Cet article passe en revue les enjeux associés au traitement de la colite à médiation immunitaire chez des patients atteints d'un cancer traité par inhibiteurs de points de contrôle immunitaire

Workup and Management of Immune-Mediated Colitis in Patients Treated with Immune Checkpoint Inhibitors

Singh, Bhavana Pendurthi ; Marshall, John L. ; He, Aiwu Ruth

As the use of immune checkpoint inhibitors for several different malignancies becomes more mainstream, their side‐effect profile raises new challenges. In 2011, the Food and Drug Administration approved the first checkpoint inhibitor for the treatment of advanced melanoma, and since then, checkpoint inhibitors have demonstrated efficacy in many other tumor types. Given the frequent use of immune checkpoint inhibitors in a wide range of cancers today, the diagnosis and management of their [...]

Menée aux Etats-Unis à partir de données d'enquêtes auprès de 3 162 patients ayant survécu à un cancer lié au tabac, cette étude analyse la prévalence de l'utilisation de la cigarette électronique et évalue son association avec des comportements tabagiques

Electronic cigarette use among survivors of smoking-related cancers in the United States

Akinboro, Oladimeji ; Nwabudike, Stanley Madu ; Elias, Rawad ; Balasire, Oluseyi ; Ola, Olatunde ; Ostroff, Jamie S.

Background: The prevalence of electronic cigarette (e-cigarette) use and its impact on smoking cessation among cancer survivors in the United States (US) is largely unknown. We sought to estimate the prevalence of e-cigarette use and examine its associations with cigarette smoking and smoking quit attempts among smoking-related cancer survivors in the US. Methods: We obtained data from the 2014-2017 annual cycles of the National Health Interview Survey for participants with self-reported [...]

Menée à partir des données des registres des cancers de 7 pays à hauts revenus (Australie, Canada, Danemark, Irlande, Nouvelle-Zélande, Norvège, Royaume-Uni) portant sur 3 764 543 de patients atteints d'un cancer diagnostiqué entre 1995 et 2014, cette étude analyse l'évolution de l'incidence de la maladie, de la survie et de la mortalité

Progress in cancer survival, mortality, and incidence in seven high-income countries 1995–2014 (ICBP SURVMARK-2): a population-based study

Arnold, Melina ; Rutherford, Mark J. ; Bardot, Aude ; Ferlay, Jacques ; Andersson, Therese M. L. ; Myklebust, Tor Åge ; Tervonen, Hanna ; Thursfield, Vicky ; Ransom, David ; Shack, Lorraine ; Woods, Ryan R. ; Turner, Donna ; Leonfellner, Suzanne ; Ryan, Susan ; Saint-Jacques, Nathalie ; De, Prithwish ; McClure, Carol ; Ramanakumar, Agnihotram V. ; Stuart-Panko, Heather ; Engholm, Gerda ; Walsh, Paul M. ; Jackson, Christopher ; Vernon, Sally ; Morgan, Eileen ; Gavin, Anna ; Morrison, David S. ; Huws, Dyfed W. ; Porter, Geoff ; Butler, John ; Bryant, Heather ; Currow, David C. ; Hiom, Sara ; Parkin, D. Max ; Sasieni, Peter ; Lambert, Paul C. ; Møller, Bjørn ; Soerjomataram, Isabelle ; Bray, Freddie

Background : Population-based cancer survival estimates provide valuable insights into the effectiveness of cancer services and can reflect the prospects of cure. As part of the second phase of the International Cancer Benchmarking Partnership (ICBP), the Cancer Survival in High-Income Countries (SURVMARK-2) project aims to provide a comprehensive overview of cancer survival across seven high-income countries and a comparative assessment of corresponding incidence and mortality trends. Methods [...]

Menée aux Etats-Unis à partir de données portant sur plus de 53 000 patients atteints d'un cancer, cette étude évalue l'incidence d'une neuropathie périphérique induite par des chimiothérapie neurotoxiques ou non

Chemotherapy-induced peripheral neuropathy (CIPN) and its treatment: an NIH Collaboratory study of claims data

Gewandter, Jennifer S. ; Kleckner, Amber S. ; Marshall, James H. ; Brown, Jeffrey S. ; Curtis, Lesley H. ; Bautista, Javier ; Dworkin, Robert H. ; Kleckner, Ian R. ; Kolb, Noah ; Mohile, Supriya G. ; Mustian, Karen M.

Purpose : Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling complication of many chemotherapies. We investigated the feasibility of using health plan claims and administrative data to identify CIPN occurrence by comparing patients who received neurotoxic and non-neurotoxic chemotherapies. Methods : The sample included over 53,000,000 patients from two regional and one national insurer in the USA (> 400,000 exposed to chemotherapy). Peripheral neuropathy was identified using a [...]

Mené sur 9 939 patientes âgées de 50 à 79 ans et ayant subi une hystérectomie, cet essai randomisé évalue les effets sur la santé (maladie coronarienne, cancer invasif du sein, fracture de la hanche, embolisme pulmonaire, etc.) et sur la mortalité toutes causes confondues, d'un traitement hormonal substitutif de la ménopause utilisant uniquement des oestrogènes conjugués, en fonction du recours à une salpingo-ovariectomie bilatérale

Menopausal Estrogen-Alone Therapy and Health Outcomes in Women With and Without Bilateral Oophorectomy: A Randomized Trial

Manson, JoAnn E. ; Aragaki, Aaron K. ; Bassuk, Shari S. ; Chlebowski, Rowan T. ; Anderson, Garnet L. ; Rossouw, Jacques E. ; Howard, Barbara V. ; Thomson, Cynthia A. ; Stefanick, Marcia L. ; Kaunitz, Andrew M. ; Crandall, Carolyn J. ; Eaton, Charles B. ; Henderson, Victor W. ; Liu, Simin ; Luo, Juhua ; Rohan, Thomas ; Shadyab, Aladdin H. ; Wells, Gretchen ; Wactawski-Wende, Jean ; Prentice, Ross L. ; for the WHI Investigators

Background: Whether health outcomes of menopausal estrogen therapy differ between women with and without bilateral salpingo-oophorectomy (BSO) is unknown. Objective: To examine estrogen therapy outcomes by BSO status, with additional stratification by 10-year age groups. Design: Subgroup analyses of the randomized Women's Health Initiative Estrogen-Alone Trial. (ClinicalTrials.gov: NCT00000611) Setting: 40 U.S. clinical centers. Participants: 9939 women aged 50 to 79 years with prior [...]

Menée à partir de données internationales sur les 5 continents, cette étude analyse l'évolution, sur la période 2008-2012, de l'incidence du cancer colorectal selon l'âge au diagnostic (20-49 ans et ≥ 50 ans)

Global patterns and trends in colorectal cancer incidence in young adults

Siegel, Rebecca L ; Torre, Lindsey A ; Soerjomataram, Isabelle ; Hayes, Richard B ; Bray, Freddie ; Weber, Thomas K ; Jemal, Ahmedin

Objective :Early-onset colorectal cancer (CRC) is increasing in the USA despite rapid declines in older ages. Similar patterns are reported in Australia and Canada, but a comprehensive global analysis of contemporary data is lacking. Design :We extracted long-term data from Cancer Incidence in Five Continents and supplemental sources to report on worldwide CRC incidence rates and trends by age (20–49 years and ≥50 years) through diagnosis year 2012 or beyond (Australia, Finland, New Zealand, [...]

Menée en Australie et en Nouvelle-Zélande, cette étude de cohorte prospective analyse l'état de santé des bébés exposés in utero à de la chimiothérapie dispensée chez des patientes atteintes d'un cancer du sein diagnostiqué pendant la grossesse, ainsi que les caractéristiques périnatales (naissance avant terme, par césarienne,etc.)

In utero exposure to breast cancer treatment: a population-based perinatal outcome study

Safi, Nadom ; Anazodo, Antoinette ; Dickinson, Jan E. ; Lui, Kei ; Wang, Alex Y. ; Li, Zhuoyang ; Sullivan, Elizabeth A.

Chemotherapy during a viable pregnancy may be associated with adverse perinatal outcomes. We conducted a prospective cohort study to examine the perinatal outcomes of babies born following in utero exposure to chemotherapy in Australia and New Zealand. Over 18 months we identified 24 births, of >400 g and/or >20-weeks’ gestation, to women diagnosed with breast cancer in the first or second trimesters. Eighteen babies were exposed in utero to chemotherapy. Chemotherapy commenced at a median of [...]

Menée aux Etats-Unis, cette étude analyse l'utilisation, par les patients atteints d'un cancer et leurs familles, de sites de financement participatif pour compléter l'assurance maladie et couvrir les dépenses liées aux soins

Use of an Online Crowdfunding Platform for Unmet Financial Obligations in Cancer Care

Cohen, Andrew J. ; Brody, Hartley ; Patino, German ; Ndoye, Medina ; Liaw, Aron ; Butler, Christi ; Breyer, Benjamin N.

Technologic innovations, expensive new therapies, and improved access to treatment have all contributed to the rising costs of oncologic care in the United States. The financial consequences for patients and their families are substantial. Patients with cancer often borrow money, avoid leisure activities, decrease food spending, sell possessions, go into debt, and/or declare bankruptcy, and they are at greater risk for disability or unemployment. These consequences are particularly great for [...]

A partir des données des registres américains des cancers portant sur des patients atteints d'un cancer du poumon diagnostiqué entre 2000 et 2011, cette étude analyse les disparités ethniques dans l'accès aux soins de fin de vie, dans leur utilisation et dans les coûts associés

Cost and Utilization of Lung Cancer End-of-Life Care Among Racial-Ethnic Minority Groups in the United States

Chen, Yufan ; Criss, Steven D. ; Watson, Tina R. ; Eckel, Andrew ; Palazzo, Lauren ; Tramontano, Angela C. ; Wang, Ying ; Mercaldo, Nathaniel D. ; Kong, Chung Yin

Background : The end‐of‐life period is a crucial time in lung cancer care. To have a better understanding of the racial‐ethnic disparities in health care expenditures, access, and quality, we evaluated these disparities specifically in the end‐of‐life period for patients with lung cancer in the U.S. Materials and Methods : We used the Surveillance, Epidemiology, and End Results (SEER)‐Medicare database to analyze characteristics of lung cancer care among those diagnosed between the years 2000 [...]

A partir des données des registres américains des cancers et de la base Medicare portant sur 19 746 patients atteints d'un cancer du poumon non à petites cellules de stade avancé et âgés de plus de 65 ans, cette étude analyse l'impact des aides financières sur leur décision de prendre des traitements anticancéreux dispensés par voie orale et sur le moment du début du traitement

The Association Between Medicare Low-income Subsidy and Anticancer Treatment Uptake in Advanced Lung Cancer

Chou, Yi-Ting ; Farley, Joel F ; Stinchcombe, Thomas E ; Proctor, Amber E ; Lafata, Jennifer Elston ; Dusetzina, Stacie B

Background : High out-of-pocket costs may impact anticancer treatment uptake. Low-income subsidies (LIS) can reduce patient out-of-pocket cost for Medicare Part D-covered treatments. We examined whether LIS increased uptake and reduced time to initiate orally-administered anticancer drugs in patients with advanced non-small cell lung cancer (NSCLC). Methods : Using SEER-Medicare data, we identified older adults (aged 65+) diagnosed with advanced NSCLC from 2007-2013 and categorized them as [...]