A partir d'une revue systématique de la littérature publiée jusqu'en avril 2016 (40 études), cette étude analyse, chez les adolescents, les jeunes adultes et les adultes, les perceptions et les comportements vis-à-vis des produits tabagiques aromatisés sans menthol

Impact of non-menthol flavours in tobacco products on perceptions and use among youth, young adults and adults : a systematic review

Huang, Li-Ling ; Baker, Hannah M. ; Meernik, Clare ; Ranney, Leah M. ; Richardson, Amanda ; Goldstein, Adam O.

Objective : This systematic review examines the impact of non-menthol flavours in tobacco products on tobacco use perceptions and behaviours among youth, young adults and adults. Data sources : English-language peer-reviewed publications indexed in 4 databases were searched through April 2016. Study selection : A search strategy was developed related to tobacco products and flavours. Of 1688 articles identified, we excluded articles that were not English-language, were not peer-reviewed, were [...]

Menée au Danemark auprès d'une cohorte de 27 178 hommes, cette étude évalue l'association entre la consommation de poisson et le risque de cancer de la prostate (1 690 cas) ou de décès par la maladie (228 cas) ou autres causes (136 cas)

Fish consumption and prostate cancer risk and mortality in a Danish cohort study

Outzen, Malene ; Tjønneland, Anne ; Christensen, Jane ; Olsen, Anja

Within the Danish 'Diet, Cancer and Health' cohort, we aimed to investigate the association between prediagnostic fish intake (total, lean, fatty) and (a) incidence of total and high-grade prostate cancer and (b) the risk of all-cause and prostate cancer-specific mortality among men with prostate cancer. Among 27 178 men, 1690 prostate cancer cases were identified through 2012. Of these, 1042 had a Gleason score of 7 or above and 498 had a Gleason score of 8 or above at the time of diagnosis; [...]

Menée à partir de données britanniques portant sur 547 566 personnes (durée de suivi : 3 040 332 personnes-années), cette étude évalue l'association entre l'utilisation de médicaments agissant sur le système rénine-angiotensine et le risque de cancer du pancréas

The use of drugs acting on the renin-angiotensin system and the incidence of pancreatic cancer

Mandilaras, Victoria ; Bouganim, Nathaniel ; Yin, Hui ; Asselah, Jamil ; Azoulay, Laurent

Background : Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are commonly used antihypertensives. Recently, these drugs have been associated with a protective effect against pancreatic cancer, but data on this putative association remain limited. Thus, the objective of this study was to determine whether the use of ACEIs and/or ARBs is associated with a decreased risk of pancreatic cancer. Methods : We conducted a population-based cohort study, using a [...]

Menée in vitro et à l'aide de modèles murins, cette étude française met en évidence un mécanisme par lequel la vitamine D3 bloque la progression, induite par le calcium, des tumeurs prostatiques de stade précoce en agissant sur l'expression des canaux cationiques TRPC6 et des récepteurs sensibles au calcium

Vitamin D3 prevents calcium-induced progression of early-stage prostate tumors by counteracting TRPC6 and calcium sensing receptor upregulation

Bernichtein, Sophie ; Pigat, Natascha ; Barry Delongchamps, Nicolas ; Boutillon, Florence ; Verkarre, Virginie ; Camparo, Philippe ; Reyes-Gomez, Edouard ; Méjean, Arnaud ; Oudard, Stephane Marie ; Lepicard, Eve M. ; Viltard, Melanie ; Souberbielle, Jean-Claude ; Friedlander, Gerard ; Capiod, Thierry ; Goffin, Vincent

Active surveillance has emerged as an alternative to immediate treatment for men with low-risk prostate cancer. Accordingly, identification of environmental factors that faciliate progression to more aggressive stages is critical for disease prevention. Although calcium-enriched diets have been speculated to increase prostate cancer risk, their impact on early-stage tumors remains unexplored. In this study, we addressed this issue with a large interventional animal study. Mouse models of fully [...]

Menée aux Etats-Unis auprès de 18 080 participants, cette étude évalue, du point de vue du taux de participants et du taux d'abstinence tabagique 42 jours après le début de l'intervention, l'intérêt d'un service en ligne automatisé délivrant par sms des messages d'encouragement ou des conseils pour arrêter de fumer

Analysing user-reported data for enhancement of SmokefreeTXT : a national text message smoking cessation intervention

Cole-Lewis, Heather ; Augustson, Erik ; Sanders, Amy ; Schwarz, Mary ; Geng, Yisong ; Coa, Kisha ; Hunt, Yvonne

Objective : This observational study highlights key insights related to participant engagement and cessation among adults who voluntarily subscribed to the nationwide US-based SmokefreeTXT program, a 42-day mobile phone text message smoking cessation program. Methods : Point prevalence abstinence rates were calculated for subscribers who initiated treatment in the program (n=18 080). The primary outcomes for this study were treatment completion and point prevalence abstinence rate at the end of [...]

Menée en Australie à partir d'enquêtes téléphoniques réalisées entre 2010 et 2013 auprès de 8 820 adolescents ou jeunes adultes (âge : 12 à 24 ans), cette étude analyse, en fonction du statut tabagique, leurs comportements vis-à-vis des produits du tabac avant et après l'introduction des paquets neutres

Australia's plain tobacco packs: anticipated and actual responses among adolescents and young adults 2010–2013

Dunlop, Sally ; Perez, Donna ; Dessaix, Anita ; Currow, David

Background : In December 2012, Australia introduced world-first legislation mandating plain packaging for all tobacco products. To date, there is very little evidence on youth responses to the changed packs. Aim : To assess attitudes towards, and responses to, tobacco plain packs preimplementation and postimplementation. Methods : The Tobacco Promotion Impact Study (TPIS) was a yearly cross-sectional telephone survey of adolescents and young adults (12–24 years) from the states of New South [...]