceptibility: Meta-Analyses Based on 24 Case-Control Studies

Zhuo, Wenlei ; Zhang, Liang ; Wang, Yan ; Ling, Junjun ; Zhu, Bo ; Chen, Zhengtang

Background : Previous reports implicate CYP2E1 RsaI/PstI polymorphism as a possible risk factor for several cancers. Published studies on the relationship of CYP2E1 RsaI/PstI polymorphisms with the susceptibility to gastric cancer are controversial. This study aimed to determine this relationship accurately. Methods : Meta-analyses that assessed the association of CYP2E1 RsaI/PstI variations with gastric cancer were conducted. Subgroup analyses on ethnicity, smoking status, alcohol consumption, [...]

Menée auprès de 328 610 femmes incluses dans la cohorte EPIC, cette étude analyse l'association entre des facteurs reproductifs, l'utilisation d'un traitement hormonal substitutif de la ménopause, 12 polymorphismes à simple nucléotide du gène CYP17A1 et le risque de cancer du pancréas (324 cas et 353 témoins)

Menstrual and reproductive factors in women, genetic variation in CYP17A1, and pancreatic cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort

Duell, Eric J. ; Travier, Noemie ; Luján-Barroso, Leila ; Dossus, Laure ; Boutron-Ruault, Marie-Christine ; Clavel-Chapelon, Françoise ; Tumino, Rosario ; Masala, Giovanna ; Krogh, Vittorio ; Panico, Salvatore ; Ricceri, Fulvio ; Redondo, Maria Luisa ; Dorronsoro, Miren ; Molina-Montes, Esther ; Huerta, Jose M. ; Barricarte, Aurelio ; Khaw, Kay-Tee ; Wareham, Nick J. ; Allen, Naomi E. ; Travis, Ruth ; Siersema, Peter D. ; Peeters, Petra H. M. ; Trichopoulou, Antonia ; Fragogeorgi, Eirini ; Oikonomou, Eleni ; Boeing, Heiner ; Schuetze, Madlen ; Canzian, Federico ; Lukanova, Annekatrin ; Tjønneland, Anne ; Roswall, Nina ; Overvad, Kim ; Weiderpass, Elisabete ; Gram, Inger Torhild ; Lund, Eiliv ; Lindkvist, Björn ; Johansen, Dorthe ; Ye, Weimin ; Sund, Malin ; Fedirko, Veronika ; Jenab, Mazda ; Michaud, Dominique S. ; Riboli, Elio ; Bueno-de-Mesquita, H. Bas

Menstrual and reproductive factors and exogenous hormone use have been investigated as pancreatic cancer risk factors in case-control and cohort studies, but results have been inconsistent. We conducted a prospective examination of menstrual and reproductive factors, exogenous hormone use and pancreatic cancer risk (based on 304 cases) in 328,610 women from the EPIC cohort. Then, in a case-control study nested within the EPIC cohort, we examined 12 single nucleotide polymorphisms (SNPs) in [...]

Menée sur 1 193 patients atteints d'un cancer de la prostate et sur 1 244 témoins, cette étude évalue l'association entre des variants génétiques communs du gène codant pour le récepteur sensible au calcium et le risque de cancer fatal de la prostate en fonction de la consommation de calcium et de la concentration plasmatique de 25-hydroxy-vitamine D

Common genetic variation of the calcium sensing receptor and lethal prostate cancer risk

Shui, Irene M ; Mucci, Lorelei A. ; Wilson, Kathryn M ; Kraft, Peter ; Penney, Kathryn L. ; Stampfer, Meir J. ; Giovannucci, Edward

Background: Bony metastases cause substantial morbidity and mortality from prostate cancer (PCa). The calcium sensing receptor (CaSR) is expressed on prostate tumors and may participate in bone metastases development. We assessed whether 1) common genetic variation in CaSR was associated with PCa risk and 2) these associations varied by calcium intake or plasma 25-hydroxyvitamin D (25(OH)D) levels. Methods: We included 1193 PCa cases and 1244 controls nested in the prospective Health [...]