A partir d'une revue systématique de la littérature publiée jusqu'en juillet 2024 (17 études), cette méta-analyse évalue l'association entre le tabagisme passif et le risque de cancer de la tête et du cou par localisation

Passive smoking and risk of head and neck cancer: a systematic review and meta-analysis

Xu, Fei ; Song, Yang

Studies on the association between passive smoking and head and neck cancer (HNC) are controversial. This meta-analysis aimed to explore this association. A systematic search of the PubMed, Embase, Web of Science, and Cochrane Library databases was conducted up to July 2024 to identify relevant studies. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using the DerSimonian–Laird random-effects model. Heterogeneity among studies was assessed, and the risk of bias was [...]

Menée en Italie à l'aide de données 2020 des registres nationaux du cancer et de la mortalité, cette étude analyse la part des cancers attribuable à l'alimentation

Cancers attributable to diet in Italy

Turati, Federica ; Alicandro, Gianfranco ; Collatuzzo, Giulia ; Pelucchi, Claudio ; Malvezzi, Matteo ; Parazzini, Fabio ; Negri, Eva ; Boffetta, Paolo ; La Vecchia, Carlo ; di Maso, Matteo

Cancer burden can be reduced by controlling modifiable risk factors, including diet. We provided an evidence-based assessment of cancer cases and deaths attributable to diet in Italy in 2020. We considered dietary factor-cancer type pairs for which the World Cancer Research Fund/American Institute for Cancer Research – Continuous Update Project reported either ‘convincing’ or ‘probable’ evidence of causal association. Relative risks were retrieved from recent meta-analyses and dietary intakes [...]

Menée à partir de données agricoles américaines 1997-2020, cette étude d'association à l'échelle de l'épigénome évalue le risque de cancer de la prostate et de décès liés à une exposition aux pesticides

Pesticides and prostate cancer incidence and mortality: An environment-wide association study

Soerensen, Simon John Christoph ; Lim, David S. ; Montez-Rath, Maria E. ; Chertow, Glenn M. ; Chung, Benjamin I. ; Rehkopf, David H. ; Leppert, John T.

Background: Prostate cancer is the most common cancer among men in the United States, yet modifiable risk factors remain elusive. In this study, the authors investigated the potential role of agricultural pesticide exposure in prostate cancer incidence and mortality. Methods: For this environment-wide association study (EWAS), linear regression was used to analyze county-level associations between the annual use of 295 distinct pesticides (measured in kg per county) and prostate cancer [...]

Menée en Angleterre auprès de 25 811 femmes et 480 hommes ayant survécu à un cancer du sein diagnostiqué entre 1995 et 2019, cette étude analyse le risque de second cancer primitif chez les patients porteurs d'une mutation BRCA

Second Primary Cancer Risks After Breast Cancer in BRCA1 and BRCA2 Pathogenic Variant Carriers

Isaac Allen ; Hend Hassan ; Yvonne Walburga ; Catherine Huntley ; Lucy Loong ; Tameera Rahman ; Sophie Allen ; Alice Garrett ; Bethany Torr ; Andrew Bacon ; Craig Knott ; Sophie Jose ; Sally Vernon ; Margreet Lüchtenborg ; Joanna Pethick ; Francesco Santaniello ; Shilpi Goel ; Ying-Wen Wang ; Katrina Lavelle ; Fiona McRonald ; Diana Eccles ; Eva Morris ; Steven Hardy ; Clare Turnbull ; Marc Tischkowitz ; Paul Pharoah ; Antonis C. Antoniou

PURPOSE: Second primary cancer (SPC) risks after breast cancer (BC) in BRCA1/BRCA2 pathogenic variant (PV) carriers are uncertain. We estimated relative and absolute risks using a novel linkage of genetic testing data to population-scale National Disease Registration Service and Hospital Episode Statistics electronic health records. METHODS: We followed 25,811 females and 480 males diagnosed with BC and tested for germline BRCA1/BRCA2 PVs in NHS Clinical Genetics centers in England between 1995 [...]

Menée à partir de données norvégiennes 1963-1975 portant sur 889 441 femmes (âge : 16-75 ans), cette étude analyse l'association entre l'indice de masse corporelle et le risque de cancer de la vulve (1 748 cas) ou du vagin (408 cas)

The association between body mass index and vulvar and vaginal cancer incidence: findings from a large Norwegian cohort study

Aune, Dagfinn ; Nordsletten, Marie ; Myklebust, Tor Åge ; Robsahm, Trude Eid ; Skålhegg, Bjørn Steen ; Mala, Tom ; Yaqub, Sheraz ; Saeed, Usman

Background: There is limited evidence of potential associations between body mass index (BMI) and risk of vulvar and vaginal cancer. We explored these associations in a large cohort of Norwegian women. Methods: The analytical dataset included 889,441 women aged 16–75 years at baseline in 1963–1975. Multivariable Cox regression analyses were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between BMI and vulvar and vaginal cancer incidence. Results: [...]

Menée notamment à l'aide d'échantillons de tissus mammaires provenant de 120 femmes exemptes de cancer ainsi qu'à partir de données pangénomiques portant sur 113 789 témoins et 133 384 patientes atteintes d'un cancer du sein, cette étude identifie 7 protéines associées au risque de développer la maladie

A proteome-wide association study identifies putative causal proteins for breast cancer risk

Zhao, Tianying ; Xu, Shuai ; Ping, Jie ; Jia, Guochong ; Dou, Yongchao ; Henry, Jill E. ; Zhang, Bing ; Guo, Xingyi ; Coté, Michele L. ; Cai, Qiuyin ; Shu, Xiao-Ou ; Zheng, Wei ; Long, Jirong

Background: Genome-wide association studies (GWAS) have identified more than 200 breast cancer risk-associated genetic loci, yet the causal genes and biological mechanisms for most loci remain elusive. Proteins, as final gene products, are pivotal in cellular function. In this study, we conducted a proteome-wide association study (PWAS) to identify proteins in breast tissue related to breast cancer risk. Methods: We profiled the proteome in fresh frozen breast tissue samples from 120 [...]

A partir d'une revue systématique de la littérature publiée jusqu'en novembre 2023 (22 études), cette méta-analyse évalue l'association entre l'obésité et le risque de cancer de la thyroïde

Associations Between Obesity and Risk of Thyroid Cancer: A Meta-Analysis of Cohort Studies

Hisan, Urfa Khairatun ; Myung, Seung-Kwon ; Nguyen, Giap Viet

Previous cohort studies have shown conflicting findings on the associations between obesity and the risk of thyroid cancer. This meta-analysis aimed to investigate the associations between them by using a meta-analysis of cohort studies. PubMed and EMBASE were searched using keywords from inception until November 2023 to identify relevant studies on this topic. Two authors independently reviewed and selected relevant studies according to the predefined criteria. Out of 475 studies searched from [...]