A partir d'une enquête auprès de 2 436 fumeurs et anciens fumeurs, cette étude américaine évalue, en fonction du sexe, de l'âge et du statut tabagique, l'influence de la réception de bons de réduction, envoyés par les compagnies cigarettières, sur leur intention d'arrêter de fumer

Receipt and redemption of cigarette coupons, perceptions of cigarette companies and smoking cessation

Choi, Kelvin ; Hennrikus, Deborah J ; Forster, Jean L ; Moilanen, Molly

Background Although it is known that cigarette companies use cigarette coupons to market their products, little is known about the characteristics of those who receive these coupons. The influence of receipt and redemption of these coupons is also unknown.Methods Participants of the Minnesota Adult Tobacco Survey Cohort Study who were smokers in 2008, completed surveys in 2008 and 2009, and had smoked for at least 6 months between those surveys, were included. In 2009, participants reported [...]

Menée sur une cohorte de 1 398 adolescentes âgées de 11 à 12 ans, cette étude analyse, trois ans après une vaccination contre le papillomavirus humain, l'association entre la vaccination et divers indicateurs d'activité sexuelle des participantes

Sexual Activity–Related Outcomes After Human Papillomavirus Vaccination of 11- to 12-Year-Olds

Bednarczyk, Robert A. ; Davis, Robert ; Ault, Kevin ; Orenstein, Walter ; Omer, Saad B.

OBJECTIVE: Previous surveys on hypothesized sexual activity changes after human papillomavirus (HPV) vaccination may be subject to self-response biases. To date, no studies measured clinical markers of sexual activity after HPV vaccination. This study evaluated sexual activity–related clinical outcomes after adolescent vaccination.METHODS: We conducted a retrospective cohort study utilizing longitudinal electronic data from a large managed care organization. Girls enrolled in the managed care [...]

Menée sur des lignées cellulaires de cancer du sein ou de leucémie et à l'aide d'un modèle murin, cette étude montre que des extraits de fraise peuvent induire le processus de l'apoptose dans les cellules cancéreuses et inhiber la progression tumorale

Extracts of Strawberry Fruits Induce Intrinsic Pathway of Apoptosis in Breast Cancer Cells and Inhibits Tumor Progression in Mice

Somasagara, Ranganatha R. ; Hegde, Mahesh ; Chiruvella, Kishore K. ; Musini, Anjaneyulu ; Choudhary, Bibha ; Raghavan, Sathees C.

Background : The consumption of berry fruits, including strawberries, has been suggested to have beneficial effects against oxidative stress mediated diseases. Berries contain multiple phenolic compounds and secondary metabolites that contribute to their biological properties. Methodology/Principal Findings : Current study investigates the anticancer activity of the methanolic extract of strawberry (MESB) fruits in leukaemia (CEM) and breast cancer (T47D) cell lines ex vivo, and its cancer [...]

A partir d'une revue systématique de la littérature publiée jusqu'en mai 2012 (10 études, 1 459 417 patients), cette méta-analyse évalue l'association entre l'utilisation de statines et le risque de carcinome hépatocellulaire (4 298 cas)

Statins Are Associated with a Reduced Risk of Hepatocellular Cancer: A Systematic Review and Meta-Analysis

Singh, Siddharth ; Singh, Preet Paul ; Singh, Abha Goyal ; Murad, Mohammad Hassan ; Sanchez, William

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide. Several studies have shown that statins could have chemopreventive effects on HCC. We performed a systematic review and meta-analysis of studies that evaluated the effects of statins on the risk of HCC. We conducted a systematic search of Medline, Embase, and Web of Science through May 2012, and manually reviewed the literature. Studies were included if they evaluated and clearly defined exposure to [...]

A partir de données médicales portant sur 209 patients ayant été atteints d'un cancer de la peau hors mélanome et ayant participé à un essai de phase III évaluant l'alpha-Difluorométhylornithine (DFMO), cette étude rétrospective analyse les données à long terme concernant l'efficacité et la toxicité du DFMO dans la chimioprévention d'un second cancer de la peau hors mélanome

A Phase III Skin Cancer Chemoprevention Study of DFMO: Long-term Follow-up of Skin Cancer Events and Toxicity

Kreul, Sarah M. ; Havighurst, Thomas C. ; Kim, KyungMann ; Mendonca, Eneida A ; Wood, Gary S ; Snow, Stephen ; Borich, Abbey L ; Verma, Ajit K ; Bailey, Howard H.

Decreasing the incidence of non-melanoma skin cancer (NMSC) is of great importance in regards to future healthcare services. Given the previously reported preventive effects of α-difluoromethylornithine (DFMO) in skin and colon cancer trials, we determined appropriate cause to update the clinical data on the subjects from the recently reported Randomized, Double-Blind, Placebo-Controlled Phase III Skin Cancer Prevention Study of DFMO. Our intention was to retrospectively assess the further [...]

A partir d'une revue de la littérature publiée entre 2005 et 2010 (7 études), cette méta-analyse évalue l'association entre l'utilisation de statines et le risque de cancer de la prostate

Association between Statin Usage and Prostate Cancer Prevention: A Refined Meta-Analysis Based on Literature from the Years 2005-2010

Zhang, Y. ; Zang, T.

Introduction: Statins are cholesterol-lowering drugs that are widely used to prevent and treat atherosclerotic cardiovascular disease. It was found that statins can be associated with the occurrence of prostate cancer. However, no consensus has been concluded. Materials and Methods: In the present study, we provide a refined meta-analysis on the association between statins and prostate cancers. Our objective is to offer a congruent recognition of the impact of statins on prostate cancer. [...]