Mené auprès de 2 303 femmes âgées de 55 ans ou plus (âge moyen : 65 ans, durée de suivi : 6 ans), cet essai évalue l'effet d'une supplémentation en vitamine D et en calcium sur le risque de cancer

Effect of vitamin D and calcium supplementation on cancer incidence in older women : A randomized clinical trial

Lappe, J. ; Watson, P. ; Travers-Gustafson, D. ; et al.,

Importance : Evidence suggests that low vitamin D status may increase the risk of cancer. Objective : To determine if dietary supplementation with vitamin D3 and calcium reduces the risk of cancer among older women. Design, Setting, and Participants : A 4-year, double-blind, placebo-controlled, population-based randomized clinical trial in 31 rural counties (June 24, 2009, to August 26, 2015—the final date of follow-up). A total of 2303 healthy postmenopausal women 55 years or older were [...]

Mené auprès de 2 303 femmes âgées de 55 ans ou plus (âge moyen : 65 ans, durée de suivi : 6 ans), cet essai évalue l'effet d'une supplémentation en vitamine D et en calcium sur le risque de cancer

Vitamin D, calcium, and cancer: Approaching daylight ?

Manson, J. E. ; Bassuk, S. S. ; Buring, J. E.

Vitamin D and calcium, long recognized as important for bone health, have attracted clinical interest in recent years for their potential nonskeletal benefits, including cancer prevention. Despite this enthusiasm, however, few completed randomized clinical trials of supplemental vitamin D administered with or without calcium have examined cancer end points, and no previously completed trial has reported cancer as a primary prespecified outcome. Moreover, few randomized trials have tested high [...]

Menée sur une cohorte danoise incluant 8 325 femmes enceintes, cette étude évalue l'association entre une vaccination quadrivalente contre le papillomavirus humain administrée par inadvertance durant une grossesse et le risque d'événements indésirables (avortement spontané, naissance prématurée, enfant mort-né, ...)

Quadrivalent HPV Vaccination and the Risk of Adverse Pregnancy Outcomes

Scheller, Nikolai M. ; Pasternak, Björn ; Mølgaard-Nielsen, Ditte ; Svanström, Henrik ; Hviid, Anders

Background : The quadrivalent human papillomavirus (HPV) vaccine is recommended for all girls and women 9 to 26 years of age. Some women will have inadvertent exposure to vaccination during early pregnancy, but few data exist regarding the safety of the quadrivalent HPV vaccine in this context. Methods : We assessed a cohort that included all the women in Denmark who had a pregnancy ending between October 1, 2006, and November 30, 2013. Using nationwide registers, we linked information on [...]

Menée sur une cohorte danoise incluant 8 325 femmes enceintes, cette étude évalue l'association entre une vaccination quadrivalente contre le papillomavirus humain administrée par inadvertance durant une grossesse et le risque d'événements indésirables (avortement spontané, naissance prématurée, enfant mort-né, ...)

Ensuring Vaccine Safety in Pregnant Women

Edwards, Kathryn M.

In this issue of the Journal, investigators from Denmark present a comprehensive review of the adverse pregnancy outcomes encountered in women who received quadrivalent human papillomavirus (HPV) vaccine during pregnancy, as compared with those who did not.1 The investigators assembled data on all the pregnancies in Denmark that occurred within a 7-year period, and they used nationwide registries to identify the dates of pregnancy, pregnancy outcomes, and maternal characteristics, including [...]