Lumpectomy Margins for Invasive Breast Cancer and Ductal Carcinoma in Situ: Current Guideline Recommendations, Their Implications, and Impact

Ce dossier présente un ensemble d'articles concernant le traitement locorégional d'un cancer du sein

Résumé en anglais

A variety of patient, treatment, and pathologic factors have been reported to be associated with an increased risk of ipsilateral breast tumor recurrence after breast conservation therapy (BCT) for invasive breast cancer and for ductal carcinoma in situ (DCIS). Perhaps the most important of these factors is the status of the microscopic margins of excision of the lumpectomy specimen. It is well documented that for patients with either invasive breast cancer or DCIS treated with BCT (which is classically defined as lumpectomy and whole-breast irradiation [WBI]), positive microscopic margins are associated with a 2-fold or greater increase in local recurrence risk when compared with negative margins.1,2 Therefore, obtaining tumor-free margins before WBI is of utmost importance in the BCT setting.