Mené sur 143 patients atteints d'un cancer colorectal, cet essai randomisé évalue l'efficacité de la prégabaline, un médicament anti-hyperalgésique, pour prévenir une neuropathie périphérique douleureuse, aiguë ou chronique, induite par l'oxaliplatine

Pregabalin for the Prevention of Oxaliplatin-Induced Painful Neuropathy: A Randomized, Double-Blind Trial

de Andrade, Daniel Ciampi ; Jacobsen Teixeira, Manoel ; Galhardoni, Ricardo ; Ferreira, Karine S.L. ; Braz Mileno, Paula ; Scisci, Nathalia ; Zandonai, Alexandra ; Teixeira, William G.J. ; Saragiotto, Daniel F. ; Silva, Valquíria ; Raicher, Irina ; Cury, Rubens Gisbert ; Macarenco, Ricardo ; Otto Heise, Carlos ; Wilson Iervolino Brotto, Mario ; Andrade de Mello, Alberto ; Zini Megale, Marcelo ; Henrique Curti Dourado, Luiz ; Mendes Bahia, Luciana ; Lilian Rodrigues, Antonia ; Parravano, Daniella ; Tizue Fukushima, Julia ; Lefaucheur, Jean‐Pascal ; Bouhassira, Didier ; Sobroza, Evandro ; Richelmann, Rachel P. ; Hoff, Paulo M. ; PreOx Workgroup ; Valério da Silva, Fernanda ; Chile, Thais ; Dale, Camila S. ; Nebuloni, Daniela ; Senna, Luiz ; Brentani, Helena ; Pagano, Rosana L. ; de Souza, Ângela M.

Background : Patients with colorectal cancer (CRC) receiving oxaliplatin (OXA) develop acute and chronic painful oxaliplatin‐induced peripheral neuropathy (OXAIPN). Acute and chronic OXA‐related neuropathies have different pathophysiological bases, but both lead to a common phenomenon: central sensitization (CS) of nociceptive neuronal networks, leading to increased sensitivity (hyperlgesia, allodynia) in the somatosensory system, the common ground of chronic neuropathic pain. Because CS is [...]

Menée en Allemagne, en Islande et en Norvège auprès de 555 patients atteints d'un cancer et recevant des opioïdes forts (âge moyen : 61,7 ans), cette étude analyse leurs opinions relatives à la prise en charge de la douleur, notamment la peur de l'addiction aux analgésiques

A multicenter study of attitudinal barriers to cancer pain management

Gunnarsdottir, Sigridur ; Sigurdardottir, Valgerdur ; Kloke, Marianne ; Radbruch, Lukas ; Sabatowski, Rainer ; Kaasa, Stein ; Klepstad, Pål

Purpose : The purpose of this study was to examine attitudinal barriers to cancer pain management and their relationship to pain, analgesic use, clinical, and demographic variables, as well as QOL, in a large sample of patients receiving strong opioids for pain in three European countries. Methods : Participants in the present study were 555 patients with cancer, 18 years and older recruited from six centers in Germany, Iceland, and Norway. All had received strong opioids for at least 72 h. [...]

Menée aux Etats-Unis auprès de 343 patients atteints de cancer et de 87 aidants, cette étude évalue les effets d'une session de massage d'une durée de 30 ou de 60 minutes sur leurs symptômes auto-déclarés (douleur, fatigue, anxiété, troubles du sommeil)

The effects of oncology massage on symptom self-report for cancer patients and their caregivers

Lopez, Gabriel ; Liu, Wenli ; Milbury, Kathrin ; Spelman, Amy ; Wei, Qi ; Bruera, Eduardo ; Cohen, Lorenzo

Background : Massage has shown benefit for symptomatic relief in cancer patients and their caregivers. We explored the effects of a single massage session on self-reported symptoms in an outpatient clinic at a comprehensive cancer center. Methods : Patients and caregivers receiving oncology massage treatments (30 or 60-min duration) at our Integrative Medicine Center outpatient clinic from September 2012 to January 2015 completed the Edmonton Symptom Assessment Scale (ESAS; 0–10 scale, 10 most [...]

Menée en Italie sur 244 patients atteints de cancer, cette étude randomisée évalue l'efficacité de l'ajout d'un extrait de gingembre à un traitement standard antiémétique, pour prévenir les nausées et vomissements induits par une chimiothérapie à base de hautes doses de cisplatine

A randomized, double-blind, placebo-controlled, multicenter study of a ginger extract in the management of chemotherapy-induced nausea and vomiting (CINV) in patients receiving high dose cisplatin

P. Bossi, ; D. Cortinovis, ; S. Fatigoni, ; M. Cossu Rocca, ; A. Fabi, ; P. Seminara, ; C. Ripamonti, ; S. Alfieri, ; R. Granata, ; C. Bergamini, ; F. Agustoni, ; P. Bidoli, ; F. Nolè, ; M.A. Pessi, ; F. Macchi, ; L. Michellini, ; F. Montanaro, ; F. Roila

Background: The activity of ginger in the management of chemotherapy-induced nausea and vomiting (CINV) has been suggested, but design inadequacies, heterogeneity of the population, small numbers and poor quality of tested products limit the possibility to offer generalizable results. Patients and methods: We conducted a randomized, double-blind, placebo-controlled, multicenter study in patients planned to receive ≥2 chemotherapy cycles with high dose (>50 mg/m2) cisplatin. Patients received [...]

Menée auprès de 60 patients atteints d'un cancer de la prostate traité par thérapie anti-androgénique, de 85 patients ayant subi une prostatectomie radicale et de 86 participants sans antécédent de cancer, cette étude évalue les effets d'une thérapie anti-androgénique sur leurs fonctions et leurs troubles sexuels

Effect of androgen deprivation therapy on sexual function and bother in men with prostate cancer: A controlled comparison

Donovan, Kristine A. ; Gonzalez, Brian D. ; Nelson, Ashley M. ; Fishman, Mayer N. ; Zachariah, Babu ; Jacobsen, Paul B.

Objectives: The adverse sexual effects of androgen deprivation therapy (ADT) on men with prostate cancer have been well described. Less well known is the relative degree of sexual dysfunction and bother associated with ADT compared to other primary treatment modalities such as radical prostatectomy. We sought to describe the trajectory and relative magnitude of changes in sexual function and bother in men on ADT and to examine demographic and clinical predictors of ADT's adverse sexual effects. [...]

A partir d'une revue systématique de la littérature (10 articles, 1 199 participantes), cette méta-analyse évalue l'efficacité d'exercices physiques pour préserver, après les traitements anticancéreux, la densité minérale osseuse et prévenir la perte osseuse chez des patientes atteintes d'un cancer du sein de stade précoce

Exercise for improving bone health in women treated for stages I–III breast cancer: a systematic review and meta-analyses

Fornusek, Canan P. ; Kilbreath, Sharon L.

Purpose : The purpose of this study was to evaluate the efficacy of exercise, either alone or in combination with other interventions, compared to a control, for the preservation of bone mineral density (BMD) in early breast cancer (BC) patients. Methods : A systematic search was conducted to identify randomized or quasi-randomized trials which met inclusion criteria including prescribed exercise for ≥12 months. Ten publications from seven randomized controlled trials (RCTs), involving 1199 [...]

Mené en Espagne sur des patientes ayant survécu à un cancer du sein, cet essai randomisé évalue l'efficacité d'un programme en ligne recommandant, pendant une durée de 8 semaines, des exercices physiques à effectuer pour améliorer les capacités fonctionnelles et cognitives des patientes (durée de suivi : 6 mois)

Effect of an Internet-based telehealth system on functional capacity and cognition in breast cancer survivors: a secondary analysis of a randomized controlled trial

Galiano-Castillo, Noelia ; Arroyo-Morales, Manuel ; Lozano-Lozano, Mario ; Fernández-Lao, Carolina ; Martín-Martín, Lydia ; Del-Moral-Ávila, Rosario ; Cantarero-Villanueva, Irene

Purpose : This trial determines the effect of an Internet-based tailored exercise program compared to usual care control for improving functional capacity and cognition among breast cancer survivors. Methods : A two-arm, assessor-blinded, parallel, randomized controlled efficacy trial was conducted. Participants were recruited from the Oncology and Breast unit at the Virgen de las Nieves Hospital (Granada, Spain) between March 2012 to November 2013 and randomized to either the experimental [...]

Mené sur 3 823 participantes à risque élévé de cancer du sein, cet essai randomisé évalue l'efficacité du tamoxifène en prévention du risque de la maladie et analyse l'association entre les symptômes déclarés par les participantes et leur adhésion à long terme à ce traitement préventif

Participant-Reported Symptoms and Their Effect on Long-Term Adherence in the International Breast Cancer Intervention Study I (IBIS I)

Samuel George Smith ; Ivana Sestak ; Anthony Howell ; John Forbes ; Jack Cuzick

Purpose : To assess the role of participant-reported symptoms on long-term adherence to preventive therapy in the United Kingdom sample of the International Breast Cancer Intervention Study (IBIS-I). IBIS-I was a randomized controlled trial that investigated the effectiveness of tamoxifen in reducing the risk of breast cancer among women at increased risk of the disease. Participants and Methods : Women were randomly assigned to tamoxifen versus placebo (20 mg/day; n = 4,279). After 456 [...]

Menée à un niveau international sur la période 1978-2007, cette étude analyse les disparités géographiques dans l'évolution de l'incidence du cancer de l'estomac

Global patterns and trends in stomach cancer incidence: Age, period and birth cohort analysis

Luo, Ganfeng ; Zhang, Yanting ; Guo, Pi ; Wang, Li ; Huang, Yuanwei ; Li, Ke

The cases of stomach cancer (SC) incidence are increasing per year and the SC burden has remained very high in some countries. We aimed to evaluate the global geographical variation in SC incidence and temporal trends from 1978 to 2007, with an emphasis on the effect of birth cohort. Joinpoint regression and age–period–cohort model were applied. From 2003 to 2007, male rate were 1.5- to 3-fold higher than female in all countries. Rates were highest in Eastern Asian and South American countries. [...]

Menée en Chine à partir de données portant sur 497 693 participants âgés entre 35 et 74 ans, cette étude de cohorte analyse les disparités, entre zones rurales et zones urbaines, dans l'évolution de l'incidence de cancer et de la mortalité, sur la période 2008–2013

Cancer incidence and mortality: A cohort study in China, 2008–2013

Pan, Rui ; Zhu, Meng ; Yu, Canqing ; Lv, Jun ; Guo, Yu ; Bian, Zheng ; Yang, Ling ; Chen, Yiping ; Hu, Zhibin ; Chen, Zhengming ; Li, Liming ; Shen, Hongbing ; China Kadoorie Biobank Collaborative, Group

The National Central Cancer Registry of China (NCCR) was the only available source of cancer monitoring in China, even though only about 70% of cancer registration sites were qualified by now. In this study, based on a national large prospective cohort-the China Kadoorie Biobank (CKB), we aimed to provide additional cancer statistics and compare the difference of cancer burden between urban and rural areas of China. A total of 497,693 cancer-free participants aged 35–74 years were recruited and [...]

Menée aux Etats-Unis, cette étude analyse l'association entre le volume et la nature d'informations recherchées sur internet concernant le cancer, l'incidence des 8 types de cancers les plus fréquents entre 2009 et 2013 (selon le programme national des registres du cancer) et la mortalité

Correlation among cancer incidence and mortality rates and internet searches in the United States

Wehner, M. R. ; Nead, K. T. ; Linos, E.

Importance : Population-level disease metrics are critical to guide the distribution of resources and implementation of public health initiatives. Internet search data reflect population interest in health topics and may be an alternative metric of disease characteristics when traditional sources are lacking, such as in basal and squamous cell carcinomas, which are not included in national cancer registries. However, these data are not yet well validated or understood. Objective : To evaluate [...]

A partir des données de 13 registres américains des cancers sur la période 1992-2013, cette étude analyse l'évolution des disparités ethniques dans l'incidence du cancer de l'œsophage

Racial and Ethnic Disparities in the Incidence of Esophageal Cancer in the United States, 1992-2013

Shao-Hua Xie, ; Sirus Rabbani, ; Jessica Petrick, ; Michael B. Cook, ; Jesper Lagergren

Racial and ethnic disparities in the incidence of esophageal cancer have not been thoroughly characterized with quantitative health disparity measures. Using data from 13 cancer registries in the Surveillance, Epidemiology, and End Results database, we assessed such disparities by histological type during 1992-2013 in the United States based on a variety of disparity metrics. The age-standardized incidence rate of squamous cell carcinoma was highest among blacks, while adenocarcinoma mainly [...]

A partir d'une revue systématique de la littérature publiée entre 1990 et 2015, cette étude analyse la présence d'une infection par le papillomavirus humain, par sous-type histologique, dans les cas de carcinomes épidermoïdes de la vulve et dans les néoplasies intraépithéliales vulvaires (92 études, 5 015 cas de cancer, 2 764 cas de néoplasie intraépithéliale)

Prevalence and type distribution of human papillomavirus in squamous cell carcinoma and intraepithelial neoplasia of the vulva

Faber, Mette T. ; Sand, Freja L. ; Albieri, Vanna ; Norrild, Bodil ; Kjær, Susanne K. ; Verdoodt, Freija

In this updated systematic review and meta-analysis, we estimate the pooled prevalence of human papillomavirus (HPV) DNA and HPV type distribution in squamous cell carcinoma of the vulva (vulvar cancer) and vulvar intraepithelial neoplasia (VIN). PubMed, Embase and Cochrane Library databases were used to identify studies published between 1990 and 2015 and using a PCR-based or hybrid capture test to evaluate the presence of HPV DNA in vulvar cancer or VIN. Pooled estimates of the HPV prevalence [...]

Menée à partir de données portant sur 1 665 patients afro-américains et sur 2 791 patients de type caucasien atteints d'un cancer de la prostate, cette étude analyse les disparités ethniques dans la survie à long terme et dans le risque de récidive de la maladie après une prostatectomie radicale

Race and risk of metastases and survival after radical prostatectomy: Results from the SEARCH database

Freedland, Stephen J. ; Vidal, Adriana C. ; Howard, Lauren E. ; Terris, Martha K. ; Cooperberg, Matthew R. ; Amling, Christopher L. ; Kane, Christopher J. ; Aronson, William J. ; For the Shared Equal Access Regional Cancer Hospital Database Study, Group

BACKGROUND: Black race is associated with prostate cancer (PC) diagnosis and poor outcome. Previously, the authors reported that black men undergoing radical prostatectomy (RP) in equal-access hospitals had an increased risk of biochemical disease recurrence (BCR), but recurrences were equally aggressive as those occurring in white men. The authors examined the association between race and long-term outcomes after RP. METHODS: Data regarding 1665 black men (37%) and 2791 white men (63%) [...]

A partir d'une revue systématique de la littérature publiée entre 1960 et 2017, cette méta-analyse évalue les disparités dans la survie selon le sexe des patients atteints d'un cancer colorectal

Gender differences in colorectal cancer survival: A meta-analysis

Yang, Yafan ; Wang, Guiying ; He, Jingli ; Ren, Shuguang ; Wu, Fengpeng ; Zhang, Jianfeng ; Wang, Feifei

A meta-analysis was conducted to determine the influence of gender on overall survival (OS) and cancer-specific survival (CSS) in colorectal cancer patients. Major databases were searched for clinical trials, which compare survival differences between male and female for colorectal cancer patients. A list of these studies and references, published in English and Chinese from 1960 to 2017, was obtained independently by two reviewers from databases such as PubMed, Medline, ScienceDirect, the [...]

Mené aux Etats-Unis sur 48 835 participantes ménopausées, cet essai randomisé évalue l'efficacité, du point de vue de la réduction de la mortalité par cancer du sein, d'une intervention destinée à promouvoir un régime alimentaire faible en graisses (durée médiane de suivi : 16,1 ans ; 1 764 cas de cancers du sein et 134 décès par cancer)

Low-Fat Dietary Pattern and Breast Cancer Mortality in the Women’s Health Initiative Randomized Controlled Trial

Rowan T. Chlebowski ; Aaron K. Aragaki ; Garnet L. Anderson ; Cynthia A. Thomson ; JoAnn E. Manson ; Michael S. Simon ; Barbara V. Howard ; Thomas E. Rohan ; Linda Snetselar ; Dorothy Lane ; Wendy Barrington ; Mara Z. Vitolins ; Catherine Womack ; Lihong Qi ; Lifang Hou ; Fridtjof Thomas ; Ross L. Prentice

Purpose : Earlier Women’s Health Initiative Dietary Modification trial findings suggested that a low-fat eating pattern may reduce breast cancers with greater mortality. Therefore, as a primary outcome-related analysis from a randomized prevention trial, we examined the long-term influence of this intervention on deaths as a result of and after breast cancer during 8.5 years (median) of dietary intervention and cumulatively for all breast cancers diagnosed during 16.1 years (median) of [...]

Menée aux Etats-Unis auprès de 2 141 patients atteints de cancer, cette étude compare l'efficacité de deux questionnaires permettant de détecter leurs symptômes de dépression

The Hospital Anxiety and Depression Scale (HADS) and the 9-item Patient Health Questionnaire (PHQ-9) as screening instruments for depression in patients with cancer

Hartung, Tim J. ; Friedrich, Michael ; Johansen, Christoffer ; Wittchen, Hans-Ulrich ; Faller, Herman ; Koch, Uwe ; Brähler, Elmar ; Härter, Martin ; Keller, Monika ; Schulz, Holger ; Wegscheider, Karl ; Weis, Joachim ; Mehnert, Anja

BACKGROUND: Depression screening in patients with cancer is recommended by major clinical guidelines, although the evidence on individual screening tools is limited for this population. Here, the authors assess and compare the diagnostic accuracy of 2 established screening instruments: the depression modules of the 9-item Patient Health Questionnaire (PHQ-9) and the Hospital Anxiety and Depression Scale (HADS-D), in a representative sample of patients with cancer. METHODS: This multicenter [...]

A partir d'une revue systématique de la littérature (23 études incluant des patients ayant survécu à un cancer colorectal), cette étude analyse leurs perceptions relatives aux visites de suivi après les traitements curatifs et leurs préférences concernant le professionnel de santé effectuant ce suivi médical (médecin spécialiste, médecin généraliste, infirmière)

A systematic review of patient perspectives on surveillance after colorectal cancer treatment

Berian, Julia R. .. ; Cuddy, Amanda ; Francescatti, Amanda B. ; O’Dwyer, Linda ; Nancy You, Y. ; Volk, Robert J. ; Chang, George J.

Purpose : Surveillance after colorectal cancer (CRC) treatment is routine, but intensive follow-up may offer little-to-no overall survival benefit. Given the growing population of CRC survivors, we aimed to systematically evaluate the literature for the patient perspective on two questions: (1) How do CRC patients perceive routine surveillance following curative treatment and what do they expect to gain from their surveillance testing or visits? (2) Which providers (specialists, nursing, [...]

Cette étude analyse l'efficacité d'une application internet destinée au patient atteint de cancer pour déclarer ses symptômes et permettre au médecin de prendre en charge les effets indésirables pendant la phase des traitements

Development of an integrated electronic platform for patient self-report and management of adverse events during cancer treatment.

P. Holch, ; L. Warrington, ; L. Bamforth, ; A. Keding, ; L. Ziegler, ; K. Absolom, ; C. Hector, ; C. Harley, ; O. Johnson, ; G. Hall, ; C. Morris, ; G. Velikova

Background : Significant adverse events (AE) during cancer therapy disrupt treatment and escalate to emergency admissions. Approaches to improve the timeliness and accuracy of AE reporting may improve safety and reduce health service costs. Reporting AE via Patient Reported Outcomes (PROs), can improve clinician-patient communication and making data available to clinicians in ‘real time’ using electronic PROs (ePROs) could potentially transform clinical practice by providing easily-accessible [...]