Menée à partir de données 1991-2016 des cohortes "the Nurses’ Health Studies" portant sur 173 688 femmes, cette étude analyse l'association entre un comportement sédentaire (au travail ou à la maison) et le risque de cancer de l'ovaire (884 cas)

Prospective Analyses of Sedentary Behavior in Relation to Risk of Ovarian Cancer

Buras, Andrea L ; Wang, Tianyi ; Whiting, Junmin ; Townsend, Mary K ; Fridley, Brooke L ; Tworoger, Shelley S

To examine the association of sedentary behavior with risk of ovarian cancer overall, by tumor subtype, and by participant characteristics in the Nurses’ Health Study (NHS) and NHSII. A total of 69,558 NHS (1992-2016) and 104,130 NHSII (1991-2015) participants were included in analysis who reported sitting time at home, work, and watching television, which included 884 histologically-confirmed ovarian cancer cases. Multivariable adjusted Cox proportional hazards models were used to estimate [...]

Menée à l'aide de données de registres portant sur 22 174 enfants atteints d'un cancer diagnostiqué entre 1960 et 2015, cette étude analyse l'association entre une exposition professionnelle des parents à la poussière d'animaux, de bois, de textile ou de papier et le risque pour leur enfant de développer la maladie

Childhood cancer risk in offspring of parents occupationally exposed to dusts: A register-based nested case-control study from Sweden of 5 decades

Rossides, Marios ; Kampitsi, Christina-Evmorfia ; Talbäck, Mats ; Wiebert, Pernilla ; Feychting, Maria ; Tettamanti, Giorgio

Background: Some largely inconsistent associations between parental occupational dust exposure and childhood cancer have been reported, with maternal exposures inadequately studied. The authors examined whether maternal or paternal occupational exposure to animal, wood, textile, or paper dust around a child's birth was associated with an increased risk of childhood cancer, both overall and by type (leukemias, lymphomas, central nervous system tumors, and other cancers). Methods: In this [...]

Cette étude passe en revue la littérature publiée jusqu'en août 2020 (37 articles) concernant l'association entre l'utilisation de parfums ou d'eaux de Cologne et les risques pour la santé tel que le cancer du sein

Evaluation of pollutants in perfumes, colognes and health effects on the consumer: a systematic review

Kazemi, Zahra ; Aboutaleb, Ehsan ; Shahsavani, Abbas ; Kermani, Majid ; Kazemi, Zohre

Cosmetic products, especially perfumes and colognes, are widely used in various communities. However, the use of these products can have side effects on consumers. This article aims to review the relevant literature published up to August 2020 to determine whether perfumes and colognes can affect people’s health. Relevant articles were identified through electronic search. A total of 562 articles were selected and finally 37 related articles were included in the study after the screening [...]

Menée à partir de données portant sur 136 834 femmes ménopausées, cette étude analyse l'association entre des variations du poids à l'âge adulte et le risque de cancer du pancréas (873 cas)

Sustained weight loss, weight cycling, and weight gain during adulthood and pancreatic cancer incidence in the Women’s Health Initiative (US)

Schwalb, Molly E ; Smith-Warner, Stephanie A ; Hou, Jianrui ; Rohan, Thomas E ; Snetselaar, Linda ; Luo, Juhua ; Genkinger, Jeanine M

Pancreatic cancer is the fourth leading cause of cancer mortality in the US. Obesity is positively associated with pancreatic cancer risk. Current health recommendations focus on weight maintenance for healthy weight individuals and weight loss for overweight/obese individuals; however, little research has assessed associations between pancreatic cancer risk and changes in weight throughout the life-course. Using prospective cohort data, we examined the relationship between baseline adulthood [...]

Menée auprès de 1 793 patientes afro-américaines atteintes d'un cancer du sein invasif, cette étude analyse l'association entre l'obésité et le sous-type de tumeur, en fonction du statut ménopausique

A pooled case-only analysis of obesity and breast cancer subtype among Black women in the southeastern United States

Moore, Jaleesa ; Pal, Tuya ; Beeghly-Fadiel, Alicia ; Fadden, Mary Kay ; Munro, Heather M. ; Dujon, Steffie-Ann ; Reid, Sonya ; Tezak, Ann ; Blasingame, Miaya ; Ware, Jeania ; Blot, William J. ; Shu, Xiao-Ou ; Zheng, Wei ; Sanderson, Maureen ; Lipworth, Loren

Purpose: To evaluate the association between obesity and the relative prevalence of tumor subtypes among Black women with breast cancer (BC). Methods: We conducted a pooled case-only analysis of 1,793 Black women with invasive BC recruited through three existing studies in the southeastern US. Multivariable case-only polytomous logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between obesity, measured by pre-diagnostic [...]

Menée en Espagne auprès de 174 patients atteints d'un glioblastome (53,6 % d'hommes), cette étude multicentrique identifie des polymorphismes de gènes ATG (liés à l'autophagie) associés au risque de développer la maladie

Polymorphisms in autophagy genes are genetic susceptibility factors in glioblastoma development

Bueno-Martínez, E. ; Lara-Almunia, M. ; Rodríguez-Arias, C. ; Otero-Rodríguez, A. ; Garfias-Arjona, S. ; González-Sarmiento, R.

Background: Glioblastoma is the most aggressive and common malignant primary brain tumor in adults. Many genetic, epigenetic and genomic mutations have been identified in this tumor, but no driving cause has been identified yet for glioblastoma pathogenesis. Autophagy has proved to be deregulated in different diseases such as cancer where it has a dual role, acting as a tumor suppression mechanism during the first steps of tumor development and promoting cancer cells survival in stablished [...]

Menée auprès de 2 404 patients pédiatriques atteint d'un neuroblastome et 9 310 témoins, cette étude identifie des variants de l'ADN mitochondrial associés au risque de développer la maladie

Identification of Mitochondrial DNA Variants Associated With Risk of Neuroblastoma

Chang, Xiao ; Liu, Yichuan ; Glessner, Joseph ; Hou, Cuiping ; Qu, Huiqi ; Nguyen, Kenny ; Sleiman, Patrick ; Lee, Lobin ; Diskin, Sharon J ; Maris, John M ; Hakonarson, Hakon

Neuroblastoma is a childhood cancer that originates in the developing sympathetic nervous system. We previously reported a crucial role of mitochondrial DNA (mtDNA) haplogroups in the pathology of neuroblastoma. To pinpoint mtDNA variants associated with neuroblastoma risk, we applied a mitochondrial genome imputation pipeline to the SNP array data of two pediatric cohorts containing a total of 2,404 neuroblastoma cases and 9,310 cancer-free controls. All statistical tests were 2-sided. The [...]

Menée à partir de données de 13 pays portant sur des témoins et 6 191 patients atteints d'un gliome, d'un méningiome ou d'un neurinome acoustique, cette étude analyse l'association entre des maladies allergiques ou une épilepsie et le risque de tumeur cérébrale

Association of allergic diseases and epilepsy with risk of glioma, meningioma and acoustic neuroma: results from the INTERPHONE international case–control study

Schlehofer, Brigitte ; Blettner, Maria ; Moissonnier, Monika ; Deltour, Isabelle ; Giles, Graham G. ; Armstrong, Bruce ; Siemiatycki, Jack ; Parent, Marie-Élise ; Krewski, Daniel ; Johansen, Christoffer ; Auvinen, Anssi ; Lahkola, Anna ; Hours, Martine ; Berg-Beckhoff, Gabriele ; Sadetzki, Siegal ; Lagorio, Susanna ; Takebayashi, Toru ; Yamaguchi, Naohito ; Woodward, Alistair ; Cook, Angus ; Tynes, Tore ; Klaboe, Lars ; Feychting, Maria ; Feltbower, Richard ; Swerdlow, Anthony ; Schoemaker, Minouk ; Cardis, Elisabeth ; Schüz, Joachim

We investigated the association of allergic diseases and epilepsy with risk of brain tumours, in Interphone, a 13-country case–control study. Data were obtained from 2693 glioma cases, 2396 meningioma cases, and 1102 acoustic neuroma cases and their 6321 controls. Conditional logistic regression models were used to estimate pooled odds ratios (ORs) and their respective 95% confidence intervals (CIs), adjusted for education and time at interview. Reduced ORs were observed for glioma in relation [...]

Menée à partir d'échantillons salivaires collectés auprès de 39 femmes âgées de 18 à 31 ans, cette étude analyse l'association entre le taux d'estradiol et de progestérone, mesuré à plusieurs moments de la journée, et la présence et/ou la persistance du papillomavirus humain

Endogenous oestradiol and progesterone as predictors of oncogenic human papillomavirus (HPV) persistence

Fischer, Susanne ; Kuebler, Ulrike ; Abbruzzese, Elvira ; Breymann, Christian ; Mernone, Laura ; Ehlert, Ulrike

Background: High-risk human papillomavirus (HR-HPV) is the main aetiological factor for the development of cervical cancer. While nearly 70% of HR-HPV infections are cleared within 12 months, in the remainder of women they persist and can progress into cervical cancer. Oestradiol and progesterone have been shown to be involved in the development and progression of cervical cancer. The objective of this study was to investigate, for the first time, whether diurnal oestradiol and progesterone are [...]